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1.
Melt crystallization of isotactic polypropylene (iPP), containing crystallites of N,N′-dicyclohexyl-2,6-naphthalenedicarboxamide (DCNDCA) as a nucleating agent of the the β-phase iPP crystal, is carried out under a magnetic field (6 T) to obtain the alignment of the iPP crystal induced by magnetic alignment of DCNDCA. In a previous paper, DCNDCA was reported to undergo magnetic alignment in a liquid suspension. The obtained iPP sample exhibits alignment of the β-phase crystal with the c-axis aligned perpendicular to the magnetic field. The comparison of this alignment of iPP with the reported magnetic alignment of DCNDCA indicates that the β-phase crystal grows epitaxially on the DCNDCA crystal. The (330)β plane of the iPP crystal lies on the bc-plane of the DCNDCA crystal in which the direction of the c-axis of the iPP coincides with the direction of the b-axis of the DCNDCA crystal. 相似文献
2.
3.
Hiroko Ishii Maram H. Zahra Atushi Takayanagi Masaharu Seno 《International journal of molecular sciences》2021,22(4)
Cripto-1 is a member of the EGF-CFC/FRL1/Cryptic family and is involved in embryonic development and carcinogenesis. We designed a novel anti-Cripto-1 artificial antibody and assessed the recognition to the antigen and the potential to suppress the growth of cancer stem cells. First, single chain antibody clones were isolated by bio-panning with the affinity to recombinant Cripto-1 protein from our original phage-display library. Then, the variable regions of heavy chain VH and light chain VL in each clone were fused to constant regions of heavy chain CH and light chain CL regions respectively. These fused genes were expressed in ExpiCHO-S cells to produce artificial humanized antibodies against Cripto-1. After evaluation of the expression levels, one clone was selected and the anti-Cripto-1 antibody was produced and purified. The purified antibody showed affinity to recombinant Cripto-1 at 1.1 pmol and immunoreactivity to cancer tissues and cell lines. The antibody was available to detect the immunoreactivity in tissue microarrays of malignant tumors as well as in Cripto-1 overexpressing cells. Simultaneously, the antibody exhibited the potential to suppress the growth of human colon cancer derived GEO cells overexpressing Cripto-1 with IC50 at approximately 110 nM. The artificially humanized antibody is proposed to be a good candidate to target cancer cells overexpressing Cripto-1. 相似文献
4.
The state of water in water-swollen poly(vinyl alcohol-co-itaconic acid) membranes, having various water contents from 0.31 to 0.83, was investigated by d.s.c. measurements and compared with those in water-swollen poly(vinyl alcohol) membranes. The amount of freezing water in the membranes was estimated by use of a relationship between the phase transition temperature and the enthalpy of the crystallization of supercooled water. The melting temperature of the water in the membranes immersed in urea and NaCl 0–2 mol l?1 aqueous solutions was also determined by d.s.c. analysis. The present study proposes a method for estimating the solubilities of urea and NaCl in both of the freezing and the non-freezing water using the melting point depression of the freezing water in the membranes immersed in the solute solution. 相似文献
5.
Ichiro Kudo Toshiyuki Kato Hidetoshi Hayashi Ryohei Yanoshita Koichi Ikizawa Hiroko Uda Keizo Inoue 《Lipids》1991,26(12):1065-1070
We have previously reported that platelet-activating factor (PAF) induces proliferation and microbicidal activity of guinea
pig bone marrow cells. In the present study, we have found that the conditioned medium of PAF- or nonmetabolizable PAF agonist-treated
guinea pig bone marrow cells augmented DNA synthesis and induced microbicial activity of bone marrow cells. A PAF specific
antagonist, CV-6209, inhibited generation of the active conditioned medium by PAF. Addition of the PAF antagonist only partially
suppressed the augmentative effect of the active conditioned medium on DNA synthesis; this is consistent with the fact that,
because of the rapid breakdown, no appreciable amount of PAF remained in the conditioned medium of PAF-treated cells. Although
mouse bone marrow cells did not respond to PAF unlike guinea pig cells, their DNA synthesis was significantly enhanced by
the conditioned medium of PAF-treated guinea pig bone marrow cells. Thus, some newly generated factor(s) distinct from the
originally inoculated PAF seemed to modulate the bioactions of PAF on bone marrow cells. An appreciable amount of PAF was
produced by calcium ionophore-treated guinea pig bone marrow cells. These findings indicate that PAF synthesized in guinea
pig bone marrow cells induces generation in the cells of some factor(s) which affects proliferation or microbicidal activity.
