Paediatric gastro-oesophageal reflux: prognostic indicators from pH monitoring

The original diagnostic 24 hour pH monitoring data in 57 children with gastro-oesophageal reflux (GOR) were retrospectively reviewed after a minimum of one year follow up. The tracings of children who responded to medical treatment were compared with those who failed to respond and required a fundoplication. Children with GOR secondary to oesophageal atresia/tracheo-oesophageal fistula and neurological conditions (n = 12) were analysed separately from those with primary GOR (n = 45). Children with primary GOR requiring a fundoplication (n = 9) had increased daytime reflux. The percentage time pH < 4 was the best discriminator (21% v 7%) with a threshold of 18% giving a 92% specificity and a 70% sensitivity. For children with secondary GOR the percentage time pH < 4 at night was significantly higher (29% v 3.7%) in those requiring a fundoplication (n = 5). A threshold of 18% gave an 80% specificity and an 86% sensitivity. These results show that both daytime and night time pH monitoring data can be of prognostic value in different subgroups of children with GOR. A percentage time pH < 4 of greater than 18% was a useful threshold to apply when evaluating the pH monitoring data.     

Generic and efficient framework for search trees on flash memory storage systems

Tree index structures are crucial components in data management systems. Existing tree index structure are designed with the implicit assumption that the underlying external memory storage is the conventional magnetic hard disk drives. This assumption is going to be invalid soon, as flash memory storage is increasingly adopted as the main storage media in mobile devices, digital cameras, embedded sensors, and notebooks. Though it is direct and simple to port existing tree index structures on the flash memory storage, that direct approach does not consider the unique characteristics of flash memory, i.e., slow write operations, and erase-before-update property, which would result in a sub optimal performance. In this paper, we introduce FAST (i.e., Flash-Aware Search Trees) as a generic framework for flash-aware tree index structures. FAST distinguishes itself from all previous attempts of flash memory indexing in two aspects: (1) FAST is a generic framework that can be applied to a wide class of data partitioning tree structures including R-tree and its variants, and (2) FAST achieves both efficiency and durability of read and write flash operations through memory flushing and crash recovery techniques. Extensive experimental results, based on an actual implementation of FAST inside the GiST index structure in PostgreSQL, show that FAST achieves better performance than its competitors.     

Catastrophic Failure of a Steel Chimney in a Lime Plant

Failure analysis of a steel chimney used in a lime plant was carried out. The chimney broke from two different locations during a storm. During the site visit, it was observed that the chimney was dislodged from weld joints. The chimney was made up of hot rolled mild steel plates. Investigations were carried out on the failed chimney plate and welding between plates. The investigation consists of visual observation, chemical analysis, characterization of macro- and microstructures, measurement of hardness, tensile property tests and energy-dispersive spectroscopy (EDS). Calculation of wind load at the location of breakage was also carried out. EDS analysis revealed entrapment of slag inside weld. Overall analysis suggested that the failure took place due to selection of improper reconditioning technique as well as poor workmanship in welding.     

Polyelectrolyte multilayers for bio‐applications: recent advancements

The synergistic relationship between structure and the bulk properties of polyelectrolyte multilayer (PEM) films has generated tremendous interest in their application for loading and release of bioactive species. Layer‐by‐layer assembly is the simplest, cost effective process for fabrication of such PEMs films, leading to one of the most widely accepted platforms for incorporating biological molecules with nanometre precision. The bulk reservoir properties of PEM films render them a potential candidate for applications such as biosensing, drug delivery and tissue engineering. Various biomolecules such as proteins, DNA, RNA or other desired molecules can be incorporated into the PEM stack via electrostatic interactions and various other secondary interactions such as hydrophobic interactions. The location and availability of the biological molecules within the PEM stack mediates its applicability in various fields of biomedical engineering such as programmed drug delivery. The development of advanced technologies for biomedical applications using PEM films has seen rapid progress recently. This review briefly summarises the recent successes of PEM being utilised for diverse bio‐applications.Inspec keywords: polymer electrolytes, multilayers, polymer films, molecular biophysics, biomedical materials, biochemistryOther keywords: bioapplications, polyelectrolyte multilayer films, bioactive species, layer‐by‐layer assembly, biological molecules, biosensing, drug delivery, tissue engineering, biomolecules, proteins, DNA, RNA, electrostatic interactions, secondary interactions, hydrophobic interactions, biomedical engineering, programmed drug delivery, biomedical applications, PEM films     

Electrochemical Behavior of Single CuO Nanoparticles: Implications for the Assessment of their Environmental Fate

The electrochemical behavior of copper oxide nanoparticles is investigated at both the single particle and at the ensemble level in neutral aqueous solutions through the electrode‐particle collision method and cyclic voltammetry, respectively. The influence of Cl^? and NO₃^? anions on the electrochemical processes occurring at the nanoparticles is further evaluated. The electroactivity of CuO nanoparticles is found to differ between the two types of experiments. At the single‐particle scale, the reduction of the CuO nanoparticles proceeds to a higher extent in the presence of chloride ion than of nitrate ion containing solutions. However, at the multiparticle scale the CuO reduction proceeds to the same extent regardless of the type of anions present in solution. The implications for assessing realistically the environmental fate and therefore the toxicity of metal‐based nanoparticles in general, and copper‐based nanoparticles in particular, are discussed.     

