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排序方式: 共有516条查询结果,搜索用时 15 毫秒
1.
Delphine Patriarche Emmanuel Ledoux Rgine Simon-Coinon Jean-Luc Michelot Justo Cabrera 《Applied Clay Science》2004,26(1-4):109
Argillites are one of the geological formations studied by IRSN for their confining properties for isolation of radioactive wastes. One of the main objectives is the study of water transport through rocks with very low water content and very low hydraulic conductivity by modeling of natural tracer profiles. This paper presents the protocol developed for and applied to the acquisition of data for chloride content in interstitial water of the Toarcian argillites at the Tournemire site (Southern France). This protocol is based on laboratory diffusion experiments and on modeling. Experimental data obtained during the transient and steady-state parts of diffusion experiments enable, respectively, the assessment of the diffusion coefficient and the determination of Cl concentration in pore water. Using this protocol, profiles with depth for both of these data sets have been acquired along the geological sequence. Taking into account the present knowledge of the geological and hydrogeological history of the Tournemire massif, a conceptual model granting the main role for mass transport to diffusion has been proposed. According to this conceptual model, a one-dimensional numerical model was built for simulating the mass transport of chloride through the sedimentary column, over 53 Ma. The good agreement between experimental data and calculated values for both diffusion coefficients and concentrations of chloride confirms that diffusion is likely the main process for mass transport in the massif. This model was also tested with the deuterium content of interstitial water, applying variable concentrations at the aquifer system boundaries for reflecting the thermal dependency of isotopic composition in precipitation. These simulations also reveal the likely important role of heterogeneities, such as fractures, in the variability of tracer concentrations with regards to a simple diffusion profile. 相似文献
2.
Dongsoo Kang Chen Liu Jean-Luc Gaudiot 《International journal of parallel programming》2008,36(4):361-385
By executing two or more threads concurrently, Simultaneous MultiThreading (SMT) architectures are able to exploit both Instruction-Level
Parallelism (ILP) and Thread-Level Parallelism (TLP) from the increased number of in-flight instructions that are fetched
from multiple threads. However, due to incorrect control speculations, a significant number of these in-flight instructions
are discarded from the pipelines of SMT processors (which is a direct consequence of these pipelines getting wider and deeper).
Although increasing the accuracy of branch predictors may reduce the number of instructions so discarded from the pipelines,
the prediction accuracy cannot be easily scaled up since aggressive branch prediction schemes strongly depend on the particular
predictability inherently to the application programs. In this paper, we present an efficient thread scheduling mechanism
for SMT processors, called SAFE-T (Speculation-Aware Front-End Throttling): it is easy to implement and allows an SMT processor
to selectively perform speculative execution of threads according to the confidence level on branch predictions, hence preventing
wrong-path instructions from being fetched. SAFE-T provides an average reduction of 57.9% in the number of discarded instructions
and improves the instructions per cycle (IPC) performance by 14.7% on average over the ICOUNT policy across the multi-programmed
workloads we simulate.
This paper is an extended version of the paper, “Speculation Control for Simultaneous Multithreading,” which appeared in the
Proceedings of the 18th International Parallel and Distributed Processing Symposium, Santa Fe, New Mexico, April 2004. 相似文献
3.
Huafeng Yu Abdoulaye Gamatié Éric Rutten Jean-Luc Dekeyser 《Innovations in Systems and Software Engineering》2008,4(3):215-222
In this paper, we use the UML MARTE profile to model high-performance embedded systems (HPES) in the GASPARD2 framework. We address the design correctness issue on the UML model by using the formal validation tools associated with
synchronous languages, i.e., the SIGALI model checker, etc. This modeling and validation approach benefits from the advantages of UML as a standard, and from the
number of validation tools built around synchronous languages. In our context, model transformations act as a bridge between
UML and the chosen validation technologies. They are implemented according to a model-driven engineering approach. The modeling
and validation are illustrated using the multimedia functionality of a new-generation cellular phone. 相似文献
4.
5.
6.
Elodie Mareux Martine Lapalus Amel Ben Saad Renaud Zelli Mounia Lakli Yosra Riahi Marion Almes Manon Banet Isabelle Callebaut Jean-Luc Decout Thomas Falguires Emmanuel Jacquemin Emmanuel Gonzales 《International journal of molecular sciences》2022,23(18)
ABCB11 is responsible for biliary bile acid secretion at the canalicular membrane of hepatocytes. Variations in the ABCB11 gene cause a spectrum of rare liver diseases. The most severe form is progressive familial intrahepatic cholestasis type 2 (PFIC2). Current medical treatments have limited efficacy. Here, we report the in vitro study of Abcb11 missense variants identified in PFIC2 patients and their functional rescue using cystic fibrosis transmembrane conductance regulator potentiators. Three ABCB11 disease-causing variations identified in PFIC2 patients (i.e., A257V, T463I and G562D) were reproduced in a plasmid encoding an Abcb11-green fluorescent protein. After transfection, the expression and localization of the variants were studied in HepG2 cells. Taurocholate transport activity and the effect of potentiators were studied in Madin–Darby canine kidney (MDCK) clones coexpressing Abcb11 and the sodium taurocholate cotransporting polypeptide (Ntcp/Slc10A1). As predicted using three-dimensional structure analysis, the three variants were expressed at the canalicular membrane but showed a defective function. Ivacaftor, GLP1837, SBC040 and SBC219 potentiators increased the bile acid transport of A257V and T463I and to a lesser extent, of G562D Abcb11 missense variants. In addition, a synergic effect was observed when ivacaftor was combined with SBC040 or SBC219. Such potentiators could represent new pharmacological approaches for improving the condition of patients with ABCB11 deficiency due to missense variations affecting the function of the transporter. 相似文献
7.
