全文获取类型
收费全文 | 11692篇 |
免费 | 614篇 |
国内免费 | 61篇 |
学科分类
医药卫生 | 12367篇 |
出版年
2023年 | 75篇 |
2022年 | 162篇 |
2021年 | 334篇 |
2020年 | 166篇 |
2019年 | 283篇 |
2018年 | 317篇 |
2017年 | 254篇 |
2016年 | 239篇 |
2015年 | 288篇 |
2014年 | 345篇 |
2013年 | 496篇 |
2012年 | 774篇 |
2011年 | 765篇 |
2010年 | 437篇 |
2009年 | 378篇 |
2008年 | 696篇 |
2007年 | 710篇 |
2006年 | 737篇 |
2005年 | 665篇 |
2004年 | 588篇 |
2003年 | 581篇 |
2002年 | 538篇 |
2001年 | 291篇 |
2000年 | 236篇 |
1999年 | 205篇 |
1998年 | 123篇 |
1997年 | 93篇 |
1996年 | 104篇 |
1995年 | 63篇 |
1994年 | 54篇 |
1993年 | 32篇 |
1992年 | 132篇 |
1991年 | 104篇 |
1990年 | 94篇 |
1989年 | 109篇 |
1988年 | 116篇 |
1987年 | 82篇 |
1986年 | 77篇 |
1985年 | 71篇 |
1984年 | 64篇 |
1983年 | 35篇 |
1982年 | 34篇 |
1981年 | 29篇 |
1979年 | 32篇 |
1978年 | 38篇 |
1977年 | 23篇 |
1976年 | 29篇 |
1975年 | 27篇 |
1974年 | 29篇 |
1973年 | 37篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
1.
2.
Esparza-Gordillo Jorge; Goicoechea de Jorge Elena; Buil Alfonso; Berges Luis Carreras; Lopez-Trascasa Margarita; Sanchez-Corral Pilar; Rodriguez de Cordoba Santiago 《Human molecular genetics》2005,14(8):1107
Some MCP SNP and aHUS-associated MCP mutation 相似文献
3.
4.
Ruben A. Mesa MD Alfonso Quintás-Cardama MD Srdan Verstovsek MD PhD 《Current hematologic malignancy reports》2007,2(1):25-33
Myelofibrosis with myeloid metaplasia (MMM) is currently classified as a classic (ie, BCR-ABL-negative) myeloproliferative
disorder characterized by anemia, multiorgan extramedullary hematopoiesis, constitutional symptoms, and premature death from
either leukemic transformation or other disease complications. Stem cell transplantation can be curative, but many patients
either are not appropriate candidates or do not choose to accept the significant risks associated with transplantation. Current
pharmacologic therapy has been beneficial mainly in terms of palliating disease-associated cytopenias, constitutional symptoms,
splenomegaly, and other organ damage from excess myeloproliferation. Novel treatment strategies are under investigation, including
targeted inhibition of JAK2V617F, the activating tyrosine kinase point mutation present in about half of patients with MMM. In this article, we review both
the old and new pharmacologic options for MMM. 相似文献
5.
Jose M. Fernández-Cebrián Peter Vorwald Kuborn Mar Pardo de Lama Alfonso Sanjuanbenito Dehesa Manuel Nevado Santos Pedro A. Pacheco Martínez Beatriz Fernández-Escudero 《Clinical & translational oncology》2005,7(3):101-109
Colorectal cancer is one of the best studied of all malignant diseases interms of genetics and/or molecular prognostic factors. These factors, and relationships with prognosis, may have important implications especially in the design of surgical and adjuvant chemo-radiotherapy options. However, the true prognostic significance of all known factors has yet to be realised. We have reviewed the literature with specific focus on the role of molecular markers involved in prognosis and the prediction of response to adjuvant treatment. 相似文献
6.
Hilda A. Perez Carmen Bracho Mirtha Romano Mercedes De la Rosa 《Parasitology research》1997,83(3):246-251
A monoclonal antibody raised by immunization of BALB/c mice with erythrocytic stages of Plasmodium vivax was shown to react with asexual erythrocytic stages of P. chabaudi. The cross-reactivity molecules are antigens of 200 and 148 kDa in P. vivax and of 190 and 70 kDa in P. chabaudi. Immunofluorescence studies of the erythrocytic stages of P. vivax and P. chabaudi indicated that expression of these antigens increased as the parasites' developed from the ring stage to the schizont stage.
In the mature trophozoites of P. chabaudi, immunoelectron microscopy revealed clusters of antigen distributed in the cytoplasm of the parasitized erythrocyte. In the
schizont, packets of antigen were found associated with the parasitophorous vacuole and the cytoplasm of the infected host
cell.
Received: 19 March 1996 / Accepted: 28 August 1996 相似文献
7.
H S Matloub C D Prevel J R Sanger N J Yousif C A Devine J Romano 《Annals of plastic surgery》1992,29(6):559-563
Several articles have been published that bring attention to the destructive potential of tire explosions. Although the severity of tire explosion injuries to the head and neck region is well established, only one previous article has reported injuries to the upper extremity. Fourteen patients with upper extremity tire explosion injuries have been treated by us from 1980 to 1988. Each injury was caused by single-piece wheel assemblies, as opposed to multipiece wheel assemblies, which have traditionally been associated with the injury. Three representative patient reports are discussed. Prevention of this injury can be achieved by increased public awareness, formal industrial safety training, tire servicing with dedicated equipment including restraining devices or barriers, complete evaluation of wheel/tire serviceability before tire mounting, separation of servicing of single and multipiece wheels, and complete tire deflation before servicing. 相似文献
8.
9.
Alfonso Ruiz-Bravo Khalil Kouwatli Gerardo Alvarez de Cienfuegos Alberto Ramos-Cormenzana 《Immunology letters》1981,3(1):39-43
Mice pretreated with Bacillus megaterium ATCC 33085 grown on TSA medium developed a significant increase in primary antibody response to SRBC. Conversely, pretreatment with a spore suspension harvested from nutrient Agar medium decreased this antibody response. A suspension of organisms grown on a defined, phosphorus-deficient medium (P-Medium) had no effect. Otherwise, only the spore suspension was able to enhance the contact sensitivity to dinitrofluorobenzene. Peritoneal leucocyte numbers were increased by inoculation with both TSA-cultured bacteria and the spore suspension, but not by P-Medium-cultured bacteria. Administration of both the spore suspension and P-Medium-cultured bacteria decreased the in vitro phagocytosis by peritoneal adherent cells. These immunomodulator properties are discussed in relation to characteristics of the strain tested. 相似文献
10.