Pd/Cu-Free Cobalt-Catalyzed Suzuki and Heck Using Green Bio-Magnetic Hybrid and DFT-Based Theoretical Study

Catalysis Letters - Several highly efficient and magnetically recyclable cobalt catalytic systems were prepared using magnetic chitosan and some safe and available organic compounds...     

A Novel Artificially Humanized Anti-Cripto-1 Antibody Suppressing Cancer Cell Growth

Cripto-1 is a member of the EGF-CFC/FRL1/Cryptic family and is involved in embryonic development and carcinogenesis. We designed a novel anti-Cripto-1 artificial antibody and assessed the recognition to the antigen and the potential to suppress the growth of cancer stem cells. First, single chain antibody clones were isolated by bio-panning with the affinity to recombinant Cripto-1 protein from our original phage-display library. Then, the variable regions of heavy chain VH and light chain VL in each clone were fused to constant regions of heavy chain CH and light chain CL regions respectively. These fused genes were expressed in ExpiCHO-S cells to produce artificial humanized antibodies against Cripto-1. After evaluation of the expression levels, one clone was selected and the anti-Cripto-1 antibody was produced and purified. The purified antibody showed affinity to recombinant Cripto-1 at 1.1 pmol and immunoreactivity to cancer tissues and cell lines. The antibody was available to detect the immunoreactivity in tissue microarrays of malignant tumors as well as in Cripto-1 overexpressing cells. Simultaneously, the antibody exhibited the potential to suppress the growth of human colon cancer derived GEO cells overexpressing Cripto-1 with IC₅₀ at approximately 110 nM. The artificially humanized antibody is proposed to be a good candidate to target cancer cells overexpressing Cripto-1.     

Using plasmonic cloaking method on infinite cylindrical structures and its applications

Journal of Computational Electronics - In recent years, cloaking using materials with negative electric permittivity or magnetic permeability has been studied and researched. It has been...     

Precautious-RM: a predictable non-preemptive scheduling algorithm for harmonic tasks

A major requirement of many real-time embedded systems is to have time-predictable interaction with the environment. More specifically, they need fixed or small sampling and I/O delays, and they cannot cope with large delay jitters. Non-preemptive execution is a known method to reduce the latter delay; however, the corresponding scheduling problem is NP-Hard for periodic tasks. In this paper, we present Precautious-RM as a predictable linear-time online non-preemptive scheduling algorithm for harmonic tasks which can also deal with the former delay, namely sampling delay. We derive conditions of optimality of Precautious-RM and show that satisfying those conditions, tight bounds for best- and worst-case response times of the tasks can be calculated in polynomial-time. More importantly, response time jitter of the tasks is analyzed and it is proven that under specific conditions, each task has either one or two values for response time, which leads to improving the predictability of the system interaction with the environment. Simulation results demonstrate efficiency of Precautious-RM in increasing accuracy of control applications.     

Implementing a one-bit reversible full adder using quantum-dot cellular automata

Quantum-dot cellular automata (QCA) technique is one of the emerging and promising nanotechnologies. It has considerable advantages versus CMOS technology in various aspects such as extremely low power dissipation, high operating frequency and small size. In this paper, designing of a one-bit full adder is investigated using a QCA implementation of Toffoli and Fredkin gates. Then, a full adder design with reversible QCA1 gates is proposed regarding to overhead and power savings. Our proposed full adder design is more preferable when considering both circuit area and speed. The proposed design uses only two QCA1 gates and maximizes the circuit density and focuses on a layout of the circuit which is minimal in using QCA cells.     

A process model for robotic disc grinding

Automation of deburring and cleaning of castings is desirable for many reasons. The major reasons are dangerous working conditions, difficulties in finding workers for cleaning sections, and improved profitability. A suitable robot cell capable of using different tools, such as cup grinders, disc grinders and rotary files, is the solution. This robot should be completed with sensors in order to keep the quality of the cleaned surface at an acceptable level. Although using sensors simplifies both the programming and quality control there are still other problems that need to be solved. These involve selection of machining data, e.g. feeding rate and grinding force in a force controlled operation based on parameters such as tool type, disc grinder and geometry. In order to decrease the programming time, a process model for disc grinders has been developed. This article investigates this process model and pays attention to problems such as wavy or burned surfaces and the effect of a robot's repetition accuracy in the results obtained. Many aspects treated in this article are quite general, and can be applied in other types of grinding operations.     

A comprehensive survey of industry practice in real-time systems

Real-Time Systems - This paper presents results and observations from a survey of 120 industry practitioners in the field of real-time embedded systems. The survey provides insights into the...