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排序方式: 共有160条查询结果,搜索用时 15 毫秒
1.
Raquel Alves dos Santos Teresinha Rosa Cabral Isabel Rosa Cabral Lusania Maria Greggi Antunes Cristiane Pontes Andrade Plínio Cerqueira dos Santos Cardoso Marcelo de Oliveira Bahia Claudia Pessoa José Luis Martins do Nascimento Rommel Rodríguez Burbano Catarina Satie Takahashi 《Biocell》2008,32(2):195-200
Physalis angulata L (Solanaceae) is a medicinal plant from North of Brazil, whose different extracts and infusions are commonly used in the popular medicine for the treatment of malaria, asthma, hepatitis, dermatitis and rheumatism. However, the genotoxic effects of P. angulata on human cells is not well known. The main purpose of the present study was to evaluate the in vitro genotoxic effects of aqueous extract of P. angulata using the comet assay and the micronucleus assay in human lymphocytes provided from 6 healthy donors. Treatments with P. angulata extracts were performed in vitro in order to access the extent of DNA damage. The comet assay has shown that treatments with P. angulata at 0.5, 1.0, 2.0, 3.0 and 6.0 microg/mL in culture medium were genotoxic. Lymphocytes treated with P. angulata at the concentrations of 3.0 and 6.0 microg/mL in culture medium showed a statistically significant increase in the frequency of micronucleus (p<0.05), however, the cytokinesis blocked proliferation index (CBPI) was not decreased after P. angulata treatment. In conclusion, the present work demonstrated the genotoxic effects of P. angulata extract on human lymphocytes in vitro. 相似文献
2.
Vanessa Migliorini Urban Ana Lucia Machado Carlos Eduardo Vergani Eunice Teresinha Giampaolo Ana Cláudia Pavarina Quezia Bezerra Cass 《应用聚合物科学杂志》2012,123(2):732-739
The effect of a post‐polymerization treatment on the leaching of methacrylic acid (MA) and benzoic acid (BA) from the reline resins [Kooliner (K), New Truliner (N), Ufi Gel hard (U), and Tokuso Rebase Fast (T)] was evaluated. Specimens of each material were divided into two groups: Group C (control) – left untreated; Group WB (water‐bath) – immersion in water at 55 ± 1°C for 10 min. Specimens were placed in artificial saliva at 37 ± 1°C and, after 1‐, 3‐, 5‐, 24‐h and 3‐, 7‐, 14‐, and 30‐day intervals, aliquots were removed and analyzed using high performance liquid chromatography. Data were analyzed by using Wilcoxon, Mann–Whitney or Kruskal–Wallis tests (α = 0.05). At 1 h, the concentration of MA released from U control specimens was higher than those of the other ones, and decreased after 3 h. WB specimens released lower amounts of MA than control specimens only for material U, at the 1‐ and 3‐h periods. For all control specimens, concentrations of leached BA progressively decreased within 5 h and from 24 h to the end. WB specimens released significantly lower amounts of BA than did the control groups. The highest concentration of MA was leached from control specimens of Ufi Gel hard. Water‐bath post‐polymerization treatment caused a significant reduction in elution of BA. © 2011 Wiley Periodicals, Inc. J Appl Polym Sci, 2011 相似文献
3.
Negar Naghavi Solange Temgoua Thibaud Hildebrandt Jean Franois Guillemoles Daniel Lincot 《Progress in Photovoltaics: Research and Applications》2015,23(12):1820-1827
The purpose of the present paper is to focus on the impact of oxygen gas partial pressure during the sputtering of i‐ZnO and ZnMgO on the transient behavior of Cu(In,Ga)Se2 (CIGSe) based solar cells parameters when a CBD‐Zn(S,O) buffer layer is used. Based on electrical characterization of cells, it is observed that the effect of light soaking is different on J–V characteristics depending on whether oxygen is or is not present during the first deposition time of the i‐ZnO or ZnMgO layers. In fact, when cells are prepared with standard i‐ZnO, the efficiencies are very low and a pronounced transient behavior is observed. However, when the first 10 nm of i‐ZnO or ZnMgO is formed by sputtered layer without adding oxygen during the process, depending on the thickness of the buffer layer, the transient effects strongly decreases. It is then possible to get stable cells reaching efficiencies quite similar to the CdS reference cells, especially with ZnMgO, without any post‐treatments. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
4.
