Surface waves on a homogeneously fluidized bed

Summary This paper examines the small-amplitude free-surface motions on a homogeneously fluidized bed for which the density ratio % MathType!MTEF!2!1!+-% feaafiart1ev1aaatCvAUfeBSjuyZL2yd9gzLbvyNv2CaerbuLwBLn% hiov2DGi1BTfMBaeXatLxBI9gBaerbd9wDYLwzYbItLDharqqtubsr% 4rNCHbGeaGqiVu0Je9sqqrpepC0xbbL8F4rqqrFfpeea0xe9Lq-Jc9% vqaqpepm0xbba9pwe9Q8fs0-yqaqpepae9pg0FirpepeKkFr0xfr-x% fr-xb9adbaqaaeGaciGaaiaabeqaamaabaabaaGcbaGaeqyWdi3aaS% baaSqaaiaadAgaaeqaaOGaai4laiabeg8aYnaaBaaaleaacaWGZbaa% beaakiablQMi9iaaigdaaaa!3E84!\[\rho _f /\rho _s \ll 1\], where _f is the fluid density and _s is the solid density. It is shown that to leading order in % MathType!MTEF!2!1!+-% feaafiart1ev1aaatCvAUfeBSjuyZL2yd9gzLbvyNv2CaerbuLwBLn% hiov2DGi1BTfMBaeXatLxBI9gBaerbd9wDYLwzYbItLDharqqtubsr% 4rNCHbGeaGqiVu0Je9sqqrpepC0xbbL8F4rqqrFfpeea0xe9Lq-Jc9% vqaqpepm0xbba9pwe9Q8fs0-yqaqpepae9pg0FirpepeKkFr0xfr-x% fr-xb9adbaqaaeGaciGaaiaabeqaamaabaabaaGcbaGaeqyWdi3aaS% baaSqaaiaadAgaaeqaaOGaai4laiabeg8aYnaaBaaaleaacaWGZbaa% beaaaaa!3C65!\[\rho _f /\rho _s \], the surface motions are independent of the dynamics of the bed varying only with the dimensions of the bed and the conditions at uniform fluidization. Also, at leading order, it is found that provided the fluidization remains homogeneous there is a direct analogy between waves on the free surface of a fluidized bed and waves on the free surface of an inviscid liquid (when surface tension is neglected).     

The evolution of a two-dimensional small-amplitude voidage disturbance in a uniformly fluidized bed

Summary The evolution of a small-amplitude localized voidage disturbance through a two-dimensional fluidized bed is considered. A solution of the full initial-value problem reveals that the stability condition for the uniform state is found to be in agreement with that given by Needham and Merkin [1] for narrow beds. Further, it is shown that for a given flow rate for which the uniform state is unstable, more and more cross-channel modes become instable with increasing bed width, in accordance with the observations of Didwania and Homsy [3]. Finally a solution is obtained forF 1, whereF is the Froude number. The resulting Fourier series is summed numerically, which enables the evolution of the initial disturbance to be followed by plotting contours of constant voidage with increasing time. This shows that in narrow beds the motion is primarily one-dimensional, confirming the supposition of [1], with cross-stream variations becoming more dominant as the bed width increases.     

Serum concentrations of polyfluoroalkyl compounds in Faroese whale meat consumers

To learn the extent of human exposure to polyfluoroalkyl compounds (PFCs) in a remote fishing population, we measured, in Faroese children and pregnant women, the serum concentrations of nine PFCs, including perfluorooctane sulfonate (PFOS), perfluorooctanoate (PFOA), and perfluorononanoate (PFNA), by using online solid-phase extraction coupled to isotope dilution high-performance liquid chromatography-tandem mass spectrometry. The serum samples analyzed had been collected between 1993 and 2005 from 103 children 7 years of age, 79 of these children at 14 years of age, and from 12 pregnant women and their children 5 years later. PFOS was detected in all samples analyzed, and both PFOA and PFNA were detected in all but one of the samples. The concentrations found are comparable tothose reported elsewhere. Correlations between paired concentrations were poor. However, PFOS and PFNA concentrations correlated well with the frequency of pilotwhale dinners and with concentrations of mercury and polychlorinated biphenyls. One whale meal every two weeks increased the PFOS concentration in 14-year-olds by about 25% and PFNA by 50%. The high frequency of detection of most PFCs suggests widespread exposure in the Faroe Islands already by the early 1990s, with whale meat being an important source.     

