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排序方式: 共有129条查询结果,搜索用时 15 毫秒
1.
Maren Stephen; DeCola Joseph P.; Fanselow Michael S. 《Canadian Metallurgical Quarterly》1994,108(3):645
Water-deprived and nondeprived rats were fear conditioned with a discrete tone CS and an aversive footshock unconditioned stimulus/stimuli (UCS). 24 and 48 hrs following conditioning, conditional fear to the tone CS and the context cues of the conditioning chamber, respectively, were assessed by measuring freezing behavior. Water deprivation had no effect on baseline responding to either tone or contextual stimuli. Following either 1 or 3 tone-shock pairings, however, water deprivation selectively enhanced conditional freezing to the contextual cues of the training chamber; conditional freezing to the tone was unaffected by water deprivation. These results are consistent with the view that water deprivation affects fear conditioning via an influence on the hippocampus. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
2.
An advanced real-time workspace monitoring for parallel kinematic machines including tasks like self-calibration and exception
handling demands integrated sensors measuring the angular position of the robot joints. This work introduces a single-axis
MEMS fluxgate magnetometer developed for the specified application. The sensor is composed of high aspect ratio helical coils
with generating and sensing functions around an electrodeposited nickel–iron core featuring ferromagnetic behavior. The core
is designed in racetrack geometry causing an excellent directional sensitivity of the sensor for measuring the magnetic orientation
of permanent magnets which rotate on the joint shaft. This approach allows the real-time detection of the required joint angle
and the simplified analytical solution of direct kinematics. 相似文献
3.
Rorick-Kehn and Steinmetz (2005) (see record 2005-13804-012) report that neurons in the central and basolateral nuclei of the amygdala exhibit learning-related spike firing to conditional stimuli associated with shock in 3 different aversive conditioning paradigms: eyeblink conditioning, fear conditioning, and signaled avoidance conditioning. Central nucleus neurons responded in all 3 tasks, whereas basolateral nucleus neurons were more activated by fear and avoidance conditioning. These results reveal that amygdala neurons are differentially engaged by aversive conditioning, but questions remain concerning the associative basis and functional role for these unit responses. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
4.
One Question,Multiple Answers: Biochemical and Biophysical Screening Methods Retrieve Deviating Fragment Hit Lists 下载免费PDF全文
Dr. Johannes Schiebel Nedyalka Radeva Dr. Helene Köster Dr. Alexander Metz Timo Krotzky Dr. Maren Kuhnert Prof. Wibke E. Diederich Prof. Andreas Heine Dr. Lars Neumann Dr. Cedric Atmanene Dominique Roecklin Dr. Valérie Vivat‐Hannah Dr. Jean‐Paul Renaud Dr. Robert Meinecke Dr. Nina Schlinck Dr. Astrid Sitte Franziska Popp Dr. Markus Zeeb Prof. Gerhard Klebe 《ChemMedChem》2015,10(9):1511-1521
Fragment‐based lead discovery is gaining momentum in drug development. Typically, a hierarchical cascade of several screening techniques is consulted to identify fragment hits which are then analyzed by crystallography. Because crystal structures with bound fragments are essential for the subsequent hit‐to‐lead‐to‐drug optimization, the screening process should distinguish reliably between binders and non‐binders. We therefore investigated whether different screening methods would reveal similar collections of putative binders. First we used a biochemical assay to identify fragments that bind to endothiapepsin, a surrogate for disease‐relevant aspartic proteases. In a comprehensive screening approach, we then evaluated our 361‐entry library by using a reporter‐displacement assay, saturation‐transfer difference NMR, native mass spectrometry, thermophoresis, and a thermal shift assay. While the combined results of these screening methods retrieve 10 of the 11 crystal structures originally predicted by the biochemical assay, the mutual overlap of individual hit lists is surprisingly low, highlighting that each technique operates on different biophysical principles and conditions. 相似文献
5.
In this review, which consists of two parts, major interactions between nitrous oxide (N2>O) and soil solution are described. In the first part, as an introduction, concentrations of dissolved N2>O in different aqueous systems are summarized. An inventory of data on maximal N2>O concentrations in soil solution (up to 9984 g N2>O-N l–1>) and in soil air (up to 8300 ppm) from literature is presented. The peak N2>O concentrations represent a N2>O supersaturation in the soil solution up to 30000 times with respect to ambient air and a soil air N2>O concentration about 25000 times higher than in the atmosphere. The main physico–chemical parameters (solubility, diffusion) controlling N2>O distribution between soil solution and soil air are outlined. The influences of cultivation practice, nitrogen turnover, water content and temperature on N2>O a ccumulation in soil solution and soil air are reviewed. In the second part some models of N2>O dynamics in soils are discussed with emphasis on N2>O transport processes. A simple qualitative scheme is developed to categorize the effects of the soil solution on N2>O dynamics in soils. In this scheme the temporary, intensive N2>O oversaturation of the soil solution is interpreted as a result of gas diffusion inhibition by water (barrier function of soil solution) resulting in an accumulation of N2>O. In addition, N2>O supersaturation is an indication that transitory much N2>O can be stored in the soil solution (storage function of soil solution). Where the soil solution flows up-, down- or sidewards it can act as a relevant transport medium for dissolved N2>O (transport function of soil solution). This scheme is applied to examples from the literature. 相似文献
6.
