Semantische Informationsextraktion in medizinischen Informationssystemen

Zusammenfassung Dieser Artikel beschreibt einige Erfahrungen und typische Problemstellungen mit Textmining in der Medizin und gibt einen Einblick in aktuelle und zukünftige Herausforderungen in Forschung & Entwicklung. Interessant ist n?mlich, dass auch im ,,Multimedia-Zeitalter“ die meiste Information immer noch als ,,Text“ vorliegt. Mithilfe von statistischen und linguistischen Verfahren wird mit sogenannter ,,Textmining-Software“ versucht, aus Freitexten Information ,,heraus zu schürfen“ (deshalb ,,Textmining“). Allerdings ist es damit noch nicht genug. Der n?chste Schritt besteht darin, die Information sowohl nutzbar als auch brauchbar zu machen. Die jeweiligen End-Benutzerinnen und End-Benutzer müssen in die Lage versetzt werden, auf der Basis der gewonnenen Information deren Wissen zu erweitern. In unserem konkreten Fall sollen damit Entscheidungen im Rahmen ?rztlichen Handelns unterstützt werden. Probleml?sungen in diesem Bereich erfordern eine holistische Sicht- und Herangehensweise. Daher wird es immer wichtiger, Erkenntnisse aus Informatik und Psychologie zusammenflie?en zu lassen und auf systemischer Ebene technologisch umzusetzen.     

Numerical Homogenization Techniques Applied to Growth and Remodelling Phenomena

Materials with inherent microstructures like granular media, foams or spongy bones often show a complex constitutive behaviour on the macroscale while the microscopic constitutive equations may be formulated in a simple fashion. Applying homogenization procedures allows to transfer the information from the microlevel to the macrolevel. In the present contribution the porous structure of hard biological tissues, i.e. of spongy bones, is investigated. On the macroscale the approach is embedded into an extended continuum mechanical setting in order to capture size effects. The constitutive equations are formulated on the microscopic level taking into account growth and reorientation of the microstructural elements. By application of a strain-driven numerical homogenization procedure the macroscopic stress response is obtained.     

Zur personellen Verankerung der IT-Funktion im Vorstand börsennotierter Unternehmen: Ergebnisse einer inhaltsanalytischen Betrachtung

On the Rate of Board Members with IT Responsibilities in Firms Listed on the Stock Exchange: Results of a Content Analysis: This article reports on a content analysis that investigates the rate of board members with IT responsibilities in firms listed on the stock exchange in the German speaking countries. Furthermore, the study ascertains the correlation of six factors – which become evident through content analysis – with the rate of board members with IT responsibilities. A total of 679 annual reports of German, Austrian, and Swiss corporations have been analyzed. The results show that in Germany and Switzerland 26 percent of the firms investigated have a board member with IT responsibilities, in Austria the rate is 23 percent. Additionally, the results show that turnover and number of employees are highly positively correlated with the rate of board members with IT responsibilities. Furthermore, the data show a correlation between industry and the rate of board members with IT responsibilities.     

Network availability prediction with hidden context

Modern mobile devices are increasingly capable of simultaneously connecting to multiple access networks with different characteristics. Restricted coverage combined with user mobility will vary the availability of networks for a mobile device. Most proposed solutions for such an environment are reactive in nature, such as performing a vertical handover to the network that offers the highest bandwidth. But the cost of the handover may not be justified if that network is only available for a short time. Knowledge of future network availability and their capabilities are the basis for proactive schemes which will improve network selection and utilization. We have previously proposed a prediction model that can use any available context such as GSM Location Area, WLAN presence or even whether the power cable is plugged in, to predict network availability.As it may not be possible to sense all of the context variables that influence future network availability, in this paper we introduce a generic, new model incorporating a hidden variable to account for this. Specifically, we propose a Dynamic Bayesian Network based context prediction model to predict network availability. Predictions performed for WLAN availability with the real user data collected in our experiments show 20% or more improvement compared to both of our earlier proposals of order 1 and 2 semi-Markov models.     

Tumor Infiltration with CD20+CD73+ B Cells Correlates with Better Outcome in Colorectal Cancer

Immunotherapy has become increasingly important in the treatment of colorectal cancer (CRC). Currently, CD73, also known as ecto-5′-nucleotidase (NT5E), has gained considerable interest as a potential therapeutic target. CD73 is one of the key enzymes catalyzing the conversion of extracellular ATP into adenosine, which in turn exerts potent immune suppressive effects. However, the role of CD73 expression on various cell types within the CRC tumor microenvironment remains unresolved. The expression of CD73 on various cell types has been described recently, but the role of CD73 on B-cells in CRC remains unclear. Therefore, we analyzed CD73 on B-cells, especially on tumor-infiltrating B-cells, in paired tumor and adjacent normal tissue samples from 62 eligible CRC patients. The highest expression of CD73 on tumor-infiltrating B-cells was identified on class-switched memory B-cells, followed by naive B-cells, whereas no CD73 expression was observed on plasmablasts. Clinicopathological correlation analysis revealed that higher CD73⁺ B-cells infiltration in the CRC tumors was associated with better overall survival. Moreover, metastasized patients showed a significantly decreased number of tumor-infiltrating CD73⁺ B-cells. Finally, neoadjuvant therapy correlated with reduced CD73⁺ B-cell numbers and CD73 expression on B-cells in the CRC tumors. As promising new immune therapies are being developed, the role of CD73⁺ B-cells and their subsets in the development of colorectal cancer should be further explored to find new therapeutic options.     

On a driven nonlinear circuit and chaotic behaviour

Abstract

The chaotic behaviour of the sinusoidally driven nonlinear circuit proposed by Hunt is investigated. The results are compared with those from other driven nonlinear circuits.