Long-term sensor measurements of lung deposited surface area of particulate matter emitted from local vehicular and residential wood combustion sources

Abstract

Lung deposited surface area (LDSA) is a relatively new metric that has been argued to be more accurate at predicting health effects from aerosol exposure. For typical atmospheric aerosol, the LDSA concentration depends mainly on the concentration of ultrafine particles (e.g. vehicular exhaust emissions and residential wood combustion) and therefore optical methods cannot be used to measure and quantify it. The objective of this study was to investigate and describe typical characteristics of LDSA under different urban environments and evaluate how a diffusion charging-based Pegasor AQ Urban sensor (Pegasor Ltd., Finland) can be used as an alternative to optical sensors when assessing local combustion emissions and respective LDSA concentrations. Long-term (12?months) sensor measurements of LDSA were carried out at three distinctly different measurement sites (four sensor nodes) in the Helsinki metropolitan area, Finland. The sites were affected mainly by vehicular exhaust emission (street canyon and urban background stations) and by residential wood combustion (two detached housing area stations). The results showed that the accuracy of the AQ Urban was good (R² = 0.90) for the measurement of LDSA when compared to differential mobility particle sizer. The mean concentrations of LDSA were more than twice as high at the street canyon (mean 22 µm² cm^?3) site when compared to the urban background site (mean 9.4 µm² cm^?3). In the detached housing area, the mean concentrations were 12 µm² cm^?3, and wood combustion typically caused high LDSA peaks in the evenings. High correlations and similar diurnal cycles were observed for the LDSA and black carbon at street canyon and urban background stations. The utilization of a small-scale sensor network (four nodes) showed that the cross-station variability in hourly LDSA concentrations was significant in every site, even within the same detached housing area (distance between the two sites ～670?m).     

Scientific and artistic investigation of multi-dimensional fractals on the AT & T pixel machine

The pipelined architecture and parallel organization of the AT&T Pixel Machine image computer are described and demonstrated with applications for the visualization of multidimensional fractals, particularly linear fractals and quaternion/ stacked Julia sets. Techniques for pushing the Pixel Machine to its peak abilities are described and apply to more recent parallel image computers as well.     

Manual dexterity of older Mexican American adults: a cross-sectional pilot experimental investigation

This paper reports results from an experimental pilot study performed to quantify the manual dexterity of older Mexican American adults. The Purdue pegboard test, a two-arm coordination test, and a hand-tool dexterity test were used in this study. To enable cross-sectional comparisons of manual dexterity measures of older Mexican American adults with young Mexican American adults, these tests were administered to 18 older Mexican American adults aged 63–85 (mean age: 71.3 years, SD: 7.0 years), recruited from senior recreation centers in El Paso, and eighteen young adults aged 21–32 (mean age: 25.6 years, SD: 3.8 years) recruited from the student body at the University of Texas at El Paso. For the Purdue pegboard test, the number of pegs placed in 30 s using the preferred hand, the non-preferred hand, and both hands were first individually monitored. Then, scores on an assembly task using the Purdue pegboard were obtained. For the two-arm coordination test, participants were required to trace a star pattern with a stylus using both hands. The time for task completion and the number of errors made during task performance were monitored. For the hand-tool dexterity test, participants were required to use common hand tools and remove nuts and bolts from one side of a wooden upright, and to assemble nuts and bolts in the corresponding holes on the other side of the upright. The time taken for task completion was recorded. Since modified Levene's test showed equality of variances, two sample t-tests, comparing the mean responses of older adults with the mean responses of young adults for each individual test, were conducted. Results indicate that responses for the older adults were statistically significant different (p<0.001) from young adults for all Purdue pegboard tasks. On the average, older adults performed significantly slower (p<0.001) than young adults on the two-arm coordination test, and committed more errors before task completion (p<0.05). Older adults also took longer to complete the hand-tool dexterity task compared to their younger counterparts (p<0.05). In addition to the t-tests, manual dexterity performance measures from older adults were regressed with age to determine the cross-sectional age effects on manual dexterity measures. Results indicate that all Purdue pegboard performance measures were significantly affected by age (p<0.05). The time to complete the two-arm coordination test was significantly linearly related to age (p<0.05). However, the number of errors committed by older adults in the performance of the two-arm coordination test was not significantly linearly related to age. Time to complete the hand-tool dexterity was also significantly linearly related to age (p<0.05). Accommodating age-related changes in manual dexterity is important for job design in industry, especially in industries employing older adults requiring significant assembly and hand-tool use.

Relevance to industry

Given the aging of the industrial workforce, it is important to understand how manual dexterity is affected by age, so that jobs requiring significant manual dexterity for task initiation, task performance and task completion are designed to fit older adult dexterity levels.     

Results of a User Study on 2D Hurricane Visualization

We present the results from a user study looking at the ability of observers to mentally integrate wind direction and magnitude over a vector field. The data set chosen for the study is an MM5 (PSU/NCAR Mesoscale Model) simulation of Hurricane Lili over the Gulf of Mexico as it approaches the southeastern United States. Nine observers participated in the study. This study investigates the effect of layering on the observer's ability to determine the magnitude and direction of a vector field. We found a tendency for observers to underestimate the magnitude of the vectors and a counter‐clockwise bias when determining the average direction of a vector field. We completed an additional study with two observers to try to uncover the source of the counter‐clockwise bias. These results have direct implications to atmospheric scientists, but may also be able to be applied to other fields that use 2D vector fields.     

