Graphical representation of survival curves in the presence of time-dependent categorical covariates with application to liver transplantation

Graphical representation of survival curves is often used to illustrate associations between exposures and time-to-event outcomes. However, when exposures are time-dependent, calculation of survival probabilities is not straightforward. Our aim was to develop a method to estimate time-dependent survival probabilities and represent them graphically. Cox models with time-dependent indicators to represent state changes were fitted, and survival probabilities were plotted using pre-specified times of state changes. Time-varying hazard ratios for the state change were also explored. The method was applied to data from the Adult-to-Adult Living Donor Liver Transplantation Cohort Study (A2ALL). Survival curves showing a ‘split’ at a pre-specified time t allow for the qualitative comparison of survival probabilities between patients with similar baseline covariates who do and do not experience a state change at time t. Time since state change interactions can be visually represented to reflect changing hazard ratios over time. A2ALL study results showed differences in survival probabilities among those who did not receive a transplant, received a living donor transplant, and received a deceased donor transplant. These graphical representations of survival curves with time-dependent indicators improve upon previous methods and allow for clinically meaningful interpretation.     

Measuring the lifetime experience of domestic violence: application of the life history calendar method

In the absence of a "gold standard," research on domestic violence relies primarily on self-report, the quality of which is known to decline as the length of the recall period increases. Eliciting valid and reliable self-report data is crucial to the development of prevention and intervention policies and services. Nevertheless, existing measures typically do not incorporate devices to facilitate respondents' recall of the lifetime experience of domestic violence. This article describes the application of the Life History Calendar (LHC) method (Freedman, Thornton, Camburn, Alwin, & Young-DeMarco, 1988) to increase a respondent's recall of domestic violence victimization over the lifecourse. The LHC method elicits memorable information of a personal nature (e.g., children's birth dates) and uses this information to facilitate the recall of less memorable events. A recent field test of this LHC measure indicates its utility in assessing domestic violence victimization, which takes place in a complex sequence of episodes and often involves multiple perpetrators over the lifecourse.     

How parental drug use and drug treatment compliance relate to family reunification

This study uses Cox regression to assess the relationships among parental drug use, drug treatment compliance, and reunification from substitute care. The study finds that drug treatment compliance is associated with faster reunification, even when accounting for ongoing drug use and three parenting measures. The findings are consistent with a conceptual framework suggesting that certain client actions, such as drug treatment compliance, may serve as markers that substantially affect client outcomes.     

简论女丹修炼的特殊机理

女丹功法,又称"坤诀",是指妇女修炼内丹之法。女性之内丹修炼活动虽可追溯至唐代,但其学说成熟则较晚。男女两性存在着生理和心理上的差异,因此,内丹修炼在功法和步骤上也应有所区别。传统中医学原理可以帮助我们阐释女丹修炼程序及"斩赤龙"的特殊机理及其意义。女丹功法的关键步骤为"太阴炼形"之术,其关窍为膻中穴和血海;"阳神出壳"是女子丹功炼至最高层次时所出现的现象,炼功者此时要格外谨慎。     

Lightning strikes twice: Lessons learned from two food poisoning incidents in Japan

This case study examines the unique occurrence of two food contamination crises at Snow Brand Milk Products Co., Ltd., the top company in the Japanese milk product industry. The separate incidents of food poisoning occurred in 1955 and 2000; the latter incident, involving more than 10,000 victims, was the worst case of food poisoning in Japanese history.     

Cognitive therapy and behavioural coping in the management of work-related stress: An intervention study

Transactional models of stress emphasize the importance of cognitive appraisal of potential stressors in the determination of the stress response. This appraisal can be modified by the use of techniques normally associated with cognitive therapy. The contribution of a specifically cognitive component when intervening in work-related stress has not been well evaluated to date. This research seeks to determine the effectiveness of stress management training in the treatment of the work-related effects of stress by comparing the role of modifying dysfunctional cognitions with the teaching of appropriate behavioural coping strategies. Participants were allocated to one of two intervention conditions or to a waiting list control group. Those in the intervention conditions received group stress management either with the focus on delivering cognitive therapy techniques or with the focus on behavioural coping skills. Measures of general health were taken at the beginning and end of intervention and at 3-month follow-up. Participants in the cognitive therapy groups who were reporting symptoms of general ill-health at the start of the intervention showed a significant improvement at follow-up. Cognitive therapy appears to have been an effective intervention in work-related stress. Those in the behavioural group showed a smaller but still clinically effective improvement. Results are discussed in terms of methodological issues and implications for future research. It is suggested that changes in cognitive appraisal may need to be developed.     

The challenges of incorporating Muslim women's views into development policy: analysis of a Dutch action research project in Yemen

This article discusses the Muslim Women and Development Action Research Project (MWDAR), an attempt by the Dutch government to introduce new discourses on Islam and the empowerment of women into their development policy. Based on a discussion of the project in Yemen, an analysis of its evaluation reports, and follow-up research with project participants, we argue that the project did not meet expectations or project goals because it failed to go beyond an essentialist view of Muslim women. The article begins with a discussion of Dutch and Yemeni discourses on gender, Islam and development, and goes on to explore how these discourses ultimately influenced the project outcomes.     

Self‐Awareness in Human and Chimpanzee Infants: What Is Measured and What Is Meant by the Mark and Mirror Test?

The objective study of self‐recognition, with a mirror and a mark applied to the face, was conducted independently by Gallup (1970) for use with chimpanzees and monkeys, and by Amsterdam (1972) for use with infant humans. Comparative psychologists have followed the model (and assumptions) set by Gallup, whereas developmental psychologists have followed a different model (e.g., Lewis & Brooks‐Gunn, 1979). This article explores the assumptions in the definitions and methods of self‐recognition assessments in the 30 years since these initial studies, and charts the divergence between the developmental mark test and the comparative mark test. Two new studies, 1 with infant chimpanzees and 1 with infant humans, illustrate a reconciliation of the 2 approaches. Overt application of the mark, or other procedures related to how the mark is discovered, did not enhance mirror self‐recognition. In contrast, maternal scaffolding appears to enhance performance, perhaps by eliciting well‐rehearsed verbal responses (i.e., naming self). When comparable testing procedures and assessment criteria are used, chimpanzee and human infants perform comparably. A combined developmental comparative approach allows us to suggest that mirror self‐recognition may be based on a specific aspect of mental representation, the cognitive ability to symbolize.