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1.
Anissa Chouikha Wasfi Fares Asma Laamari Sondes Haddad-Boubaker Zeineb Belaiba Kais Ghedira Wafa Kammoun Rebai Kaouther Ayouni Marwa Khedhiri Samar Ben Halima Henda Krichen Henda Touzi Imen Ben Dhifallah Fatma Z. Guerfali Chiraz Atri Saifeddine Azouz Oussema Khamessi Monia Ardhaoui Mouna Safer Nissaf Ben Alaya Ikram Guizani Rym Kefi Mariem Gdoura Henda Triki 《Viruses》2022,14(3)
Documenting the circulation dynamics of SARS-CoV-2 variants in different regions of the world is crucial for monitoring virus transmission worldwide and contributing to global efforts towards combating the pandemic. Tunisia has experienced several waves of COVID-19 with a significant number of infections and deaths. The present study provides genetic information on the different lineages of SARS-CoV-2 that circulated in Tunisia over 17 months. Lineages were assigned for 1359 samples using whole-genome sequencing, partial S gene sequencing and variant-specific real-time RT-PCR tests. Forty-eight different lineages of SARS-CoV-2 were identified, including variants of concern (VOCs), variants of interest (VOIs) and variants under monitoring (VUMs), particularly Alpha, Beta, Delta, A.27, Zeta and Eta. The first wave, limited to imported and import-related cases, was characterized by a small number of positive samples and lineages. During the second wave, a large number of lineages were detected; the third wave was marked by the predominance of the Alpha VOC, and the fourth wave was characterized by the predominance of the Delta VOC. This study adds new genomic data to the global context of COVID-19, particularly from the North African region, and highlights the importance of the timely molecular characterization of circulating strains. 相似文献
2.
Preoperative concurrent chemotherapy and radiation therapy in cervix cancer: preliminary results 总被引:2,自引:0,他引:2
Kochbati L Ben Ammar CN Benna F Hechiche M Boussen H Besbes M Ben Abdallah M Rahal K Ben Ayed F Ben Romdhane K Maalej M 《La Tunisie médicale》2005,83(3):146-149
This is a retrospective study of patients treated for cervix cancer staged IB2, IIA or IIB with bulky tumor (> 4cm). Treatment was concurrent radiotherapy (45Gy with 1,8Gy daily fraction) and chemotherapy (5 cycles of Platinum 40mg/m2/week). All patients underwent Brachytherapy (15Gy on the reference isodose according to Paris system) followed by surgery (radical abdominal hysterectomy and bilateral pelvic lymphadenectomy: Piver 3) Between October 1999 and December 2002, forty five patients were treated in this protocol. Median age was 46 years (21- 68). Histology was squamous cell carcinoma in 93% and glandular carcinoma in 7%. Average external radiation dose was 44Gy (20-50). Ninety three percent of patients had at least 3 cycles of chemotherapy and 46,5% received the planned 5 cycles. On the operative specimens, there was 62,5% complete response and only 7 pelvic node involvement (17,5%). Four postoperative complications were noted (one vascular injury, one urinary fistula, one phlebitis and one lymph collection). Preoperative combined radiotherapy and chemotherapy in the early bulky stages of uterine cervix cancer is well tolerated and "gives" a high rate of sterilisation. There was no increase in surgical morbidity. 相似文献
3.
Asma K Dalila G Olfa B Malika R Afef K Najet B Jamel K Abdeljabbar G Sarra S Chiraz J Mohamed HD Slim K Anis BM Abdelmajid L 《La Tunisie médicale》2005,83(8):495-498
Osler Weber Rendu Disease is an hereditary haemorrhagic télangectasia habitually revealed by reccurent bleeding (epistaxis). Hepatic involvement in Osler disease is found in 8 to 31%, manifested by cholestasis. We report an original observation of a cholangitis revealing Osler disease. 相似文献
4.
