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排序方式: 共有107条查询结果,搜索用时 15 毫秒
1.
2.
R. Kumar R. Kapoor B. Mittal A. Kumar R. D. Mittal 《Indian journal of clinical biochemistry : IJCB》2003,18(2):209-215
Metabolic abnormalities were investigated in 44 stone patients with first time (group 1) and 56 with 2 times stone formation
(group 2), and in 25 normal individuals. 24hr urine was analysed spectrophotometrically for oxalate, calcium, magnesium, citrate,
uric acid, phosphate and creatinine. Hypocitraturia and hyperoxaluria were the common abnormalities in the stone formers.
Stone patients had significantly higher urinary oxalate, calcium and uric acid and lower phosphate than normal individuals.
Citrate/calcium and magnesium/calcium ratio were significantly high in normal individuals than stone formers. Patients in
group 2 excreted significantly higher urinary calcium and lower citrate that patients in group 1. Citrate/calcium ratio was
higher in group 1 than group 2. Hypocitraturia, hyperoxaluria, hypercalciuria and increased citrate/calcium and magnesium/calcium
ratio seem to be an essential risk factor for stone formation. Patients with recurrent stone formation could be distinguished
from patients with first time stone formation on the basis of urinary calcium and citrate. 相似文献
3.
Apurva Srivastava Neena Srivastava Balraj Mittal 《Indian journal of clinical biochemistry : IJCB》2016,31(4):361-371
Numerous classical genetic studies have proved that genes are contributory factors for obesity. Genes are directly responsible for obesity associated disorders such as Bardet–Biedl and Prader–Willi syndromes. However, both genes as well as environment are associated with obesity in the general population. Genetic epidemiological approaches, particularly genome-wide association studies, have unraveled many genes which play important roles in human obesity. Elucidation of their biological functions can be very useful for understanding pathobiology of obesity. In the near future, further exploration of obesity genetics may help to develop useful diagnostic and predictive tests for obesity treatment. 相似文献
4.
S. Suchalatha C. S. Shyamala Devi 《Indian journal of clinical biochemistry : IJCB》2004,19(2):184-189
To study the protective role of Arogh on isoproterenol induced myocardial damage in rats. The effect of Arogh pretreatment
on isoproterenol induced myocardial damage was assessed by studying the levels of lipid peroxides and changes in the activity
of marker enzymes such as creatine kinase, lactate dehydrogenase and transaminases in serum and heart tissue. In isoproterenol
administered rats, a significant decrease was observed in the activity of marker enzymes in the heart with a corresponding
increase in their levels in serum. Lipid peroxide levels increased significantly in the serum and heart. In rats pretreated
with arogh, the level of lipid peroxides and the activity of marker enzymes were maintained at near normal values. Pretreatment
with Arogh offered a protective effect against isoproterenol induced myocardial damage in rats as evidenced by LDH isoenzyme
patterm and histopathological studies of heart tissue. 相似文献
5.
Serum glycoproteins were evaluated in oral squamous cell carcinoma patients treated with radiotherapy and also the effect
of vitamin E was studied. Cell surface glycoconjugates are important parameters in the detection of malignancy. Thus, the
objective of the present study is to evaluate the efficacy of vitamin E on glycoproteins in oral cavity cancer patients treated
with radiotherapy. The study includes 26 age and sex matched normal healthy individuals and 26 patients with squamous cell
carcinoma of oral cavity. These patients were divided into two groups, one for radiotherapy alone (at a dosage of 6000 cGy
in five fractions per week for a period of six weeks) and the other for radiotherapy plus vitamin E supplementation (at a
dosage of 400 IU / day of vitamin E) for the entire period of radiotherapy. Levels of hexose, hexosamine, fucose and sialic
acid were increased in oral squamous cell carcinoma patients and a significant decrease was observed in radiation treated
patients when compared to control. The levels of glycoconjugates were significantly decreased in radiation treated patients
supplemented with vitamin E. This measurement may be useful in assessing disease progression and identifying patients resistant
to therapy and a possible role of vitamin E on reduction in glycoconjugate levels of radiation treated oral squamous cell
carcinoma patients. 相似文献
6.
