排序方式: 共有72条查询结果,搜索用时 15 毫秒
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Annick Moens C. Janneke van der Woude Mette Julsgaard Evelien Humblet Juliette Sheridan Daniel C. Baumgart Cyrielle Gilletta De Saint-Joseph Stéphane Nancey Jean-François Rahier Peter Bossuyt Anneline Cremer Sophie Dewit Carl Eriksson Frank Hoentjen Thomas Krause Edouard Louis Elisabeth Macken Zoran Milenkovic Jochen Nijs Annelies Posen Anneleen Van Hootegem Wouter Van Moerkercke Séverine Vermeire Ariella Bar-Gil Shitrit Marc Ferrante 《Alimentary pharmacology & therapeutics》2020,51(1):129-138
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Sarra Smati MD Blandine Tramunt MD Matthieu Wargny MD Cyrielle Caussy MD Bénédicte Gaborit MD Camille Vatier MD Bruno Vergès MD Deborah Ancelle MD Coralie Amadou MD Leila A. Bachir MD Olivier Bourron MD Christine Coffin-Boutreux MD Sara Barraud MD Anne Dorange MD Bénédicte Fremy MD Jean-François Gautier MD Natacha Germain MD Etienne Larger MD Stéphanie Laugier-Robiolle MD Laurent Meyer MD Arnaud Monier MD Isabelle Moura MD Louis Potier MD Nadia Sabbah MD Dominique Seret-Bégué MD Patrice Winiszewski MD Matthieu Pichelin PharmD Pierre-Jean Saulnier MD Samy Hadjadj MD Bertrand Cariou MD Pierre Gourdy MD for the CORONADO investigators 《Diabetes, obesity & metabolism》2021,23(2):391-403
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Julien Rohmer Amélie Couteau-Chardon Julie Trichereau Kewin Panel Cyrielle Gesquiere Raouf Ben Abdelali Audrey Bidet Jean-Sébastien Bladé Jean-Michel Cayuela Pascale Cony-Makhoul Vincent Cottin Eric Delabesse Mikaël Ebbo Olivier Fain Pascale Flandrin Lionel Galicier Catherine Godon Nathalie Grardel Aurélien Guffroy Mohamed Hamidou Mathilde Hunault Etienne Lengline Faustine Lhomme Ludovic Lhermitte Irène Machelart Laurent Mauvieux Catherine Mohr Marie-Joelle Mozicconacci Dina Naguib Franck E. Nicolini Jerome Rey Philippe Rousselot Suzanne Tavitian Louis Terriou Guillaume Lefèvre Claude Preudhomme Jean-Emmanuel Kahn Matthieu Groh CEREO GBMHM collaborators 《American journal of hematology》2020,95(11):1314-1323
FIP1L1-PDGFRA-positive myeloid neoplasm with eosinophilia (F/P+ MN-eo) is a rare disease: robust epidemiological data are lacking and reported issues are scarce, of low sample-size and limited follow-up. Imatinib mesylate (IM) is highly efficient but no predictive factor of relapse after discontinuation has yet been identified. One hundred and fifty-one patients with F/P+ MN-eo (143 males; mean age at diagnosis 49 years; mean annual incidence: 0.18 case per million population) were included in this retrospective nationwide study involving all French laboratories who perform the search of F/P fusion gene (study period: 2003-2019). The main organs involved included the spleen (44%), skin (32%), lungs (30%), heart (19%) and central nervous system (9%). Serum vitamin B12 and tryptase levels were elevated in 74/79 (94%) and 45/57 (79%) patients, respectively, and none of the 31 patients initially treated with corticosteroids achieved complete hematologic remission. All 148 (98%) IM-treated patients achieved complete hematologic and molecular (when tested, n = 84) responses. Forty-six patients eventually discontinued IM, among whom 20 (57%) relapsed. In multivariate analysis, time to IM initiation (continuous HR: 1,01 [0.99-1,03]; P = .05) and duration of IM treatment (continuous HR: 0,97 [0,95-0,99]; P = .004) were independent factors of relapse after discontinuation of IM. After a mean follow-up of 80 (56) months, the 1, 5- and 10-year overall survival rates in IM-treated patients were 99%, 95% and 84% respectively. In F/P+ MN-eo, prompt initiation of IM and longer treatment durations may prevent relapses after discontinuation of IM. 相似文献
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Mitra RN Doshi M Zhang X Tyus JC Bengtsson N Fletcher S Page BD Turkson J Gesquiere AJ Gunning PT Walter GA Santra S 《Biomaterials》2012,33(5):1500-1508
