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1.
Matej Vizovisek Dragana Ristanovic Stefano Menghini Michael G. Christiansen Simone Schuerle 《International journal of molecular sciences》2021,22(5)
In recent decades, dysregulation of proteases and atypical proteolysis have become increasingly recognized as important hallmarks of cancer, driving community-wide efforts to explore the proteolytic landscape of oncologic disease. With more than 100 proteases currently associated with different aspects of cancer development and progression, there is a clear impetus to harness their potential in the context of oncology. Advances in the protease field have yielded technologies enabling sensitive protease detection in various settings, paving the way towards diagnostic profiling of disease-related protease activity patterns. Methods including activity-based probes and substrates, antibodies, and various nanosystems that generate reporter signals, i.e., for PET or MRI, after interaction with the target protease have shown potential for clinical translation. Nevertheless, these technologies are costly, not easily multiplexed, and require advanced imaging technologies. While the current clinical applications of protease-responsive technologies in oncologic settings are still limited, emerging technologies and protease sensors are poised to enable comprehensive exploration of the tumor proteolytic landscape as a diagnostic and therapeutic frontier. This review aims to give an overview of the most relevant classes of proteases as indicators for tumor diagnosis, current approaches to detect and monitor their activity in vivo, and associated therapeutic applications. 相似文献
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Milica Jovanovi Krivokua Aleksandra Viloti Mirjana Nacka-Aleksi Andrea Pirkovi Danica uji Janko Legner Dragana Dekanski
anka Boji-Trbojevi 《International journal of molecular sciences》2022,23(1)
Galectins are a family of conserved soluble proteins defined by an affinity for β-galactoside structures present on various glycoconjugates. Over the past few decades, galectins have been recognized as important factors for successful implantation and maintenance of pregnancy. An increasing number of studies have demonstrated their involvement in trophoblast cell function and placental development. In addition, several lines of evidence suggest their important roles in feto-maternal immune tolerance regulation and angiogenesis. Changed or dysregulated galectin expression is also described in pregnancy-related disorders. Although the data regarding galectins’ clinical relevance are still at an early stage, evidence suggests that some galectin family members are promising candidates for better understanding pregnancy-related pathologies, as well as predicting biomarkers. In this review, we aim to summarize current knowledge of galectins in early pregnancy as well as in pregnancy-related pathologies. 相似文献
5.
Glycation of the Major Milk Allergen β‐Lactoglobulin Changes Its Allergenicity by Alterations in Cellular Uptake and Degradation 下载免费PDF全文
Marija Perusko Manon van Roest Dragana Stanic‐Vucinic Peter J. Simons Raymond H. H. Pieters Tanja Cirkovic Velickovic Joost J. Smit 《Molecular nutrition & food research》2018,62(17)
1 Scope
During food processing, the Maillard reaction (МR) may occur, resulting in the formation of glycated proteins. Glycated proteins are of particular importance in food allergies because glycation may influence interactions with the immune system. This study compared native and extensively glycated milk allergen β‐lactoglobulin (BLG), in their interactions with cells crucially involved in allergy.2 Methods and results
BLG was glycated in MR and characterized. Native and glycated BLG were tested in experiments of epithelial transport, uptake and degradation by DCs, T‐cell cytokine responses, and basophil cell degranulation using ELISA and flow cytometry. Glycation of BLG induced partial unfolding and reduced its intestinal epithelial transfer over a Caco‐2 monolayer. Uptake of glycated BLG by bone marrow–derived dendritic cells (BMDC) was increased, although both BLG forms entered BMDC via the same mechanism, receptor‐mediated endocytosis. Once inside the BMDC, glycated BLG was degraded faster, which might have led to observed lower cytokine production in BMDC/CD4+ T‐cells coculture. Finally, glycated BLG was less efficient in induction of degranulation of BLG‐specific IgE sensitized basophil cells.3 Conclusions
This study suggests that glycation of BLG by MR significantly alters its fate in processes involved in immunogenicity and allergenicity, pointing out the importance of food processing in food allergy. 相似文献6.
Duško Minić Jelena Đokić Vladan Ćosović Jasna Stajić-Trošić Dragana Živković Irma Dervišević 《Materials Chemistry and Physics》2010
Phase diagram of the ternary Bi–Sb–Zn system was investigated experimentally by DTA and SEM-EDS methods and analytically by CALPHAD method. The liquidus projection, invariant equilibria, several vertical sections and isothermal section at 300 °C were predicted using COST 531 thermodynamic database. Phase transition temperatures of alloys along three predicted vertical sections of the Bi–Sb–Zn ternary system with molar ratio Bi:Sb = 1, Bi:Zn = 1 and Sb:Zn = 1, were measured by differential thermal analysis (DTA). Predicted isothermal section at 300 °C was compared with the results of the scanning electron microscope (SEM) with energy dispersive spectrometry (EDS) analysis from this work. 相似文献
7.
