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1.
H Gonen I Stancovski D Shkedy T Hadari B Bercovich E Bengal S Mesilati O Abu-Hatoum AL Schwartz A Ciechanover 《Canadian Metallurgical Quarterly》1996,271(1):302-310
Degradation of a protein via the ubiquitin system involves two discrete steps, conjugation of ubiquitin to the substrate and degradation of the adduct. Conjugation follows a three-step mechanism. First, ubiquitin is activated by the ubiquitin-activating enzyme, E1. Following activation, one of several E2 enzymes (ubiquitin-carrier proteins or ubiquitin-conjugating enzymes, UBCs) transfers ubiquitin from E1 to the protein substrate that is bound to one of several ubiquitin-protein ligases, E3s. These enzymes catalyze the last step in the process, covalent attachment of ubiquitin to the protein substrate. The binding of the substrate to E3 is specific and implies that E3s play a major role in recognition and selection of proteins for conjugation and subsequent degradation. So far, only a few ligases have been identified, and it is clear that many more have not been discovered yet. Here, we describe a novel ligase that is involved in the conjugation and degradation of non "N-end rule" protein substrates such as actin, troponin T, and MyoD. This substrate specificity suggests that the enzyme may be involved in degradation of muscle proteins. The ligase acts in concert with E2-F1, a previously described non N-end rule UBC. Interestingly, it is also involved in targeting lysozyme, a bona fide N-end substrate that is recognized by E3 alpha and E2-14 kDa. The novel ligase recognizes lysozyme via a signal(s) that is distinct from the N-terminal residue of the protein. Thus, it appears that certain proteins can be targeted via multiple recognition motifs and distinct pairs of conjugating enzymes. We have purified the ligase approximately 200-fold and demonstrated that it is different from other known E3s, including E3 alpha/UBR1, E3 beta, and E6-AP. The native enzyme has an apparent molecular mass of approximately 550 kDa and appears to be a homodimer. Because of its unusual size, we designated this novel ligase E3L (large). E3L contains an -SH group that is essential for its activity. Like several recently described E3 enzymes, including E6-AP and the ligase involved in the processing of p105, the NF-kappa B precursor, the novel ligase is found in mammalian tissues but not in wheat germ. 相似文献
2.
Yiling Chen Stanko Dimitrov Rahul Sami Daniel M. Reeves David M. Pennock Robin D. Hanson Lance Fortnow Rica Gonen 《Algorithmica》2010,58(4):930-969
We study the equilibrium behavior of informed traders interacting with market scoring rule (MSR) market makers. One attractive feature of MSR is that it is myopically incentive compatible: it is optimal for traders to report their true beliefs about the likelihood of an event outcome provided that they ignore
the impact of their reports on the profit they might garner from future trades. In this paper, we analyze non-myopic strategies
and examine what information structures lead to truthful betting by traders. Specifically, we analyze the behavior of risk-neutral
traders with incomplete information playing in a dynamic game. We consider finite-stage and infinite-stage game models. For
each model, we study the logarithmic market scoring rule (LMSR) with two different information structures: conditionally independent
signals and (unconditionally) independent signals. In the finite-stage model, when signals of traders are independent conditional
on the state of the world, truthful betting is a Perfect Bayesian Equilibrium (PBE). Moreover, it is the unique Weak Perfect
Bayesian Equilibrium (WPBE) of the game. In contrast, when signals of traders are unconditionally independent, truthful betting
is not a WPBE. In the infinite-stage model with unconditionally independent signals, there does not exist an equilibrium in which
all information is revealed in a finite amount of time. We propose a simple discounted market scoring rule that reduces the
opportunity for bluffing strategies. We show that in any WPBE for the infinite-stage market with discounting, the market price
converges to the fully-revealing price, and the rate of convergence can be bounded in terms of the discounting parameter.
When signals are conditionally independent, truthful betting is the unique WPBE for the infinite-stage market with and without
discounting. 相似文献
3.
Demet Korucu Ercan Ertekin İbrahim Belenli Semsettin Altindal 《Journal of Superconductivity and Novel Magnetism》2013,26(6):2165-2170
The dielectric loss (ε″) properties of MgB2 composites were investigated by using the conductance–voltage (G/w–V) measurements in the wide frequency and applied bias voltage range at four different temperature levels. Experimental results show that both G/w and ε″ are found strong functions of frequency and applied bias voltage for each temperature level. These changes in G/w and ε″ are considerably high especially at low frequencies and temperatures. The values of ε″ decrease exponentially with increasing frequency until 100 kHz and then become almost constant. Such behavior of G/w and ε″ shows that interfacial polarization is more effective especially at low frequencies. In addition, the current–voltage (I–V) characteristics were also evaluated for 100, 200, and 300 K, and the I–V curves for each temperature show linear behavior. Results indicate that the G/w–V measurements may be a useful tool to characterize the dielectric properties and conductivity of MgB2. 相似文献
4.
