排序方式: 共有86条查询结果,搜索用时 0 毫秒
1.
Yevgeniy Kim Sanzhar Nurakhayev Ayan Nurkesh Zharylkasyn Zharkinbekov Arman Saparov 《International journal of molecular sciences》2021,22(5)
Cardiovascular disease is the leading cause of mortality and morbidity around the globe, creating a substantial socio-economic burden as a result. Myocardial infarction is a significant contributor to the detrimental impact of cardiovascular disease. The death of cardiomyocytes following myocardial infarction causes an immune response which leads to further destruction of tissue, and subsequently, results in the formation of non-contractile scar tissue. Macrophages have been recognized as important regulators and participants of inflammation and fibrosis following myocardial infarction. Macrophages are generally classified into two distinct groups, namely, classically activated, or M1 macrophages, and alternatively activated, or M2 macrophages. The phenotypic profile of cardiac macrophages, however, is much more diverse and should not be reduced to these two subsets. In this review, we describe the phenotypes and functions of macrophages which are present in the healthy, as well as the infarcted heart, and analyze them with respect to M1 and M2 polarization states. Furthermore, we discuss therapeutic strategies which utilize macrophage polarization towards an anti-inflammatory or reparative phenotype for the treatment of myocardial infarction. 相似文献
2.
In this paper, a pipelined architecture using CORDIC for realization of transform domain equalizer is presented. Transform domain equalizer has much faster convergence than its time domain counterpart for practical hardware realization having nonzero adaptation delay. Here running DFT is employed as the transform, and CORDIC is used for realization of running DFT. Pipelining is applied throughout the architecture, thus limiting the critical path delay to the propagation delay of a single 16 bit adder for 16 bit arithmetic. For N tap equalizer, primary clock speed is N times of the sample clock speed, so that on arrival of each sample, the computation of whole transform and weight update is possible. In the proposed architecture, hardware complexity is reduced by fully utilizing the pipeline without using parallel structures. The adaptation delay is only 2 sample clock periods resulting in fast convergence. The proposed architecture is suitable for VLSI implementation with primary clock speed limited by the binary adder propagation delay which could be as low as 2 ns in the present state-of-the-art technology. 相似文献
3.
Souvik Biswas Ayan Roynaskar Chetan Kumar Hirwani Subrata Kumar Panda 《国际能源研究杂志》2018,42(12):3977-3986
The current article discussed the detail design and development of an experimental test rig to derive usable energy by utilizing the waste heat energy through a heat exchanger made of Bi2Te3 material. The accuracy including the efficiency of the fabricated device is demonstrated further by verifying the associated parameter through a simulation model (commercial finite element package, ANSYS 15.0). To imitate the waste hot air from the industry is achieved via a heat gun and fed to the test rig for the generation of thermoelectric power. The simulation model accuracy has been demonstrated by juxtaposing the associated experimental data and computational readings. Subsequently, the feasibility and optimum range of design parameters are established by comparing the experimental and the simulation data (triggered temperature difference, voltage output, and heat flux) generated at the interface of the thermoelectric power generators. In addition, the coefficient of determination (R2) value has been evaluated statistically and verified with the current experimental results for the demonstration of the relevancy. The statistical study shows the existence of the correlation between the current experimental and the simulation model. Also, the experimental result indicates the possible implementation of the newly developed system for the recovery from the waste heat either the automobile exhaust or any other kind of dissipated heat from the industries. 相似文献
4.
Xiaoyu Che Christopher R. Brydges Yuanzhi Yu Adam Price Shreyas Joshi Ayan Roy Bohyun Lee Dinesh K. Barupal Aaron Cheng Dana March Palmer Susan Levine Daniel L. Peterson Suzanne D. Vernon Lucinda Bateman Mady Hornig Jose G. Montoya Anthony L. Komaroff Oliver Fiehn W. Ian Lipkin 《International journal of molecular sciences》2022,23(14)
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic and debilitating disease characterized by unexplained physical fatigue, cognitive and sensory dysfunction, sleeping disturbances, orthostatic intolerance, and gastrointestinal problems. People with ME/CFS often report a prodrome consistent with infections. Using regression, Bayesian and enrichment analyses, we conducted targeted and untargeted metabolomic analysis of plasma from 106 ME/CFS cases and 91 frequency-matched healthy controls. Subjects in the ME/CFS group had significantly decreased levels of plasmalogens and phospholipid ethers (p < 0.001), phosphatidylcholines (p < 0.001) and sphingomyelins (p < 0.001), and elevated levels of dicarboxylic acids (p = 0.013). Using machine learning algorithms, we were able to differentiate ME/CFS or subgroups of ME/CFS from controls with area under the receiver operating characteristic curve (AUC) values up to 0.873. Our findings provide the first metabolomic evidence of peroxisomal dysfunction, and are consistent with dysregulation of lipid remodeling and the tricarboxylic acid cycle. These findings, if validated in other cohorts, could provide new insights into the pathogenesis of ME/CFS and highlight the potential use of the plasma metabolome as a source of biomarkers for the disease. 相似文献
5.
