Out-of-Field Hippocampus from Partial-Body Irradiated Mice Displays Changes in Multi-Omics Profile and Defects in Neurogenesis

The brain undergoes ionizing radiation exposure in many clinical situations, particularly during radiotherapy for brain tumors. The critical role of the hippocampus in the pathogenesis of radiation-induced neurocognitive dysfunction is well recognized. The goal of this study is to test the potential contribution of non-targeted effects in the detrimental response of the hippocampus to irradiation and to elucidate the mechanisms involved. C57Bl/6 mice were whole body (WBI) or partial body (PBI) irradiated with 0.1 or 2.0 Gy of X-rays or sham irradiated. PBI consisted of the exposure of the lower third of the mouse body, whilst the upper two thirds were shielded. Hippocampi were collected 15 days or 6 months post-irradiation and a multi-omics approach was adopted to assess the molecular changes in non-coding RNAs, proteins and metabolic levels, as well as histological changes in the rate of hippocampal neurogenesis. Notably, at 2.0 Gy the pattern of early molecular and histopathological changes induced in the hippocampus at 15 days following PBI were similar in quality and quantity to the effects induced by WBI, thus providing a proof of principle of the existence of out-of-target radiation response in the hippocampus of conventional mice. We detected major alterations in DAG/IP3 and TGF-β signaling pathways as well as in the expression of proteins involved in the regulation of long-term neuronal synaptic plasticity and synapse organization, coupled with defects in neural stem cells self-renewal in the hippocampal dentate gyrus. However, compared to the persistence of the WBI effects, most of the PBI effects were only transient and tended to decrease at 6 months post-irradiation, indicating important mechanistic difference. On the contrary, at low dose we identified a progressive accumulation of molecular defects that tended to manifest at later post-irradiation times. These data, indicating that both targeted and non-targeted radiation effects might contribute to the pathogenesis of hippocampal radiation-damage, have general implications for human health.     

Expert-driven genetic algorithms for simulating evaluation functions

In this paper we demonstrate how genetic algorithms can be used to reverse engineer an evaluation function’s parameters for computer chess. Our results show that using an appropriate expert (or mentor), we can evolve a program that is on par with top tournament-playing chess programs, outperforming a two-time World Computer Chess Champion. This performance gain is achieved by evolving a program that mimics the behavior of a superior expert. The resulting evaluation function of the evolved program consists of a much smaller number of parameters than the expert’s. The extended experimental results provided in this paper include a report on our successful participation in the 2008 World Computer Chess Championship. In principle, our expert-driven approach could be used in a wide range of problems for which appropriate experts are available.     

Optimal shape design of functionally graded thickness inversion tubes subjected to oblique loading

This paper aims to understand and optimize the crush response of Functionally Graded Thickness (FGT) tubes with various thickness distributions subjected to oblique loading using multi-objective optimization method. Hence, finite element (FE) models are established and their results are validated by experimental tests. Two objective functions (specific energy absorption and peak load) are approximated by four different multi-objective optimization models: the weighted average, multi-design optimization (MDO) technique, constrained single-objective optimization, and geometrical average methods. The optimum design results demonstrate that the selection of appropriate inversion tube parameters such as the die radius, the coefficient of friction between the die and tube, and thickness distribution function have significant roles in the crashworthiness design. The results give new ideas to improve the crashworthiness performance of inversion tubes under oblique loading conditions.     

Algorithm for Increasing the Speed of Evolutionary Optimization and its Accuracy in Multi-objective Problems

Optimization algorithms are important tools for the solution of combinatorial management problems. Nowadays, many of those problems are addressed by using evolutionary algorithms (EAs) that move toward a near-optimal solution by repetitive simulations. Sometimes, such extensive simulations are not possible or are costly and time-consuming. Thus, in this study a method based on artificial neural networks (ANN) is proposed to reduce the number of simulations required in EAs. Specifically, an ANN simulator is used to reduce the number of simulations by the main simulator. The ANN is trained and updated only for required areas in the decision space. Performance of the proposed method is examined by integrating it with the non-dominated sorting genetic algorithm (NSGAII) in multi-objective problems. In terms of density and optimality of the Pareto front, the hybrid NSGAII-ANN is able to extract the Pareto front with much less simulation time compared to the sole use of the NSGAII algorithm. The proposed NSGAII-ANN methodology was examined using three standard test problems (FON, KUR, and ZDT1) and one real-world problem. The latter addresses the operation of a reservoir with two objectives (meeting demand and flood control). Thus, based on this study, use of the NSGAII-ANN integrative algorithm in problems with time-consuming simulators reduces the required time for optimization up to 50 times. Results of the real-world problem, despite lower computational-time requirements, show a performance similar to that achieved in the aforementioned test problems.     

