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Sinuo Liu Xiaokun Wang Xiaojuan Ban Yanrui Xu Jing Zhou Jií Kosinka Alexandru C. Telea 《Computer Graphics Forum》2021,40(1):54-67
A major issue in smoothed particle hydrodynamics (SPH) approaches is the numerical dissipation during the projection process, especially under coarse discretizations. High‐frequency details, such as turbulence and vortices, are smoothed out, leading to unrealistic results. To address this issue, we introduce a vorticity refinement (VR) solver for SPH fluids with negligible computational overhead. In this method, the numerical dissipation of the vorticity field is recovered by the difference between the theoretical and the actual vorticity, so as to enhance turbulence details. Instead of solving the Biot‐Savart integrals, a stream function, which is easier and more efficient to solve, is used to relate the vorticity field to the velocity field. We obtain turbulence effects of different intensity levels by changing an adjustable parameter. Since the vorticity field is enhanced according to the curl field, our method can not only amplify existing vortices, but also capture additional turbulence. Our VR solver is straightforward to implement and can be easily integrated into existing SPH methods. 相似文献
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Popa Iolanda V. Burlacu Alexandru Gavrilescu Otilia Dranga Mihaela Prelipcean Cristina Cijevschi Mihai Cătălina 《Neural computing & applications》2021,33(21):14133-14146
Neural Computing and Applications - Colonoscopy is the “gold” standard for evaluating disease activity in ulcerative colitis (UC). An important area of research is finding a... 相似文献
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Bianca Stoean Dumitrita Rugina Monica Focsan Ana-Maria Craciun MÎdÎlina Nistor Tamas Lovasz Alexandru Turza Ioan-Dan Porumb Emese Gl Castelia Cristea Luminita Silaghi-Dumitrescu Simion Astilean Luiza Ioana Gaina 《International journal of molecular sciences》2021,22(6)
We report here the synthesis and structural characterization of novel cationic (phenothiazinyl)vinyl-pyridinium (PVP) dyes, together with optical (absorption/emission) properties and their potential applicability as fluorescent labels. Convective heating, ultrasound irradiation and mechanochemical synthesis were considered as alternative synthetic methodologies proficient for overcoming drawbacks such as long reaction time, nonsatisfactory yields or solvent requirements in the synthesis of novel dye (E)-1-(3-chloropropyl)-4-(2-(10-methyl-10H-phenothiazin-3-yl)vinyl)pyridin-1-ium bromide 3d and its N-alkyl-2-methylpyridinium precursor 1c. The trans geometry of the newly synthesized (E)-4-(2-(7-bromo-10-ethyl-10H-phenothiazin-3-yl)vinyl)-1-methylpyridin-1-ium iodide 3b and (E)-1-methyl-4-(2-(10-methyl-10H-phenothiazin-3-yl)vinyl)pyridin-1-ium tetrafluoroborate 3a′ was confirmed by single crystal X-ray diffraction. A negative solvatochromism of the dyes in polar solvents was highlighted by UV-Vis spectroscopy and explanatory insights were supported by molecular modeling which suggested a better stabilization of the lowest unoccupied molecular orbitals (LUMO). The photostability of the dye 3b was investigated by irradiation at 365 nm in different solvents, while the steady-state and time-resolved fluorescence properties of dye 3b and 3a′ in solid state were evaluated under one-photon excitation at 485 nm. The in vitro cytotoxicity of the new PVP dyes on B16-F10 melanoma cells was evaluated by WST-1 assay, while their intracellular localization was assessed by epi-fluorescence conventional microscopy imaging as well as one- and two-photon excited confocal fluorescence lifetime imaging microscopy (FLIM). PVP dyes displayed low cytotoxicity, good internalization inside melanoma cells and intense fluorescence emission inside the B16-F10 murine melanoma cells, making them suitable staining agents for imaging applications. 相似文献
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We present a novel approach for extreme simplification of point set models, in the context of real-time rendering. Point sets
are often rendered using simple point primitives, such as oriented discs. However, this requires using many primitives to
render even moderately simple shapes. Often, one wishes to render a simplified model using only a few primitives, thus trading
accuracy for simplicity. For this goal, we propose a more complex primitive, called a splat, that is able to approximate larger and more complex surface areas than oriented discs. We construct our primitive by decomposing
the model into quasi-flat regions, using an efficient algebraic multigrid algorithm. Next, we encode these regions into splats
implemented as planar support polygons textured with color and transparency information and render the splats using a special
blending algorithm. Our approach combines the advantages of mesh-less point-based techniques with traditional polygon-based
techniques. We demonstrate our method on various models. 相似文献
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Daniela PatrascuAuthor VitaeIulia DavidAuthor Vitae Vasile DavidAuthor VitaeConstantin MihailciucAuthor Vitae Ioan StamatinAuthor VitaeJean CiureaAuthor Vitae Livia NagyAuthor VitaeGéza NagyAuthor Vitae Anton Alexandru CiucuAuthor Vitae 《Sensors and actuators. B, Chemical》2011,156(2):731-736
Iron(II) phthalocyanine (FePc) modified multi-wall carbon nanotubes paste electrodes (MWCNTPEs) were used as voltammetric sensors to selectively detect dopamine (DA) in the presence of serotonin (5-HT). The electrochemical behavior of DA at the new modified electrode was investigated using CV. The enhanced current response of DA indicates that FePc modification of the MWCNTPE surface results in a high catalytic activity for the redox reaction of DA. Differential pulse voltammetry was applied in detection of DA and 5-HT at FePc-MWCNTPE. The method parameters were optimized. Detection limit of 2.05 × 10−7 M was obtained for DA by using the electrocatalytic oxidation signal corresponding to the FeII/FeIII redox process. The separation between the peak potentials of DA and 5-HT is 170 mV which is large enough for the simultaneously, selective determination of the two chemical species in their mixtures. There was no electrochemical response for ascorbic acid (AA) added in the sample. The monoamine neurotransmitter measuring method has been tested in analyzing deproteinized serum samples. 相似文献
8.