Alkylation of Staurosporine to Derive a Kinase Probe for Fluorescence Applications

The natural product staurosporine is a high‐affinity inhibitor of nearly all mammalian protein kinases. The labelling of staurosporine has proven effective as a means of generating protein kinase research tools. Most tools have been generated by acylation of the 4′‐methylamine of the sugar moiety of staurosporine. Herein we describe the alkylation of this group as a first step to generate a fluorescently labelled staurosporine. Following alkylation, a polyethylene glycol linker was installed, allowing subsequent attachment of fluorescein. We report that this fluorescein–staurosporine conjugate binds to cAMP‐dependent protein kinase in the nanomolar range. Furthermore, its binding can be antagonised with unmodified staurosporine as well as ATP, indicating it targets the ATP binding site in a similar fashion to native staurosporine. This reagent has potential application as a screening tool for protein kinases of interest.     

Retarding effects of DNA on the autoxidation of liposomal suspensions

Deoxyribonucleic acid (DNA) is associated with the cell membrane of prokaryotes and the inner nuclear membrane of eukaryotes. The unsaturated fatty acids of phospholipids, which constitute the bilaminar structure of membranes, undergo autoxidation in the presence of O₂. Calf thymus DNA was incubated with methyl archidonate-enriched phosphatidyl choline liposomes in order to study the effect of DNA upon the oxidation of phospholipids while present in their natural in vivo bilayer configuration. DNA retarded the rate of lipid oxidation and the TBA test, but it did not alter the induction period. These results suggest that DNA is scavenging free radicals produced within the phospholipid bilayer.     

Snowpack response in the Assiniboine-Red River basin associated with projected global warming of 1.0 °C to 3.0 °C

This study assesses snow response in the Assiniboine-Red River basin, located in the Lake Winnipeg watershed, due to anthropogenic climate change. We use a process-based distributed snow model driven by an ensemble of eight statistically downscaled global climate models (GCMs) to project future changes under policy-relevant global mean temperature (GMT) increases of 1.0 °C to 3.0 °C above the pre-industrial period. Results indicate that basin scale seasonal warmings generally exceed the GMT increases, with greater warming in winter months. The majority of GCMs project wetter winters and springs, and drier summers, while autumn could become either drier or wetter. An analysis of snow water equivalent (SWE) responses under GMT changes reveal higher correlations of snow cover duration (SCD), snowmelt rate, maximum SWE (SWE_max) and timing of SWE_max with winter and spring temperatures compared to precipitation, implying that these variables are predominantly temperature controlled. Consequently, under the GMT increases from 1.0 °C to 3.0 °C, the basin will experience successively shorter SCD, slower snowmelt, smaller monthly SWE and SWE_max, earlier SWE_max, and a transition from snow-dominated to rain-snow hybrid regime. Further, while the winter precipitation increases for some GCMs compensate the temperature-driven changes in SWE, the increases for most GCMs occur as rainfall, thus limiting the positive contribution to snow storage. Overall, this study provides a detailed diagnosis of the snow regime changes under the policy-relevant GMT changes, and a basis for further investigations on water quantity and quality changes.     

Autonet: a high-speed, self-configuring local area network usingpoint-to-point links

Autonet is a self-configuring local area network composed of switches interconnected by 100 Mb/s, full-duplex, point-to-point links. The switches contain 12 ports that are internally connected by a full crossbar. Switches use cut-through to achieve a packet forwarding latency as low as 2 ms/switch. Any switch port can be cabled to any other switch port or to a host network controller. A processor in each switch monitors the network's physical configuration. A distributed algorithm running on the switch processor computes the routes packets are to follow and fills in the packet forwarding table in each switch. With Autonet, distinct paths through the set of network links can carry packets in parallel, allowing many pairs of hosts to communicate simultaneously at full link bandwidth. A 30-switch network with more than 100 hosts has been the service network for Digital's Systems Research Center since February 1990     

A System for the Rapid Acquisition of Surface Potential Maps of Human Skeletal Muscle Motor Units

Inability to predict the intramusclar orientation, depth, and distribution of a motor unit's muscle fibers within a human skeletal muscle complicates unit size estimation. A data collection system is described that is suitable for systematic study of this problem.