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1.
Bottomley Stephen P.; Popplewell Andrew G.; Scawen Michael; Wan Tommy; Sutton Brian J.; Gore Michael G. 《Protein engineering, design & selection : PEDS》1994,7(12):1463-1470
The stability and unfolding of an immunoglobulin (Ig) G bindingprotein based upon the B domain of protein A (SpAB) from Staphylococcusaureus were studied by substituting tryptophan residues at strategiclocations within each of the three a-helical regions (al-a3)of the domain. The role of the C-terminal helix, a3, was investigatedby generating two protein constructs, one corresponding to thecomplete SpAB, the other lacking a part of ct3; the Trp substitutionswere made in both one-and two-domain versions of each of theseconstructs. The fluorescence properties of each of the single-tryptophanmutants were studied in the native state and as a function ofguanidine-HCl-mediated unfolding, and their IgG binding activitieswere determined by a competitive enzyme-linked immunosorbentassay. The free energies of folding and of binding to IgG foreach mutant were compared with those for the native domains.The effect of each substitution upon the overall structure andupon the IgG binding interface was modelled by molecular graphicsand energy minimization. These studies indicate that (i) 3 contributesto the overall stability of the domain and to the formationof the IgG binding site in l and 2, and (ii) al unfolds first,followed by 2 and 3 together. 相似文献
2.
Robustness of ISS systems to inputs with limited moving average: Application to spacecraft formations 下载免费PDF全文
Esten Ingar Grøtli Elena Panteley Antoine Chaillet Jan Tommy Gravdahl 《国际强度与非线性控制杂志
》2016,26(4):816-833
》2016,26(4):816-833
We provide a theoretical framework that fits realistic challenges related to spacecraft formation with disturbances. We show that the input‐to‐state stability of such systems guarantees some robustness with respect to a class of signals with bounded average‐energy, which encompasses the typical disturbances acting on spacecraft formations. Solutions are shown to converge to the desired formation, up to an offset, which is somewhat proportional to the considered moving average of disturbances. In the presence of fast peaking perturbations, the approach provides a tighter evaluation of the disturbances' influence, which allows for the use of more parsimonious control gains. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
3.
Michael Shneier Tommy Chang Tsai Hong Will Shackleford Roger Bostelman James S. Albus 《Autonomous Robots》2008,24(1):69-86
Autonomous mobile robots need to adapt their behavior to the terrain over which they drive, and to predict the traversability
of the terrain so that they can effectively plan their paths. Such robots usually make use of a set of sensors to investigate
the terrain around them and build up an internal representation that enables them to navigate. This paper addresses the question
of how to use sensor data to learn properties of the environment and use this knowledge to predict which regions of the environment
are traversable. The approach makes use of sensed information from range sensors (stereo or ladar), color cameras, and the
vehicle’s navigation sensors. Models of terrain regions are learned from subsets of pixels that are selected by projection
into a local occupancy grid. The models include color and texture as well as traversability information obtained from an analysis
of the range data associated with the pixels. The models are learned without supervision, deriving their properties from the
geometry and the appearance of the scene.
The models are used to classify color images and assign traversability costs to regions. The classification does not use the
range or position information, but only color images. Traversability determined during the model-building phase is stored
in the models. This enables classification of regions beyond the range of stereo or ladar using the information in the color
images. The paper describes how the models are constructed and maintained, how they are used to classify image regions, and
how the system adapts to changing environments. Examples are shown from the implementation of this algorithm in the DARPA
Learning Applied to Ground Robots (LAGR) program, and an evaluation of the algorithm against human-provided ground truth is
presented.
相似文献
James S. AlbusEmail: |
4.
A novel approach of combining flexible molecular docking, GRID molecular interaction fields, analysis of ligand-protein hydrogen bond interactions, conformational energy penalties and 3D-QSAR analysis was used to propose a binding mode in the dimer interface of the iGluR2 receptor for the biarylpropylsulfonamide class of positive allosteric AMPA modulators. Possible binding poses were generated by flexible molecular docking. GRID molecular interaction fields of the binding site, ligand-protein hydrogen bonding interactions and conformational energy penalties were used to select the most likely binding mode. The selected binding poses were subjected to a 3D-QSAR analysis using previously published activity data. The resulting model (2 LVs, R2=0.89, q2=0.61) predicted the activities of the compounds in the test set with a standard deviation on error of prediction of 0.17. The proposed binding mode was validated by interpretation of the PLS-coefficient regions from the 3D-QSAR analysis in terms of interactions between the receptor and the modulators. 相似文献
5.
