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1.
VN Dobrovolsky OV Lagutin TV Vinogradova IS Frolova VP Kuznetsov OA Larionov 《Canadian Metallurgical Quarterly》1993,319(1-2):181-184
Transgenic mice carrying a hybrid gene consisting of ovine beta-lactoglobulin gene sequences and human gamma-interferon (hIFN-g) cDNA were produced. hIFN-g expression in the mammary gland of two lactating transgenic founder females was found. The concentration of active hIFN-g in the milk was estimated as being ca. 1800 IU/ml. The hIFN-g ability to express in the mammary gland was found in the progeny of transgenic founder male. 相似文献
2.
EK Khusnutdinova TV Viktorova IM Khidiiatova RI Fatkhlislamova TE Ivashchenko 《Canadian Metallurgical Quarterly》1997,33(9):1291-1296
Data on allelic polymorphism of MET and D7S23 DNA loci linked to the human cystic fibrosis gene studied in three Bashkir ethnic groups and some Volga-Ural populations (Tartars, Maris, Mordovians, Udmurts, Chuvashs, and Komis) are presented. Udmurts were found to be substantially different from Bashkirs, Tartars, Mordovians, and Chuvashs by the allele frequency distribution observed for MET, while Komis and Bashkirs differed by this parameter from Mordovians and Maris. Comparative analysis of restriction fragment length polymorphism (RFLP) at the D7S23 locus revealed statistically significant differences in genotype frequencies between Bashkirs of the Arkhangel' skii region and populations of Mordva and Udmurtia. In this respect, the Mordovian population appeared to be notably different from the populations of Bashkortostan, Tatarstan, Marii-El, Udmurtiya, Chuvashiya, and Komis. Genetic distances were calculated and corresponding dendrograms were constructed on the basis of data on Met-H, CS.7, and the ApoB locus hypervariable region allelic frequencies. Three ethnogeographic Bashkir groups belonging to one tree branch were found to be closely related to the populations of Tartars, Maris, Udmurts, and Chuvashs and substantially different from Komis and Mordovians. Thus, the position of Volga-Ural populations on the dendrogram corresponds to the degree of relationship between the Finno-Ugric and Turkic populations, confirming the usefulness of DNA polymorphism analysis for the study of the genetic structure of populations. 相似文献
3.
TV Martyniuk IE Chazova VP Masenko VN Volkov IuN Belenkov 《Canadian Metallurgical Quarterly》1998,70(4):33-36
AIM: Assessment of RAAS and vasopressin in patients with primary pulmonary hypertension (PPH). MATERIALS AND METHODS: Activity of plasma renin (APR), angiotensin-converting enzyme (ACE), plasma levels of angiotensin II (AII) and vasopressin (VP), serum concentration of aldosteron (AS) were measured by radioimmunoassay and enzyme immunoassay in 21 PPH patients with circulatory failure (age 34.7 +/- 2.1 years), 11 patients with NYHA functional class II-III, 10 with class IV, and 10 control subjects (age 29.8 +/- 1.5 years). RESULTS: Compared to controls, 21 PPH patients had elevated RAAS parameters: APR up to 3.52 ng/ml/h (p < 0.05), activity of ACE up to 43.13 units, AII level up to 33.93 ng/ml (p < 0.01), AS up to 468.86 ng/ml (p < 0.01), VP up to 5.26 ng/ml (p < 0.001). Circulatory failure progression resulted in activation of all the RAAS components. This and VP activation was the greatest in PPH patients with ACE > 5 ng/ml/h. PPH patients with mean pressure in the pulmonary artery higher than 60 mm Hg demonstrated higher ARP, AS, VP, AII, ACE than those who had this pressure under 60 mm Hg. CONCLUSION: PPH patients display a noticeable activation of RAAS and VP. This activation seems to be secondary as the changes increase with elevation of the pressure in the pulmonary artery and aggravation of circulatory insufficiency. Plasma renin activity determines the degree of RAAS activation as a whole. The discovered activation of RAAS in PPH gives grounds for doubts in the validity of using ACE inhibitors in the treatment of PPH. 相似文献
4.
Influence of the prenatal hypoinsulinaemia (streptozocin diabetes) on the behaviour of the offsprings of Wistar rats was studied from 1 to 20 postnatal days. In experimental pups there were slower weight increment, later eye opening, later development of elementary behavioural acts (grooming elements, rearing, sniffing), and later formation of complex behavioural patterns (investigation of an environment) than in the control offsprings of healthy females. 相似文献
5.
