Profiles of daily secretion of ACTH, beta-endorphins and cortisol in patients after minor craniocerebral trauma

In 12 men aged 20-25 men who had minor craniocerebral trauma the profiles of daily secretion of ACTH, beta-endorphin and cortisol were studied. The studies were carried out on the second day after the trauma. Plasma concentrations of the hormones were determined on 8.00, 12.00, 17.00 and 22.00 hours. Statistically significantly increased, in relation to healthy persons, (p < 0.01) values of plasma hormone concentration were found at all time points. In 50% of the patients (six cases) a disturbance was found of the profile of daily secretion of ACTH and beta-endorphin. The disturbance of the profile of cortisol secretion was found only in one patient.     

Optimization of ceramics bonding in the area of pressure sensor manufacturing

Ceramics joints are applied for producing products that should be made in a general shapes and dimensions for more advantageous usage. The article presents the research work related to ceramic joint quality evaluation, the thermal-structural analysis of ceramic joining and ceramic bond design and implementation. The role of ceramic material in the electronics industry and motivation for joining ceramics is described in the introduction. The requirements and methods for improving the quality of joints are summarized. Also, the results of simulations of pressure sensor cooling after removal from the oven during joining are discussed. The experimental results are evaluated by using a t-test before and after process cooling modification. Important directions for future research are summarized, with emphasis on the statistical determination of poor connection, and how the interface of modification of joint technology and process setting affects results and parameters that have been achieved.     

Characterisation of cut and chip behaviour for NR,SBR and BR compounds with an instrumented laboratory device

ABSTRACT

Understanding the cut and chip (CC) effect in rubber is important for successful product development for tires used in off-road or poor road conditions and for other demanding applications of rubber. This research describes a laboratory testing method for characterising the CC fracture behaviour of rubber using a device that controls and records multiple applied loads and displacements during cyclic impact to the surface of a solid rubber specimen to mimic and quantify the CC damage experienced by tire tread compounds. To study the capabilities of the instrument, three model compounds were studied that are based on carbon black reinforced compounds of common elastomers used in tire treads: natural rubber (NR), styrene-butadiene rubber (SBR), and butadiene rubber (BR). These polymers have well-established CC tendencies in field performance of tire treads, with NR exhibiting the best CC resistance followed by SBR and finally BR. The same trend was found with the rubber impact testing approach that allowed the CC behaviour to be quantified using a new physical parameter which is the CC propensity (P). The relative ranking for CC resistance for the three compounds followed the fatigue crack growth resistances of the materials but was exactly opposite to the ranking of DIN abrasion resistance. This provides evidence that CC damage from impact by mm-scale asperities and abrasion of rubber against μm-scale asperities exhibit distinct characteristics in rubber.     

Higher‐order extensions of a discontinuous Galerkin method for mid‐frequency Helmholtz problems

Recently, a discontinuous Galerkin method with plane wave basis functions and Lagrange multiplier degrees of freedom was proposed for the efficient solution of Helmholtz problems in the mid‐frequency regime. In this paper, this method is extended to higher‐order elements. Performance results obtained for various two‐dimensional problems highlight the advantages of these elements over classical higher‐order Galerkin elements such as Q₂ and Q₄ for the discretization of interior and exterior Helmholtz problems. Copyright © 2004 John Wiley & Sons, Ltd.     

A hybrid discontinuous in space and time Galerkin method for wave propagation problems

Medium‐frequency regime and multi‐scale wave propagation problems have been a subject of active research in computational acoustics recently. New techniques have attempted to overcome the limitations of existing discretization methods that tend to suffer from dispersion. One such technique, the discontinuous enrichment method, incorporates features of the governing partial differential equation in the approximation, in particular, the solutions of the homogeneous form of the equation. Here, based on this concept and by extension of a conventional space–time finite element method, a hybrid discontinuous Galerkin method (DGM) for the numerical solution of transient problems governed by the wave equation in two and three spatial dimensions is described. The discontinuous formulation in both space and time enables the use of solutions to the homogeneous wave equation in the approximation. In this contribution, within each finite element, the solutions in the form of polynomial waves are employed. The continuity of these polynomial waves is weakly enforced through suitably chosen Lagrange multipliers. Results for two‐dimensional and three‐dimensional problems, in both low‐frequency and medium‐frequency regimes, show that the proposed DGM outperforms the conventional space–time finite element method. Copyright © 2014 John Wiley & Sons, Ltd.     