Presented at The Third International Conference on Platelet-Activating Factor and Structurally Related Ether Lipids, Tokyo,
Japan, May 1989. 相似文献
6.
Poly(ethylene phthalate) (PEP) and poly(ethylene phthalate–co‐ethylene terephthalate) were used to improve the brittleness of the cycloaliphatic epoxy resin 3,4‐epoxycyclohexylmethyl 3,4‐epoxycyclohexane carboxylate (Celoxide 2021?), cured with methyl hexahydrophthalic anhydride. The aromatic polyesters used were soluble in the epoxy resin without solvents and effective as modifiers for toughening the cured epoxy resin. For example, the inclusion of 20 wt % PEP (MW, 7400) led to a 130% increase in the fracture toughness (KIC) of the cured resin with no loss of mechanical and thermal properties. The toughening mechanism is discussed in terms of the morphological and dynamic viscoelastic behaviors of the modified epoxy resin system. © 2002 Wiley Periodicals, Inc. J Appl Polym Sci 84: 388–399, 2002; DOI 10.1002/app.10363 相似文献
7.
本文是在国际服饰文化与教育研讨会期间,本栏目主持人、我校服装艺术与工程学院讲师孙雪飞对日本著名时装设计师小筱弘子进行访谈的整理. 相似文献
8.
Hoshiaki Iijima Osamu Taguchi Ken-Ichi Hirano 《Metallurgical and Materials Transactions A》1977,8(6):991-995
Interdiffusion coefficient
in cobalt-manganese alloys has been determined by Matano's method in the temperature range between 1133 and 1423 K on (pure
Co)-(Co-30.28 at. pct Mn alloy) and (pure Co)-(Co-51.76 at. pct Mn alloy) couples. This, ∼D, has been found to increase with the increase of manganese content. However, the activation energy (∼Q) and frequency factor (
0) show a maximum at about 10 at. pct Mn. The concentration dependence of
and
has been discussed taking into account the thermodynamic properties of the alloy. The difference in
between the ferro- and paramagnetic phases in Co-5 at. pct Mn alloy has been found to be 24 kJ/mol, which is larger, than
that for the diffusion of Mn54 in this alloy. Further it has been found that the Kirkendall marker moves toward manganese-rich side, showing that manganese
atoms diffuse faster than cobalt atoms. From the marker shift, the intrinsic diffusion coefficients,D
Co andD
Mn, at 33 at. pct Mn have been determined as follows:D
Co=0.22×10−4 exp(−263 kJ mol−1/RT) m2/s, andD
Mn=0.98×10−4 exp(−229 kJ mol−1/RT) m2/s. 相似文献
9.
T. Goto N. Wakamatsu H. Kamemizu M. Iijima Y. Doi Y. Moriwaki 《Journal of materials science. Materials in medicine》1991,2(3):149-152
The sintering mechanism of hydroxyapatite (HAp) by addition of lithium phosphate (Li3PO4) has been investigated. Using the X-ray diffraction method, HAp was confirmed to decompose into -Ca3(PO4)2 (-TCP) by addition of Li3PO4. The measurement of shrinkage rate by the isothermal firing made it clear that the densification process at the initial stage of sintering took place in the presence of liquid phase. Furthermore, the examination of the phase diagram on the binary system -TCP-Li3PO4 revealed that there was an eutectic point at 1010°C in the composition of 60 wt% Li3PO4. From these evidences, we concluded that -TCP produced by the decomposition of a part of HAp has formed the liquid phase by reacting with Li3PO4 above 1010°C, and that this liquid phase has largely promoted the densification by the rearrangement of HAp particles at the initial stage of sintering. 相似文献
10.
Norman Makoto Su Hiroko N. Wilensky David F. Redmiles 《Computer Supported Cooperative Work (CSCW)》2012,21(2-3):111-162
We explore how the notion of communities of practice (CoPs) was translated and popularized from its original inception by Lave and Wenger in 1991. We argue that the Institute for Research on Learning (IRL), a spin-off of Xerox PARC, proved instrumental in enrolling CoPs into the knowledge management (KM) discipline. IRL objectified, packaged, and made a business out of CoPs. CoPs in KM are now a formalized process coupled with technological artifacts to build groups of people who effectively share knowledge across boundaries. Drawing from participant observations, archival documents, and interviews with KM practitioners in the aerospace industry as well as key players of IRL, our research seeks to unveil the invisible history that the popularization of a theory can often obscure. We argue that CoPs provide a case study for understanding how abstract concepts in science are strategically and subconsciously reified, or made objects of inquiry, and appropriated by actors. This reification of a “soft” science blurs the line between theory and technology. 相似文献