A STUDY OF EXPERIMENTAL DESIGN OPTIMALITY FOR WIENER SYSTEMS

In the context of nonlinear dynamic system identification for Hammerstein systems, Rollins et al. (2003a) studied the information efficiency of the following two competing experimental design approaches: statistical design of experiments (SDOE) and pseudo-random sequences design (PRSD). The focus of this study is the Wiener system and evaluates SDOE against PRS under D-optimal efficiency. Three cases are evaluated and the results strongly support SDOE as the better approach.     

Free-living inferential modeling of blood glucose level using only noninvasive inputs

The goal of this work is to present a causation modeling methodology with the ability to accurately infer blood glucose levels using a large set of highly correlated noninvasive input variables over an extended period of time. These models can provide insight to improve glucose monitoring, and glucose regulation through advanced model-based control technologies. The efficacy of this approach is demonstrated using real data from a type 2 diabetic (T2D) subject collected under free-living conditions over a period of 25 consecutive days. The model was identified and tested using eleven variables that included three food variables as well as several activity and stress variables. The model was trained using 20 days of data and validated using 5 days of data. This gave a fitted correlation coefficient of 0.70 and an average absolute error (AAE) (i.e., the average of the absolute values for the measured glucose concentration minus modeled glucose concentration) of 13.3 mg/dL for the validation data. This AAE result was significantly better than the subject’s personal glucose meter AAE of 15.3 mg/dL for replicated measurements.     

Fracture experiments on through wall cracked elbows under in-plane bending moment: Test results and theoretical/numerical analyses

Fracture assessment of pipe bends or elbows with postulated through wall crack is very essential for leak-before-break qualification of primary heat transport system piping of nuclear power plants. The methodology for fracture assessment of cracked elbows is still in developing stage. Any new development in theoretical aspect requires experimental validation. However, fracture test data on cracked elbows is not so abundant as straight pipes. The earlier experiments on cracked elbows were focused mainly on the determination of limit load. Other fracture parameters e.g. crack growth, crack initiation load or crack opening displacement were not reported in the open literature. Against this backdrop, a comprehensive experimental and theoretical program on component integrity has been initiated at Reactor Safety Division (RSD) of Bhabha Atomic Research Center (BARC), India. Under this program, a number of fracture tests have been carried out on elbows with through wall circumferential/axial cracks subjected to in-plane closing/opening bending moment. These test data are then thoroughly analysed numerically through non-linear finite element analyses, analytically through limit load comparison and also through comparison of crack initiation loads by finite element and R6 methods. These test data may be utilized in future for validation of new theoretical developments in the integrity assessment of through wall cracked elbows.     

Fault-Tolerant Convergence Routing

This paper presents fault-tolerant protocols for fast packet switch networks withconvergence routing. The objective is to provide fast reconfiguration and continuous host-to-host communication after a link or a node (switch) failure,Convergence routingcan be viewed as a variant ofdeflection routing,which combines, in a dynamic fashion, the on-line routing decision with the traffic load inside the network. Unlike other deflection techniques, convergence routing operates withglobal sense of directionand guarantees that packets will reach or converge to their destinations. Global sense of direction is achieved by embedding of virtual rings to obtain a linear ordering of the nodes. We consider virtual ring embeddings over (i) a single spanning tree, and (ii) over two edge-disjoint spanning trees. Thus, the fault-tolerant solution is based on spanning trees and designed for a switch-based (i.e., arbitrary topology) architecture called MetaNet. In this work, the original MetaNet's convergence routing scheme has been modified in order to facilitate the property that the packet header need not be recomputed after a failure and/or a reconfiguration. This is achieved by having, at the network interface, a translator that maps the unique destination address to a virtual address. It is argued that virtual rings embedded over two-edge disjoint spanning trees increase the fault tolerance for both node and link faults and provides continuous host-to-host communication.     

