Gas holdup and overall volumetric mass transfer coefficient in a modified reversed flow jet loop reactor

Experiments were conducted in a modified reversed flow jet loop reactor having the liquid outlet at the top of the reactor to determine the gas holdup and overall volumetric mass transfer coefficient in the air-water system. The influence of gas and liquid flow rates, and the draft tube to reactor diameter ratio were studied. It was observed that both gas holdup and volumetric mass transfer coefficient increased with increased gas and liquid flow rates and were found to be significantly higher in the modified reactor compared to the conventional one. The optimum draft tube to reactor diameter ratio was found to be in the range of 0.4 to 0.5. Empirical correlations are presented to predict gas holdup and overall volumetric mass transfer coefficient in terms of operational and geometrical variables.     

Integrin β1 Promotes Pancreatic Tumor Growth by Upregulating Kindlin-2 and TGF-β Receptor-2

The tumor microenvironment plays a critical role in defining the growth and malignancy of solid tumors. Extracellular matrix (ECM) proteins such as collagen, vitronectin, and fibronectin are major components of the tumor microenvironment. Tumor growth-promoting reciprocal interaction between ECM and cytoplasmic proteins is regulated by the cell surface receptors called integrins. This study investigated the mechanism by which integrin β1 promotes pancreatic tumor growth. In MIA PaCa-2 pancreatic cancer cell line, the loss of integrin β1 protein reduced the ability of cells to proliferate in a 3D matrix and compromised the ability to form a focal adhesion complex. Decreased expression of integrin α5 was observed in KO cells, which resulted in impaired cell spreading and adhesion on vitronectin and fibronectin. Reduced expression of the integrin-associated protein, kindlin-2 was also recorded. The downregulation of kindlin-2 decreased the phosphorylation of Smad2/3 by reducing the expression of TGF-β receptor 2. These results unravel a new mechanism of integrin β1 in tumor growth by modifying the expression of kindlin-2 and TGF-β receptor 2 signaling.     

Studies on heat transfer and friction factor characteristics of turbulent flow through a micro-finned tube fitted with left–right inserts

Experimental investigation on heat transfer and friction factor characteristics of micro-finned tube fitted with full-length twisted tape and left–right twisted tape inserts of twist ratio 7.44, 8.27 and 11.17 has been presented. The experimental data obtained were compared with those obtained from plain tube published data. The heat transfer coefficient enhancement for left–right twisted inserts is higher than that for full-length twisted tape inserts for a given twist ratio. The empirical correlation for Nusselt number, friction relating Reynolds number and twist ratio was formed for both twisted tape inserts and left–right inserts and found to fit the experimental data within ±3.6% and ±2.5% for Nusselt number and ±7% and ±8.5% friction factor, respectively. Performance evaluation analysis was made and the maximum performance ratio was obtained for left–right twisted tape inserts.