Lower bound on minimum lee distance of algebraic?geometric codes over finite fields

Algebraic-geometric (AG) codes over finite fields with respect to the Lee metric have been studied. A lower bound on the minimum Lee distance is derived, which is a Lee-metric version of the well-known Goppa bound on the minimum Hamming distance of AG codes. The bound generalises a lower bound on the minimum Lee distance of Lee-metric BCH and Reed-Solomon codes, which have been successfully used for protecting against bitshift and synchronisation errors in constrained channels and for error control in partial-response channels.     

Optimal and Suboptimal Quadriphase Sequences Derived from Maximal Length Sequences over Z _{{\bf 4}}

The paper presents families of quadriphase sequences derived from maximal length sequences over having good correlation properties. These are: (i) families of quadriphase sequences of period from maximal length sequences over ; each family consisting of sequences, (ii) families of quadriphase sequences of period from interleaved maximal length sequences over ; each family consisting of sequences. Such sequences are of interest in quadriphase modulated code division multiple access communication systems, where it is desirable to have large sets of sequences that possess low value of , the maximum magnitude of the periodic crosscorrelation and out of phase auto-correlation values. The sequences over are viewed as trace functions of appropriately chosen unit elements of Galois extension rings of . Quadriphase sequences are then obtained from sequences, by a quadriphase mapping, , from to roots of unity, given by, ; where and . Periodic correlation properties (correlation values and their distribution) of the quadriphase sequences are obtained by using an Abelian association scheme on the elements of the corresponding Galois extension ring of . The majority of the families of sequences derived are optimal with respect to the Welch lower bound on ; the rest being suboptimal with bounded by , where is the period\newpage of the sequences. However nearly half of the sequences in these families are balanced. Received July 18, 1995; revised version November 29, 1996     

Out-of-Field Hippocampus from Partial-Body Irradiated Mice Displays Changes in Multi-Omics Profile and Defects in Neurogenesis

The brain undergoes ionizing radiation exposure in many clinical situations, particularly during radiotherapy for brain tumors. The critical role of the hippocampus in the pathogenesis of radiation-induced neurocognitive dysfunction is well recognized. The goal of this study is to test the potential contribution of non-targeted effects in the detrimental response of the hippocampus to irradiation and to elucidate the mechanisms involved. C57Bl/6 mice were whole body (WBI) or partial body (PBI) irradiated with 0.1 or 2.0 Gy of X-rays or sham irradiated. PBI consisted of the exposure of the lower third of the mouse body, whilst the upper two thirds were shielded. Hippocampi were collected 15 days or 6 months post-irradiation and a multi-omics approach was adopted to assess the molecular changes in non-coding RNAs, proteins and metabolic levels, as well as histological changes in the rate of hippocampal neurogenesis. Notably, at 2.0 Gy the pattern of early molecular and histopathological changes induced in the hippocampus at 15 days following PBI were similar in quality and quantity to the effects induced by WBI, thus providing a proof of principle of the existence of out-of-target radiation response in the hippocampus of conventional mice. We detected major alterations in DAG/IP3 and TGF-β signaling pathways as well as in the expression of proteins involved in the regulation of long-term neuronal synaptic plasticity and synapse organization, coupled with defects in neural stem cells self-renewal in the hippocampal dentate gyrus. However, compared to the persistence of the WBI effects, most of the PBI effects were only transient and tended to decrease at 6 months post-irradiation, indicating important mechanistic difference. On the contrary, at low dose we identified a progressive accumulation of molecular defects that tended to manifest at later post-irradiation times. These data, indicating that both targeted and non-targeted radiation effects might contribute to the pathogenesis of hippocampal radiation-damage, have general implications for human health.     

