全文获取类型
收费全文 | 748篇 |
免费 | 29篇 |
国内免费 | 9篇 |
学科分类
医药卫生 | 786篇 |
出版年
2022年 | 6篇 |
2021年 | 11篇 |
2020年 | 11篇 |
2019年 | 5篇 |
2018年 | 9篇 |
2017年 | 9篇 |
2016年 | 6篇 |
2015年 | 11篇 |
2014年 | 16篇 |
2013年 | 24篇 |
2012年 | 20篇 |
2011年 | 40篇 |
2010年 | 25篇 |
2009年 | 18篇 |
2008年 | 25篇 |
2007年 | 47篇 |
2006年 | 25篇 |
2005年 | 27篇 |
2004年 | 23篇 |
2003年 | 29篇 |
2002年 | 24篇 |
2001年 | 23篇 |
2000年 | 16篇 |
1999年 | 19篇 |
1998年 | 23篇 |
1997年 | 32篇 |
1996年 | 25篇 |
1995年 | 10篇 |
1994年 | 16篇 |
1993年 | 14篇 |
1992年 | 11篇 |
1991年 | 16篇 |
1990年 | 12篇 |
1989年 | 23篇 |
1988年 | 22篇 |
1987年 | 13篇 |
1986年 | 7篇 |
1985年 | 7篇 |
1984年 | 7篇 |
1983年 | 5篇 |
1979年 | 4篇 |
1978年 | 4篇 |
1977年 | 4篇 |
1976年 | 10篇 |
1975年 | 6篇 |
1974年 | 6篇 |
1973年 | 4篇 |
1972年 | 7篇 |
1970年 | 4篇 |
1968年 | 5篇 |
排序方式: 共有786条查询结果,搜索用时 15 毫秒
1.
2.
Regulation of G proteins by chronic antidepressant drug treatment in rat brain: tricyclics but not clorgyline increase Go alpha subunits. 总被引:4,自引:0,他引:4
K P Lesch C S Aulakh T J Tolliver J L Hill D L Murphy 《European journal of pharmacology》1991,207(4):361-364
The effect of long-term (3-week) administration of various antidepressant drugs on the steady-state concentrations of G protein alpha subunits, Gs alpha, Gi alpha, and Go alpha, has been investigated in rat brain using an enzyme-linked immunosorbent assay. Tricyclic antidepressants and clorgyline decreased Gs alpha and, to a lesser extent, Gi alpha in several brain regions, while Go alpha was increased by tricyclics but not clorgyline. We conclude that long-term treatment with antidepressant drugs exerts differential effects on G protein alpha subunits, and that antidepressant efficacy may potentially be based on functional modifications of signal transduction. 相似文献
3.
4.
Ignatius KP CHENG 《Nephrology (Carlton, Vic.)》1997,3(1):109-111
Summary: The involvement of the IgA immune system and complement components in IgA glomerulonephritis (IgAGN) has prompted the use of immunosuppressive drugs in therapy, but none has so far been shown to alter the natural course of the disease. Because most patients with IgAGN present during the chronic phase of their illness, at the time when the initiating immune events may no longer be active, nonimmune therapy which targets the common pathway of progressive renal injury is likely to be more useful. There is increasing evidence that angiotensin-converting enzyme inhibitors (ACEI) reduce proteinuria and renal injury in patients with IgAGN, and this effect may be observed in both normotensive and hypertensive patients. Yet to be determined is whether this effect is specific for ACEI and whatever other effective antihypertensive drugs may achieve a similar result. Fish oil has recently been shown to retard the progression of renal failure in patients with aggressive IgAGN, but a narrow therapeutic window appears to exist for this form of treatment. Antiplatelet agents on their own appear to be ineffective but in combination with anticoagulation (low dose warfarin) have been shown to have an antiproteinuric effect and may preserve renal function in patients with progressive disease. Future directions of non-immune therapy of IgAGN include evaluation of the renoprotective effect of angiotensin II receptor antagonists, free-radical scavengers and antilipid drugs. More work should also be done to identify factors which put the patients at risk of developing progressive disease and which predict therapeutic response, as has been done recently with the identification of the deletion polymorphism of the angiotensin-converting enzyme gene as a marker of progressive disease and therapeutic response to ACEI in patients with IgAGN. 相似文献
5.
6.
Myosin VIIA gene: heterogeneity of the mutations responsible for Usher syndrome type IB 总被引:8,自引:1,他引:8
Levy G; Levi-Acobas F; Blanchard S; Gerber S; Larget-Piet D; Chenal V; Liu XZ; Newton V; Steel KP; Brown SD; Munnich A; Kaplan J; Petit C; Weil D 《Human molecular genetics》1997,6(1):111-116
Usher syndrome is recognized as the most frequent cause of hereditary
deaf-blindness. Usher syndrome type I (USH1), the most severe form of the
disease, is characterized by profound congenital sensorineural deafness,
constant vestibular dysfunction, and retinitis pigmentosa of prepubertal
onset. This form is genetically heterogeneous and five loci (USH1A-E) have
been mapped thusfar. However, only the gene responsible for USH1 B (which
accounts for approximately 75% of USH1 cases) has been characterized. It
encodes a long-tailed unconventional myosin, myosin VIIA, with a predicted
2215 amino acid sequence. Primers covering the complete myosin VIIA coding
sequence as well as the 3' non coding sequence were designed, allowing
direct sequence analysis of each of the 48 coding exons and flanking splice
sites in seven patients affected by USH1. Four novel mutations were thereby
identified. The possibility should now be considered of a sequence-based
prenatal diagnosis in some of the families affected by this very severe
form of Usher syndrome.
相似文献
7.
8.
K P Lesch G Laux H M Schulte H Pfüller H Beckmann 《Journal of affective disorders》1988,14(3):245-250
Plasma growth hormone (GH) release after injection of 100 micrograms synthetic human corticotropin-releasing hormone (hCRH) was investigated in 11 patients with major depressive disorder and normal controls matched for gender, age, body weight and ovarian status. In contrast to controls, who exhibited no significant GH response to CRH, depressed patients showed a significant net increase in GH secretion following CRH administration. The abnormal GH response to CRH was not correlated with baseline corticotropin (ACTH) and cortisol nor with CRH-induced ACTH and cortisol response. The implications of these findings are discussed with reference to such factors as alpha-adrenergic hyperactivity, hypothalamic-pituitary system dysregulation, drug interference, non-specific stress responses and abnormal neuroendocrine circadian rhythms in major depression. 相似文献
9.
10.