Iuliana Armaş Mihaela Gheorghe Ana Maria Lendvai Paul Daniel Dumitru Octavian Bădescu Alexandru Călin 《International journal of remote sensing》2016,37(23):5565-5580
This research aims to complex validate radar displacement products over Bucharest based on Global Navigation Satellite System or GNSS. Validation was represented by the comparison of the recent TerraSAR-X (TSX) displacement results with field GNSS data. For this purpose, 24 and 27 high-resolution images acquired from the TSX satellite between 2011 and 2014 were processed by Permanent Scatterer Inteferometry (PSI) and Small BASeline Subset (SBAS) – interferometric techniques using synthetic aperture radar (SAR) images. The images were selected from a larger pool of SAR images, after consulting weather databases, which helped eliminate the images acquired under adverse weather conditions. GNSS locations were cross-checked on high-resolution optical images and 21 ground points (including three permanent stations) were selected. All these points were (1) characterized by high coherence on radar images; (2) were on the ground; (3) were situated in large vacant spaces; and (4) far away from radar obstacles such as trees. A major challenge in achieving the research goal was to overcome the lack of permanent stations at the ground level within the area of Bucharest. Instead of permanent stations, our team designed and installed forced centring systems that remained stable over time, eliminating the instalment errors of GNSS receivers. The line-of-site (LOS) components derived from GNSS data have been compared with those of the SAR scatterers closest to the GNSS markers (never coinciding). For each location, the vertical reading was projected in the LOS of the SAR sensor. These readings were compared with the displacement values determined at the locations of permanent scatterers (PSs) within 100 m from the GNSS nodes, by eliminating all scatterers on buildings. The comparison has shown a good agreement. 相似文献
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Alexandru Marian Bologa Ileana Stoica Attila Cristian Ratiu Nicoleta Denisa Constantin Alexandru Al. Ecovoiu 《International journal of molecular sciences》2022,23(23)
To date, different strategies of whole-genome sequencing (WGS) have been developed in order to understand the genome structure and functions. However, the analysis of genomic sequences obtained from natural populations is challenging and the biological interpretation of sequencing data remains the main issue. The MinION device developed by Oxford Nanopore Technologies (ONT) is able to generate long reads with minimal costs and time requirements. These valuable assets qualify it as a suitable method for performing WGS, especially in small laboratories. The long reads resulted using this sequencing approach can cover large structural variants and repetitive sequences commonly present in the genomes of eukaryotes. Using MinION, we performed two WGS assessments of a Romanian local strain of Drosophila melanogaster, referred to as Horezu_LaPeri (Horezu). In total, 1,317,857 reads with a size of 8.9 gigabytes (Gb) were generated. Canu and Flye de novo assembly tools were employed to obtain four distinct assemblies with both unfiltered and filtered reads, achieving maximum reference genome coverages of 94.8% (Canu) and 91.4% (Flye). In order to test the quality of these assemblies, we performed a two-step evaluation. Firstly, we considered the BUSCO scores and inquired for a supplemental set of genes using BLAST. Subsequently, we appraised the total content of natural transposons (NTs) relative to the reference genome (ISO1 strain) and mapped the mdg1 retroelement as a resolution assayer. Our results reveal that filtered data provide only slightly enhanced results when considering genes identification, but the use of unfiltered data had a consistent positive impact on the global evaluation of the NTs content. Our comparative studies also revealed differences between Flye and Canu assemblies regarding the annotation of unique versus repetitive genomic features. In our hands, Flye proved to be moderately better for gene identification, while Canu clearly outperformed Flye for NTs analysis. Data concerning the NTs content were compared to those obtained with ONT for the D. melanogaster ISO1 strain, revealing that our strategy conducted to better results. Additionally, the parameters of our ONT reads and assemblies are similar to those reported for ONT experiments performed on various model organisms, revealing that our assembly data are appropriate for a proficient annotation of the Horezu genome. 相似文献