Onome Scott-Emuakpor Tommy George Todd Letcher M.-H. Herman Shen Charles Cross 《Journal of Failure Analysis and Prevention》2012,12(1):109-115
The proposed work analyzes the possibility of improving the capabilities of an energy-based fatigue life prediction method.
The improvement being addressed is regarding the variation of empirical monotonic strain energy density calculations and the
effects on the energy-based fatigue life prediction capability. Since the prediction method was developed from the concept
that the strain energy accumulated during both monotonic failure and an entire fatigue process are equal, meaning the strain
energy accumulated during monotonic failure is a physical damage quantity, it was important to understand the variation of
monotonic strain energy density. The process for incorporating this variation into the prediction method explores a probabilistic,
Three-Sigma analysis that is applicable for all deterministic methods of measuring experimental monotonic strain energy density.
The accuracy of the probabilistic energy-based lifing method was admirably assessed by comparison with experimental fatigue
life results, between 103 and 105 cycles, conducted on Titanium 6Al–4V specimens at room temperature. 相似文献
6.
Jonathan M. Polfus Wen Xing Marit Riktor Martin F. Sunding Paul Inge Dahl Sidsel M. Hanetho Tommy Mokkelbost Yngve Larring Marie‐Laure Fontaine Rune Bredesen 《Journal of the American Ceramic Society》2016,99(3):1071-1078
Dense symmetric membranes of CaTi0.85?xFe0.15MnxO3?δ (x = 0.1, 0.15, 0.25, 0.4) are investigated in order to determine the optimal Mn dopant content with respect to highest O2 flux. O2 permeation measurements are performed as function of temperature between 700°C–1000°C and as function of the feed side ranging between 0.01 and 1 bar. X‐ray photoelectron spectroscopy is utilized to elucidate the charge state of Mn, and synchrotron radiation X‐ray powder diffraction (SR‐XPD) is employed to investigate the structure symmetry and cell volume of the perovskite phase at temperatures up to 800°C. The highest O2 permeability is found for x = 0.25 over the whole temperature and ranges, followed by x = 0.4 above 850°C. The O2 permeability for x = 0.25 reaches 0.01 mL(STP) min?1 cm?1 at 925°C with 0.21 bar feed side and Ar sweep gas. X‐ray photoelectron spectroscopy indicates that the charge state of Mn changes from approx. +3 to +4 when x > 0.1, which implies that Mn mainly improves electronic conductivity for x > 0.1. The cell volume is found to decrease linearly with Mn content, which coincides with an increase in the activation energy of O2 permeability. These results are consistent with the interpretation of the temperature and dependency of O2 permeation. The sintering behavior and thermal expansion properties are investigated by dilatometry, which show improved sinterability with increasing Mn content and that the thermal expansion coefficient decreases from 12.4 to 11.9 × 10?6 K?1 for x = 0 and x = 0.25, respectively. 相似文献
7.
Tommy W. Sutor Jayachandra Kura Alex J. Mattingly Dana M. Otzel Joshua F. Yarrow 《International journal of molecular sciences》2022,23(2)
Spinal cord injury (SCI) produces paralysis and a unique form of neurogenic disuse osteoporosis that dramatically increases fracture risk at the distal femur and proximal tibia. This bone loss is driven by heightened bone resorption and near-absent bone formation during the acute post-SCI recovery phase and by a more traditional high-turnover osteopenia that emerges more chronically, which is likely influenced by the continual neural impairment and musculoskeletal unloading. These observations have stimulated interest in specialized exercise or activity-based physical therapy (ABPT) modalities (e.g., neuromuscular or functional electrical stimulation cycling, rowing, or resistance training, as well as other standing, walking, or partial weight-bearing interventions) that reload the paralyzed limbs and promote muscle recovery and use-dependent neuroplasticity. However, only sparse and relatively inconsistent evidence supports the ability of these physical rehabilitation regimens to influence bone metabolism or to increase bone mineral density (BMD) at the most fracture-prone sites in persons with severe SCI. This review discusses the pathophysiology and cellular/molecular mechanisms that influence bone loss after SCI, describes studies evaluating bone turnover and BMD responses to ABPTs during acute versus chronic SCI, identifies factors that may impact the bone responses to ABPT, and provides recommendations to optimize ABPTs for bone recovery. 相似文献
8.