Thin film evaporation in microchannels with interfacial slip

We investigate the role of interfacial slip on evaporation of a thin liquid film in a microfluidic channel. The effective slip mechanism is attributed to the formation of a depleted layer adhering to the substrate–fluid interface, either in a continuum or in a rarefied gas regime, as a consequence of intricate hydrophobic interactions in the narrow confinement. We appeal to the fundamental principles of conservation in relating the evaporation mechanisms with fluid flow and heat transfer over interfacial scales. We obtain semi-analytical solutions of the pertinent governing equations, with coupled heat and mass transfer boundary conditions at the liquid–vapor interface. We observe that a general consequence of interfacial slip is to elongate the liquid film, thereby leading to a film thickening effect. Thicker liquid films, in turn, result in lower heat transfer rates from the wall to liquid film, and consequently lower mass transfer rates from the liquid film to the vapor phase. Nevertheless, the total mass of evaporation (or equivalently, the net heat transfer) turns out to be higher in case of interfacial slip due to the longer film length. We also develop significant physical insights on the implications of the relative thickness of the depleted layer with reference to characteristic length scales of the microfluidic channel on the evaporation process, under combined influences of the capillary pressure, disjoining pressure, and the driving temperature differential for the interfacial transport.     

A general framework for efficient geographic routing in wireless networks

We propose a new link metric called normalized advance (NADV) for geographic routing in multihop wireless networks. NADV selects neighbors with the optimal trade-off between proximity and link cost. Coupled with the local next hop decision in geographic routing, NADV enables an adaptive and efficient cost-aware routing strategy. Depending on the objective or message priority, applications can use the NADV framework to minimize various types of link cost.We present efficient methods for link cost estimation and perform detailed experiments in simulated environments. Our results show that NADV outperforms current schemes in many aspects: for example, in high noise environments with frequent packet losses, the use of NADV leads to 81% higher delivery ratio. When compared to centralized routing under certain settings, geographic routing using NADV finds paths whose cost is close to the optimum. We also conducted experiments in Emulab testbed and the results demonstrate that our proposed approach performs well in practice.     

In-house contamination of potable water in urban slum of Kolkata, India: a possible transmission route of diarrhea

We have investigated and determined the potentiality of different water sources, both for drinking and domestic purposes, in diarrheal disease transmission in diarrhea endemic foci of urban slums in Kolkata, India in a one and half year prospective study. Out of 517 water samples, collected from different sources, stored water (washing) showed higher prevalence of fecal coliforms (58%) (p < 0.0001) in comparison with stored (drinking) samples (28%) and tap/tubewell water (8%) respectively. Among different sources, stored water (washing) samples had the highest non-permissible range of physico-chemical parameters. Fecal coliform levels in household water containers (washing) were comparatively high and almost 2/3 of these samples failed to reach the satisfactory level of residual chlorine. Interestingly, 7% stored water (washing) samples were found to be harboring Vibrio cholerae Improper usage of stored water and unsafe/poor sanitation practices such as hand washing etc. are highlighted as contributory factors for sustained diarrheal episodes. Vulnerability of stored water for domestic usage, a hitherto unexplored source, at domiciliary level in an urban slum where enteric infections are endemic, is reported for the first time. This attempt highlights the impact of quality of stored water at domiciliary level for fecal-oral contamination vis-à-vis disease transmission.     

Effect of near-critical swirl on the Burke-Schumann reaction sheet

The influence of swirl on the shape of the Burke-Schumann reaction sheet in a straight cylindrical pipe is investigated by asymptotic and numerical means. Attention is confined to swirl levels that are near the critical value at which vortex breakdown occurs. A high-Reynolds-number, laminar, isothermal, low-Mach-number reacting flow is considered. An asymptotic analysis is developed to study the nonlinear interaction between near-critical swirl and mixture fraction distribution within the flow. It is first shown that leading-order perturbation of the velocity field from the columnar state, generated by the interaction of near-critical swirl and low viscosity, can be described by a nonlinear reduced-order model. This flow perturbation is computed, and then employed to determine the correction to the classical Burke-Schumann solution. Under lean conditions of reaction the reaction sheet becomes shorter and more compact as swirl is increased. For rich conditions of reaction, increasing swirl first causes the reaction-sheet length to decrease, and then increase after vortex breakdown has appeared. Numerical simulations of the flow and reaction-zone shape are substantiated by, and supplement, the asymptotic results.     

Robust H∞ stabilization via parametrized Lyapunovbounds

The parametrized Lyapunov bounding technique of Haddad and Bernstein (1991, 1993, 1995) is extended to include an H_∞ -disturbance attenuation constraint. The results presented in this paper provide a framework for designing fixed-order (i.e., full- and reduced-order) controllers that guarantee robust H₂ and H_∞ performance in the presence of structured constant real parameter variations in the state space model