J Kato Alice Abraham Ruram S Sekharjit Singh S Bilasini Devi Th Ibetombi Devi W Gyaneshwar Singh 《Indian journal of clinical biochemistry : IJCB》2007,22(1):128-130
The present, study was conducted to determine the level of malondialdehyde (MDA) as an index of free radial induced lipid
peroxidation and antioxidant vitamins-vitamins A, vitamin C and vitamin E in 75 confirmed cases of urolithiasis. Significantly
high level of MDA (p<0.001) with significantly low levels of vitamin E (p<0.001) and vitamin A (p<0.001) with no significant
decrease in vitamin C (p>0.05) were observed in the plasma of urolithiasis cases as compared to normal controls. In conclusion,
it appears that a role of lipid peroxidation and oxidative function exists in the pathogenesis of urolithiasis. But, the exact
mechanism how this occurs remains to be elucidated. 相似文献
7.
8.
Davinder Mittal 《Resonance》1997,2(7):64-66
A simple chemical process is described for extracting amorphous silica from rice husk. 相似文献
9.
During the last decade it has been argued by some investigators that the distribution of galaxies in the Universe is a fractal.
This is contrary to the standard view that the Universe is homogeneous and isotropic on large scales. In this article, the
basic concepts of fractals and their characterization are introduced with the help of simple examples. The applications of
these concepts in the context of cosmology will be discussed in the second part.
A K Mittal is currently a visiting scientist at Harish-Chandra Research Institute, Allahabad, on leave from the University
of Allahabad. His research interests include chaos, fractals and their applications, partleularly in cosmology and in weather
prodiction.
T H Seshadri is at the Department of Physics and Astrophysics, University of Delhi. He is presently on lien from Harish-Chandra
Research Institute, Allahabad. Areas of his interest include cosmic microwave background radiation, large scale structures
in the Universe and application of fractals in these. 相似文献
10.
Thyagaraju K. Hemavathi B. Vasundhara K. Rao A. D. Devi K. N. 《Journal of Zhejiang University. Science. B》2005,6(8):759-769
A comparative study was made on the tissue specific expression of glutathione transferases (GST) in brain and testis after
exposure of rat to phenobarbitol (PB) and β-methylcholanthrene (MC). Glutathione transferases, a family of multifunctional
proteins are involved in intracellular transport processes and in detoxication of electrophilic xenobiotics by catalyzing
reactions such as conjugation, isomerization, reduction and thiolysis. On purification, the yield of GST proteins by affinity
chromatography was 39% in testis and 32% in brain. The affinity purified testis GSTs were resolved by chromatofocusing into
six anionic and four cationic isozymes, and in brain glutathione transferases were resolved into four anionic and three cationic
isozymes, suggesting the presence of multiple isozymes with Yc, Yb, Yβ and Yδ in both of them. In testis and brain, these
isozymes at identical pI values showed variable functions with a battery of substrates and the cationic isozymes of brain
and testis showed identical properties in CHP (cumene hydroperoxide) at pH values of above 7.0. Substrate specificity studies
and immunoblot analysis of testis and brain proteins revealed that they play a predominant role in the detoxication of phenobarbitol
or β-methylcholanthrene. Expression of the isozymes in testis and brain on exposure to PB and MC indicated elevated subunit
variation. In both testis and brain, Yδ of π class was expressed on PB treatment and Yc of α class and Yβ of μ class was expressed
in MC treated testis and only Yc was predominantly expressed in MC treated brain. Thus these subunits expression is considered
as markers for carcinogenesis and specific to chemical toxicity under phenobarbitol and β-methylcholanthrene stress.
Project supported by Department of Science and Technology and Council for Scientific and Industrial Research, New Delhi 相似文献