Preclinical evaluation of 188 Re-HYNIC-PSMA as a novel therapeutic agent

Journal of Radioanalytical and Nuclear Chemistry - In this study, optimized preparation, quality control, cell assessments and biostribution of 188Re-HYNIC-PSMA in normal rats and tumor bearing...     

Binding affinity prediction for binary drug–target interactions using semi-supervised transfer learning

Journal of Computer-Aided Molecular Design - In the field of drug–target interactions prediction, the majority of approaches formulated the problem as a simple binary classification task....     

Optimized production,quality control and biodistribution assessment of <Superscript>166</Superscript>Ho–DOTATOC: a novel radiolabelled somatostatin analog

Nowadays, peptide receptor radionuclide therapy is used to treat a specific type of cancer called neuroendocrine tumors. In this research, the optimized conditions for ¹⁶⁶Ho-DOTATOC production are presented. The radiolabeled compound was prepared with the specific activity of 11.1 TBq/mmol and radiochemical purity of more than 99% (using ITLC and HPLC). Stability tests of the complex were investigated in room temperature and in human serum at 37 °C. Biodistribution studies in Syrian rats showed considerable accumulation in pancreas as the somatostatin receptor-positive tissue. ¹⁶⁶Ho-DOTATOC can be considered as a novel agent for treatment of somatostatin receptor-positive tumors.     

A spectroscopic study on the interaction between ferric oxide nanoparticles and human hemoglobin

Magnetic nanoparticles can promote many attractive functions in biomedicine, which may contribute to the prevention of human disease but also may be potentially harmful. In the present study, the interaction of Fe₂O₃ nanoparticles with human hemoglobin (Hb) was studied by fluorescence, circular dichroism and UV/vis spectroscopies. Fluorescence data revealed that the fluorescence quenching of Hb by Fe₂O₃ nanoparticles was the result of the formed complex of Fe₂O₃ nanoparticles-Hb. Binding constants and other thermodynamic parameters were determined at three different temperatures. The hydrophobic interactions are the predominant intermolecular forces to stabilize the complex. Circular dichroism studies did not show any changes in the content of secondary structure of hemoglobin after Fe₂O₃ nanoparticles treatment. This study provides important insight into the interaction of Fe₂O₃ nanoparticles with hemoglobin, which may be a useful guideline for further using of these nanoparticles in biomedical applications.     

Interaction between silver nanoparticle and bovine hemoglobin at different temperatures

The binding of silver nanoparticles to bovine hemoglobin (BHb) was studied by fluorescence, UV–Visible, and circular dichroism (CD) spectroscopic techniques at different temperatures of 20, 37, and 42 °C. The absorption spectrum of soret band, in the presence of silver nanoparticle, showed a significant spectral change, which indicated the heme groups of BHb were directly attacked and degraded by silver nanoparticle. The fluorescence data explained that the nanoparticle binding to BHb occurred at a single binding site, which demonstrated a dynamic quenching procedure. Nanoparticles could reduce the fluorescence of tryptophanyl residues of BHb to a lesser extent. Circular dichroism studies demonstrated a conformational change of BHb in the presence of silver nanoparticles. The helicity of BHb was reduced by increasing silver nanoparticle concentration at different temperatures. Thermodynamic analysis of the protein interaction by silver nanoparticles suggested that the binding process is only entropy driven.     

Adaptive fuzzy sliding mode control scheme for uncertain systems

Most physical systems inherently contain nonlinearities which are commonly unknown to the system designer. Therefore, in modeling and analysis of such dynamic systems, one needs to handle unknown nonlinearities and/or uncertain parameters. This paper proposes a new adaptive tracking fuzzy sliding mode controller for a class of nonlinear systems in the presence of uncertainties and external disturbances. The main contribution of the proposed method is that the structure of the controlled system is partially unknown and does not require the bounds of uncertainty and disturbance of the system to be known; meanwhile, the chattering phenomenon that frequently appears in the conventional variable structure systems is also eliminated without deteriorating the system robustness. The performance of the proposed approach is evaluated for two well-known benchmark problems. The simulation results illustrate the effectiveness of our proposed controller.