Abdelmoula LC Chaabouni L Ben Hadj Yahia C Montacer Kchir M Zouari R 《Joint, bone, spine : revue du rhumatisme》2005,72(5):427-429
Trochanteric tuberculosis represents less than 2% of all musculo-skeletal tuberculosis. The diagnosis is difficult especially if abscess and fistula are missing. The authors report 3 cases of trochanteric tuberculosis. The diagnosis was established, respectively, 4, 9 months and 1 year after the beginning of the symptoms. The tuberculosis was plurifocal in all cases. Diagnosis was based on the presence of caseum granuloma in the first case, positive Lowenstein culture in the second case and on clinical and paraclinical arguments in the third one. Healing was obtained after medical treatment alone. The authors discuss the potential role of the newer imaging modalities in diagnosis of trochanteric tuberculosis and the indications of medical and surgical treatment. 相似文献
5.
Khosrof-Ben Jaâfar S Gharbi N El Fazaâ S Beji C Farhat A Cherif S Haddad S Kamoun A 《La Tunisie médicale》2004,82(3):263-270
A foodstuffs survey has been carried out on young women aged from 15 to 49 in order to determine the total and available iron supplies, in proteins and in energy so as to establish the link between an iron deficiency and the protein-energy supplies in comparison to the needs required by the FAO and the WHO. The regions studied are the Great Tunis (GT) and the South West (SW) both in urban and rural backgrounds. These two regions have been selected because of the high prevailing rate of deficiency discovered after the 1996/1997 nutritional survey. Women have been divided into two groups: those who have a deficiency and those who don't have. The study concerned 1151 homes therefore about 1468 women and from them 712 are from GT and 756 from SW. The results of foodstuffs survey demonstrated that supply of meat is more elevated in non anemic women than anemic women concerning proteins supplies. A moderate energetic deficit is noticed in non deficient women and those anemic who have an iron deficiency. Women presented anemia have total and available iron deficient and a deficiency in energy supplies. 相似文献
6.
Khosrof-Ben Jaâfar S el Fazaâ S Kamoun A Beji C Farhat A Cherif S Haddad S Gharbi N 《La Tunisie médicale》2003,81(8):540-547
Our study is going to analyse the foodstuffs consumption of the people who have an iron deficiency and then compare it to the consumption of the people who don't have a deficiency. The anemic children who suffer from an iron deficiency have shown an average supply of iron inferior to the required needs which is of 86%. 22.7% of these children have an available iron supply below the recommended average which represents the limit of a severe deficiency risk. No child exceed the severe deficiency risk limit in proteins. 31% of the deficient children have daily energetic supplies inferior to the minimum limit of the daily-required supplies and they are on the brink of a deficiency. The protein needs are common in children but not the energetic ones. 相似文献
7.
Zouari IB Gouiaa N Charfi S Ellouze S Chaari C Kessentini M Hssini A Boudawara TS 《Annales de pathologie》2011,31(2):98-101
Uterine leiomyoma with massive lymphoid infiltration is a rare and unusual pathological finding; only 20 cases have been reported in the literature. We report a case of this unusual lesion in a 35-year-old woman who underwent a myomectomy. On gross examination, the tumor was of white color and firm consistency. Histological sections showed interlacing bundles of spindle shaped cells of low density with moderate to severe lymphocytic infiltrate associated to lymphoid follicles and few plasma cells. Immunohistochemically, the diffusely infiltrating lymphoid cells were predominantly of T cell phenotype. The interspersed spindle shaped cells were positive with alpha smooth muscle actin, desmin and h-caldesmon. The cause of this unusual lesion is not clear, but the recognition of its distinct histological features is important to avoid possible confusion with differential diagnosis including malignant lymphoma, inflammatory pseudotumor and pyomyoma. 相似文献
8.
