Long-wavelength 640×486 GaAs-AlGaAs quantum well infraredphotodetector snap-shot camera

A 9-μm cutoff 640×486 snap-shot quantum well infrared photodetector (QWIP) camera has been demonstrated. The performance of this QWIP camera is reported including indoor and outdoor imaging. The noise equivalent differential temperature (NEΔT) of 36 mK has been achieved at 300 K background with f/2 optics. This is in good agreement with expected focal plane array sensitivity due to the practical limitations on charge handling capacity of the multiplexer, read noise, bias voltage, and operating temperature     

Experience with Applying Formal Methods to Protocol Specification and System Architecture

In the last three years or so we at Enterprise Platforms Group at Intel Corporation have been applying formal methods to various problems that arose during the process of defining platform architectures for Intel's processor families. In this paper we give an overview of some of the problems we have worked on, the results we have obtained, and the lessons we have learned. The last topic is addressed mainly from the perspective of platform architects.     

Recursive solution technique in a multi-server bi-level queueingsystem with server breakdowns

The authors present a multiserver, first-come first-served queuing system that alternates between two modes of system operation. In one mode, all s servers are available, and in the other mode, only s-1 servers are available for serving the customers. This is due to breakdown of one of the servers. The random variables representing the system with s servers and s-1 servers have exponential distributions. In such a system, the steady-state birth/death equations are coupled because of the two modes of operation. A recursive solution is presented for computing the steady-state probabilities of such a system. Once these probabilities are known, the performance measures of interest can be easily obtained. Two practical examples validate the results and show the utility of this method. A distinct advantage of the recursive technique is that it is much faster and requires much less memory than the existing nonrecursive techniques. In a bilevel situation, the system performance measures are always bounded by two independent queuing systems with s and s-1 servers. A procedure has been outlined for extension to multiple modes of system operation     

Green synthesis of highly stable carbon nanodots and their photocatalytic performance

The present study reports a novel, facile, biosynthesis route for the synthesis of carbon nanodots (CDs) with an approximate quantum yield of 38.5%, using Musk melon extract as a naturally derived‐precursor material. The synthesis of CDs was established by using ultraviolet–visible (UV–vis) spectroscopy, Dynamic light scattering, photoluminescence spectroscopy, X‐ray diffraction, transmission electron microscopy and Fourier transform infrared (FTIR) spectroscopy. The as‐prepared CDs possess an eminent fluorescence under UV–light (λ _ex  = 365 nm). The size range of CDs was found to be in the range of 5–10 nm. The authors further explored the use of such biosynthesised CDs as a photocatalyst material for removal of industrial dye. Degradation of methylene blue dye was performed in a photocatalytic reactor and monitored using UV–vis spectroscopy. The CDs show excellent dye degradation capability of 37.08% in 60 min and reaction rate of 0.0032 min⁻¹. This study shows that synthesised CDs are highly stable in nature, and possess potential application in wastewater treatment.Inspec keywords: carbon, nanostructured materials, nanofabrication, catalysis, photochemistry, ultraviolet spectra, visible spectra, photoluminescence, X‐ray diffraction, transmission electron microscopy, Fourier transform infrared spectra, fluorescence, dyesOther keywords: green synthesis, highly stable CD, photocatalytic performance, biosynthesis route, carbon nanodots, quantum yield, Musk melon extract, naturally derived‐precursor material, ultraviolet‐visible spectroscopy, dynamic light scattering, photoluminescence spectroscopy, X‐ray diffraction, transmission electron microscopy, Fourier transform infrared spectroscopy, FTIR spectroscopy, fluorescence, biosynthesised CD, photocatalyst material, industrial dye, methylene blue dye degradation, photocatalytic reactor, UV‐vis spectroscopy, wastewater treatment, size 5 nm to 10 nm, time 60 min     

Mobility-Aware RSVP: A framework for improving the performance of multimedia services over wireless IP-based mobile networks

This paper proposes the Mobility-Aware Resource Reservation Protocol (MARSVP) in which mobility and QoS signaling are performed as a single functional block. The key concept of MARSVP is to convey mobility-specific information (binding updates and their associated acknowledgments) by using newly defined RSVP objects embedded in existing RSVP messages. An appealing feature of MARSVP is that it adheres to the current RSVP standard (RFC 2205) and thus requires minimal changes to end nodes without affecting any of the conventional RSVP routers in between. The proposed mechanism is evaluated using a simulation model for application-level performance and an analytical model for network-level signaling cost. Simulation results indicate a 27.9% improvement in QoS interruption when using Mobile IPv6 (MIPv6), 12.5% when using Hierarchical Mobile IPv6 (HMIPv6), and no improvement when using Fast Handovers for MIPv6 (FMIPv6). On the network-level, signaling cost savings of 9.4% and 11.9% are achieved for MIPv6 and HMIPv6, respectively, while FMIPv6 achieves savings of 17.9% when using Voice-over-IP traffic and 26.7% for Video-over-IP traffic. The results of the conducted studies indicate MARSVP’s superiority to conventional RSVP when deployed over wireless networks.     

