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排序方式: 共有321条查询结果,搜索用时 15 毫秒
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Malgorzata Kloc Ahmed Uosef Jacek Z. Kubiak Rafik Mark Ghobrial 《International journal of molecular sciences》2021,22(1)
The development, progression, or stabilization of the atherosclerotic plaque depends on the pro-inflammatory and anti-inflammatory macrophages. The influx of the macrophages and the regulation of macrophage phenotype, inflammatory or anti-inflammatory, are controlled by the small GTPase RhoA and its downstream effectors. Therefore, macrophages and the components of the RhoA pathway are attractive targets for anti-atherosclerotic therapies, which would inhibit macrophage influx and inflammatory phenotype, maintain an anti-inflammatory environment, and promote tissue remodeling and repair. Here, we discuss the recent findings on the role of macrophages and RhoA pathway in the atherosclerotic plaque formation and resolution and the novel therapeutic approaches. 相似文献
3.
Marta Nowacka-Chmielewska Konstancja Grabowska Mateusz Grabowski Patrick Meybohm Malgorzata Burek Andrzej Maecki 《International journal of molecular sciences》2022,23(21)
Chronic stress, even stress of a moderate intensity related to daily life, is widely acknowledged to be a predisposing or precipitating factor in neuropsychiatric diseases. There is a clear relationship between disturbances induced by stressful stimuli, especially long-lasting stimuli, and cognitive deficits in rodent models of affective disorders. Regular physical activity has a positive effect on the central nervous system (CNS) functions, contributes to an improvement in mood and of cognitive abilities (including memory and learning), and is correlated with an increase in the expression of the neurotrophic factors and markers of synaptic plasticity as well as a reduction in the inflammatory factors. Studies published so far show that the energy challenge caused by physical exercise can affect the CNS by improving cellular bioenergetics, stimulating the processes responsible for the removal of damaged organelles and molecules, and attenuating inflammation processes. Regular physical activity brings another important benefit: increased stress robustness. The evidence from animal studies is that a sedentary lifestyle is associated with stress vulnerability, whereas a physically active lifestyle is associated with stress resilience. Here, we have performed a comprehensive PubMed Search Strategy for accomplishing an exhaustive literature review. In this review, we discuss the findings from experimental studies on the molecular and neurobiological mechanisms underlying the impact of exercise on brain resilience. A thorough understanding of the mechanisms underlying the neuroprotective potential of preconditioning exercise and of the role of exercise in stress resilience, among other things, may open further options for prevention and therapy in the treatment of CNS diseases. 相似文献
4.
Malgorzata Kardynska Jaroslaw Smieja Pawel Paszek Krzysztof Puszynski 《International journal of molecular sciences》2022,23(12)
Mathematical modeling of signaling pathways and regulatory networks has been supporting experimental research for some time now. Sensitivity analysis, aimed at finding model parameters whose changes yield significantly altered cellular responses, is an important part of modeling work. However, sensitivity methods are often directly transplanted from analysis of technical systems, and thus, they may not serve the purposes of analysis of biological systems. This paper presents a novel sensitivity analysis method that is particularly suited to the task of searching for potential molecular drug targets in signaling pathways. Using two sample models of pathways, p53/Mdm2 regulatory module and IFN--induced JAK/STAT signaling pathway, we show that the method leads to biologically relevant conclusions, identifying processes suitable for targeted pharmacological inhibition, represented by the reduction of kinetic parameter values. That, in turn, facilitates subsequent search for active drug components. 相似文献
5.
Malgorzata Plaza 《Information Systems Frontiers》2008,10(3):347-359
Although the Earned Value Method (EVM), a multi-dimensional project control system, has been widely used since 1960, there
has been little research focused specifically on its application in IS implementation. The management of IS projects—including
the accurate forecasting of project duration—is complicated by the strong impact of the learning curve on the effectiveness
of EVM. This study makes new contributions by advancing formulas for the accurate prediction of project duration, and by developing
a decision support model in which the learning curve is fully integrated with EVM, and performance changes due to learning
are isolated from other factors affecting project duration. The study makes three contributions to the understanding and use
of EVM in IS implementation: (1) It provides an extended version of EVM, (2) it provides an illustration of the application
of EVM to a real project situation based on empirical data from an ERP implementation project, and (3) it provides a theoretical
basis for empirical studies of IS project control techniques. The decision support model can be used to determine both the
learning curve coefficient and the project completion date during the early stages of a project, and it thus offers a significant
practical contribution to the management of IS projects.
