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1.
Tested whether the global shape of objects can be processed without accessing semantic or identity information. Ss judged which of 2 fragmented forms had the same global shape as a reference stimulus. Matching stimuli could be physically identical, semantically related, or unrelated. The reference stimulus and nonmatching (distractor) form could be semantically related or unrelated. Similarity effects in the related condition were unconfounded with matches nameable and nonnameable forms. For nameable forms, related matching forms facilitated performance; a related distractor disrupted performance. Semantic interference was eliminated when nameable distractors were replaced with nonnameable partners; semantic similarity effects on matching were eliminated with a nonnameable reference stimulus and with inverted targets and distractors. Access to information concerning global shape does not normally occur without object identification. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
2.
Tohru Morii Hiroyuki Hamada Muriel Desaeger Akihiko Gotoh Atsushi Yokoyama Ignaas Verpoest Zen-ichiro Maekawa 《Composite Structures》1995,32(1-4):133-139
This study deals with the impact property and damage tolerance of matrix hybrid composite laminates with different laminate constitution. The matrix hybrid composite laminates consisted of the laminae with a conventional epoxy resin and the laminae with a flexible epoxy resin modified from the conventional resin to avoid the interlaminar delamination. The impact energy absorption ratio greatly depended on the matrix resin placed at the impact face. The energy absorption was almost constant if the conventional resin was placed at the impact surface layer, while it increased exponentially with the increasing fraction of the flexible resin if the flexible resin was placed at the impact face. The impact energy was absorbed by the damage development and propagation in the laminate with conventional resin laminae as the impacted face, while it was absorbed by both the recoverable deformation of the flexible resin and the damage propagation in the laminate with flexible resin laminae as the impacted face. 相似文献
3.
ABSTRACT: To protect and transport iron, we investigated the trapping properties of a network formed from β-lactoglobulin. We studied the influence of different parameters—pH, iron, and protein concentrations—on gel properties (optical and mechanical properties, WHC, and microstructure). For all conditions tested, the results show the formation of a cold gel in the presence of iron. The mechanical properties reveal that the elastic behavior and the strength of rupture increase with higher protein concentrations and decrease with higher iron concentrations. The water-holding capacity is high for low iron concentrations. The microstructure shows that, at low iron/protein ratios, a homogeneous filamentous network is obtained whereas, at high iron/protein ratios, more random aggregated particles are present. 相似文献
4.
Mônica Macedo-Rouet Muriel Ney Sandrine Charles Geneviève Lallich-Boidin 《Computers & Education》2009
The use of computers to deliver course-related materials is rapidly expanding in most universities. Yet the effects of computer vs. printed delivery modes on students’ performance and motivation are not yet fully known. We compared the impacts of Web vs. paper to deliver practice quizzes that require information search in lecture notes. Hundred and twenty two undergraduate students used either a web site or printed documents to answer 18 mathematics questions during a tutored session. A revised Web site was designed based on ergonomic criteria, to test the hypothesis that improved usability would decrease time spent on the task, the number of pages consulted, and students’ perceived cognitive load. The group working with printed documents had the highest performance. Furthermore, students perceived the paper materials as less effortful to read, and expressed preference for printing lecture notes and questions. However, students appreciated having a Web site available. No differences were found between the two sites. We conclude that Web delivery imposed higher perceived cognitive load due to the need to read lengthy documents. We suggest possible ways to improve Web-based practice materials, such as simultaneous display of questions and lecture notes. 相似文献
5.
Smail Meziani Messaouda Kaci Muriel Jacquot Jordane Jasniewski Pablo Ribotta Jean-Marc Muller Mohamed Ghoul Stéphane Desobry 《Journal of food engineering》2012
The frozen bakery market has grown significantly in developed countries over the past decade. 相似文献
6.
Savvas Petrou Terence M. Sloan Muriel Mewissen Thorsten Forster Michal Piotrowski Bartosz Dobrzelecki Peter Ghazal Arthur Trew Jon Hill 《Concurrency and Computation》2011,23(17):2258-2268
The statistical language R and its Bioconductor package are favoured by many biostatisticians for processing microarray data. The amount of data produced by some analyses has reached the limits of many common bioinformatics computing infrastructures. High Performance Computing systems offer a solution to this issue. The Simple Parallel R Interface (SPRINT) is a package that provides biostatisticians with easy access to High Performance Computing systems and allows the addition of parallelized functions to R. Previous work has established that the SPRINT implementation of an R permutation testing function has close to optimal scaling on up to 512 processors on a supercomputer. Access to supercomputers, however, is not always possible, and so the work presented here compares the performance of the SPRINT implementation on a supercomputer with benchmarks on a range of platforms including cloud resources and a common desktop machine with multiprocessing capabilities. Copyright © 2011 John Wiley & Sons, Ltd. 相似文献
7.
Pochet S Dugué L Labesse G Delepierre M Munier-Lehmann H 《Chembiochem : a European journal of chemical biology》2003,4(8):742-747
Thymidine monophosphate kinase (TMPK) from Mycobacterium tuberculosis (TMPKmt) is an attractive target for the design of specific inhibitors. This fact is the result of its key role in the thymidine pathway and of unique structural features in the active site observed by X-ray crystallography, especially in comparison to its human counterpart (TMPKh). Different 5-modified thymidine derivatives, as well as purine and pyrimidine analogues or C-nucleosides were tested on TMPKmt and TMPKh, and the results were rationalized by docking studies. 5-Halogenated 2'-deoxyuridines are the best inhibitors of TMPKmt found and present the highest selectivity indexes in favor of TMPKmt. 相似文献
8.
