Sucralfate attenuates gastric mucosal lesions and increased vascular permeability induced by ischaemia and reperfusion in rats

Recent evidence suggests that oxygen-derived free radicals are involved in mediating gastric microvascular and parenchymal cell injuries induced by ischaemia and reperfusion. Therefore, the effect of the locally acting anti-ulcer drug, sucralfate, was studied on ischaemia and reperfusion (e.g. induced gastric lesions, intraluminal bleeding, changes in vascular permeability and non-protein sulfhydryl levels in the rat stomach). Allopurinol was used as a known standard antioxidant drug. Rats were subjected to 30 min of gastric ischaemia in the presence of 100 mmol/L hydrochloric acid and reperfusion periods of 15, 30 or 60 min duration. The gastric lesions were assessed microscopically under an inverted microscope. The vascular permeability was quantified by measuring the extravasated Evans blue in the stomach. There were significantly greater numbers of gastric lesions, intraluminal bleeding and leakage of Evans blue during all reperfusion periods as compared with those of ischaemia, with maximum effects occurring at 60 min following reperfusion. Pretreatment with sucralfate (31.25-250 mg/kg, p.o.) or allopurinol (12.5-50 mg/kg, i.p.) 30 min before the procedure, dose-dependently reduced the gastric lesions, intraluminal bleeding, and decreased the vascular permeability induced by ischaemia and reperfusion. Furthermore, sucralfate dose-dependently reverses the ischaemia and reperfusion-induced depletion of mucosal non-protein sulfhydryl levels and inhibited the superoxide radical production in both cell-free xanthine-xanthine oxidase and in the stimulated polymorphonuclear cellular systems. These results suggest that the protection produced by sucralfate against gastric injury may be due to its antioxidant effects.     

On a large-gain theorem

The aim of this paper is to give a general quantitative requirement which the loop gain must satisfy in order to stabilize a given unstable (possibly nonlinear and time-varying) plant, namely that the gain must exceed one.     

Optimal design of elastic beams with segmentwise constant height in the case of dynamic loading

A shape optimization method for elastic beams with segmentwise constant height is proposed. The ends of the beam are simply supported, clamped or free. Two problems are discussed; (i) a beam is loaded by lateral pressure, (ii) a beam is struck by an attached mass. External loads and volume of the beam are prescribed and the deflection in a given cross-section is to be minimized. For solving this problem, the deflections are expanded into a Fourier series by eigenfunctions. Numerical results are given for two-, three- and four-stepped beams.     

Effect of flexure induced transverse crack and self-healing on chloride diffusivity of reinforced mortar

Cracks in reinforced concrete are unavoidable. Durability is of increasing concern in the concrete industry, and it is significantly affected by the presence of cracks. The corrosion of reinforcing steel due to chloride ions in deicing salts or sea-water is a major cause of premature deterioration of reinforced concrete structures. Although, it is generally recognized that cracks accelerate the ingress of chlorides in concrete, a lack of consensus on this subject does not yet allow reliable quantification of their effects. The present work studies the relationship between crack widths and chloride diffusivity. Flexural load was introduced to generate cracks of width ranging between 29 and 390 μm. As crack width was increased, the effective diffusion coefficient was also increased, thus reducing the initiation period of corrosion process. For cracks with widths less than 135 μm, the effect of crack widths on the effective diffusion coefficient of mortar was found to be marginal, whereas for crack widths higher than 135 μm the effective diffusion coefficient increased rapidly. Therefore, the effect of crack width on chloride penetration was more pronounced when the crack width is higher than 135 μm. Results also indicate that the relation between the effective diffusion coefficient and crack width was found to be power function. In addition, a significant amount of self-healing was observed within the cracks with width below 50 μm subjected to NaCl solution exposure. The present research may provide insight into developing design criteria for a durable concrete and in predicting service life of a concrete structures.     

Conceptual damage-sensitive features for structural health monitoring: Laboratory and field demonstrations

The use of damage-sensitive features to evaluate structural condition or health is a very critical aspect of structural health monitoring. The purpose of this paper is to investigate the potential of two different damage-sensitive features for detecting damage. Different damage scenarios are simulated on a large-scale laboratory structure and a three-span highway bridge for demonstration. The features presented in this paper are the modal flexibility-based deflection and curvature both of which are obtained directly from dynamic properties. In the literature, flexibility associated with mode shapes and mode shapes curvatures have been mostly explored. In this study, multi-input–multi-output dynamic data are used to obtain modal flexibility, which is a close approximation to the actual flexibility. A main novelty is that the curvature is calculated from the deflected shapes using the modal flexibility as opposed to using modal vectors. In this paper, the theory of the methodology is explained and then experimental studies and results are presented. For the experimental studies, the laboratory specimen and the three-span bridge were gradually damaged. It is shown that both deflection and curvature are conceptual and physically meaningful features for damage detection and localization. The issues and the requirements for these features to perform successfully are also presented.     