Multifunctional nanoparticles integrated with imaging modalities (such as magnetic resonance and optical) and therapeutic drugs are promising candidates for future cancer diagnostics and therapy. While targeted drug delivery and imaging of tumor cells have been the major focus in engineering nanoparticle probes, no extensive efforts have been made towards developing sensing probes that can confirm and monitor intracellular drug release events. Here, we present quantum dot (Qdot)-iron oxide (IO) based multimodal/multifunctional nanocomposite probe that is optically and magnetically imageable, targetable and capable of reporting on intracellular drug release events. Specifically, the probe consists of a superparamagnetic iron oxide nanoparticle core (IONP) decorated with satellite CdS:Mn/ZnS Qdots where the Qdots themselves are further functionalized with STAT3 inhibitor (an anti-cancer agent), vitamin folate (as targeting motif) and m-polyethylene glycol (mPEG, a hydrophilic dispersing agent). The Qdot luminescence is quenched in this nanocomposite probe (“OFF” state) due to combined electron/energy transfer mediated quenching processes involving IONP, folate and STAT3 agents. Upon intracellular uptake, the probe is exposed to the cytosolic glutathione (GSH) containing environment resulting in restoration of the Qdot luminescence (“ON” state), which reports on uptake and drug release. Probe functionality was validated using fluorescence and MR measurements as well as in vitro studies using cancer cells that overexpress folate receptors. 相似文献
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Cyrielle Tomich Sabrina Debruxelles Yahsou Delmas Sharmila Sagnier Mathilde Poli Stéphane Olindo Pauline Renou François Rouanet Igor Sibon 《Journal of stroke and cerebrovascular diseases》2018,27(11):3163-3171
Introduction
Immune thrombotic thrombocytopenic purpura (i-TTP), related to acquired ADAMTS-13 dysfunction, can lead to various neurological symptoms including ischemic stroke. To date the clinical, radiological, and biological characteristics of patients having a stroke as the inaugural manifestation of i-TTP are largely unknown.Methods
Probable immune-TTP was defined by a low ADAMTS-13 activity associated with the presence of ADAMTS-13 inhibitors and/or favorable clinicobiological response under immunological treatments. The clinical, radiological, biological data and outcome under treatment are described in a cohort of 17 patients coming from 3 local cases and a literature review.Results
Fourteen of the 17 patients were female and the mean age was 41 years. None of the patients had the classical pentad of TTP. Only 41% had a combination of thrombocythemia and hemolysis. Stroke was multifocal in 35% and included large artery strokes. No adverse event was observed following intravenous thrombolysis. Refractory and relapsing forms were observed in 47%.Discussion
The clinical, radiological, and biological presentation of patients with stroke as the inaugural presentation of i-TTP is heterogeneous. This diagnosis should be discussed in every young adult with ischemic stroke of undetermined source. 相似文献9.
Asma Amrani-Midoun Soto Romuald Kiando Cyrielle Treard Xavier Jeunemaitre Nabila Bouatia-Naji 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2019,13(2):1317-1320
BackgroundEssential hypertension is an important risk factor for the development of cardiovascular disease. Important candidate genes such as NOS3 gene have been widely studied and reported to be associated with essential hypertension (HTN) in human populations.AimWe aim in this study to analyze the relationship between NOS3 -786T/C, a common genetic variant and HTN in a sample of the Algerian population of the Oran city.MethodsA case-control study has been performed in 154 subjects including 77 hypertensives and 77 normotensives. The recruitment of these subjects was done in local Health Centers of the city of Oran, West Algeria. HTN was defined as elevated systolic blood pressure SBD140 mmHg and or sustained diastolic blood pressure DBP≥90 mmHg, measured using an Omron® Automatic BP Monitor - M-3W machine. Consents were obtained from all participants. Polymerase chain reaction (PCR) combined with restrictive fragment length polymorphism (RFLP) was used to genotype the NOS -786T/C variant.ResultsThe distribution of the allelic frequencies did not differ between cases and controls (OR = 1.48; 95%CI [0.94–2.32], P = 0.09). However, after adjustment with the age, sex, and body mass index, we observed significant association between NOS -786C allele and HTN status (OR = 2.08; 95%CI [1.18–3.66], P = 0.01).ConclusionOur results indicate that the C allele of the NOS3 gene is associated with increased risk of essential hypertension in this sample of the Algerian population of the Oran city. Further validation in larger samples is needed to confirm this finding. 相似文献
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Ina Gesquiere Adam S Darwich Bart Van der Schueren Jan de Hoon Matthias Lannoo Christophe Matthys Amin Rostami Veerle Foulon Patrick Augustijns 《British journal of clinical pharmacology》2015,80(5):1021-1030