Low voltage second-order alpha function synapse

This paper introduces a Transimpedance Amplifier (TIA) design capable of producing an incremental input resistance in the ohmic range, for input signals in the microampere range, such as are encountered in the design of instrumentation for electrochemical ampero-metric sensors, optical-sensing and current-mode circuits. This low input-resistance is achieved using an input stage incorporating negative feedback. In a Cadence simulation of an exemplary design using a 180 nm CMOS process and operating with?±?1.8 V supply rails, the input resistance is 1.05 ohms and the power dissipation is 93.6 µW. The bandwidth, for a gain of 100 dBohm, exceeded 9 MHz. For a 1µA, 1 MHz sinusoidal input signal the Total Harmonic Distortion, with this gain, is less than 1%. The input referred noise current with zero photodiode capacitance is 2.09 pA/√Hz and with a photodiode capacitance of 2pF is 8.52 pA/√Hz. Graphical data is presented to show the effect of a photodiode capacitance varying from 0.5 to 2 pF, when the TIA is used in optical sensing. In summary, the required very low input resistance, at a low input current level (µA) is achieved and furthermore a Table is included comparing the characteristics and a widely used Figure of Merit (FOM) for the proposed TIA and similar published low-power TIAs. It is apparent from the Table that the FOM of the proposed TIA is better than the FOMs of the other TIAs mentioned.

     

Task migration in three-dimensional meshes

As a result of the emerging use of mesh-based multicomputers (and recently mesh-based multiprocessor systems-on-chip), issues related to processor management have attracted much attention. In a mesh-based multiprocessor, after repeated submesh allocations and de-allocations, the system network may be fragmented, i.e. there might be unallocated nodes in the network. As a result, in a system with contiguous processor allocation, no new tasks can start running due to the lack of enough free adjacent processors to form a suitable submesh. Although there might be enough free processors available, they remain idle until the allocator can find a set of adjacent free nodes forming a submesh to be used for the new task. This can lead to low system performance. Task migration was introduced as a solution to this problem through migration of tasks running on some submeshes to other free areas in order to reduce fragmentation by chaining the newly freed areas and disengaging nodes to form larger submeshes. In this paper, we propose a novel structured and formulated way to code task migration, which is helpful for congestion detection in different steps of task migration algorithms. Moreover, considering the fact that the 3D mesh-based multicomputers are now very popular, a new task migration algorithm in 3D meshes is proposed. We also address the special case of the 2D migration in a 3D mesh multicomputer.     

Deposition and Characterization of Si Substituted Cu2ZnSnS4 Thin Films

Silicon - The influence of the Si substitution ratio on the structural, morphological, and optical properties of Cu2ZnSnS4 (CZTS) thin films was examined. The Cu2Zn(SixSn1–x)S4 thin films...     

A Case Report of Germline Compound Heterozygous Mutations in the BRCA1 Gene of an Ovarian and Breast Cancer Patient

The germline carrier of the BRCA1 pathogenic mutation has been well proven to confer an increased risk of breast and ovarian cancer. Despite BRCA1 biallelic pathogenic mutations being extremely rare, they have been reported to be embryonically lethal or to cause Fanconi anemia (FA). Here we describe a patient who was a 48-year-old female identified with biallelic pathogenic mutations of the BRCA1 gene, with no or very subtle FA-features. She was diagnosed with ovarian cancer and breast cancer at the ages of 43 and 44 and had a strong family history of breast and gynecological cancers.     

有色人种护发品市场增长的空间

论述了有色人种护发品市场的现状及未来发展趋势。指出,虽然与有色人种相关的产品大多仅限于美国市场,而且这一市场增长缓慢,但这一市场仍有发展潜力。随着社会就业岗位的增加,有色人种消费者在购买护发产品时变得越来越挑剔,越来越多的非洲女性开始喜炊她们天生的自然卷发,并在市场七寻找可以满足这种需求的创新性优质产品。因此,有色人种护发产品市场将呈现出多样化的趋势。     

Screening of phytochemicals in fresh lamb meat patties stored in modified atmosphere packs: influence on selected meat quality characteristics

This study was carried out to determine the antioxidant activity of phytochemicals and plant extracts in fresh lamb patties. Quality indices such as colour (Hunter L* a* b*), lipid oxidation (TBARS) and pH were measured over an 8‐day storage period. Resveratrol, citroflavan‐3‐ol, olive leaf extract and Echinacea purpurea were added to raw minced M. longissimus dorsi lamb patties, at concentrations ranging from 0–400 mg kg^?1 lamb meat, stored in high oxygen modified atmospheres packs (75% O₂:25% CO₂) for up to 8 days at 4 °C. The pH of the lamb meat was not significantly affected by the addition of the phytochemicals and plant extracts examined (P > 0.05). Resveratrol and citroflavan‐3‐ol decreased (P < 0.05) lipid oxidation in raw lamb patties during storage and increased a* values (P < 0.05), relative to controls. By contrast, olive leaf extract and Echinacea purpurea did not exhibit antioxidant activity or promote higher a* values relative to controls. Results obtained demonstrate potential for the development of functional meats using plant extracts such as resveratrol and citroflavan‐3‐ol.     

洗浴用品市场观览

对洗浴用品市场进行了分析,指出功能单一的块皂时代已经不复存在了,而代之以多种香型、不同成分、不同色泽和花样翻新的清洁用品。块皂这个美国个人卫生用品的基本组分也同样遭受到了来自液体皂、沐浴液和凝胶的残酷竞争。块皂除了仅仅作为清洁用品外,还得到了广泛的应用,其功能包括护肤、防晒、晒黑、抗黑斑、抗衰老和减脂等。目前,家庭使用洗液和沐浴露已非常流行,洗液制品逐渐趋向于不同年龄段的男、女消费者,目标已纷纷瞄准了少女群体和成年女性群体以及男性消费者。     

Surface Modifications for Improved Delivery and Function of Therapeutic Bacteria

Live therapeutic bacteria (LTBs) hold promise to treat microbiome‐related diseases. However, few approaches to improve the colonization of LTBs in the gastrointestinal tract exist, despite colonization being a prerequisite for efficacy of many LTBs. Here, a modular platform to rapidly modify the surface of LTBs to enable receptor‐specific interactions with target surfaces is reported. Inspired by bacterial adhesins that facilitate colonization, synthetic adhesins (SAs) are developed for LTBs in the form of antibodies conjugated to their surface. The SA platform is nontoxic, does not alter LTB growth kinetics, and can be used with any antibody or bacterial strain combination. By improving adhesion, SA‐modified bacteria demonstrate enhanced in vitro pathogen exclusion from cell monolayers. In vivo kinetics of SA‐modified LTBs is tracked in the feces and intestines of treated mice, demonstrating that SA‐modified bacteria alter short‐term intestinal transit and improve LTB colonization and pharmacokinetics. This platform enables rapid formation of an intestinal niche, leading to an increased maximum concentration and a 20% improvement in total LTB exposure. This work is the first application of traditional pharmacokinetic analysis to design and evaluate LTB drug delivery systems and provides a platform toward controlling adhesion, colonization, and efficacy of LTBs.