6.
Two-dimensional incompressible Navier-Stokes equations are solved using SIMPLER method in the intrinsic curvilinear coordinates
system to study the unsteady viscous flow physics over two-dimensional ellipses Unsteady viscous flows over various thickness-to-chord
ratios of 06, 08, 10, and 1 2 elliptic cylinders are simulated at different Reynolds numbers of 200, 400, and 1,000 This study
is focused on the understanding the effects of Reynolds number and elliptic cylinder thickness on the drag and lift forces
The present numerical solutions are compared with available experimental and numerical results and show a good agicement Through
this study, it is observed that the Reynolds number and the cylinder thickness affect significantly the frequencies of the
force oscillations as well as the mean values and the amplitudes of the drag and lift forces 相似文献
7.
Synthesis,Characterization, and drug release study of acrylamide‐co‐itaconic acid based smart hydrogel 下载免费PDF全文
A new kind of pH and temperature responsive poly(acrylamide‐co‐itaconic acid) hydrogel was prepared by free radical polymerization using ammonium persulfate as initiator and different comonomer ratios. The hydrogels were characterized in terms of chemical composition, swelling‐deswelling behavior, morphology, crystallographic behavior, and drug release properties. All the hydrogels showed high swelling ability in aqueous solutions, the maximum being at pH 7. Swelling decreased on either side of pH 7 (i.e., both in acidic and alkaline region) and increased with increase in temperature. The hydrogel with 10 mol% itaconic acid (IA) absorbed maximum water among the copolymer gels. The cellular structures of the hydrogels were clearly revealed by microscopic analysis and SEM pictures. Swelling of the gels in water followed non‐Fickian type of diffusion principle. The hydrogel was proved to be a controlled release vehicle, for example in drug delivery by using its smart properties. The hydrogel with 10 mol% IA also absorbed maximum amount of drug (ascorbic acid) under study. Incorporation of drug in hydrogel matrix was established from XRD peak analysis. POLYM. ENG. SCI., 55:113–122, 2015. © 2014 Society of Plastics Engineers 相似文献
8.
Pal Debasish Singhal Rahul Bandyopadhyay Ayan Kumar 《Wireless Personal Communications》2022,124(2):1897-1897
Wireless Personal Communications - 相似文献
9.
I. Dumanoglu N. Akchurin U. Akgun S. Ayan P. Bruecken E. Eskut A. Fenyvesi A. Kayis Topkasu N. Koca K. Makonyi J. -P. Merlo D. Novak Y. Onel G. Onengut A. Polatoz I. Schmidt M. Serin M. Zeyrek 《Nuclear instruments & methods in physics research. Section A, Accelerators, spectrometers, detectors and associated equipment》2002,490(3):444-455
We investigated the darkening of nine high OH− fibre types irradiated with 500 MeV electrons from the Linac Injector of LEP (LIL) at CERN. The transmission of Xe light was measured in situ in the 350–800 nm range. The induced attenuation at 450 nm is typically 1.52±0.15 dB/m for a 100 Mrad absorbed dose. Two-parameter fits for darkening and recovery are presented. After irradiation the tensile strength remains essentially unchanged. For Polymicro quartz core fibres the tensile strength is typically 4.6±0.4 GPa. 相似文献
10.
Distributed topology management for wireless multimedia sensor networks: exploiting connectivity and cooperation 下载免费PDF全文
Sudip Misra Goutam Mali Ayan Mondal 《International Journal of Communication Systems》2015,28(7):1367-1386
In this paper, we propose a distributed topology management algorithm, named T‐Must, which orchestrates coalition formation game between camera and scalar sensor (SS) nodes, for use in wireless multimedia sensor networks. In the proposed solution, connectivity among the peer camera sensor (CS) nodes is maintained, and coverage is ensured between them. Only the scalar data are not sufficient to describe an event in a particular monitored area. In many cases, multimedia data (specifically, video data) are required to provide more precise information about the event. As the CS nodes, which sense and transmit multimedia data, are costlier than the SS nodes, the former are deployed in the monitored area in lesser numbers compared to the latter ones. In case of CS nodes, power consumption due to sensing is also significant, similar to power consumption for the transmission and reception of packets. Therefore, in this work, in order to increase the network lifetime, topology is controlled by forming coalition between the CS and SS nodes. Upon occurrence of an event, the SS nodes send scalar data to their associated CS nodes. If the scalar data received from SS nodes cross a preconfigured threshold, the associated CS node in the coalition starts sensing the event, captures the video data, and forwards the video data toward other coalitions or sink. Copyright © 2014 John Wiley & Sons, Ltd. 相似文献