Hot Corrosion Behaviour of HVOF Sprayed Stellite-6 Coatings on Gas Turbine Alloys

The coal burned natural gas in contact with gas turbine can contain impurities of sodium, sulfur, vanadium, silicon and possibly lead and phosphorous, induce accelerated hot corrosion during long term operation. Coatings are frequently applied on gas turbine components in order to restrict surface degradation and to obtain accurate lifetime expectancies. High velocity oxy-fuel thermal spraying has been used to deposit Stellite-6 alloy coatings on turbine alloys. Hot corrosion behavior of the coatings were investigated for 50 cycles of 1 h heating at 800 °C followed by 20 min cooling in presence of Na₂SO₄ + 50 % V₂O₅ measuring weight gain (or loss). X-ray diffraction and SEM/EDAX techniques were used to characterize the oxide scale formed. The superior performance of Stellite-6 coating can be attributed to continuous and protective thin oxide scale of CoO, Cr₂O₃ and SiO₂ formed on the surface. The coating region beneath this thin oxide scale was partially oxidized. Uncoated SuperCo-605 and MDN-121 showed less weight gain than Stellite-6 coated samples, but they showed spalling or sputtering during cyclic oxidation. Stellite-6 coating was dense and pore free even after 50 cycles, indicating that it can resist the hot corrosion cycle.     

Assessment of the MODIS LAI product for Australian ecosystems

The leaf area index (LAI) product from the Moderate Resolution Imaging Spectroradiometer (MODIS) is important for monitoring and modelling global change and terrestrial dynamics at many scales. The algorithm relies on spectral reflectances and a six biome land cover classification. Evaluation of the specific behaviour and performance of the product for regions of the globe such as Australia are needed to assist with product refinement and validation. We made an assessment of Collection 4 of the MODIS LAI product using four approaches: (a) assessment against a continental scale Structural Classification of Australian Vegetation (SCAV); (b) assessment against a continental scale land use classification (LUC); (c) assessment against historical field-based measurement of LAI collected prior to the Terra Mission; and (d) direct comparison of MODIS LAI with coincident field measurements of LAI, mostly from hemispherical photography. The MODIS LAI product produced a wide variety of geographically and structurally specific temporal response profiles between different classes and even for sub-groups within classes of the SCAV. Historical and concurrent field measurements indicated that MODIS LAI was giving reasonable estimates for LAI for most cover types and land use types, but that major overestimation of LAI occurs in some eastern Australian open forests and woodlands. The six biome structural land cover classification showed some significant deviations in class allocation compared to the SCAV particularly where grasslands are allocated to shrubland, savanna woodlands are allocated to shrubland, savanna and broadleaf forest, and open forests are allocated to savanna and broadleaf forest. The land cover and LAI products could benefit from some additional examination of Australian data addressing the structural representation of Eucalypt canopies in the “space of canopy realisation” for savanna and broadleaf forest classes.     

Differential scanning calorimetric studies on structured lipids from coconut oil triglycerides containing stearic acid

Triglycerides from coconut oil contain high levels of lauric acid. They were replaced by incremental amounts of stearic acid by interesterification reactions catalyzed by immobilized lipase (IM 60 from Rhizomucor miehei). The reactions were carried out in organic solvents such as hexane. Maximum incorporation of stearic acid was observed by 4 h at 37vv°C or by 2 h at 60vv°C when triglycerides to fatty acid (stearic acid) ratio was maintained at 1v:Ң. The stearic acid level in coconut oil triglycerides was increased from an initial value of 2% to 60% under these conditions. The stearic acid replaced lauric, myristic, and palmitic acids in unmodified triglycerides. A major portion of stearic acid incorporated was found in positions 1 and 3 of triglycerides. Differential scanning calorimetry indicated that stearic acid enrichment increased the solid fat content and also the higher melting polymorphs in modified lipids. The studies also indicated that low melting polymorphic forms of coconut oil triglycerides are converted to higher melting forms by stearic acid enrichment. The modified lipids thus obtained can find use in various food applications.     

Micro-RNA and Proteomic Profiles of Plasma-Derived Exosomes from Irradiated Mice Reveal Molecular Changes Preventing Apoptosis in Neonatal Cerebellum