Samira Lotfian Tommy Vikström Andreas Lennartsson Bo Björkman Hesham Ahmed Caisa Samuelsson 《Canadian Metallurgical Quarterly》2019,58(2):164-176
Shredder residue materials are produced after the removal of ferrous and non-ferrous fractions from end-of-life electronic equipment. Despite the high plastic content and metal value in the ash, high percentages of these materials are currently sent to landfills. In this study, the potential of utilising shredder residue material and other plastic-containing materials as reducing agents was studied. Plastic-containing materials were co-injected with coal into a zinc-fuming furnace in Boliden-Rönnskär smelter. The data obtained from the trial, such as the data from the chemical analysis of the slag and the steam production, are discussed. The observations indicate that plastic-containing material can replace up to 1?ton?h?1 of coal without a significant decrease in the zinc reduction rate. 相似文献
9.
Pubudu Jayawardana David P. Thambiratnam Nimal Perera Tommy Chan G.H.M.J. Subashi De Silva 《Soils and Foundations》2019,59(4):874-887
Development activities in a city often generate ground vibration that can cause discomfort to the occupants in nearby buildings, disturbances to the activities undertaken in the buildings and possible damage to nearby structures. This ground vibration is caused by construction activities such as pile driving, ground compaction etc., and road and rail traffic. The use of trenches has been an effective way to mitigate the adverse effects of such ground vibration. The effectiveness of the trench depends on many parameters including the properties of the vibration source, soil medium and trench in-fill material, trench dimensions and the requirements of the receiver. The process of selecting an effective trench for vibration mitigation can therefore become complex due to the influence of a number of parameters and their wide range of values. This paper investigates the use of artificial neural network (ANN) as a smart and efficient tool to predict the effectiveness of geofoam-filled trenches to mitigate ground vibration. Towards this end, a database is developed from an extensive study on the effects of the controlling parameters through numerical simulations with a validated finite element (FE) model. At a certain distance from the vibration source, a geofoam-filled trench is introduced to evaluate the efficiency of vibration mitigation with changes in key parameters such as excitation frequency, amplitude of load, trench configuration (i.e. depth and width), soil shear wave velocity, soil density and damping ratio. These were selected as the input parameters for the ANN while amplitude reduction ratio and peak particle velocity (PPV) were considered as outputs. A multilayer feed forward network was used and trained with the Levenberg-Marquardt algorithm. Neural networks with different configurations were evaluated by comparing coefficient of determination (R2) and mean square error (MSE). The optimum architecture was then used to predict previous results, which revealed the accuracy and the effectiveness of the ANN approach. The findings of this study will provide useful information for vibration mitigation using geofoam-filed trenches. 相似文献
10.
Jong-Tae Park Antonius Suwanto Irawan Tan Tommy Nuryanto Rudy Lukman Kan Wang Jay-lin Jane 《Food science and biotechnology》2014,23(1):125-132
An α-amylase gene was cloned from the thermophilic bacterium Bacillus subtilis isolated from Indonesian oil palm shell waste. The gene expressed an extracellular enzyme. Optimal hydrolysis conditions for the enzyme were 70°C and pH 6.0. The specific activity of the enzyme was 16.0 kU per mg of protein, which was higher than for other thermostable amylases. Hydrolytic products of the enzyme using starch and glycogen were mainly maltohexaose and maltopentaose. The enzyme had a K m value of 0.099 mg/mL for amylopectin, more than 10 times lower than for amylose. The catalytic efficiency of the enzyme using amylopectin was 39,200 mL/mg·s and was 3,270 mL/mg·s using amylose. The enzyme liquefied corn starch at pH 5.0, which was successfully converted to glucose using commercial glucoamylase and pullulanase without pH adjustment. The enzyme has advantages for industrial applications. 相似文献