Results of Finnish national survey on EU legislation concerning computer work

The European Directive on computer work (VDU 90/270/EEC) is implemented in the Finnish Government Decree. The aim of the present study was to evaluate the effects of the legislation and its applications in practice. The quantitative method used an online questionnaire. The respondents were employers (N = 934), employees (N = 1872) and occupational health care (OHC) units (N = 289). The majority of all these three groups considered the provisions clear and easy to understand, comprehensive, and easy to comply with. The provisions had a great impact on preventing mental overloading, arranging sight tests at the employer's cost, and on the refunding of eyeglasses for computer work. Most employers felt they did not need any more specific provisions, whereas half of the employees and OHC professionals would have liked the provisions to be more detailed. More explicit and specific regulations were also needed for practice applications in particular, as well as for the refunding of the costs of special eyeglasses for computer work. A total of 59% of the employers reported that costs of glasses are refunded, whereas the figure for employees was clearly lower (37%). OHC professionals reported that the costs of glasses were refunded in 82% of their customer workplaces. The practical conclusion is that employees' sight examinations and compensation for eyeglasses should be promoted in computer work. Moreover, ergonomic applications are best carried out in co-operation with OHC personnel.     

Correcting for the influence of frozen lakes in satellite microwave radiometer observations through application of a microwave emission model

The spatial resolution of passive microwave observations from space is of the order of tens of kilometers with currently available instruments, such as the Special Sensor Microwave/Imager (SSM/I) and Advanced Microwave Scanning Radiometer (AMSR-E). The large field of view of these instruments dictates that the observed brightness temperature can originate from heterogeneous land cover, with different vegetation and surface properties.In this study, we assess the influence of freshwater lakes on the observed brightness temperature of AMSR-E in winter conditions. The study focuses on the geographic region of Finland, where lakes account for 10% of the total terrestrial area. We present a method to mitigate for the influence of lakes through forward modeling of snow covered lakes, as a part of a microwave emission simulation scheme of space-borne observations. We apply a forward model to predict brightness temperatures of snow covered sceneries over several winter seasons, using available data on snow cover, vegetation and lake ice cover to set the forward model input parameters. Comparison of model estimates with space-borne observations shows that the modeling accuracy improves in the majority of examined cases when lakes are accounted for, with respect to the case where lakes are not included in the simulation. Moreover, we present a method for applying the correction to the retrieval of Snow Water Equivalent (SWE) in lake-rich areas, using a numerical inversion method of the forward model. In a comparison to available independent validation data on SWE, also the retrieval accuracy is seen to improve when applying the influence of snow covered lakes in the emission model.     

Volatile monocarbonyl compounds of carrot roots at various stages of maturity

Summary Volatile carbonyl compounds of carrot varietyFeonia Hunderup S-64 at various stages of maturity were analysed as their 2,4-DNPH's by a combined TLC-GLC-MS method. Twenty-three different carbonyl compounds were identified, of which undecanal, buten-2-al, methylbutenal, pentan-2-one, 6-methyl-5-hepten-2-one and 5-methylfurfural have not previously been found in carrot. During maturation the content of acetaldehyde and acetone increased significantly, while that of methylbutenal decreased.

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Die leichtflüchtigen Monocarbonylverbindungen der Karotten in verschiedenen Stufen der Reife

Zusammenfassung Die leichtflüchtigen Carbonylverbindungen der Karotten Varietät Feonia Hunderup S-64 wurden in verschiedenen Stufen der Reife als 2,4-DNPH mit der kombinierten DC-GC-MS-Methode analysiert. Dreiundzwanzig verschiedene Carbonylverbindungen wurden nachgewiesen. Von diesen sind Undecanal, 2-Butenal, Methylbutenal, 2-Pentanon, 6-Methyl-5-hepten-2-on und 5-Methylfurfural noch nicht in Karotten aufgefunden worden. Während des Reifens nahm der Gehalt an Acetaldehyd und Aceton bedeutend zu. Der Gehalt an Methylbutenal verminderte sich.

     

Feasibility of multi-temporal interferometric SAR data for stand-level estimation of boreal forest stem volume

The feasibility of interferometric SAR (INSAR) coherence observations for stem volume (biomass) retrieval is investigated by applying coherence data determined from 14 ERS-1 and ERS-2 C-band SAR image pairs. The image set covers a single forested test area in Finland, and both summer (snow-free) and winter conditions are represented. The data set enabled (a) the study of stem volume retrieval performance under varying conditions, (b) the analysis of the seasonal behavior of interferometric coherence, and (c) the determination of the accuracy characteristics of empirical (nonlinear) coherence modeling. Additionally, a new technique to estimate forest stem volume from INSAR data was developed based on constrained iterative inversion of the applied empirical model. The results indicate that the usability of winter images with snow-covered terrain is superior to that of images obtained under summer conditions. The applied empirical model appears to be adequate for describing the stand-wise coherence of boreal forest. Hence, a practical stem volume estimation method can be established based on it. The highest correlation coefficient between the estimated stem volume and the ground truth stem volume showed values as high as r=0.9 and a relative RMSE level of 48% was obtained, respectively.     