Dr. Margaret Plaza is an Associate Professor of Information Technology Management at Ryerson University and a Senior Research Scientist in IITM. She holds an M.Sc. in Mechanical Engineering and a Ph.D. in Production Engineering from Politechnika Krakowska (Cracow University of Technology) where she specialized in flexible manufacturing systems. Dr. Plaza is also a PEng. (Ontario), PMP, and CIA and has over 20 years’ industry experience working with consulting and manufacturing firms in both private and public sectors. She managed or provided consulting for ERP and supply chain implementations. Her current research focuses on organizational learning, technology management and the supply chain. She has developed decision models and decision support technologies to assist managers with problems in new technology implementations. 相似文献
Malgorzata PlazaEmail: |
Dr. Margaret Plaza is an Associate Professor of Information Technology Management at Ryerson University and a Senior Research Scientist in IITM. She holds an M.Sc. in Mechanical Engineering and a Ph.D. in Production Engineering from Politechnika Krakowska (Cracow University of Technology) where she specialized in flexible manufacturing systems. Dr. Plaza is also a PEng. (Ontario), PMP, and CIA and has over 20 years’ industry experience working with consulting and manufacturing firms in both private and public sectors. She managed or provided consulting for ERP and supply chain implementations. Her current research focuses on organizational learning, technology management and the supply chain. She has developed decision models and decision support technologies to assist managers with problems in new technology implementations. 相似文献
6.
An alternative RP‐HPLC method for the separation and determination of tocopherol and tocotrienol homologues as butter authenticity markers: A comparative study between two European countries 下载免费PDF全文
7.
Viscosity is one of the most important attributes of rye-based products related to some health benefits. To identify the factors affecting arabinoxylan-dependent extract viscosity (AX-EV) of rye bread, the structural features of water-extractable arabinoxylans (WE-AXs) and their ammonium sulphate precipitated subfractions were investigated in breads with varied viscosities. Also, an endoxylanase activity in the starting flours was examined. The HPSEC-RI profiles revealed the higher extent of AX depolymerisation in whole-meal bread (WMB) when compared to that in endosperm bread (EB), resulting in its lower AX-EV. This was mostly related to lower molecular weight of the parent WE-AX fraction with distinctly lower proportion of 2-Xylp in the chain. The AX-EV of rye bread decreased with decreasing proportion of AX-I, the major subfraction with 3-Xylp as only branching site. The endoxylanase activity was at least two times lower in endosperm flour than that in WM and negatively correlated with the AX-EV of WMB. The importance of densely substituted AX subfractions with exclusively 2-Xylp and 2,3-Xylp branches, protecting the AX-I from enzymic degradation during bread-making, has been evidenced. 相似文献
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Malgorzata Młynarczyk Malgorzata Sznitowska Dorota Watrobska-Swietlikowska 《Drug development and industrial pharmacy》2013,39(4):355-362
Antimicrobial efficacy of methyl and propylparaben combination as potential preservatives for submicron emulsions, and the effect of oil and lecithin concentration on the microbial growth were investigated. Parabens were ineffective in standard or doubled concentrations as per pharmacopoeial criteria. Poor growth inhibition and multiplication of reference strains point to protective and growth properties of submicron emulsions. No correlation was observed between oil/lecithin ratio and efficacy of parabens; partitioning of the latter into the oily phase and lipophilic domains could be the reason for such effect. Further studies are necessary to establish a stable and safe composition of such formulations. 相似文献
10.
Renata Rybakiewicz David Djurado Hubert Cybulski Ewelina Dobrzynska Irena Kulszewicz-Bajer Damien Boudinet Jean-Marie Verilhac Malgorzata Zagorska Adam Pron 《Synthetic Metals》2011,161(15-16):1600-1610
New solution processable organic semiconductors, consisting of pyrromelitic, naphthalene or perylene bisimide core and triarylamine N-substituents, have been synthesized. All three compounds are electrochemically active and undergo quasi-reversible oxidation and reduction as evidenced by cyclic voltammetry investigations. The oxidation process involves the transformation of the triarylamine substituents into radical cations as proven spectroscopically and spectroelectrochemically. The reduction process occurs at the arylene bisimide core leading to the formation of a radical anion and eventually a dianion in the second step. These findings are in perfect agreement with the DFT calculations which show that in the synthesized molecules the HOMO orbital is located on the triarylamine moiety whereas the LUMO one on the bisimide core. In all molecules studied the electrochemically determined ionization potential (IP) is slightly higher than 5.0 eV whereas in naphthalene and perylene derivatives the electron affinity (EA) is close to ?3.9 eV. These values fulfill the requirements for n-type (electron) semiconductors in air operating n-channel field effect transistors (FETs) as well as for p-type (hole) conductors in p-channel FETs. To verify whether the newly synthesized compounds exhibit the expected electrical transport properties all organic (CYTOP dielectric) test transistors were fabricated. All three semiconductors showed no field effect in the n-channel configuration. To the contrary, they could be used in p-channel FETs showing, in the saturation regime, the hole mobility approaching 10?4 cm2 V?1 s?1 – the value which slightly exceeds that measured for low molecular weight, amorphous triarylamine semiconductors. 相似文献