Effect of vanadium and chromium on the microstructural features of V–Cr–Mn–Ni spheroidal carbide cast irons 总被引:2,自引:0,他引:2
V.G.Efremenko ;K.Shimizu ;A.P.Cheiliakh ;T.V.Kozarevskaya ;K.Kusumoto ;K.Yamamoto 《北京科技大学学报(英文版)》2014,(11):1096-1108
The objective of this investigation is to study the influence of vanadium(5.0wt%–10.0wt%) and chromium(0–9.0wt%) on the microstructure and hardness of Cr-V-Mn-Ni white cast irons with spheroidal vanadium carbides. The alloys' microstructural features are presented and discussed with regard to the distribution of phase elements. The structural constituents of the alloys are spheroidal VC, proeutectoid cementite, ledeburite eutectic, rosette-shaped carbide eutectic(based on M7C3), pearlite, martensite, and austenite. Their combinations and area fraction(AF) ratios are reported to be influenced by the alloys' chemical composition. Spheroidized VC particles are found to be sites for the nucleation of carbide eutectics. Cr and V are shown to substitute each other in the VC and M7C3 carbides, respectively. Chromium alloying leads to the formation of a eutectic(γ-Fe + М7С3), preventing the appearance of proeutectoid cementite in the structure. Vanadium and chromium are revealed to increase the total carbide fraction and the amount of austenite in the matrix. Cr is observed to play a key role in controlling the metallic matrix microstructure. 相似文献
6.
7.
VA Belitser TV Varetskaia SN Tsynkalovskaia LA Tsariuk LI Shevchenko 《Canadian Metallurgical Quarterly》1976,48(4):521-532
A new diagnostic method to determine fibrinogen and fibrin splitting products is based on the fact that high-molecular fragments acting as specific inhibitors of fibrin self-assembly compose these products. Fibrinogen and fibrin splitting products are detected and determined quantitatively by prolongation of coagulation time in the test with the standard monomeric fibrin. The number of units of anticoagulating activity in the studied urine are the results of the determinations. Sensitivity of the method if necessary may be increased by adding of a certain amount of the fibrinogen and fibrin splitting products to the test that makes a favourable background for the action of the products. The method is rather sensitive, reliable and simple. It may be used in ordinary clinical laboratories. The method proved to be quite satisfactory when testing renal diseases at the clinic. It is of great significance for early detection of the transplanted kidney rejection. The new method is compared with the known immunological method which consist in determination of the inhibitory effect of the fibrinogen and fibrin splitting products on agglutination of erythrocytes of specific antibodies; the erythrocytes being subjected to "tanning" and "loading" with fibrinogen. A satisfactory correlation is found between the results of two methods. 相似文献
8.
张海燕 《网络安全技术与应用》2011,(10):30-32
本文针对局域网中发生的ARP欺骗基本原理进行介绍,分析了ARP协议所存在的安全漏洞,同时介绍几种常见的ARP欺骗和攻击方式,并且从客户端、网关等多个方面提出关于如何防御ARP攻击的多种方法,以达到全面防御维护局域网络安全的目的。 相似文献
9.
通过钢渣桩在湿陷性黄土中的静荷载试验、土压力测试等试验结果的基础上,对钢渣桩复合地基、桩间土和钢渣单桩的p-s曲线以及其各自的承载力和相应的沉降量进行了分析,探讨了附加应力沿深度变化规律;研究了桩间土承载力、桩土应力比和桩土荷载比的变化规律,对钢渣单桩和碎石桩以及钢渣桩复合地基和石灰粉煤灰桩复合地基等的承载力特性进行了对比分析;对单桩施工影响范围和施工时地基隆起量进行了观测。 相似文献
10.
Andreev B. V. Ustinov A. S. Akopyan A. V. Anisimov A. V. Eseva E. A. Kleimenov A. V. Kondrashev D. O. Khrapov D. V. Esipenko R. V. 《Theoretical Foundations of Chemical Engineering》2020,54(5):1078-1082
Theoretical Foundations of Chemical Engineering - A technology for the demercaptanization of light hydrocarbon fractions and liquefied petroleum gas with 25% aqueous ammonia is proposed. One... 相似文献