Performance of hashed cache data migration schemes on multicomputers

Many researchers approach the problem of programming distributed memory machines by assuming a global shared name space. Thus the user views the distributed memory of the machine as though it were shared. A major issue that arises at this point is how to manage the memory. When a processor accesses data stored on another processor's memory, data must be moved between the two processors. Once these data are retrieved from another processor's memory, several interesting issues are raised. Where should these data be stored locally? What transformations must be performed to the code to guarantee that the nonlocal accesses reference the correct memory location? What optimizations can be performed to reduce the time spent in accessing the nonlocal data? In this paper we examine various data migration mechanisms that allow an explicit and controlled mapping of data to memory. We describe, experimentally evaluate, and model a set of schemes for storing and retrieving off-processor array elements. The schemes are all based on using hash tables for efficient access of nonlocal data. The three different techniques evaluated are the basic hashed cache, partial enumeration, and full enumeration, the details of which are described in the paper. In all three schemes, nonlocal data are stored in hash tables—the difference is in the amount of memory used by the schemes and the retrieval mechanisms for nonlocal data.     

Dantrolene inhibition of sarcoplasmic reticulum Ca2+ release by direct and specific action at skeletal muscle ryanodine receptors

The skeletal muscle relaxant dantrolene inhibits the release of Ca2+ from the sarcoplasmic reticulum during excitation-contraction coupling and suppresses the uncontrolled Ca2+ release that underlies the skeletal muscle pharmacogenetic disorder malignant hyperthermia; however, the molecular mechanism by which dantrolene selectively affects skeletal muscle Ca2+ regulation remains to be defined. Here we provide evidence of a high-affinity, monophasic inhibition by dantrolene of ryanodine receptor Ca2+ channel function in isolated sarcoplasmic reticulum vesicles prepared from malignant hyperthermia-susceptible and normal pig skeletal muscle. In media simulating resting myoplasm, dantrolene increased the half-time for 45Ca2+ release from both malignant hyperthermia and normal vesicles approximately 3.5-fold and inhibited sarcoplasmic reticulum vesicle [3H]ryanodine binding (Ki approximately 150 nM for both malignant hyperthermia and normal). Inhibition of vesicle [3H]ryanodine binding by dantrolene was associated with a decrease in the extent of activation by both calmodulin and Ca2+. Dantrolene also inhibited [3H]ryanodine binding to purified skeletal muscle ryanodine receptor protein reconstituted into liposomes. In contrast, cardiac sarcoplasmic reticulum vesicle 45Ca2+ release and [3H]ryanodine binding were unaffected by dantrolene. Together, these results demonstrate selective effects of dantrolene on skeletal muscle ryanodine receptors that are consistent with the actions of dantrolene in vivo and suggest a mechanism of action in which dantrolene may act directly at the skeletal muscle ryanodine receptor complex to limit its activation by calmodulin and Ca2+. The potential implications of these results for understanding how dantrolene and malignant hyperthermia mutations may affect the voltage-dependent activation of Ca2+ release in intact skeletal muscle are discussed.     

Preventing and managing board complaints: The downside risk of custody evaluation.

Data compiled by the American Psychological Association (APA) revealed that 7%–10% of ethics complaints filed were against custody evaluators. Comparative data from various state and provincial psychology boards remain too sketchy to permit an accurate appraisal of this problem at the local level. Nevertheless, vulnerability to ethics complaints remains an occupational hazard for the private practitioner who engages in custody assessment. This article offers practitioners who conduct custody evaluations suggestions for reducing their risk of incurring an ethics complaint and discusses variables to consider when responding to a review board inquiry. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

From dissonance to disidentification: Selectivity in the self-affirmation process.

Two studies examined the relationship between the content of a self-threat and the attractiveness of available self-affirmations (C. M. Steele, 1988). After self-threat was induced by means of a cognitive dissonance procedure, participants' choices for affirmations were examined in order to explore whether the attractiveness of a given affirmation depends on its relevance to the threatened domain of the self-concept. The authors hypothesized that when faced with a threat to a specific self-conception or standard, individuals may forego affirmations within the threatened self-concept domain in favor of affirmations of unrelated, compensatory domains. Both studies supported this hypothesis and further suggested that such selective self-affirmation can lead individuals to modify their self-concepts by identifying with self-aspects that justify dissonant behavior and by disidentifying with the standards that such behavior violates. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Undersea optical stationkeeping: Improved methods

Submersibles require the capability to accurately maintain their position when they are observing, photographing, or working at a site. The most direct way for an ROV or AUV to maintain position in the near bottom environment is to track or lock onto stationary objects on the ocean floor. A particular advantage of an optical stationkeeping system is its ability to use natural rather than manmade beacons. Several improvements to our previously reported optical flow methods for the detection of vehicle motion have been investigated. Experimental results indicate that an adaptation of Newton-Raphson search combined with the use of a low-noise, high accuracy camera can drastically reduce the number of image points at which computations need be made. Other experiments with an algorithm, which accounts for illumination variations that one may encounter in undersea environments, show significant improvement in the estimation of optical flow and vehicle motion.     

Using mechatronics to teach mechanical design and technical communication

It is commonly accepted that hands-on experiences increase both learning and enjoyment during coursework. Mechatronics projects provide both interesting and relevant hands-on experiences for a wide range of topics including design processes, basic mechatronics concepts, technical communication, and working in a group environment. ME2110: Creative Decisions and Design at Georgia Tech integrates mechatronics and technical communication into a sophomore level mechanical design class. This paper describes the course in detail, highlighting the course goals and layout, tools provided to the students, industry involvement, and the main challenges of administering such a course.