The two-regime method for optimizing stochastic reaction–diffusion simulations

Spatial organization and noise play an important role in molecular systems biology. In recent years, a number of software packages have been developed for stochastic spatio-temporal simulation, ranging from detailed molecular-based approaches to less detailed compartment-based simulations. Compartment-based approaches yield quick and accurate mesoscopic results, but lack the level of detail that is characteristic of the computationally intensive molecular-based models. Often microscopic detail is only required in a small region (e.g. close to the cell membrane). Currently, the best way to achieve microscopic detail is to use a resource-intensive simulation over the whole domain. We develop the two-regime method (TRM) in which a molecular-based algorithm is used where desired and a compartment-based approach is used elsewhere. We present easy-to-implement coupling conditions which ensure that the TRM results have the same accuracy as a detailed molecular-based model in the whole simulation domain. Therefore, the TRM combines strengths of previously developed stochastic reaction–diffusion software to efficiently explore the behaviour of biological models. Illustrative examples and the mathematical justification of the TRM are also presented.     

Comparison of Isolated Indentation and Grid Indentation Methods for HVOF Sprayed Cermets

This paper compares the results of two approaches of instrumented indentation for characterization of mechanical properties of HVOF coatings. Three types of HVOF sprayed coatings (Cr₃C₂-NiCr, WC-Co, (Ti, Mo)(C,N)-NiCo) were investigated by the means of isolated nanoindentation and grid indentation methods. The results of the isolated indentation revealed hardness and elastic modulus of the individual phases in very good agreement with the corresponding bulk material. The grid indentation method, based on statistical evaluation of a large number of indentations, was influenced by the carbide-matrix interface, which gave rise to a third peak apart from the two peaks corresponding to the carbides and metallic matrix. As a consequence, the bimodal Gaussian fit was insufficient and a trimodal fit had to be used. The results extracted from low load grid nanoindentations were quite close to the results of isolated indentations whereas higher load grid nanoindentation revealed overall properties of the coating.     

The details matter: methodological nuances in the evaluation of student models

The core of student modeling research is about capturing the complex learning processes into an abstract mathematical model. The student modeling research, however, also involves important methodological aspects. Some of these aspects may seem like technical details not worth significant attention. However, the details matter. We discuss three important methodological issues in student modeling: the impact of data collection, the splitting of data into a training set and a test set, and the details concerning averaging in the computation of predictive accuracy metrics. We explicitly identify decisions involved in these steps, illustrate how these decisions can influence results of experiments, and discuss consequences for future research in student modeling.     

Long-term lining performance - Civil engineering problem of potential retrieval of buried spent nuclear fuel

The current solution for the spent fuel, high-level and long-lived radioactive waste is to store them at surface facilities from which they will be subsequently moved to a deep repository. No such repositories are in operation currently but several such facilities are close to the construction phase. A deep repository can be situated in several types of geological conditions including clay formations, salt sediments, argillites and tuffitic and granitic rocks. The character of the host rock is the key factor determining the design and specific requirements of individual components of such a facility. The future potential retrieval of canisters containing nuclear waste from the repository is a further influential factor. The reason for retrieval of containers lies in the development of fast reactors and increased interest for spent fuel reprocessing. Naturally, the decision as to whether retrievability is technically feasible must be made before finalising the design and construction process of the repository. If the decision is made to retrieve, a design which will include all the relevant safety aspects for the potential retrieval of canisters must be determined. The lay-out of the repository, the materials to be used and the design of the various structures of the facility (e.g. access tunnels, disposal shafts, buffer and backfill) are not the only issues to be addressed. The long-term stability of the system as a whole, i.e. of all the components, is crucial. Depending on the disposal concept chosen, the thermal load generated by the waste in the disposal container, saturation by water from the surrounding environment and the loading of the host rock massif will constitute the main processes which will affect the behaviour, safety and future functioning of the repository from the civil engineering point of view. The long-term stability of the lining of disposal galleries is a basic precondition for the safe removal of spent nuclear waste from deep underground repositories. The stability problems of tunnel linings exposed to long-term thermal load have not yet been properly addressed and form the subject of the European TIMODAZ project (Thermal Impact on the Damaged Zone around a Radioactive Waste Disposal in Clay Host Rocks) and also supported by the “Complex System of Methods for Directed Design and Assessment of Functional Properties of Building Materials” project. This paper describes the design, construction and currently available results of a 1:1 scale “in situ” disposal tunnel model which has been built at the Josef Underground Educational Facility in the Czech Republic.