Daniel A. Barber Lee Stickells Daniel J. Ryan Maren Koehler Philip Goad 《Architectural Theory Review》2013,18(2):249-286
There is increasing interest among architectural historians in addressing environmental concerns on both historical and theoretical terms. Simultaneously, other fields have been looking to architectural scholarship to understand the historical relationship between the built and the natural environment. For architectural historians, and others, this has also involved correlating the shifting discourse on environment with a history of architectural transformations and disciplinary expansions. These engagements have made clear that the environmental history of architecture does not simply add more objects to the historical database, but also changes the terms of historical analysis, as new matters of concern and new conceptual frameworks come to the fore. This paper gathers together a dialogic set of projections from scholars responding to the question of how we might newly understand the historical relationship between the built and the natural environment, and the opportunities and challenges this new phase presents to scholars, design researchers, and architects. 相似文献
7.
Armin Hornung Kai M. Wurm Maren Bennewitz Cyrill Stachniss Wolfram Burgard 《Autonomous Robots》2013,34(3):189-206
Three-dimensional models provide a volumetric representation of space which is important for a variety of robotic applications including flying robots and robots that are equipped with manipulators. In this paper, we present an open-source framework to generate volumetric 3D environment models. Our mapping approach is based on octrees and uses probabilistic occupancy estimation. It explicitly represents not only occupied space, but also free and unknown areas. Furthermore, we propose an octree map compression method that keeps the 3D models compact. Our framework is available as an open-source C++ library and has already been successfully applied in several robotics projects. We present a series of experimental results carried out with real robots and on publicly available real-world datasets. The results demonstrate that our approach is able to update the representation efficiently and models the data consistently while keeping the memory requirement at a minimum. 相似文献
8.
Maren Schubert Christoph Dauberschmidt Christian Eltschig Dirk Nechvatal Markus Rapolder Tobias Schedl 《Beton- und Stahlbetonbau》2016,111(9):564-575
Research of production and maintenance costs for alternative concepts to ensure the durability of parking buildings There is currently an intense discussion about how to ensure the durability of parking buildings. Without having carried out a comprehensive cost analysis for the alternatives for durability concepts costs are nevertheless used as an argument for or against a certain execution. In this publication the costs of various execution concepts are compared on the basis of a virtual two‐storey underground garage with standard dimensions for the two major components of ”suspended ceiling“ and ”baseplate“. For instance the cost analysis includes the production costs for the minimum reinforcement in dependence of the examined surface protection or of the waterproofing system respectively. Furthermore the costs for maintenance, inspection and repair among other aspects are compared in dependence of the surface protecting system for a service life of 50 years. This cost approach takes into account consists of market fluctuations as well as scheduled maintenance cycles by considering medium, minimum and maximum costs. For the suspended ceiling the following coating or waterproofing systems respectively are examined: surface protection system ”OS 11“; ”mastic asphalt (single/double layer) with asphalt sheeting ”; ”mastic asphalt (single/double layer) with surface protection systems OS 10“ and ”PMMA“ protecting surface system. For the base plate two load cases are investigated: ”water exchange zone“ (WW) and ”water pressure“ (WD) in combination with the following surface protection systems: ”OS 11“, ”mastic asphalt (single/double layer) with asphalt sheeting“ and ”OS 8 with accompanying crack treatment“. For the ongoing maintenance costs, engineering values are chosen in accordance to the current state of knowledge. It is expected that current research projects are going to provide scientific results in the near future allowing an update of this cost analysis. 相似文献
9.
Žarko Barjaktarović Maren Babbick Alfred Nordheim Tobias Lamkemeyer Elisabeth Magel Rüdiger Hampp 《Microgravity science and technology》2009,21(1-2):191-196
Callus cell cultures of Arabidopsis thaliana exposed to hypergravity (8×g), 2D clinorotation and random positioning exhibit changes in gene expression (Martzivanou et al., Protoplasma 229:155–162, 2006). In a recent investigation we could show that after 2 h of exposure also the protein complement shows treatment-related changes which are indicative for reactive oxygen species being involved in the perception of/response to changes in the gravitational field. In the present study we have extended these investigations for a period of up to 16 h of exposure. We report on changes in abundance of 28 proteins which have been identified by nano HPLC-ESI-MS/MS, and which were altered in amount after 2 h of treatment. According to changes between 2 and 16 h we could distinguish four groups of proteins which either declined, increased from down-regulated to control levels, showed a transient decline or a transient increase. With regard to function, our data indicate stress relief or adaptation to a new gravitational steady state under prolonged exposure. The latter assumption is supported by the appearance of a new set of 19 proteins which is changed in abundance after 8 h of hypergravity. A comparative analysis of the different treatments showed some similarities in response between 8×g centrifugation and 2D clinorotation, while random positioning showed the least responses. 相似文献
10.
The neural correlates of infant and adult goal prediction: Evidence for semantic processing systems.
Reid Vincent M.; Hoehl Stefanie; Grigutsch Maren; Groendahl Anna; Parise Eugenio; Striano Tricia 《Canadian Metallurgical Quarterly》2009,45(3):620
The sequential nature of action ensures that an individual can anticipate the conclusion of an observed action via the use of semantic rules. The semantic processing of language and action has been linked to the N400 component of the event-related potential (ERP). The authors developed an ERP paradigm in which infants and adults observed simple sequences of actions. In one condition the conclusion of the sequence was anticipated, whereas in the other condition the conclusion was not anticipated. Adults and infants at 9 months and 7 months were assessed via the same neural mechanisms—the N400 component and analysis of the theta frequency. Results indicated that adults and infants at 9 months produced N400-like responses when anticipating action conclusions. The infants at 7 months displayed no N400 component. Analysis of the theta frequency provided support for the relation between the N400 and semantic processing. This study suggests that infants at 9 months anticipate goals and use similar cognitive mechanisms to adults in this task. In addition, this result suggests that language processing may derive from understanding action in early development. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献