Indoloazepinone‐Constrained Oligomers as Cell‐Penetrating and Blood–Brain‐Barrier‐Permeating Compounds 下载免费PDF全文
Olivier Van der Poorten Dr. Baptiste Legrand Dr. Lubomir L. Vezenkov Dr. Júlia García‐Pindado Dr. Nadir Bettache Dr. Astrid Knuhtsen Prof. Dr. Daniel Sejer Pedersen Dr. Macarena Sánchez‐Navarro Prof. Dr. Jean Martinez Dr. Meritxell Teixidó Dr. Marcel Garcia Prof. Dr. Dirk Tourwé Dr. Muriel Amblard Dr. Steven Ballet 《Chembiochem : a European journal of chemical biology》2018,19(7):696-705
Non‐cationic and amphipathic indoloazepinone‐constrained (Aia) oligomers have been synthesized as new vectors for intracellular delivery. The conformational preferences of the [l ‐Aia‐Xxx]n oligomers were investigated by circular dichroism (CD) and NMR spectroscopy. Whereas Boc‐[l ‐Aia‐Gly]2,4‐OBn oligomers 12 and 13 and Boc‐[l ‐Aia‐β3‐h‐l ‐Ala]2,4‐OBn oligomers 16 and 17 were totally or partially disordered, Boc‐[l ‐Aia‐l ‐Ala]2‐OBn ( 14 ) induced a typical turn stabilized by C5‐ and C7‐membered H‐bond pseudo‐cycles and aromatic interactions. Boc‐[l ‐Aia‐l ‐Ala]4‐OBn ( 15 ) exhibited a unique structure with remarkable T‐shaped π‐stacking interactions involving the indole rings of the four l ‐Aia residues forming a dense hydrophobic cluster. All of the proposed FITC‐6‐Ahx‐[l ‐Aia‐Xxx]4‐NH2 oligomers 19 – 23 , with the exception of FITC‐6‐Ahx‐[l ‐Aia‐Gly]4‐NH2 ( 18 ), were internalized by MDA‐MB‐231 cells with higher efficiency than the positive references penetratin and Arg8. In parallel, the compounds of this series were successfully explored in an in vitro blood–brain barrier (BBB) permeation assay. Although no passive diffusion permeability was observed for any of the tested Ac‐[l ‐Aia‐Xxx]4‐NH2 oligomers in the PAMPA model, Ac‐[l ‐Aia‐l ‐Arg]4‐NH2 ( 26 ) showed significant permeation in the in vitro cell‐based human model of the BBB, suggesting an active mechanism of cell penetration. 相似文献
9.
Tristan F. Burns Kraft Barbara M. Schmidt G.G. Yousef Christopher T.G. Knight Muriel Cuendet Young-Hwa Kang John M. Pezzuto David S. Seigler Mary Ann Lila 《Journal of food science》2005,70(3):S159-S166
ABSTRACT: Wild lowbush blueberry fruit extract was fractionated using vacuum chromatography and analyzed for chemopreventive potential using bioassays that test the ability of compounds to inhibit the initiation, promotion, and progression stages of carcinogenesis. A fraction containing phytosterols was active against the initiation stage (quinone reductase assay). However, more polar compounds were inhibitors of later stages of carcinogenesis; a fraction containing flavan-3-ols and fractions containing mainly anthocyanins, phenolic acids, flavan-3-ols, and some proanthocyanidin dimers demonstrated activity against the promotion stage (cyclooxygenase and ornithine decarboxylase assays, respectively), and a proanthocyanidin-rich fraction demonstrated antiproliferation activity (inhibition of cancerous murine hepatocyte proliferation is associated with the progression stage). These results indicate that lowbush blueberries contain a range of compounds that have bioactivity against multiple stages of carcinogenesis, and different types of phenolic compounds are active at different stages. 相似文献
10.
Clémence Demangel Delphine Auzène Muriel Vayssade Jean-Luc Duval Pascale Vigneron Marie-Danièle Nagel Jean-Claude Puippe 《Materials science & engineering. C, Materials for biological applications》2012,32(7):1919-1925
Metal injection molding (MIM) is a near net shape manufacturing method that allows for the production of components of small to moderate size and complex shape. MIM is a cost-effective and flexible manufacturing technique that provides a large innovative potential over existing methods for the industry of implantable devices. Commercially pure titanium (CP-Ti) samples were machined to the same shape as a composite feedstock with titanium and polyoxymethylene, and these metals were injected, debinded and sintered to assess comparative biological properties. Moreover, we treated MIM-Ti parts with BIOCOAT®, BIODIZE® and BIOCER®, three different anodic oxidation techniques that treat titanium using acid, alkaline and anion enriched electrolytes, respectively. Cytocompatibility as well as morphological and chemical features of surfaces was comparatively assessed on each sample, and the results revealed that MIM-Ti compared to CP-Ti demonstrated a specific surface topography with a higher roughness. MIM-Ti and BIOCER® samples significantly enhanced cell proliferation, cell adhesion and cell differentiation compared to CP-Ti. Interestingly, in the anodization post-treatment established in this study, we demonstrated the ability to improve osseointegration through anionic modification treatment. The excellent biological response we observed with MIM parts using the injection molding process represents a promising manufacturing method for the future implantable devices in direct contact with bones. 相似文献