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Synthesis of Novel Phosphonic‐Type Activity‐Based Probes for Neutrophil Serine Proteases and Their Application in Spleen Lysates of Different Organisms 下载免费PDF全文
Dr. Renata Grzywa Dr. Ewa Burchacka Maria Łęcka Dr. Łukasz Winiarski Maciej Walczak Agnieszka Łupicka‐Słowik Dr. Magdalena Wysocka Prof. Timo Burster Dr. Kamila Bobrek Dr. Keri Csencsits‐Smith Prof. Adam Lesner Dr. Marcin Sieńczyk 《Chembiochem : a European journal of chemical biology》2014,15(17):2605-2612
Neutrophils are a type of granulocyte important in the “first line of defense” of the innate immune system. Upon activation, they facilitate the destruction of invading microorganisms by the production of superoxide radicals, as well as the release of the enzymatic contents of their lysozymes. These enzymes include specific serine proteases: cathepsin G, neutrophil elastase, proteinase 3, as well as the recently discovered neutrophil serine protease 4 (NSP4). Under normal conditions, the proteolytic activity of neutrophil proteases is tightly regulated by endogenous serpins; however, this mechanism can be subverted during tissue stress, thereby resulting in the uncontrolled activity of serine proteases, which induce chronic inflammation and subsequent pathology. Herein, we describe the development of low‐molecular‐weight activity‐based probes that specifically target the active sites of neutrophil proteases. 相似文献
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Polypropylene hybrid composites reinforced with short glass fiber (SGF) and toughened with styrene–ethylene butylenes–styrene (SEBS) elastomer were prepared using extrusion and injection‐molding techniques. Moreover, hybrids compatibilized with SEBS‐grafted maleic anhydride (SEBS‐g‐MA) and hybrid compatibilized with PP grafted with maleic anhydride (PP‐g‐MA) were also fabricated. The matrix of the latter hybrid was designated as mPP and consisted of 95% PP and 5% PP‐g‐MA. Tensile dilatometry was carried out to characterize the fracture mechanisms of hybrid composites. Dilatometric responses showed that the elastic deformation was the dominant deformation mechanism for the SGF/SEBS/PP and SGF/SEBS‐g‐MA/PP hybrids. However, cavitation deformation prevailed over shearing deformation for both hybrids at the higher strain regime. The cavitation strain resulted from the debonding of glass fibers and from the crazing of the matrix in the SGF/SEBS/PP hybrid. In contrast, the cavitation was caused by the debonding of SEBS particles from the matrix of the SGF/SEBS‐g‐MA/PP hybrid. The use of PP‐g‐MA resulting in elastic deformation was the main mode of deformation in the low‐strain region for the SGF/SEBS/mPP and SEBS/SEBS‐g‐MA/mPP hybrids; thereafter, shearing appeared to dominate at the higher strain regime. This was attributed to the MA functional group improving the bonding between the SGF and PP. The correlation between fracture morphology and dilatometric responses also is presented in the article. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 87: 441–451, 2003 相似文献
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Nickel oxide nanoclusters were intercalated to layered niobate, K4Nb6O17, to improve the photocatalytic hydrogen production for water splitting under visible light irradiation. A K4Nb6O17–SSRx (Ni/Nb ratio range of 0.8–5%) series of nickel oxide intercalated layered niobates was prepared by a two-step solid-state reaction and characterized by Extended X-ray Absorption Fine Structure (EXAFS), Transmission Electron Microscopy (TEM), Scanning Electron Microscopy (SEM), Energy Dispersive Spectrometer (EDS), X-ray Photoelectron Spectroscopy (XPS) and Ultraviolet–visible spectroscopy (UV–vis). The photocatalytic reaction was carried out in a quartz reactor irradiated under a 500-W halogen lamp. The K4Nb6O17–SSR0.2 catalyst exhibited a much higher photocatalytic activity for water splitting than unloaded K4Nb6O17 catalyst and NiOy/K4Nb6O17 catalyst prepared by the conventional impregnation method. The high catalytic performance was attributed to the well dispersed nickel oxide nanoclusters intercalated into the bulk structure of K4Nb6O17 catalyst and the lack of NiO particles on the external particle surface. 相似文献
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Saif Ullah Pierrick Anthony Mindykowski Rolff Ripke Leisted Sergey Chernyy Sie Woldum Tordrup Grunde Jomaas Kristoffer Almdal 《火与材料》2020,44(7):966-974
A novel intumescent (carbonization, acid donor and foaming) fire retardant that mimics carbon nanotubes was introduced into bitumen roofing and characterized using cone calorimetry as the main analytical tool. The experimental results indicate that 18% (by mass) attapulgite mineral (ATTP) mixed with base bitumen decreased the peak heat release rate per unit area (pHRRPUA) by 10%. Further, incorporation of melamine coated ammonium polyphosphate (MAPP) decreased the pHRRPUA by 52% and a mixture of these (3:1, ATTP:MAPP) decreased the pHRRPUA by 25% as compared to adding CaCO3 as a filler. The residual mass loss after the cone test was also improved with up to 3%. The indication of a positive synergistic flame retardant effect of the ATTP-MAPP mixture is supported by thermogravimetric analysis. The addition of this rod-like mineral improved the general fire retardant properties of the base bitumen and increased the viscosity. Therefore, the polymer-modified bitumen with both fire retardant and rheological properties (providing mechanical strength) is a promising novel approach in the design of bitumen roofing membranes. 相似文献
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木犀科植物花粉的扫描电镜研究 总被引:7,自引:1,他引:7
植物花粉的形态特征具有种属特异性。本文用扫描电子显微镜观察了木犀科(Oleaceae)的六属八种植物花粉的形态特征。结果表明,除迎春有个别四萌发沟外,其它花粉都是三沟型,外壁纹饰均为网状。但各种植物花粉的细微形态仍有明显差异。因此,用扫描电镜观察研究植物花粉的亚微形态特征,可为植物分类提供一些必要的形态依据。 相似文献
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Teng Fuchen Sie Yong-Cheng Ouedraogo Colette 《Bulletin of Engineering Geology and the Environment》2021,80(8):6359-6371
Bulletin of Engineering Geology and the Environment - The application of MICP (microbial-induced calcite precipitation) to clays has been restricted due to their low permeability and small pore... 相似文献
10.
Caleb Acquah Yi Wei Chan Charles K. S. Moy Clarence M. Ongkudon Sie Yon Lau 《分离科学与技术》2018,53(13):2100-2111
The introduction of aptameric ligands onto disk-monolithic adsorbent, representing a unique strategy for convective isolation of target molecules with high specificity and selectivity, is investigated for the first time. Experimental results showed that the disk monolith possessed a good permeability of 1.67 ± 0.05 × 10–14 m2 (RSD = 3.2%). The aptameric ligand density for the aptamer-modified disk monolith was 480 pmol/uL. Chromatographic analysis of the aptamer disk-monolith efficiency showed an optimum linear velocity of 126 cm/min (≈0.25 mL/min) at room temperatures 25 ± 2°C. The theoretical number of plates corresponding to the optimum linear velocity was 128.2 with an height equivalent to the theoretical plate of 0.022 mm. The disk aptamer-immobilised monolithic system demonstrated good selectivity and isolation of thrombin from non-targets. 相似文献