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1.
Mandal Tarun K.; Mukhopadhyay Chaitali 《Protein engineering, design & selection : PEDS》2002,15(12):979-986
Galectins show remarkable binding specificity towards ß-galactosides.A recently developed method for calculating binding free energiesbetween a protein and its substrates has been used to evaluatethe binding specificity of galectin-3. Five disaccharides anda tetrasaccharide were used as the substrates. The calculatedbinding free energies agree quite well with the experimentaldata and the ranking of binding affinities is well reproduced.For all the six proteinligand complexes it was observedthat electrostatic interactions oppose binding whereas the non-polarcontributions drive complex formation. The observed bindingspecificity of galectin-3 for galactosides rather than glucosidesis discussed in light of our results. 相似文献
2.
Silicon - In this article, the electrical behavior of short channel SiGe Heterostructure Junction-Less DG-MOSFET have been studied by incorporating the quantum mechanical effect and short channel... 相似文献
3.
In an attempt to toughen the epoxy resin matrix for fiber-reinforced composite applications, a chemical modification procedure of a commercially available bisphenol-A-based epoxy resin using reactive liquid rubber HTBN [hydroxy-terminated poly(butadiene-co-acrylonitrile)] and TDI (tolylene diisocyanate) is described. The progress of the reaction and the structural changes during modification process are studied using IR spectroscopy, viscosity data, and chemical analysis (epoxy value determination). The studies support the proposition that TDI acts as a coupling agent between the epoxy and HTBN, forming a urethane linkage with the former and an oxazolidone ring with the latter. The chemical reactions that possibly take place during the modification are discussed. 相似文献
4.
Silicon - In this paper Junctionless Double Gate MOSFET based Efficient Charge Recovery Logic (JL-ECRL) circuits have been driven in sub-threshold regime for the first time in literature to... 相似文献
5.
Priyam Sinha Shruti Srivastava Nidhi Mishra Dhananjay Kumar Singh Suaib Luqman Debabrata Chanda 《Drug development and industrial pharmacy》2016,42(9):1434-1445
Purpose: To develop and optimize nanoemulsion (NE)-based emulgel (EG) formulation as a potential vehicle for topical delivery of tea tree oil (TTO).Methodology: Central composite design was adopted for optimizing the processing conditions for NE preparation by high energy emulsification method viz. surfactant concentration, co-surfactant concentration, and stirring speed. The optimized NE was developed into emulgel (EG) using pH sensitive polymer Carbopol 940 and triethanolamine as alkalizer. The prepared EG was evaluated for its pH, viscosity, and texture parameters, ex vivo permeation at 37?°C and stability. Antimicrobial evaluation of EG in comparison to conventional gel and pure TTO was also carried out against selected microbial strains.Results and discussion: Optimized NE had particle size and zeta potential of 16.23?±?0.411?nm and 36.11?±?1.234?mV, respectively. TEM analysis revealed the spherical shape of droplets. The pH of EG (5.57?±?0.05?) was found to be in accordance with the range of human skin pH. EG also illustrated efficient permeation (79.58?μL/cm2) and flux value (JSS) of 7.96?μL cm2/h through skin in 10?h. Viscosity and texture parameters, firmness (9.3?±?0.08?g), spreadability (2.26?±?0.06?mJ), extrudability (61.6?±?0.05?mJ), and adhesiveness (8.66?±?0.08?g) depict its suitability for topical application. Antimicrobial evaluation of EG with same amount of TTO as conventional gel revealed broader zones of growth inhibitions against all the selected microbial strains. Moreover, EG was also found to be nonirritant (PII 0.0833). These parameters were consistent over 90 d.Conclusion: TTO EG turned out to be a promising vehicle for the topical delivery of TTO with enhanced therapeutic efficacy. 相似文献
6.