Distributed Coordination and Workflow on the World Wide Web 总被引:5,自引:0,他引:5
Antonietta Grasso Jean-Luc Meunier Daniele Pagani Remo Pareschi 《Computer Supported Cooperative Work (CSCW)》1997,6(2-3):175-200
This paper describes WebFlow, an environment thatsupports distributed coordination services on theWorld Wide Web. WebFlow leverages the HTTP Webtransport protocol and consists of a number of toolsfor the development of applications that require thecoordination of multiple, distributed servers.Typical applications of WebFlow include distributeddocument workspaces, inter/intra-enterprise workflow,and electronic commerce. In this paper we describe thegeneral WebFlow architecture for distributedcoordination, and then focus on the environment fordistributed workflow. 相似文献
8.
In this paper we design an interval observer for the estimation of unmeasured variables of uncertain bioreactors. The observer is based on a bounded error observer, as proposed in [Lemesle, V., & Gouzé, J.-L. (2005). Hybrid bounded error observers for uncertain bioreactor models. Bioprocess and Biosystems Engineering, 27, 311-318], that makes use of a loose approximation of the bacterial kinetics. We first show how to generate guaranteed upper and lower bounds on the state, provided that known intervals for the initial condition and the uncertainties are available. These so-called framers depend on a tuning gain. They can be run in parallel and the envelope provides the best estimate. An optimality criterion is introduced leading to the definition of an optimal observer. We show that this criterion provides directly a gain set containing the best framers. The method is applied to the estimation of the total biomass of an industrial wastewater treatment plant, demonstrating its efficiency. 相似文献
9.
Hsiao-Hsi Wang Kuan-Ching Li Ssu-Hsuan Lu Chun-Chieh Yang Jean-Luc Gaudiot 《International journal of parallel programming》2008,36(6):521-542
In recent years, cluster computing has been widely investigated and there is no doubt that it can provide a cost-effective
computing infrastructure by aggregating computational power, communication, and storage resources. Moreover, it is also considered
to be a very attractive platform for low-cost supercomputing. Distributed shared memory (DSM) systems utilize the physical
memory of each computing node interconnected in a private network to form a global virtual shared memory. Since this global
shared memory is distributed among the computing nodes, accessing the data located in remote computing nodes is an absolute
necessity. However, this action will result in significant remote memory access latencies which are major sources of overhead
in DSM systems. For these reasons, in order to increase overall system performance and decrease this overhead, a number of
strategies have been devised. Prefetching is one such approach which can reduce latencies, although it always increases the
workload in the home nodes. In this paper, we propose a scheme named Agent Home Scheme. Its most noticeable feature, when compared to other schemes, is that the agent home distributes the workloads of each computing
nodes when sending data. By doing this, we can reduce not only the workload of the home nodes by balancing the workload for
each node, but also the waiting time. Experimental results show that the proposed method can obtain about 20% higher performance
than the original JIAJIA, about 18% more than History Prefetching Strategy (HPS), and about 10% higher than Effective Prefetch
Strategy (EPS). 相似文献
10.
Stigliani JL Arnaud P Delaine T Bernardes-Génisson V Meunier B Bernadou J 《Journal of molecular graphics & modelling》2008,27(4):536-545
The front-line antituberculosis drug isoniazid (INH) inhibits InhA, the NADH-dependent fatty acid biosynthesis enoyl ACP-reductase from Mycobacterium tuberculosis, via formation of covalent adducts with NAD (INH-NAD adducts). While ring tautomers were found the main species formed in solution, only the 4S chain INH-NAD tautomer was evidenced in the crystallized InhA:INH-NAD complex. In this study we attempted to explore the modes of interaction and energy binding of the different isomers placed in the active site of InhA with the help of various molecular modelling techniques. Ligand and enzyme models were generated with the help of the Vega ZZ program package. Resulting ligands were then docked into the InhA active site individually using computational automated docking package AUTODOCK 3.0.5. The more relevant docked conformations were then used to compute the interaction energy between the ligands and the InhA cavity. The AM1 Hamiltonian and the QM/MM ONIOM methodologies were used and the results compared. The various tautomers were found docked in almost the same place where INH-NAD was present as predicted by earlier X-ray crystallographic studies. However, some changes of ligand conformation and of the interactions ligand-protein were evidenced. The lower binding energy was observed for the 4S chain adduct that probably represents the effective active form of the INH-NAD adducts, as compared to the 4R epimer. The two 4S,7R and 4R,7S ring tautomers show intermediate and similar binding energies contrasting with their different experimental inhibitory potency on InhA. As a possible explanation based on calculated conformations, we formulated the hypothesis of an initial binding of the two ring tautomers to InhA followed by opening of only the ring hemiamidal 4S,7R tautomer (possibly catalyzed by Tyr158 phenolate basic group) to give the 4S chain INH-NAD tight-binding inhibitor. The predictions of ligand-protein interactions at the molecular level can be of primary importance in elucidating the mechanisms of action of isoniazid and InhA-related resistances, in identifying the effective mycobactericidal entities and, in further step, in the design of a new generation of antitubercular drugs. 相似文献