Talbi C Cabon J Baud M Bourjaily M de Boisséson C Castric J Bigarré L 《Archives of virology》2011,156(12):2133-2144
Despite the increasing impact of rhabdoviruses in European percid farming, the diversity of the viral populations is still
poorly investigated. To address this issue, we sequenced the partial nucleoprotein (N) and complete glycoprotein (G) genes
of nine rhabdoviruses isolated from perch (Perca fluviatilis) between 1999 and 2010, mostly from France, and analyzed six of them by immunofluorescence antibody test (IFAT). Using two
rabbit antisera raised against either the reference perch rhabdovirus (PRhV) isolated in 1980 or the perch isolate R6146,
two serogroups were distinguished. Meanwhile, based on partial N and complete G gene analysis, perch rhabdoviruses were divided
into four genogroups, A-B-D and E, with a maximum of 32.9% divergence (G gene) between isolates. A comparison of the G amino
acid sequences of isolates from the two identified serogroups revealed several variable regions that might account for antigenic
differences. Comparative analysis of perch isolates with other rhabdoviruses isolated from black bass, pike-perch and pike
showed some strong phylogenetic relationships, suggesting cross-host transmission. Similarly, striking genetic similarities
were shown between perch rhabdoviruses and isolates from other European countries and various ecological niches, most likely
reflecting the circulation of viruses through fish trade as well as putative transfers from marine to freshwater fish. Phylogenetic
relationships of the newly characterized viruses were also determined within the family Rhabdoviridae. The analysis revealed a genetic cluster containing only fish viruses, including all rhabdoviruses from perch, as well as
siniperca chuatsi rhabdovirus (SCRV) and eel virus X (EVEX). This cluster was distinct from the one represented by spring
viraemia of carp vesiculovirus (SVCV), pike fry rhabdovirus (PFRV) and mammalian vesiculoviruses. The new genetic data provided
in the present study shed light on the diversity of rhabdoviruses infecting perch in France and support the hypothesis of
circulation of these viruses between other hosts and regions within Europe. 相似文献
9.
Bouchlaka C Maktouf C Mahjoub B Ayadi A Sfar MT Sioud M Gueddich N Belhadjali Z Rebaï A Abdelhak S Dellagi K 《Journal of human genetics》2007,52(3):262-270
Megaloblastic anaemia 1 (MGA1) is a rare autosomal recessive condition characterized by selective intestinal vitamin B12 malabsorption
and proteinuria. More than 200 MGA1 patients have been identified worldwide, but the disease is relatively prevalent in Finland,
Norway and several Eastern Mediterranean regions. MGA1 is genetically heterogeneous and can be caused by mutations in either
the cubilin (CUBN) or the amnionless (AMN) gene. In the present study we investigated the molecular defect underlying MGA1 in nine Tunisian patients belonging to six
unrelated consanguineous families. Haplotype and linkage analyses, using microsatellite markers surrounding both CUBN and AMN genes, indicated that four out of the six families were likely to be linked to the CUBN gene. Patients from these families were screened for the Finnish, Mediterranean and Arabian mutations already published.
None of the screened mutations could be detected in our population. One family showed a linkage to AMN gene. Direct screening of the AMN gene allowed the identification of the c.208-2A>G mutation, previously described in a Jewish Israeli patient of Tunisian
origin and in Turkish patients. This suggests that the c.208-2A>G mutation may derive from a single Mediterranean founder
ancestor. For the last family, haplotype analysis excluded both CUBN and AMN genes, suggesting the existence of a third locus that may cause MGA1. 相似文献
10.
Ben Gamra O Mbarek C Charfi S Ouni H Hariga I Chedly A Zribi S El Khedim A 《La Tunisie médicale》2007,85(8):641-643
BACKGROUND: Chronic laryngitis is a lingering inflammation of the laryngeal mucosa, caused by specific aetiology and often irritative factors. AIM: To discuss clinic and therapeutic aspects of the pathology. METHODS: We report a retrospective stuy about 25 patients treated and followed for non specific chronic laryngitis over a period of 11 years (1994-2004). RESULTS: The average age of the patients was 54.2 years. Tobacco intoxication was noted in 72.7 of cases and Gastroesophageal reflux in 2 cases. The endoscopic examination of laryngeal lesions, realised in all cases, notes laryngeal keratosis in 88% of cases and congestive laryngitis in 12%. Histological analysis of the lesions reveals a dysplasia in 44% of cases. Clinical and endoscopic follow up of the patients discover malignant development in 5 patients. CONCLUSION: The treatment of chronic laryngitis is based on the suppression of etiologic factors and on laryngeal microsurgery with micro instruments and with laser techniques. 相似文献