Ravi Kumar Arun Anjali Moumita Sardar Preeti Singh Bishnu Mohan Jha Nripen Chanda 《国际能源研究杂志》2019,43(14):8834-8840
Microchannel geometry, electrode surface area, and better fuel utilization are important aspects of the performance of a microfluidic fuel cell (MFC). In this communication, a membraneless spiral‐shaped MFC fabricated with Ni as anode and C as a cathode supported over a porous filter paper substrate is presented. Vanadium oxychloride and dilute sulfuric acid solutions are used as fuel and electrolyte, respectively, in this fuel cell system. The device generates a maximum open‐circuit voltage of ~1.2 V, while the maximum energy density and current density generated from the fuel cell are ~10 mW cm?2 and ~51 mA cm?2, respectively. The cumulative energy density generated from the device after five cycles are measured as ~200 mW after regeneration of the fuel by applying external voltage. The spiral design of the fuel cell enables improved fuel utilization, rapid diffusive transport of ions, and in‐situ regeneration of the fuel. The present self‐standing spiral‐shaped MFC will eliminate the challenges associated with two inlet membrane‐less fuel cells and has the potential to scale up for commercial application in portable energy generation. 相似文献
7.
De Paramita Mandal Sekhar Bhowmick Partha Chanda Bhabatosh 《Pattern Analysis & Applications》2019,22(4):1341-1359
Pattern Analysis and Applications - Decomposition and representation of electrical circuit drawings to a suitable vector form has widespread applications related to data compression, storage,... 相似文献
8.
R. R. Chanda R. J. Fincham P. Venter 《Critical reviews in food science and nutrition》2014,54(4):488-494
The food safety risk analysis framework of the FAO/WHO is used in the review of veterinary drug and residue regulation in South Africa to determine possible inefficiencies within this system. Results indicate that a variety of challenges relating to the processes of risk assessment, management, and communication do exist, although these occur within a fragmented system of legislation, functions, and structures. Addressing these challenges therefore requires a change to a more collaborative and integrated system. It is indicated that for such a change, the underlying challenges of inadequate horizontal communication, poor conceptualization, and awareness of functions of the system are required to be dealt with. 相似文献
9.
Abhijit Chanda Rajdeep SinghaRoy Weichung Xue Susmita Bose Amit Bandyopadhyay 《Materials science & engineering. C, Materials for biological applications》2009,29(4):1201-1206
The objective of this work was to study adhesion, proliferation and differentiation of osteoblast cells (OPC1) on alumina ceramic, a bio-inert material. Alumina ceramic with different average grain sizes, 1 μm and 12 μm, respectively, were used in as-prepared condition without any grinding and polishing to understand the influence of grain size on cell–material interactions. Scanning electron microscopy and confocal imaging were used to study attachment, adhesion and differentiation of OPC1 cells. Cells attached, proliferated and differentiated well on both the substrates. Adhesion of cells, as assessed by observing the production of vinculin, was found to be a consistent phenomenon on both the substrates. On day 5 of cell culture, significant cell-attachment was observed and vinculin was detected throughout cytoplasm. MTT assay showed that proliferation of OPC1 cells was consistently higher in the case of 12 μm-alumina. Cells of different morphology, nodular, plate-like as well as elongated, were found to get anchored at grains, grain boundaries as well as pores. On day 16, there were clear signs of mineralization as well. Over all, alumina with average grain size of 12 μm showed better cell-attachment, growth and differentiation compared to 1 μm grain size samples. 相似文献
10.
Ishita De Bhabatosh Chanda Buddhajyoti Chattopadhyay 《Image and vision computing》2006,24(12):1278-1287
Reduced depth-of-field (DOF) poses a problem in the light optical imaging system, since the objects present outside this zone appear blurry in the recorded image. The effective DOF of the sensor may be enhanced considerably without compromising the quality of the image by fusing images captured with different focused regions. This paper presents an image fusion technique suitable for combining multifocus images of a scene. The method employs morphological filters to select sharply focused regions from various images and then combines them together to reconstruct the image in which all the regions are properly focused. A performance measure based on image gradients is used to compare the results obtained by the proposed method with those obtained by other image fusion techniques. 相似文献