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排序方式: 共有96条查询结果,搜索用时 15 毫秒
1.
OBJECTIVE: The purpose of this study was to investigate the effects of exogenous local Insulin like growth factor-I (IGF-I) on the repair of full-thickness articular cartilage defects in immature rabbits. DESIGN: Thirty-six skeletally immature New Zealand rabbits between 6 and 8 weeks old were used. A single defect, 3.5-mm-wide by 4-mm-deep full-thickness articular cartilage defect in the medial femoral condyle, was created. The defect was either filled with a collagen sponge or with a collagen sponge impregnated with 5 mug of recombinant IGF-I. The animals were sacrificed at 4, 8 or 12 weeks, and the repair tissue was examined macroscopically and histologically. Repair tissue was also examined immunohistochemically for the presence of type-I collagen, type-II collagen and PCNA at all weeks. RESULTS: Newly formed tissue in all of the defects in the IGF-I group had the gross, histological and histochemical appearance of a smooth, intact hyaline articular cartilage. The average total scores on the histological grading scale were significantly better (p<0.05) for the defects treated with recombinant IGF-I at all time points. Immunostaining with an antibody against type-II collagen showed the diffuse presence of the repair cartilage in the IGF-I treated defects. The control groups demonstrated minimum staining with type-II collagen antibody. CONCLUSIONS: These findings suggest that repair of full-thickness immature cartilage defects can be enhanced by recombinant IGF-I. 相似文献
2.
Aytemir K Oto A Ozkutlu S Kaya EB Canpolat U Yorgun H Sahiner L Kabakçi G 《Journal of interventional cardiology》2012,25(4):375-381
Background: Percutaneous closure of secundum type atrial septal defect (ASD) and patent foramen ovale (PFO) has gained widespread use in recent years. Herein, we evaluated the safety and efficacy of the Occlutech® Figulla devices for PFO and ASD closure in a reference tertiary center. Methods: All 143 patients (46.9% male, mean age 39.3 ± 12.2 years) who underwent transcatheter PFO (n = 85) and ASD (n = 58) closure with Occlutech® Figulla devices between February 2009 and October 2011 were included in this study. An echocardiographic follow‐up examination was performed at the 1st, 6th, and 12th month visits. Results: The devices were successfully implanted in all 143 patients (100%). In‐hospital periprocedural complications were device embolization (0.7%; 1 ASD patient), atrial fibrillation (1.4%; 1 ASD and 1 PFO patients), supraventricular tachycardia (0.7%; 1 PFO patient), and vascular access hematoma (0.7%; 1 ASD patient). Among ASD patients, 2 patients had trivial (jet width <1 mm in diameter) and 1 patient had small (1–2 mm) residual shunts before hospital discharge, which disappeared after the 6‐month visit. During the mean 15.4 ± 9.6 months follow‐up, all patients were asymptomatic and no ischemic stroke, cardiac perforation, device erosion, embolization, thrombus formation, or malposition of the device was observed. Conclusions: Percutaneous PFO and secundum type ASD closure with the novel Occlutech® Figulla Occluder devices without left atrial central pin and with significantly reduced meshwork was safe, feasible, and effective. (J Interven Cardiol 2012;25:375–381) 相似文献
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4.
Kabak YS Abbott PV 《Australian endodontic journal : the journal of the Australian Society of Endodontology Inc》2007,33(1):27-31
The root canal anatomy of mandibular incisors can present a number of variations, including multiple canals. Two case reports are presented to illustrate the serendipitous discovery and successful non-surgical endodontic management of complex canal systems in mandibular incisors. In both cases, all four mandibular incisors had two canals each. 相似文献
5.
Sleep and Breathing - Obstructive sleep apnea (OSA) is defined as the cessation of respiration due to recurrent and partial or complete blockade of the upper airways during sleep. Nocturnal... 相似文献
6.
