Working memory and articulation rate in children with spastic diplegic cerebral palsy.

A. D. Baddeley, N. Thomson, and M. Buchanan (1975) suggested that articulatory rehearsal rate determines the amount of verbal material that can be maintained in working memory. In the current study, 12 children with spastic diplegic cerebral palsy (SDCP) and 38 normal children were tested on measures of articulation rate and memory span for 1-, 2-, and 3-syllable words. Across all conditions, articulation rate for the SDCP group was significantly slower than for the normal group; nonetheless, memory span was equivalent for both groups. This finding implies that covert rehearsal proceeded normally for the SDCP group, in spite of decrements in speech rate. Thus, the relationship between overt and covert rehearsal rates differs for children with SDCP compared with normal children. Findings from the current study further suggest that normal speech rates are not necessary for development of normal covert rehearsal rates. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Beam purification by photodetachment (invited)

Ion beam purity is of crucial importance to many basic and applied studies in nuclear science. Selective photodetachment has been proposed to suppress unwanted species in negative ion beams while preserving the intensity of the species of interest. A highly efficient technique based on photodetachment in a gas-filled radio frequency quadrupole ion cooler has been demonstrated. In off-line experiments with stable ions, up to 10(4) times suppression of the isobar contaminants in a number of interesting radioactive negative ion beams has been demonstrated. For selected species, this technique promises new experimental possibilities in studies on exotic nuclei, accelerator mass spectrometry, and fundamental properties of negative atomic and molecular ions.     

Nitroreductase-Mediated Release of Inhibitors of Lysine-Specific Demethylase 1 (LSD1) from Prodrugs in Transfected Acute Myeloid Leukaemia Cells

Lysine-specific demethylase 1 (LSD1) has evolved as a promising therapeutic target for cancer treatment, especially in acute myeloid leukaemia (AML). To approach the challenge of site-specific LSD1 inhibition, we developed an enzyme-prodrug system with the bacterial nitroreductase NfsB (NTR) that was expressed in the virally transfected AML cell line THP1-NTR⁺. The cellular activity of the NTR was proven with a new luminescent NTR probe. We synthesised a diverse set of nitroaromatic prodrugs that by design do not affect LSD1 and are reduced by the NTR to release an active LSD1 inhibitor. The emerging side products were differentially analysed using negative controls, thereby revealing cytotoxic effects. The 2-nitroimidazolyl prodrug of a potent LSD1 inhibitor emerged as one of the best prodrug candidates with a pronounced selectivity window between wild-type and transfected THP1 cells. Our prodrugs are selectively activated and release the LSD1 inhibitor locally, proving their suitability for future targeting approaches.     

Integrierte Wertschöpfungsnetzwerke – Chancen und Potenziale durch Industrie 4.0

The Smart Factory is the central element of Industry 4.0 and establishes the foundation to enable integrated value chains across companies. The linkage of information along value chains offers a wide range of opportunities and potentials to realize new innovative solutions.     

Downstream channel changes after a small dam removal: Using aerial photos and measurement error for context; Calapooia River,Oregon

Dam removal is often implemented without adequate baseline monitoring to distinguish background variability from channel changes due to the removal. This study evaluated aerial photos as substitutes for multiple‐year pre‐removal field data to assess downstream channel changes associated with a small dam removal. The Brownsville Dam, a 2.1 m tall concrete dam on the Calapooia River, Oregon, was removed in 2007. We mapped bars and the low flow channel downstream from the dam and in an upstream control reach using aerial photos (1994–2008) and in the field prior to (2007) and following (2008) removal. The locations and magnitudes of changes in bar area and wetted width, relative to errors, indicate that downstream channel changes were a result of the removal. The maximum changes (?3520 ± 1460 m² for bar area, 32 ± 8 m for wetted width) observed prior to dam removal with aerial photos were far downstream. In contrast, the maximum changes after removal were immediately below the dam (200 ± 90 m² for bar area, ?11 ± 3 m for wetted width), and small in the upstream control (?150 ± 130 m² for bar area, 9 ± 4 m for wetted width). The dominant errors were photo specific: exposure error for spring to summer comparisons, position error for photos not processed for this study and identification error for small scale photos not scanned from film. We found aerial photos to be an acceptable but coarse substitute for multi‐year pre‐removal field data, and suggest best practices to minimize errors. Copyright © 2009 John Wiley & Sons, Ltd.     

A mini review on two-dimensional nanomaterial assembly

Two-dimensional (2D) nanomaterials have attracted a great deal of attention since the discovery of graphene in 2004, due to their intriguing physicochemical properties and wide-ranging applications in catalysis, energy-related devices, electronics and optoelectronics. To maximize the potential of 2D nanomaterials for their technological applications, controlled assembly of 2D nanobulding blocks into integrated systems is critically needed. This mini review summarizes the reported strategies of 2D materials-based assembly into integrated functional nanostructures, from in-situ assembly method to post-synthesis assembly. The applications of 2D assembled integrated structures are also covered, especially in the areas of energy, electronics and sensing, and we conclude with discussion on the remaining challenges and potential directions in this emerging field.

     

Predicting friction reliably and accurately in journal bearings—A systematic validation of simulation results with experimental measurements

It is the aim of this work to predict friction in journal bearings reliably and accurately under realistic dynamic working conditions. To this purpose elastohydrodynamic (EHD) calculations using an extensive oil-model and including an approach to the conformal roughnesses of the bearing surfaces are carried out for transient loads typical for current utility vehicles (40 MPa) as well as for considerably higher specific loads (70 MPa) and for different lubricants (SAE10, SAE20, SAE30 and SAE40) to account for a large span of working conditions ranging from full film lubrication to mixed lubrication with metal-metal contact.The results obtained from this simulation model are compared to measurements performed on a journal bearing test rig. We find that the results of the presented approach agree very closely with the experimental values. The presented approach allows consequently to investigate the effectiveness of changes in bearing geometry, bearing materials, bearing surface roughness, lubricant viscosity and engine operating conditions to reduce friction in journal bearings.     

CFD methods for the reduction of reactive gas emission from a paper laminating machine

In cooperation with the world's second largest manufacturer of beverage cartons (SIG Combibloc) for liquid foodstuffs an innovative off-take for neutralisation of reactive gas in a paper laminating machine was constructed. A great challenge during engineering work was ensuring a high concentration of the reactive gas where needed and at the same time minimising work place impact in a machine basically without housing. Preliminary 2D-models of the machine geometry proved to be insufficient in describing all the governing flow phenomena. A simplified 3D-geometry containing all important parts of the complex machinery was necessary for accurate predictions. It was found that the driving force of air movement and transport of reactive gas (which acts as an adhesive agent) from the reaction zone in the interior of the laminating machine to the outside is a boundary flow caused by the rapid movement of carton material and rotating cylinders. A physically correct simulation result of the boundary flow is a premise for correct prediction of air flow in and around the machinery. Lacking experimental data (due to an inaccessible geometry) a worst case scenario was constructed by generating a grid and using turbulence models that maximised mass transport in the boundary layer region and thus emission of (tracer)gas from the machine. CFD simulations were done using the geometry preprocessor Gambit, and the finite volume solver Fluent. The results of the analysis of the emission paths from the machine were surprising and led to the construction of an effective off-take relatively far away from the emission source. The chosen position ensures low disturbance of highly sensitive flow patterns inside the machine and diffusive mixing, dilution and contamination of the surroundings. The effect of the new off-take is an immediate and significant rise in air quality in the vicinity of the laminating machine and ensures maximum allowed concentration in the plant area. The product quality furthermore is uncompromised by the working off-take which was another important goal of this work.