Multi-product multi-chance-constraint stochastic inventory control problem with dynamic demand and partial back-ordering: A harmony search algorithm

In this paper, a multiproduct inventory control problem is considered in which the periods between two replenishments of the products are assumed independent random variables, and increasing and decreasing functions are assumed to model the dynamic demands of each product. Furthermore, the quantities of the orders are assumed integer-type, space and budget are constraints, the service-level is a chance-constraint, and that the partial back-ordering policy is taken into account for the shortages. The costs of the problem are holding, purchasing, and shortage. We show the model of this problem is an integer nonlinear programming type and to solve it, a harmony search approach is used. At the end, three numerical examples of different sizes are given to demonstrate the applicability of the proposed methodology in real world inventory control problems, to validate the results obtained, and to compare its performances with the ones of both a genetic and a particle swarm optimization algorithms.     

New Approaches in Monitoring Multivariate Categorical Processes based on Contingency Tables in Phase II

In some statistical process control (SPC) applications, quality of a process or product is characterized by contingency table. Contingency tables describe the relation between two or more categorical quality characteristics. In this paper, two new control charts based on the WALD and Stuart score test statistics are designed for monitoring of contingency table‐based processes in Phase‐II. The performances of the proposed control charts are compared with the generalized linear test (GLT) control chart proposed in the literature. The results show the better performance of the proposed control charts under small and moderate shifts. Moreover, new schemes are proposed to diagnose which cell corresponding to different levels of categorical variables is responsible for out‐of‐control signal. In addition, we propose EWMA–WALD and EWMA–Stuart score test control charts to improve the performance of Shewhart‐based control charts in detecting small and moderate shifts in contingency table parameters. Meanwhile, we compare the performances of two proposed EWMA‐based control charts with the ones of three existing control charts called EWMA–GLT, EWMA–GLRT and an EWMA‐type control chart for multivariate binomial/multinomial processes along with the ones of the corresponding Shewhart‐based control charts. A numerical example is given to show the efficiency of the proposed methods. Finally, the effect of parameter estimation in Phase I based on m historical contingency table on the performance of the Shewhart‐based control charts is studied. Copyright © 2016 John Wiley & Sons, Ltd.     

A comparison of Zayandehrood River water values for agriculture and the environment

River water management is challenging not only since they are open systems with changing physical structures, but also because the water values are mostly unknown over varied sectors. If policymakers grasp water values, water management will be more efficient. This research intends to examine the values of water in agriculture, which receives the most substantial portion of water resources, with the values of water in the environment in Isfahan located in the Zayandehrood River basin of Iran. The consequences of contingent valuation and production function methods revealed that per cubic metre value of water is 13 times higher in the environment than agriculture. The government should reconsider the higher value of the environment despite it is a non‐market value. The contingent valuation model additionally proved that women exhibited 21% more willingness to pay than men in order to protect the environment; however, they are paid less by 36%.     

Quantifying the effects of crack width,tortuosity, and roughness on water permeability of cracked mortars

The existing service-life prediction models rarely account for the effect of cracks on mass transport and durability of concrete. To correct this deficiency, transport in fractured porous media must be studied. The objective of this paper is to quantify the water permeability of localized cracks as a function of crack geometry (i.e., width, tortuosity, and surface roughness). Plain and fiber-reinforced mortar disk specimens were cracked by splitting tension; and the crack profile was digitized by image analysis and translated into crack geometric properties. Crack permeability was measured using a Darcian flow-thru cell. The results show that permeability is a function of crack width square. Crack tortuosity and roughness reduce the permeability by a factor of 4 to 6 below what is predicted by the theory for smooth parallel plate cracks. Although tortuosity and roughness exhibit fractal behavior, their proper measurement is possible and results in correct estimation of crack permeability.     

Automatic navigation of mobile robots in unknown environments

Online navigation with known target and unknown obstacles is an interesting problem in mobile robotics. This article presents a technique based on utilization of neural networks and reinforcement learning to enable a mobile robot to learn constructed environments on its own. The robot learns to generate efficient navigation rules automatically without initial settings of rules by experts. This is regarded as the main contribution of this work compared to traditional fuzzy models based on notion of artificial potential fields. The ability for generalization of rules has also been examined. The initial results qualitatively confirmed the efficiency of the model. More experiments showed at least 32 % of improvement in path planning from the first till the third path planning trial in a sample environment. Analysis of the results, limitations, and recommendations is included for future work.