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1.
MJ Prado AL Nicastri PL Costa T Rockman IL Tersariol HB Nader RT Barros EB Prado 《Canadian Metallurgical Quarterly》1997,30(7):865-872
The aim of the present study was to evaluate renal and liver distribution of two monoclonal immunoglobulin light chains. The chains were purified individually from the urine of patients with multiple myeloma and characterized as lambda light chains with a molecular mass of 28 kDa. They were named BJg (high amount of galactose residues exposed) and BJs (sialic acid residues exposed) on the basis of carbohydrate content. A scintigraphic study was performed on male Wistar rats weighing 250 g for 60 min after i.v. administration of 1 mg of each protein (7.4 MBq), as the intact proteins and also after carbohydrate oxidation. Images were obtained with a Siemens gamma camera with a high-resolution collimator and processed with a MicroDelta system. Hepatic and renal distribution were established and are reported as percent of injected dose. Liver uptake of BJg was significantly higher than liver uptake of BJs (94.3 vs 81.4%) (P < 0.05). This contributed to its greater removal from the intravascular compartment, and consequently lower kidney accumulation of BJg in comparison to BJs (5.7 vs 18.6%) (P < 0.05). After carbohydrate oxidation, there was a decrease in hepatic accumulation of both proteins and consequently a higher renal overload. The tissue distribution of periodate-treated BJg was similar to that of native BJs: 82.7 vs 81.4% in the liver and 17.3 vs 18.6% in the kidneys. These observations indicate the important role of sugar residues of Bence Jones proteins for their recognition by specific membrane receptors, which leads to differential tissue accumulation and possible toxicity. 相似文献
2.
Real-time processing and compression of DNA microarray images. 总被引:1,自引:0,他引:1
Shadrokh Samavi Shahram Shirani Nader Karimi 《IEEE transactions on image processing》2006,15(3):754-766
In this paper, we present a pipeline architecture specifically designed to process and compress DNA microarray images. Many of the pixilated image generation methods produce one row of the image at a time. This property is fully exploited by the proposed pipeline that takes in one row of the produced image at each clock pulse and performs the necessary image processing steps on it. This will remove the present need for sluggish software routines that are considered a major bottleneck in the microarray technology. Moreover, two different structures are proposed for compressing DNA microarray images. The proposed architecture is proved to be highly modular, scalable, and suited for a standard cell VLSI implementation. 相似文献
3.
Influence of thermal boundary conditions on natural convection in a square enclosure partially heated from below 总被引:1,自引:0,他引:1
Nader Ben Cheikh Brahim Ben BeyaTaieb Lili 《International Communications in Heat and Mass Transfer》2007
Natural convection in air-filled 2D square enclosure heated with a constant source from below and cooled from above is studied numerically for a variety of thermal boundary conditions at the top and sidewalls. Simulations are performed for two kinds of lengths of the heated source, i.e., a small and a large source corresponding to 20% and 80% of the total length of the bottom wall, respectively. The Rayleigh number varied from 103 to 107. Results are presented in the form of streamline and isotherm plots as well as the variation of the Nusselt number and maximum temperature at the heat source surface. Comparisons among the different thermal configurations considered are reported. 相似文献
4.
5.
Modified sets of response equations have been derived for a single inclined hot-wire probe introduced in various orientations in a flow field having a dominant tangential velocity component. By means of these equations, the components of the three dimensional mean velocity vectors, the turbulence intensity and the Reynolds stresses can be easily determined at any location in a swirling flow which is stationary with time. This method is particularly applicable to the characterization of the flow field in chemical processing equipment where this type of swirling flow is increasingly being used. It has been successfully applied to a study of the flow field in a spray-drying chamber, in the course of which good reproducibility and consistency of results were obtained. 相似文献
6.
Nader Vahdat 《应用聚合物科学杂志》1991,42(12):3165-3171
Diffusion coefficients are needed for the analysis of many mass transfer problems involving polymers. Since the diffusivity for such systems are strong functions of temperature and concentration, the analysis of these problems is greatly facilitated if predictive methods are available for the determination of the required diffusion coefficient. Because of the limitations of the theoretical approaches for estimating diffusivity, empirical correlation of solute–polymer diffusion coefficient data with physical properties of the solute were investigated. Chemical permeation measurements were made for several organic liquids through three elastomers (polychoroprene, butyl and nitrile rubber) at five different temperatures, ranging from 25 to 65°C. The collected diffusivities were correlated with liquid kinematic viscosity. Diffusivities (at different temperatures) depend mainly on the kinematic viscosity of solutes. The results also indicate a close relation between the variation of diffusivity and viscosity with temperature. 相似文献
7.
This paper proposes a novel QoS-aware and congestion-aware Network-on-Chip architecture that not only enables quality-oriented network transmission and maintains a feasible implementation cost but also well balance traffic load inside the network to enhance overall throughput. By differentiating application traffic into different service classes, bandwidth allocation is managed accordingly to fulfill QoS requirements. Incorporating with congestion control scheme which consists of dynamic arbitration and adaptive routing path selection, high priority traffic is directed to less congested areas and is given preference to available resources. Simulation results show that average latency of high priority and overall traffic is improved dramatically for various traffic patterns. Cost evaluation results also show that the proposed router architecture requires negligible cost overhead but provides better performance for both advanced mesh NoC platforms. 相似文献
8.
High‐pressure vapour‐liquid equilibria for binary and ternary high polar and asymmetric systems are calculated using the Peng‐Robinson‐Stryjek‐Vera equation of state coupled with the Twu‐Coon (TWMR), the Orbey‐Sandler (OSMR) and the Wong‐Sandler (WSMR) mixing rules. Modified UNIFAC model is used for determining the activity coefficient and excess Gibbs free energy. The calculated results are compared with the experimental data and good agreement is observed. The average absolute deviation percents (AAD%)s indicated that the WSMR has less AAD% than other mixing rules in most of cases. 相似文献
9.
Multimedia Tools and Applications - Image retargeting is the task of making images capable of being displayed on screens with different sizes. This work should be done so that high-level visual... 相似文献
10.
Amir Khakbaz Ali S. Nookabadi S. Nader Shetab-bushehri 《Networks and Spatial Economics》2013,13(1):43-66
Traffic congestion is one of the main problems in large cities for which several approaches have been proposed. Park-and-ride is one of the best approaches that can remove traffic from the traffic network. Park-and-ride facilities are an important part of urban mass transit systems, effectively extending the service area and attracting commuters and other people who may not otherwise have used mass transit. However, its efficiency depends on its location in the urban network. In this research, we focus on travel time of shortest paths instead of the distance criterion for computing network traffic and develop a model for finding the best location(s) for siting park-and-ride systems so as to minimize the network traffic. The model is formulated based on population points, potential sites for park-and-ride establishment, and several Central Business District (CBDs). Then we present a Genetic algorithm that has been proved to be efficient in solving large size problems. Finally, the proposed model is used to locate park-and-ride facilities in the city of Isfahan, Iran. 相似文献