Automated Cellular Modeling and Prediction on a Large Scale

We describe CHAMP (CHurn Analysis, Modeling, andPrediction), an automated system for modeling cellularsubscriber churn that is predicting which customerswill discontinue cellular phone service. We describevarious issues related to developing and deployingthis system including automating data access from aremote data warehouse, preprocessing, featureselection, model validation, and optimization toreflect business tradeoffs. Using data from GTE'sdata warehouse for cellular phone customers, CHAMP iscapable of developing churn models customized byregion for over one hundred GTE cellular phone marketstotaling over 5 million customers. Every month churnfactors are identified for each geographic region andmodels are updated to generate churn scores predictingwho is likely to churn in the short term. Learningmethods such as decision trees and genetic algorithmsare used for feature selection and a cascade neuralnetwork is used for predicting churn scores. Inaddition to producing churn scores, CHAMP alsoproduces qualitative results in the form of rules andcomparison of market trends that are disseminatedthrough a web based interface.     

Mixture Effects of Tryptophan Intestinal Microbial Metabolites on Aryl Hydrocarbon Receptor Activity

Aryl hydrocarbon receptor (AHR) plays pivotal roles in intestinal physiology and pathophysiology. Intestinal AHR is activated by numerous dietary, endogenous, and microbial ligands. Whereas the effects of individual compounds on AHR are mostly known, the effects of real physiological mixtures occurring in the intestine have not been studied. Using reporter gene assays and RT-PCR, we evaluated the combinatorial effects (3520 combinations) of 11 microbial catabolites of tryptophan (MICTs) on AHR. We robustly (n = 30) determined the potencies and relative efficacies of single MICTs. Synergistic effects of MICT binary mixtures were observed between low- or medium-efficacy agonists, in particular for combinations of indole-3-propionate and indole-3-lactate. Combinations comprising highly efficacious agonists such as indole-3-pyruvate displayed rather antagonist effects, caused by saturation of the assay response. These synergistic effects were confirmed by RT-PCR as CYP1A1 mRNA expression. We also tested mimic multicomponent and binary mixtures of MICTs, prepared based on the metabolomic analyses of human feces and colonoscopy aspirates, respectively. In this case, AHR responsiveness did not correlate with type of diet or health status, and the indole concentrations in the mixtures were determinative of gross AHR activity. Future systematic research on the synergistic activation of AHR by microbial metabolites and other ligands is needed.     

Process standardization for optimal virus recovery and removal of substrate DNA and bovine serum proteins in Vero cell-derived rabies vaccine

Purification of a rabies vaccine by a single zonal centrifugation run was replaced by two runs with optimal standardization of the sucrose density gradient. As a result, significant reductions in the levels of substrate DNA and bovine serum protein in the Vero cell-derived human rabies vaccine were achieved. Following many trials, for the first run, loading of the 3.2-l capacity K-3 rotor with 1800 ml of 60% sucrose solution and 1400 ml of vaccine PBS buffer solution gave a satisfactory linear gradient. However, after the first run, the substrate DNA and bovine serum contents exceeded the required levels. After protamine sulphate and Tween-80 treatment of the concentrated inactivated material, a second run using the same procedure as in the first run was tried. However, these purification procedures resulted in low virus recovery. To achieve optimal virus recovery, and removal of substrate DNA and bovine serum protein, the peak fractions from the first run as indicated by the haemagglutination, sucrose concentration, and optical density values were pooled and the sucrose concentration of the pooled fractions was increased to 60%. A second (flotation) run was then carried out. Using this method, the virus recovery rate was more than 95% that of the first run, and the levels of cellular DNA and bovine serum protein were well within the acceptable limits of less than 100 pg/dose and one part per million, respectively. The substrate DNA was quantified by both radioactive labeling and non-radioactive biotin labeling methods. For the quantification of calf serum protein, a counter-immunoelectrophoresis method was developed and effectively applied. A potency assay was performed using the National Institutes of Health (NIH) and well-standardized in vitro single radial immuno diffusion (SRD) methods. Finally, an immunogenicity study was conducted with human volunteers and the results were confirmed by a rapid fluorescent focus inhibition test (RFFIT).