Cell communication via exosomes is capable of influencing cell fate in stress situations such as exposure to ionizing radiation. In vitro and in vivo studies have shown that exosomes might play a role in out-of-target radiation effects by carrying molecular signaling mediators of radiation damage, as well as opposite protective functions resulting in resistance to radiotherapy. However, a global understanding of exosomes and their radiation-induced regulation, especially within the context of an intact mammalian organism, has been lacking. In this in vivo study, we demonstrate that, compared to sham-irradiated (SI) mice, a distinct pattern of proteins and miRNAs is found packaged into circulating plasma exosomes after whole-body and partial-body irradiation (WBI and PBI) with 2 Gy X-rays. A high number of deregulated proteins (59% of WBI and 67% of PBI) was found in the exosomes of irradiated mice. In total, 57 and 13 miRNAs were deregulated in WBI and PBI groups, respectively, suggesting that the miRNA cargo is influenced by the tissue volume exposed to radiation. In addition, five miRNAs (miR-99b-3p, miR-200a-3p, miR-200a, miR-182-5p, miR-182) were commonly overexpressed in the exosomes from the WBI and PBI groups. In this study, particular emphasis was also given to the determination of the in vivo effect of exosome transfer by intracranial injection in the highly radiosensitive neonatal cerebellum at postnatal day 3. In accordance with a major overall anti-apoptotic function of the commonly deregulated miRNAs, here, we report that exosomes from the plasma of irradiated mice, especially in the case of WBI, prevent radiation-induced apoptosis, thus holding promise for exosome-based future therapeutic applications against radiation injury.     

Improved fatigue crack growth resistance by retrogression and re‐aging heat treatment in 7010 aluminum alloy

Aircraft grade 7010 aluminum alloy was heat treated to two different conditions: (1) standard peak aging (T6) and (2) retrogression and re‐aging (RRA). The microstructures of these alloys were characterized by using transmission electron microscope. Fatigue crack growth rate (FCGR) tests were conducted using standard compact tension specimens, following ASTM standards. Tests were conducted at various stress ratios, R ranging from 0.1 to 0.7. The RRA‐treated alloy was observed to contain coarsened η′ (MgZn₂) precipitates with higher inter‐particle spacing when compared with T6‐treated alloy. The grain boundary precipitates (GBPs) were also coarsened and discontinuous in RRA‐treated alloy as compared with continuous GBPs in T6 condition. The FCGR was lower and ΔK_th was higher in RRA‐treated alloy compared with T6‐treated alloy at all the stress ratios investigated. Improved fatigue crack growth resistance in RRA‐treated alloy was correlated to the modified microstructure and enhanced crack closure levels.     

Process standardization for optimal virus recovery and removal of substrate DNA and bovine serum proteins in Vero cell-derived rabies vaccine

Purification of a rabies vaccine by a single zonal centrifugation run was replaced by two runs with optimal standardization of the sucrose density gradient. As a result, significant reductions in the levels of substrate DNA and bovine serum protein in the Vero cell-derived human rabies vaccine were achieved. Following many trials, for the first run, loading of the 3.2-l capacity K-3 rotor with 1800 ml of 60% sucrose solution and 1400 ml of vaccine PBS buffer solution gave a satisfactory linear gradient. However, after the first run, the substrate DNA and bovine serum contents exceeded the required levels. After protamine sulphate and Tween-80 treatment of the concentrated inactivated material, a second run using the same procedure as in the first run was tried. However, these purification procedures resulted in low virus recovery. To achieve optimal virus recovery, and removal of substrate DNA and bovine serum protein, the peak fractions from the first run as indicated by the haemagglutination, sucrose concentration, and optical density values were pooled and the sucrose concentration of the pooled fractions was increased to 60%. A second (flotation) run was then carried out. Using this method, the virus recovery rate was more than 95% that of the first run, and the levels of cellular DNA and bovine serum protein were well within the acceptable limits of less than 100 pg/dose and one part per million, respectively. The substrate DNA was quantified by both radioactive labeling and non-radioactive biotin labeling methods. For the quantification of calf serum protein, a counter-immunoelectrophoresis method was developed and effectively applied. A potency assay was performed using the National Institutes of Health (NIH) and well-standardized in vitro single radial immuno diffusion (SRD) methods. Finally, an immunogenicity study was conducted with human volunteers and the results were confirmed by a rapid fluorescent focus inhibition test (RFFIT).     

A new family of nonbinary sequences with three-level correlation property and large linear span

In this correspondence, we present a new family of nonbinary sequences with three-level nontrivial correlations and large linear complexity. The sequences may be considered as nonlinear analogues of the well-known sequences by Trachtenberg and Helleseth. It is shown that the family is optimal with respect to the Welch bound in terms of root mean square of all nontrivial correlations. We also determine the correlation distribution of the new family.