Comprehensive performance modeling and analysis of multicasting in optical networks

Multicasting is becoming increasingly important in today's networks. In optical networks, optical splitters facilitate the multicasting of optical signals. By eliminating the transmission of redundant traffic over certain links, multicasting can improve network performance. However, in a wavelength-division multiplexed (WDM) optical network, the lack of wavelength conversion necessitates the establishment of a single multicast circuit (light-tree) on a single wavelength. On the other hand, establishing several unicast connections (lightpaths) to satisfy a multicast request, while requiring more capacity, is less constrained in terms of wavelength assignment. The objective of the paper is to evaluate the tradeoff between capacity and wavelength continuity in the context of optical multicasting. To this end, we develop accurate analytical models with moderate complexity for computing the blocking probability of multicast requests realized using light-trees, lightpaths, and combinations of light-trees and lightpaths. Numerical results indicate that a suitable combination of light-trees and lightpaths performs best when no wavelength conversion is present.     

The isolated air perfused rat heart

A simple method has been developed for continuous monitoring of metabolic activity of an isolated, perfused rat heart by O2/CO2 respirometer. Since respirometer provides vital data on oxygen consumption and carbon dioxide production of a preserved organ on a continuous basis over a long period of time, it will be possible to use this method to monitor viability of not only isolated heart but also any given donor organ under preservation.     

HotSpot: a compact thermal modeling methodology for early-stage VLSI design

This paper presents HotSpot-a modeling methodology for developing compact thermal models based on the popular stacked-layer packaging scheme in modern very large-scale integration systems. In addition to modeling silicon and packaging layers, HotSpot includes a high-level on-chip interconnect self-heating power and thermal model such that the thermal impacts on interconnects can also be considered during early design stages. The HotSpot compact thermal modeling approach is especially well suited for preregister transfer level (RTL) and presynthesis thermal analysis and is able to provide detailed static and transient temperature information across the die and the package, as it is also computationally efficient.     

Mathematical and Scientific Foundations for an Integrative Engineering Curriculum

All fields of engineering, whether chemical, civil, electrical, materials, mechanical, etc., encompass a common body of essential mathematics and science. In the freshman year of Drexels E⁴ program, this common mathematical and scientific foundation is cultivated in the Mathematical and Scientific Foundations of Engineering I, II and III (MSFE I, MSFE II, MSFE III). In an integrated fashion, MSFE I presents the essential calculus, physics and engineering mechanics vital to the freshman engineering student. In the first two quarters, MSFE II presents chemistry with clearly defined engineering applications and significance: in the third quarter, MSFE II presents living systems with the same thrust. Also in the third quarter, MSFE III presents basic circuits and circuit elements, and a brief introduction to electromagnetic theory.     

Comparison of the indentation and elasticity of E. coli and its spheroplasts by AFM

Atomic force microscopy (AFM) provides a unique opportunity to study live individual bacteria at the nanometer scale. In addition to providing accurate morphological information, AFM can be exploited to investigate membrane protein localization and molecular interactions on the surface of living cells. A prerequisite for these studies is the development of robust procedures for sample preparation. While such procedures are established for intact bacteria, they are only beginning to emerge for bacterial spheroplasts. Spheroplasts are useful research models for studying mechanosensitive ion channels, membrane transport, lipopolysaccharide translocation, solute uptake, and the effects of antimicrobial agents on membranes. Furthermore, given the similarities between spheroplasts and cell wall-deficient (CWD) forms of pathogenic bacteria, spheroplast research could be relevant in biomedical research. In this paper, a new technique for immobilizing spheroplasts on mica pretreated with aminopropyltriethoxysilane (APTES) and glutaraldehyde is described. Using this mounting technique, the indentation and cell elasticity of glutaraldehyde-fixed and untreated spheroplasts of E. coli in liquid were measured. These values are compared to those of intact E. coli. Untreated spheroplasts were found to be much softer than the intact cells and the silicon nitride cantilevers used in this study.     

Path curvature of a geared seven-bar mechanism

This paper presents a graphical technique to locate the center of curvature of the path traced by a coupler point of a planar, single-degree-of-freedom, geared seven-bar mechanism. Since this is an indeterminate mechanism then the pole for the instantaneous motion of the coupler link; i.e., the point coincident with the instantaneous center of zero velocity for this link, cannot be obtained from the Aronhold–Kennedy theorem. The graphical technique that is presented in the first part of the paper to locate the pole is believed to be an important contribution to the kinematics literature. The paper then focuses on the graphical technique to locate the center of curvature of the path traced by an arbitrary coupler point. The technique begins with replacing the seven-bar mechanism by a constrained five-bar linkage whose links are kinematically equivalent to the second-order properties of motion. Then three kinematic inversions are investigated and a four-bar linkage is obtained from each inversion. The motion of the coupler link of the final four-bar linkage is equivalent up to and including the second-order properties of motion of the coupler of the geared seven-bar. Then the center of curvature of the path traced by an arbitrary coupler point can be obtained from existing techniques, such as the Euler–Savary equation. An analytical method, referred to as the method of kinematic coefficients, is presented as an independent check of the graphical technique.     