A procedure based on the use of a quadrupole inductively coupled plasma-mass spectrometer equipped with a collision-reaction interface (CRI) for control of spectral overlap interferences was developed for simultaneous determination of Cd, Cr, Hg, and Pb in plastics from waste electrical and electronic equipment (WEEE). The injection of H(2) and He (80 and 60 mL min(-1), respectively) into the sampled plasma, colliding and reacting with potentially interfering polyatomic ions, allows interference-free determination of chromium via its isotopes (52)Cr and (53)Cr that are freed from overlap due to the occurrence of (40)Ar(12)C(+), (40)Ar(12)C(1)H(+), (36)S(16)O(+) or (1)H(36)S(16)O(+). Cadmium, Hg and Pb were directly determined via their isotopes (110)Cd, (111)Cd, (112)Cd, (199)Hg, (200)Hg, (201)Hg, (202)Hg, (206)Pb, (207)Pb, and (208)Pb, without using CRI. The CRI can be quickly activated or deactivated before each analyte measurement. Limits of detection for (52)Cr were 0.04 or 0.14 μg L(-1) with He or H(2) injected in CRI. Cadmium and Pb have LODs between 0.02 and 0.08 μg L(-1) and Hg had 0.93-0.98 μg L(-1), without using CRI. Analyte concentrations for samples varied from 16 to 43, 1 to 11, 4 to 12, and 5 to 13 mg kg(-1) for Cr, Cd, Hg and Pb, respectively. 相似文献
5.
Goren Y Davrath LR Pinhas I Toledo E Akselrod S 《IEEE transactions on bio-medical engineering》2006,53(1):35-42
Heart rate variability (HRV) is a major noninvasive technique for evaluating the autonomic nervous system (ANS). Use of time-frequency approach to analyze HRV allows investigating the ANS behavior from the power integrals, as a function of time, in both steady-state and non steady-state. Power integrals are examined mainly in the low-frequency and the high-frequency bands. Traditionally, constant boundaries are chosen to determine the frequency bands of interest. However, these ranges are individual, and can be strongly affected by physiologic conditions (body position, breathing frequency). In order to determine the dynamic boundaries of the frequency bands more accurately, especially during autonomic challenges, we developed an algorithm for the detection of individual time-dependent spectral boundaries (ITSB). The ITSB was tested on recordings from a series of standard autonomic maneuvers with rest periods between them, and the response to stand was compared to the known physiological response. A major advantage of the ITSB is the ability to reliably define the mid-frequency range, which provides the potential to investigate the physiologic importance of this range. 相似文献
6.
We investigate how to take advantage of the particular features of the calculus of inductive constructions in the framework of hardware verification. First, we emphasize in a short case study the use of dependent types and of the constructive aspect of the logic for specifying and synthesizing combinatorial circuits. Then, co-inductive types are introduced to model the temporal aspects of sequential synchronous devices. Moore and Mealy automata are co-inductively axiomatized and are used to represent uniformly both the structures and the behaviors of the circuits. This leads to clear, general and elegant proof processes as is illustrated on the example of a realistic circuit: the ATM Switch Fabric. All the proofs are carried out using Coq.Accepted in revised form 29 February 2004 by C.B. Jones 相似文献
7.
8.
Solange Mongoué-Tchokoté Jong-Sung Kim 《Computational statistics & data analysis》2008,52(9):4272-4286
Currently, there are some statistical software packages such as intcox, survBayes, and BITE that are designed to analyze current status data (in which failure times are known to be either left- or right-censored) based on the proportional hazards model. They, however, either fail to directly provide standard errors for the estimated regression parameters or require frailty terms. As a result, practitioners often analyze their data using packages for right-censored data. By so doing, they mistreat left-censored observations as exact. This paper describes our newly developed statistical software for the proportional hazards model with current status data. The software is implemented in the R and C languages and consists of the following two simple steps: (a) find MLEs of the regression parameter and the cumulative hazard function; (b) compute the variance-covariance matrix of the regression parameter estimator by using the generalized missing information principle (GMIP) developed by Kim [Kim, J.S., 2003b. Efficient estimation for the proportional hazards model with left-truncated and Case 1 interval-censored data. Statista Sinica 13 (2), 519-537]. Our simulation study results show that our method works well in terms of bias, standard error, and power. By treating current status data as right-censored data, we also show the discrepancy in terms of bias, standard error, and power. Real examples are provided to illustrate the use of the software. This method can be extended to both general interval-censored data and truncated and interval-censored data. 相似文献
9.
An Efficient Algorithm for Spectral Analysis of Heart Rate Variability 总被引:21,自引:0,他引:21
Berger Ronald D. Akselrod Solange Gordon David Cohen Richard J. 《IEEE transactions on bio-medical engineering》1986,(9):900-904
We present a simple efficient algorithm for the derivation of a heart rate signal from the electrocardiogram. We demonstrate that the amplitude spectrum of this heart rate signal more closely matches that of the input signal to an integral pulse frequency modulation (IPFM) model of the heart's pacemaker than do the spectra of other ECG-derived heart rate signals. The applicability of this algorithm in cross-spectral analysis between heart rate and other physiologic signals is also discussed. 相似文献
10.