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1.
E Arvat R Giordano J Ramunni G Arnaldi A Colao R Deghenghi G Lombardi F Mantero F Camanni E Ghigo 《Canadian Metallurgical Quarterly》1998,83(12):4207-4211
We previously reported that in Cushing's disease (CD) the ACTH- and cortisol (F)-releasing activity of Hexarelin (HEX), a GH secretagogue, is exaggerated with respect to that in normal subjects and is higher than that of human CRH (hCRH), but it is absent in Cushing's syndrome. Our aim was to extend the study about the effects of HEX (2.0 microg/kg, iv) on ACTH and F secretion in 21 patients with CD (3 men and 18 women, 16-68 yr old). Based on magnetic resonance imaging, 15 CD patients had pituitary microadenoma, and 6 had macroadenoma. The results in CD patients were compared with those in 27 normal age-matched controls (NS; 10 men and 17 women, 24-69 yr old). Basal ACTH and F levels in CD were similar in patients with microadenom (mean+/-SEM, 78.3+/-7.2 pg/mL and 237.1+/-23.6 microg/L, respectively) and macroadenoma (57.4+/-9.0 pg/mL and 196.9+/-20.1 microg/L, respectively) and were higher (P < 0.001) than those in NS (17.7+/-2.0 pg/mL and 115.3+/-6.7 microg/L, respectively). In microadenoma CD patients, HEX induced marked ACTH and F increases (delta peak, mean+/-SEM: 261.2+/-77.6 pg/mL and 226.1+/-87.2 microg/L, respectively), which were higher (P < 0.04) than those induced by hCRH (45.6+/-16.9 pg/mL and 84.6+/-25.7 microg/L, respectively). Moreover, in microadenoma CD patients, the ACTH and F responses to HEX were higher (P < 0.001) than those in NS (18.5+/-4.0 pg/mL and 36.1+/-6.8 microg/L, respectively). In macroadenoma CD patients, HEX induced a slight, but significant increase (P < 0.02) in ACTH and F levels (33.9+/-18.0 pg/mL and 89.6+/-34.3 microg/L, respectively), which was not significantly different from that elicited by hCRH (20.0+/-7.0 pg/mL and 54.8+/-21.3 microg/L, respectively). In macroadenoma CD patients, the ACTH and F responses to HEX and hCRH were, in turn, similar to those in NS. In conclusion, our findings demonstrate that the ACTH and F hyperresponsiveness to HEX is present in Cushing's disease with micro-, but not macro- ACTH-secreting pituitary adenoma. This finding agrees with other evidence pointing toward differences in the hormonal behavior between micro- and ACTH-secreting pituitary macroadenomas. 相似文献
2.
G Giordano 《Canadian Metallurgical Quarterly》1996,67(3):327-334
Thyroid nodules are among the most common clinical problems in endocrinology. Among several factors responsible for the development of goiter, circulating TSH plays a major role because of its direct growth-promoting effects on the thyroid cells; moreover TSH may enhance the effects of other local growth factors which act in a paracrine mode in the thyroid gland. In addition, autoimmune thyroiditis can clinically appear as thyroid nodules frequently with the functional aspect of a subclinical hypothyroidism. For these reasons a therapeutical approach based on the thyroxine suppression of TSH secretion has become largely used by 1970s and is correctly employed in 75% of the patients with thyroid nodules whose biopsies result benign. 相似文献
3.
All over the world there are enormous unexploited renewable energy reserves (hydro, geothermic, solar, wind, etc.). Most originate far from the location of the users, so their exploitation would greatly benefit from the disclosure of new, more economical, and technically feasible transmission systems.A possible alternative to electricity is the use of hydrogen as a medium for transportation of energy. This work proposes a chemical closed-loop cycle based upon catalytic reversible reactions as a means to transmit hydrogen. A real example for the application of the proposed system for transportation of secondary energy was considered. In particular, choosing a large hydro-electric source as reference, a comparison was made between costs and efficiencies in transferring energy as hydrogen (in its different forms) over long distances, with respect to transportation of the same energy as electricity. 相似文献
4.
Thai Binh Wan Rachel Seneviratne Aruna Rakotoarivelo Thierry 《Mobile Networks and Applications》2003,8(1):27-36
The high expectations and demand for users to access the Internet from anywhere at anytime has made user mobility an important part of the design and development of the next generation mobile communications and computing. Traditionally user mobility has been divided into two areas: Terminal Mobility and Personal Mobility. In recent years terminal mobility has focused on the movement of the terminal and developed extensions to IP protocols such as Mobile IP. In contrast, personal mobility has only received limited attention, and is somewhat lagging behind. This research has either focussed on personal mobility in communications or personalisation of operating environments. As a result, to date no framework for providing true personal mobility has emerged. In this paper, we introduce a new personal mobility framework called IPMoA (Integrated Personal Mobility Architecture), which integrates both aspects of personal mobility to provide a complete personal mobility solution, and illustrate the viability of this approach through a proof-of-concept implementation. 相似文献
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7.
Mixture-proportioning of high-performance concrete 总被引:6,自引:0,他引:6
The paper presents a new approach to design concrete mixtures. It is based upon a set of models relating composition and engineering properties of concrete, to be implemented into software, linked with a material database. The principles underlying the various models are summarized, most of which focus on the granular structure of fresh/hardened concrete. A global approach to concrete is promoted, where performance specifications can be formulated in terms of fresh concrete (yield stress, plastic viscosity, slump and air content), hardening concrete (adiabatic temperature rise and autogenous shrinkage) and hardened concrete (compressive strength at any age, tensile strength, elastic modulus, creep and shrinkage). This approach is illustrated through the design of a special high-shrinkage high-performance concrete (HPC) for road application. To date, durability is lacking in the model and requires further research. 相似文献
8.