Do automated program repair techniques repair hard and important bugs?

Existing evaluations of automated repair techniques focus on the fraction of the defects for which the technique can produce a patch, the time needed to produce patches, and how well patches generalize to the intended specification. However, these evaluations have not focused on the applicability of repair techniques and the characteristics of the defects that these techniques can repair. Questions such as “Can automated repair techniques repair defects that are hard for developers to repair?” and “Are automated repair techniques less likely to repair defects that involve loops?” have not, as of yet, been answered. To address such questions, we annotate two large benchmarks totaling 409 C and Java defects in real-world software, ranging from 22K to 2.8M lines of code, with measures of the defect’s importance, the developer-written patch’s complexity, and the quality of the test suite. We then analyze relationships between these measures and the ability to produce patches for the defects of seven automated repair techniques —AE, GenProg, Kali, Nopol, Prophet, SPR, and TrpAutoRepair. We find that automated repair techniques are less likely to produce patches for defects that required developers to write a lot of code or edit many files, or that have many tests relevant to the defect. Java techniques are more likely to produce patches for high-priority defects. Neither the time it took developers to fix a defect nor the test suite’s coverage correlate with the automated repair techniques’ ability to produce patches. Finally, automated repair techniques are less capable of fixing defects that require developers to add loops and new function calls, or to change method signatures. These findings identify strengths and shortcomings of the state-of-the-art of automated program repair along new dimensions. The presented methodology can drive research toward improving the applicability of automated repair techniques to hard and important bugs.     

Thermal depolarization and electromechanical hardening in Zn2+-doped Na1/2Bi1/2TiO3-BaTiO3

Na_1/2Bi_1/2TiO₃-based materials have been earmarked for one of the first large-volume applications of lead-free piezoceramics in high-power ultrasonics. Zn²⁺-doping is demonstrated as a viable route to enhance the thermal depolarization temperature and electromechanically harden (1-y)Na_1/2Bi_1/2TiO₃-yBaTiO₃ (NBT100yBT) with a maximum achievable operating temperature of 150 °C and mechanical quality factor of 627 for 1 mole % Zn²⁺-doped NBT6BT. Although quenching from sintering temperatures has been recently touted to enhance T_F-R, with quenching the doped compositions featuring an additional increase in T_F-R by 17 °C, it exhibits negligible effect on the electromechanical properties. The effect is rationalized considering the missing influence on conductivity and therefore, negligible changes in the defect chemistry upon quenching. High-resolution diffraction indicates that Zn²⁺-doped samples favor the tetragonal phase with enhanced lattice distortion, further corroborated by ²³Na Nuclear Magnetic Resonance investigations.     

A single active site mutation inverts stereoselectivity of 16-hydroxylation of testosterone catalyzed by engineered cytochrome P450 BM3

Inversion of stereoselectivity: screening of a minimal mutant library revealed a cytochrome P450?BM3 variant M01?A82W?S72I capable of producing 16?α-OH-testosterone. Remarkably, a single active site mutation S72I in M01?A82W inverted the stereoselectivity of hydroxylation from 16?β to 16?α. Introduction of S72I mutation in another 16?β-OH-selective variant M11?V87I, also resulted in similar inversion of stereoselectivity.     

Nano-AlN particle reinforced Mg composites: microstructural and mechanical properties

In this study, nano-AlN particles were introduced into pure Mg matrix through the powder metallurgy technique incorporating microwave assisted two-directional sintering followed by hot extrusion. The effect of varying volume fraction of nano-AlN addition on the microstructural and mechanical properties of pure Mg was investigated. Microstructural characterisation revealed marginal grain refinement due to the fairly uniform distribution of AlN nano-particulates. X-ray diffraction results indicated basal texture weakening in Mg/0·2AlN composite. Tensile property measurements revealed an overall increase in strength properties and ductility. Among the developed composites, Mg/0·8AlN displayed superior strength (～30% improvement) and Mg/0·2AlN showed enhanced ductility (～80% enhancement). Under compressive loading, the developed Mg/AlN nanocomposite formulations exhibited improved strength properties without significant effect on compressibility.