Effects of Ospemifene on Drug Metabolism Mediated by Cytochrome P450 Enzymes in Humans in Vitro and in Vivo

The objective of these investigations was to determine the possible effects of the novel selective estrogen receptor modulator, ospemifene, on cytochrome P450 (CYP)-mediated drug metabolism. Ospemifene underwent testing for possible effects on CYP enzyme activity in human liver microsomes and in isolated human hepatocytes. Based on the results obtained in vitro, three Phase 1 crossover pharmacokinetic studies were conducted in healthy postmenopausal women to assess the in vivo effects of ospemifene on CYP-mediated drug metabolism. Ospemifene and its main metabolites 4-hydroxyospemifene and 4′-hydroxyospemifene weakly inhibited a number of CYPs (CYP2B6, CYP2C9, CYP2C19, CYP2C8, and CYP2D6) in vitro. However, only CYP2C9 activity was inhibited by 4-hydroxyospemifene at clinically relevant concentrations. Induction of CYPs by ospemifene in cultured human hepatocytes was 2.4-fold or less. The in vivo studies showed that ospemifene did not have significant effects on the areas under the plasma concentration-time curves of the tested CYP substrates warfarin (CYP2C9), bupropion (CYP2B6) and omeprazole (CYP2C19), demonstrating that pretreatment with ospemifene did not alter their metabolism. Therefore, the risk that ospemifene will affect the pharmacokinetics of drugs that are substrates for CYP enzymes is low.     

在靠近流浆箱处淀粉和填料同时混合工艺

采用闪急混合工艺使得在最接近流浆箱处向浆料中加入助留剂和施胶化学品等造纸添加剂,并使之迅速和有效地混合。这项多功能混合技术可以做到在同一地点同时将填料、助留剂一起加入到流浆箱中。该工艺操作简单,具有非常短的响应时间,填料留着率更高,纸张性能更优越。由于减少了添加剂在过程中的循环,响应时间非常快速,减少了传统混合过程的水或滤液的量,从而降低了能源消耗,降低了添加剂用量并使工艺过程净化。     

Water hydraulic manipulator for fail safe and fault tolerant remote handling operations at ITER

Department of Intelligent Hydraulics and Automation (IHA) of Tampere University of Technology has been involved in the European Fusion program since 1994 within the ITER reactor maintenance activities. In this paper we discuss the design and development of a six degrees of freedom water hydraulic manipulator with a force feedback for teleoperation tasks. The manipulator is planned to be delivered to Divertor Test Platform 2 (DTP2) during year 2008. The paper also discusses the possibility to improve the fail safe and redundant operation of the manipulator. During the design of the water hydraulic manipulator, special provisions have been made in order to meet the safety requirements such as servo valve block for redundant operation and safety vane brakes for fail safe operation.     

A framework for generating tunable test functions for multimodal optimization

Multimodal function optimization, where the aim is to locate more than one solution, has attracted growing interest especially in the evolutionary computing research community. To evaluate experimentally the strengths and weaknesses of multimodal optimization algorithms, it is important to use test functions representing different characteristics and various levels of difficulty. The available selection of multimodal test problems is, however, rather limited and no general framework exists. This paper describes an attempt to construct a software framework which includes a variety of easily tunable test functions. The aim is to provide a general and easily expandable environment for testing different methods of multimodal optimization. Several function families with different characteristics are included. The framework implements new parameterizable function families for generating desired landscapes. Additionally the framework implements a selection of well known test functions from the literature, which can be rotated and stretched. The software module can easily be imported to any optimization algorithm implementation compatible with the C programming language. As an application example, 8 optimization approaches are compared by their ability to locate several global optima over a set of 16 functions with different properties generated by the proposed module. The effects of function regularity, dimensionality and number of local optima on the performance of different algorithms are studied.     

Development of LC/MS/MS methods for cocktail dosed Caco-2 samples using atmospheric pressure photoionization and electrospray ionization

Good reliability of Caco-2 permeability studies requires competent sampling and analytical methods to ensure the comparability of day-to-day experiments. In this work, two n-in-one LC/MS/MS methods based on two different ionization techniques were developed and validated for a group of reference compounds; eight of them are recommended by the Food and Drug Administration (FDA) for the evaluation of oral drug permeability. The performance of a new ionization technique, atmospheric pressure photoionization (APPI), as an interface for quantitative LC/MS analysis was evaluated in comparison to the electrospray ionization (ESI). Generally, the validation parameters, including sensitivity, accuracy, and repeatability, were comparable for the APPI and ESI methods. The main difference was that the linear quantitative range of APPI was 3-4 orders of magnitude (r(2) >/= 0.998) whereas in ESI it was typically 2-3 orders of magnitude (r(2) >/= 0.990). By the APPI and ESI methods, the simultaneous analysis of nine highly heterogeneous compounds was achieved within 5.5-7 min, which leads to significant savings in time and cost of the analyses. The successful validation data indicate the usefulness of both the methods for the rapid and sensitive (LOD values typically 相似文献   

AUTOMATED OBJECT LOCATOR IN A FOREST FORWARDER

A double approach method for versatile detection of similar objects from the real environment is introduced. By searching both the shape and textural data from the video image, it is possible to solve a generalized location problem without a loss in overall reliability in near–real time. A forest forwarder is used as a proof-of-concept application for the technique.