Milena Premović Milica Tomović Duško Minić Dragan Manasijević Dragana Živković Vladan Ćosović Vladan Grković Aleksandar Đorđević 《Journal of Materials Engineering and Performance》2017,26(6):2491-2501
Ternary Al-Ag-Ga system at 200 °C was experimentally and thermodynamically assessed. Isothermal section was extrapolated using optimized thermodynamic parameters for constitutive binary systems. Microstructure and phase composition of the selected alloy samples were analyzed using light microscopy, scanning electron microscopy combined with energy-dispersive spectrometry and x-ray powder diffraction technique. The obtained experimental results were found to be in a close agreement with the predicted phase equilibria. Hardness and electrical conductivity of the alloy samples from four vertical sections Al-Ag80Ga20, Al-Ag60Ga40, Ag-Al80Ga20 and Ag-Al60Ga40 of the ternary Al-Ag-Ga system at 200 °C were experimentally determined using Brinell method and eddy current measurements. Additionally, hardness of the individual phases present in the microstructure of the studied alloy samples was determined using Vickers microhardness test. Based on experimentally obtained results, isolines of Brinell hardness and electrical conductivity were calculated for the alloys from isothermal section of the ternary Al-Ag-Ga system at 200 °C. 相似文献
8.
Anita Valmarska Dragana Miljkovic Nada Lavrač Marko Robnik-Šikonja 《Journal of Intelligent Information Systems》2018,51(2):301-337
Parkinson’s disease is a neurodegenerative disorder that affects people worldwide. Careful management of patient’s condition is crucial to ensure the patient’s independence and quality of life. This is achieved by personalized treatment based on individual patient’s symptoms and medical history. The aim of this study is to determine patient groups with similar disease progression patterns coupled with patterns of medications change that lead to the improvement or decline of patients’ quality of life symptoms. To this end, this paper proposes a new methodology for clustering of short time series of patients’ symptoms and prescribed medications data, and time sequence data analysis using skip-grams to monitor disease progression. The results demonstrate that motor and autonomic symptoms are the most informative for evaluating the quality of life of Parkinson’s disease patients. We show that Parkinson’s disease patients can be divided into clusters ordered in accordance with the severity of their symptoms. By following the evolution of symptoms for each patient separately, we were able to determine patterns of medications change which can lead to the improvement or worsening of the patients’ quality of life. 相似文献
9.
Automatic Estimation of Multiple Target Positions and Velocities Using Passive TDOA Measurements of Transients 总被引:3,自引:0,他引:3
Dragana Carevic 《Signal Processing, IEEE Transactions on》2007,55(2):424-436
This paper considers the problem of the estimation of the motion parameters of multiple targets moving linearly in a three-dimensional (3-D) observation area contaminated by clutter. The measurements are limited to time differences of arrival (TDOAs) of short-duration acoustic emissions, or transients, generated by the targets. This problem can arise in situations where the level of continuous broadband target-related noise is very low. Owing to the fact that transient emissions are nonstationary and can have low signal-to-noise ratio (SNR), the corresponding TDOA measurement errors are usually non-Gaussian. Therefore, Gaussian mixture distributions are used to appropriately model these errors. An iterative maximum-likelihood optimization technique based on a modified deterministic annealing expectation-maximization (MDAEM) algorithm is applied to this problem. In each iteration, the algorithm uses a nonlinear least-squares (LS) technique in computing the motion parameters for each target. It generalizes the variance deflation method previously used for the initialization of target tracking algorithms and increases the possibility of attaining a globally optimal solution for random initial conditions. Simulation results are presented for several different numbers of targets, clutter densities, and probabilities of gross error of the target related measurements and are found to be comparable to the estimates obtained when the measurement-to-target assignments are exactly known 相似文献
10.
Marija Kuzmanovic Gordana Savic Bisera Andric Gusavac Dragana Makajic-Nikolic Biljana Panic 《Expert systems with applications》2013,40(10):4083-4089
In recent years, the need for greater accountability and improvement in teaching’s quality has become a major issue in higher education. The results of student evaluation of teaching are increasingly used to make judgments about teaching quality, career advancement, and the funding of teaching itself. An important component of any such student evaluation is the communication of rating results in a manner that allows for fair and meaningful interpretations and comparisons of results by a wide range of evaluation users. In this paper, an approach for a more objective evaluation of university teachers is proposed, one which is based on previously obtained conjoint analysis data concerning criteria importance from a student’s point of view. Therein, an illustrative example is given to demonstrate the efficiency and practical usage of such a proposed approach. 相似文献