Ozer S Uluşahin A Batur S Kabakçi E Saka MC 《Social psychiatry and psychiatric epidemiology》2002,37(1):31-37
Background We aimed to study the correlations of several outcome measures in bipolar patients with the clinical features of interepisode
period. Methods Bipolar patients who were diagnosed according to DSM-III-R or IV were contacted and asked for a further evaluation. Interepisode
bipolar patients (n = 100) were interviewed with the Schedule for Affective Disorders and Schizophrenia (SADS). In addition
the Brief Disability Questionnaire (BDQ), the Quality of Life Enjoyment and Satisfaction Questionnaire (Q-LES-Q) and the Global
Assessment Scale (GAS) were administered to assess outcome. They were also asked to check the List of Life Events (LLE) for
the last six months. Results Our results can be summarised as follows: (1) quality of life was predicted by current subthreshold depressive symptoms;
(2) the number of previous depressive episodes, current subthreshold depressive and manic symptoms predicted disability; (3)
the number of previous depressive episodes and the duration of hospitalisation as well as current subthreshold depressive
and manic symptoms predicted overall functioning; (4) the number and distress level of life events were correlated with suicidal
symptoms. Conclusions Our findings suggest that outcome measures were correlated with subsyndromal disorder, the number of previous depressive
episodes and the duration of hospitalisation.
Accepted: 2 October 2001 相似文献
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8.
The purpose of this study was to investigate the characteristics of a group of Turkish vaginismus patients who benefited from Cognitive Behavioral Therapy (CBT) and to study which factors this treatment model changes. Twenty-eight couples who applied to Psychiatry Clinic of Hacettepe University Hospital, Ankara, for treatment of vaginismus within the 6-month period participated in the study. Fourteen subjects quit the therapy after the initial assessment sessions. Other couples successfully completed the treatment. We assessed all the couples that completed the CBT at three times: during the initial session, at the end of the treatment, and during the follow-up session (4 weeks after the end of the treatment). In terms of anxiety levels, and quality of marital and sexual relationships, the characteristics of the couples that quit the therapy could not be identified. But we found that all of the participants were treated effectively by CBT. At the end of the therapy, anxiety levels of the women decreased. There also were improvements on parameters related to marital harmony and overall sexual functioning of the women. We discuss the findings of our study within a cultural perspective. 相似文献
9.
Tiryaki A Yazici MK Anil AE Kabakçi E Karaağaoğlu E Göğüş A 《European archives of psychiatry and clinical neuroscience》2003,253(5):221-227
The aim of this study was to reexamine and compare the
characteristics of the deficit and nondeficit schizophrenic
patients. This cross-sectional study consisted of 62 in- and
out-patients, 18–65 years of age, diagnosed with schizophrenia
according to DSM-IV. The sociodemographic variables, premorbid
adjustment, clinical course and general functioning level in the
past five years were evaluated by utilizing the appropriate
sections of Comprehensive Assessment of Symptoms and History
(CASH). In addition, GAF, the Schedule for the Deficit Syndrome
(SDS), Positive and Negative Syndrome Scale (PANSS), Montgomery
Äsberg Depression Scale (MADRS), the Neurological Evaluation
Scale (NES) and the Simpson Angus Extrapyramidal Side Effects
(EPS) Rating Scale, Trail A and B, Verbal Fluency, Stroop, Block
Design and Finger Tapper tests were administered. Using the SDS,
19 patients (30.6 %) were categorized as deficit; 43 (69.4 %)
were categorized as nondeficit. The deficit patients were worse
on the Functioning During Past Five Years score of CASH. The
PANSS and MADRS mean scores were not significantly different
between the two groups, except a higher level of negative
symptoms observed in the deficit group. NES scores were also
significantly higher in the deficit group. However,
sociodemographic and other clinical variables, neurocognitive
measures and EPS symptoms did not show any significant
difference between the two groups. Our findings suggest that the
deficit schizophrenia is a distinct subgroup comprised of
patients who have more negative symptoms, neurological
impairment and poor functioning which may have a common
underlying pathology. 相似文献
10.
A. Elif Anil Berna B. Kivircik Senar Batur Elif Kabakçi Arzu Kitis Ersen Güven 《The Clinical neuropsychologist》2013,27(2):159-169
The following study was conducted to adapt the Auditory Consonant Trigram Test (ACT) to Turkish, acquire a new and larger set of normative data, and finally investigate the reliability and validity of the adapted version. The data were collected from a sample of 236 healthy individuals. To test the validity of the Turkish version of ACT, the normative results of ACT were first compared with those obtained from the Digit Span Test (DST) backwards section. Secondly, the ACT performance of 53 schizophrenic patients was compared with that of a matched group selected from the normative sample. Age and education variables influenced performance, whereas gender did not in the normal sample. The ACT and DST backwards scores were positively correlated. As expected, the ACT performance was worse in schizophrenic patients compared to controls. The internal consistency of the adapted version of ACT was found to be at a reliable level (a=0.8535). The Turkish version of ACT can be considered to be a reliable and valid measure of working memory. 相似文献