The IEEE 802.11e medium access control (MAC) layer protocol is an emerging standard to support quality of service (QoS) in
802.11 wireless networks. Some recent work shows that the 802.11e hybrid coordination function (HCF) can improve significantly
the QoS support in 802.11 networks. A simple HCF referenced scheduler has been proposed in the 802.11e which takes into account
the QoS requirements of flows and allocates time to stations on the basis of the mean sending rate. As we show in this paper,
this HCF referenced scheduling algorithm is only efficient and works well for flows with strict constant bit rate (CBR) characteristics.
However, a lot of real-time applications, such as videoconferencing, have some variations in their packet sizes, sending rates
or even have variable bit rate (VBR) characteristics. In this paper we propose FHCF, a simple and efficient scheduling algorithm
for 802.11e that aims to be fair for both CBR and VBR flows. FHCF uses queue length estimations to tune its time allocation
to mobile stations. We present analytical model evaluations and a set of simulations results, and provide performance comparisons
with the 802.11e HCF referenced scheduler. Our performance study indicates that FHCF provides good fairness while supporting
bandwidth and delay requirements for a large range of network loads.
Pierre Ansel received a multidisciplinary in-depth scientific training in different fields such as Pure and Applied Mathematics, Physics,
Mechanics, Computer Science and Economics from the Ecole Polytechnique, Palaiseau, France. Then, he joined the Ecole Nationale
Superieure des Telecommunications, Paris, France in 2005 where he went further into electronics, databases, computer network
security and high speed networks. He received a multidisciplinary master of sciences degree and an additional master of sciences
degree in telecommunications in 2005. He did a summer internship in 2003 in INRIA, Sophia Antipolis, France where he worked
on the Quality of Service in 802.11 networks at Planete Group, France. Then in 2004, he joined France Telecom R&D, Issy-les-Moulineaux,
France to work on Intranet Security issues. He designed a WiFi security supervision architecture based on WiFi Intrusion Detection
Sensors. He is currently a French civil servant and belongs to the French Telecommunications Corps.
Qiang Ni received the B.Eng., M.Sc. and Ph.D. degrees from Hua Zhong University of Science and Technology (HUST), Wuhan City, China
in 1993, 1996 and 1999 respectively. He is currently a faculty member in the Electronic and Computer Engineering Division,School
of Engineering and Design, Brunel University, West London, U.K. Between 2004 and 2005 he was a Senior Researcher at the Hamilton
Institute, National University of Ireland, Maynooth. From 1999 to 2001, he was a post-doctoral research fellow in the multimedia
and wireless communication laboratory, HUST, China. He visited and conducted research at the wireless and networking group
of Microsoft Research Asia Lab during the year of 2000. From Sept. 2001 until may 2004, he was a research staff member at
the Planète group of INRIA Sophia Antipolis France. Since 2002, he has been active as a voting member at the IEEE 802.11 wireless
LAN standard working group. His current research interests include communication protocol design and performance analysis
for wireless networks, cross-layer optimizations, vertical handover and mobility management in mobile wireless networks, and
adaptive multimedia transmission over hybrid wired/wireless networks. He has authored /co-authored over 40 international journal/conference
papers, book chapters, and standard drafts in this field. He is a member of IEEE. E-mail: Qiang.Ni@ieee.org
Thierry Turletti received the M.S. (1990) and the Ph.D. (1995) degrees in computer science both from the University of Nice – Sophia Antipolis,
France. He has done his PhD studies in the RODEO group at INRIA Sophia Antipolis. During the year 1995–96, he was a postdoctoral
fellow in the Telemedia, Networks and Systems group at LCS, MIT. He is currently a research scientist at the Planete group
at INRIA Sophia Antipolis. His research interests include multimedia applications, congestion control and wireless networking.
Dr. Turletti currently serves on the Editorial Board of Wireless Communications and Mobile Computing. 相似文献
9.
In recent years biodegradable polymers, particularly polyesters such as the poly(lactic acid) (PLA) and polycaprolactone (PCL), have gained high interests for their applicability in the biomedical and pharmaceutical fields where they're used for manufacturing various different resorbable devices, from tissue engineering scaffolds to controlled drug release systems. Despite many positive characteristics, processability of these materials still remains a critical issue as they easily tend to degrade during manufacturing. In this article we aimed to assess microextrusion as a nondegradative process for manufacturing PLA and PCL. The results we experimentally obtained, that are hereby presented, set a new point in the on‐going debate on degradation during processing of resorbable polymers as they allow to affirm that microextrusion leaves unmodified molecular weight distributions without producing any evident reductions in mean molecular weight. Microextrusion thus represents a risk‐free high molecular weight polymer processing solution for obtaining nondegraded products within pharmaceutical and biomedical production lines, such as for scaffolds for tissue engineering applications or drug delivery. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008 相似文献
10.
We compare, in this paper, the far field radiated by two fractal distributions of current. The first one is obtained by a fractal cut following the Cantor arrangement, the second one keeps the length of each previous current element, but modifies the distance between the elements which is now taken as a constant. We establish the analytical formulations of the far field at any step n of the Cantor set. Then, we extract the array factor and we analyse and compare the following properties : convergence of the radiation pattern, wide of the main lobe, side lobes level and directivity. 相似文献