The adsorption of Th4+ ions was studied on composites of polyacrylamide (PAAm) with montmorillonite (Mt), clinoptilolite (Z) and zeolite Y (ZY), and after phytic acid (Phy) modification.The monolayer adsorption capacity was 0.33 and 0.65 mol kg? 1 for PAAm-Mt and PAAm-Mt-Phy, 0.07, 0.21 and 0.60 mol kg? 1 for Z, PAAm-Z and PAAm-Z-Phy, and 0.74, 0.89 and 1.18 mol kg? 1 for ZY, PAAm-ZY and PAAm-ZY-Phy. The enthalpy and entropy changes were positive for all adsorbents. The adsorption kinetics followed the pseudo-second order model indicating that the rate controlling step was chemical adsorption by ion exchange. The reusability tests for five uses proved that the PAAm-Mt and PAAm-Z were reusable and complete recovery of the adsorbed ions was possible. ZY and the composites modified with Phy were not reusable. The presence of foreign metal cations did not influence the Th4+ adsorption. The adsorbed Th4+ onto the columns was effectively recovered with diluted HNO3. 相似文献
5.
We present two fully sequential indifference-zone procedures to select the best system from a number of competing simulated systems when best is defined in terms of the maximum or minimum expected performance. These two procedures have parabola shaped continuation regions rather than the triangular continuation regions employed in several papers in the existing literature. The procedures we present accommodate unequal and unknown variances across systems and the use of common random numbers. However, we assume that basic observations are independent and identically normally distributed. We compare the performance of our procedures with those of other fully sequential procedures available in the literature. 相似文献
6.
Mithat Gonen Madan L. Puri Frits H. Ruymgaart & Martien C. A. van Zuijlen 《时间序列分析杂志》2000,21(3):249-260
In this note we introduce a simple principle to derive a constructive expression for the density of the limiting distribution, under the null hypothesis, of unit root statistics for an AR(1)-process in a variety of situations. We consider the case of unknown mean and reconsider the well-known situation where the mean is zero. For long-range dependent errors we indicate how the principle might apply again. We also show that in principle the method also works for a near unit root case. Weak convergence and subsequent Karhunen-Loeve expansion of the weak limit of the partial sum process of the errors plays an important role, along with the evaluation of a certain normal type integral with complex mean and variance. For independent and long range dependent errors this weak limit is ordinary and fractional Brownian motion respectively.
AMS 1991 subject classification. Primary 62M10; secondary 62E20. 相似文献
AMS 1991 subject classification. Primary 62M10; secondary 62E20. 相似文献
7.
8.
Determination of photoinitiated polymerization of multifunctional acrylates with acetic acid derivatives of thioxanthone by RT-FTIR 总被引:1,自引:0,他引:1
Feyza Karasu Meral AydinM. Arif Kaya Demet Karaca BaltaNergis Arsu 《Progress in Organic Coatings》2009
Photopolymerization of multifunctional acrylates with 2-thioxanthone-thioacetic acid (TXSCH2COOH) and 2-(carboxymethoxy) thioxanthone (TXOCH2COOH) as the one-component photoinitiator has been investigated by real-time Fourier transform infrared (RT-FTIR) spectroscopy. The photobleaching of these one-component nature initiators was performed in air. The irradiation time for total bleaching was 240 s for TXSCH2COOH and 540 s for TXOCH2COOH. 相似文献
9.
Smart structures and their applications on active vibration control: Studies in the Department of Aerospace Engineering, METU 总被引:1,自引:0,他引:1
Melin Sahin Fatih Mutlu Karadal Yavuz Yaman Omer Faruk Kircali Volkan Nalbantoglu Fatma Demet Ulker Tarkan Caliskan 《Journal of Electroceramics》2008,20(3-4):167-174
This work presents the theoretical and experimental studies conducted in Aerospace Engineering Department of Middle East Technical
University on smart structures with particular attention given to the structural modelling characteristics and active suppression
of in-vacuo vibrations. The smart structures considered in these analyses are finite and flat aluminium cantilever beam-like
(called as smart beam) and plate-like (called as smart fin) structures with surface bonded lead–zirconate–titanate patches.
Finite element models of smart beam and smart fin are obtained. Then the experimental studies regarding open loop behaviour
of the structures are performed by using strain gauges and laser displacement sensor to determine the system models. Further
studies are carried out to obtain H
∞ and μ-synthesis controllers which are intended to be used in the suppression of free and forced vibrations of the smart structures.
It is observed that satisfactory attenuation levels are achieved and robust performance of the systems in the presence of
uncertainties is ensured. In that respect a comparative study involving H
∞ and sliding mode controls is also conducted. Recently, the studies involving aerodynamic loading are also gathering pace. 相似文献