Mapping Conjugate Gradient Algorithms for Neutron Diffusion Applications onto SIMD, MIMD, and Mixed-Mode Machines

The performance of conjugate gradient (CG) algorithms for the solution of the system of linear equations that results from the finite-differencing of the neutron diffusion equation was analyzed on SIMD, MIMD, and mixed-mode parallel machines. A block preconditioner based on the incomplete Cholesky factorization was used to accelerate the conjugate gradient search. The issues involved in mapping both the unpreconditioned and preconditioned conjugate gradient algorithms onto the mixed-mode PASM prototype, the SIMD MasPar MP-1, and the MIMD Intel Paragon XP/S are discussed. On PASM , the mixed-mode implementation outperformed either SIMD or MIMD alone. Theoretical performance predictions were analyzed and compared with the experimental results on the MasPar MP-1 and the Paragon XP/S. Other issues addressed include the impact on execution time of the number of processors used, the effect of the interprocessor communication network on performance, and the relationship of the number of processors to the quality of the preconditioning. Applications studies such as this are necessary in the development of software tools for mapping algorithms onto either a single parallel machine or a heterogeneous suite of parallel machines.     

Field Performance of High Oleic Soybeans with Mutant FAD2-1A and FAD2-1B Genes in Tennessee

Soybean [Glycine max (L.) Merr.] oil with high oleic acid (>75%) has increased oxidative stability and health benefits that are valuable for food, fuel, and industrial products. It has been determined that two naturally occurring mutations in genes FAD2-1A and FAD2-1B can combine to produce high oleic soybeans. The objective of this study was to test the effect of these mutant alleles on seed yield and oil and protein concentration. Molecular markers assisted in the creation of a population of 48 BC₃F_2:4 lines (93.75% expected genome commonality). Each line was classified into one of four genotypic groups where both FAD2-1A and FAD2-1B genes were either homozygous wild type or mutant, respectively. Twelve lines for each genotypic group were evaluated in three replications at six locations across Tennessee. There was no seed yield difference between the high oleic genotypic group and the other groups (P < 0.05). On the other hand, there were differences in fatty acid profiles and oil and protein concentrations. In combination, the mutant FAD2-1A and FAD2-1B alleles produced a mean of 803.1 g kg⁻¹ oleic acid. This is, on average, approximately 500 g kg⁻¹ more oleic acid compared to soybean lines with only one mutant FAD2-1 allele. The high oleic double mutant group had more total oil (228.0 g kg⁻¹) and protein (401.0 g kg⁻¹) compared to all other genotypic groups (P < 0.05). Overall, this specific combination of mutant FAD2-1A and FAD2-1B alleles appears to generate conventional high oleic soybeans without a yield drag.     

Design,Synthesis, and Self-Assembly Studies of a Suite of Monodisperse,Facially Amphiphilic,Protein–Dendron Conjugates

The custom design of protein–dendron amphiphilic macromolecules is at the forefront of macromolecular engineering. Macromolecules with this architecture are very interesting because of their ability to self-assemble into various biomimetic nanoscopic structures. However, to date, there are no reports on this concept due to technical challenges associated with the chemical synthesis. Towards that end, herein, a new chemical methodology for the modular synthesis of a suite of monodisperse, facially amphiphilic, protein–dendron bioconjugates is reported. Benzyl ether dendrons of different generations (G1–G4) are coupled to monodisperse cetyl ethylene glycol to form macromolecular amphiphilic activity-based probes (AABPs) with a single protein reactive functionality. Micelle-assisted protein labeling technology is utilized for site-specific conjugation of macromolecular AABPs to globular proteins to make monodisperse, facially amphiphilic, protein–dendron bioconjugates. These biohybrid conjugates have the ability to self-assemble into supramolecular protein nanoassemblies. Self-assembly is primarily mediated by strong hydrophobic interactions of the benzyl ether dendron domain. The size, surface charge, and oligomeric state of protein nanoassemblies could be systematically tuned by choosing an appropriate dendron or protein of interest. This chemical method discloses a new way to custom-make monodisperse, facially amphiphilic, protein–dendron bioconjugates.