CMV infection and cytomegalovirus disease in immunodepressed patients

An active entomologic survey was conducted by a team of trained health workers in a rural area endemic for Chagas' disease in central Brazil. They used pyrethrum as a flushing agent and 4,232 houses were inspected for triatomine bugs both inside and in the immediate environs. Houses with Triatoma infestans or evidence of an established colony were identified and defined as infested houses (cases). The building and environmental characteristics of 161 randomly selected infested houses were compared with 161 matched, noninfested houses (controls) that were the shortest distance from the infested house. Domestic and peridomestic potential risk factors associated with house infestation by Triatoma infestans were assessed by logistic regression analysis. Incomplete house construction (odds ratio [OR] = 2.5, 95% confidence interval [CI] = 1.5-4.1) was confirmed as a risk factor related to the presence or evidence of Triatoma infestans in the dwellings. The study also disclosed a statistically significant association between the presence of rats (OR = 1.6, 95% CI = 1.1-2.6) and indoor crop storage (OR = 2.3, 95% CI = 1.1-5.2) and house infestation. Further experimental field studies using tagged rodents should be conducted to assess their epidemiologic role in the domestic chain of Trypanosoma cruzi transmission.     

Effects of circumferential pick spacing on boom type roadheader cutting head performance

Effects of equal and unequal circumferential pick spacing on the performance of boom type roadheaders having cylindrical cutting heads are investigated. For this purpose, two experimental cutting heads with equal and unequal circumferential spacing are designed and manufactured. The cutting head with unequal circumferential spacing is specifically designed to prevent tool-holder overlap at the nose section. Manufacturing difficulties associated with equal circumferential pick spacing due to tool-holder overlap are discussed with solid modeling and practical applications. The heads are tested at Park Cayirhan Coal Mine in Turkey and their cutting performances are analysed. Although better cutting performance for equal circumferential spacing are predicted by force–balance analysis, in situ measurements of instantaneous (net) traversing speed and cutting rate, pick consumption rate and machine vibration show that no significant difference exists between the performances of the two cutting heads.     

Synthesis and characterization of poly(N‐vinyl‐2‐pyrrolidone) grafted sodium alginate hydrogel beads for the controlled release of indomethacin

Graft copolymers of sodium alginate (NaAlg) with N‐vinyl‐2‐pyrrolidone were prepared using azobisisobutyronitrile as initiator. The graft copolymers (NaAlg‐g‐PVP) were characterized with Fourier transform infrared spectroscopy, elemental analysis, and differential scanning calorimetry. Polymeric hydrogel beads of NaAlg and NaAlg‐g‐PVP were prepared by crosslinking method using glutaraldehyde (GA) as a crosslinker in the hydrochloric acid catalyst (HCl) and these beads were used to deliver anti‐inflammatory drug, indomethacin (IM). Chemical stability of the IM after encapsulation into beads was confirmed by FTIR. Preparation conditions of the NaAlg‐g‐PVP beads were optimized by considering the percentage entrapment efficiency, particle size, swelling capacity and their release data. In vitro release studies were performed in simulated gastric fluid (pH 1.2) for the initial 2 h, followed by simulated intestinal fluid (pH 7.4) for 4 h. Effects of GA concentration, exposure time to GA, drug/polymer (d/p) ratio, and concentration of HCl on the release of IM were discussed. It was observed that IM release from the beads decreased with increasing GA concentration and exposure time. IM release also decreases with increasing d/p ratio and HCl concentration. The highest IM release was obtained to be 77% for beads crosslinked with 0.027M GA. Swelling experiments were also performed to compute molecular mass between crosslinks of the beads. © 2008 Wiley Periodicals, Inc. J Appl Polym Sci, 2008     

Steady-state and transient photoconductivity in hydrogenated amorphous silicon nitride films

Amorphous SiN_x:H films were prepared by the rf glow-discharge decomposition of ammonia/silane gas mixture with varying nitrogen content. The steady-state photoconductivity and its dependence on light intensity have been investigated in a-SiN_x:H as a function of temperature between 100 and 420 K. The electron drift mobility of a set of SiN_x:H samples has been determined from their steady-state photoconductivity and response time measurements. The results suggest that electron drift mobility of the samples was nearly unchanged for a low nitrogen content. Two samples containing lowest nitrogen showed higher photoconductivity than that of unalloyed sample within a temperature range including the room temperature.