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Response surface methodology is often used by researchers in different fields to determine the optimum values for controlled variables to maximize or minimize the response variables. Either maximization or minimization might be necessary depending on the response property. For example, if the response variable represents the yield of a process, maximization could be necessary; on the other hand, if the response variable is the biological oxygen demand (BOD) of an effluent the aim would definitely be minimization

Response surface methodology can be used two ways. It can be applied to the full-scale production or it can be scaled to a laboratory or the pilot plant. When applied to the full-scale production, the method is known as evolutionary operation (EVOP). EVOP is the continuous optimization of a process. The optimum conditions in a production plant can change depending on many factors such as raw material, ambient temperature, and equipment wear. Therefore, controlled variables should be optimized continuously to keep the response variable as close as possible to the maximum or minimum value. Hence, controlled variables are systematically changed around a center point to depict any shift of the response variable from the extreme. A thorough discussion of EVOP is given by Box, Evolutionary Operation: A Method for Increasing Industrial Productivity, Appl. Statist., 6, 81-101 (1957).  相似文献   
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The aqueous leaf extracts of five different deciduous plants, namely, silver oak, flame of the forest, tanner’s senna, wattle and serviceberry, were used on their own and in combination with aluminium sulphate, stannous chloride and ferrous sulphate to dye wool by a simultaneous mordanting technique. The washing and light fastness properties of the developed shades were moderate to good. Based on the CIE 2000 spectral colour coordinate values (K/S, ΔL, Δa, Δb and ΔE), the developed shades were classified into four groups: yellow/brown, yellow, orange and dark grey. The use of aluminium sulphate gave medium shades (K/S = 8.24), while the stannous chloride and ferrous sulphate mordants provided deep shades (K/S = 30.5). Statistical analyses have shown that only the type of mordant and not the dye source significantly influenced the development of colour on wool. Hence, it was theoretically possible to use five selected leaves as a single mixture to produce four different colours on wool.  相似文献   
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A survey is given of the catalytic methods potentially available for the production of adipic acid by the oxidation of readily available hydrocarbon precursors under environmentally benign conditions. Encouraging results are reported using H2O2 as oxidant and microporous FeAlPO-5 as catalyst at moderate temperatures.  相似文献   
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Monolayer and bilayer coatings of TiAlN, AlCrN, and AlCrN/TiAlN were deposited onto tungsten carbide inserts using the plasma enhanced physical vapor deposition process. The microstructures of the coatings were characterized using scanning electron microscopy (SEM) and atomic force microscopy (AFM). The SEM micrographs revealed that the AlrN and AlCrN/TiAlN coatings were uniform and highly dense and contained only a limited number of microvoids. The TiAIN coating was non-uniform and highly porous and contained more micro droplets. The hardness and scratch resistance of the specimens were measured using a nanoindentation tester and scratch tester, respectively. Different phases formed in the coatings were analyzed by X-ray diffraction (XRD). The AlCrN/TiAlN coating exhibited a higher hardness (32.75 GPa), a higher Young's modulus (561.97 GPa), and superior scratch resistance (LcN = 46 N) compared to conventional coatings such as TiAlN, A1CrN, and TiN.  相似文献   
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Wireless Personal Communications - One of the applications of Sparse Linear Wireless Sensor Networks is environmental monitoring. In these networks, sensors are deployed in sensitive and strategic...  相似文献   
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Neural Computing and Applications - In the present study, a novel application of backpropagated neurocomputing heuristics (BNCH) is presented for epidemic virus model that portrays the Stuxnet...  相似文献   
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The recent research in biocompatible materials has been useful in replacing and supporting the fractured natural human bones/joints. Under some condition, negative reaction like release of ions from the bare metal toward the human body fluid leads to corrosion. In this proposed research paper, the biocompatibility of the laser surface-modified austenitic stainless steel (SS316L) and nickel-based superalloy (Inconel 718) was studied. The investigation on laser-modified surfaces is evaluated through electrochemical polarization analysis using simulated body fluid (SBF). The samples subjected to electrochemical polarization analysis were characterized by optical image analysis, SEM, EDS, and XRD analysis. It was inferred that laser surface-modified materials provided enhanced corrosion resistance and bare nickel alloy is more susceptible to corrosion by SBF.  相似文献   
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Introduction: Staphylococcal infection of endogenous origin is an important cause of morbidity and mortality in patients who receive hemodialysis (HD). The risk of such infections in nasal carriers of the organism is well defined. Extranasal carriage of the organism at extranasal sites may pose similar risks. Methods: A total of 70 patients about to undergo internal jugular vein catheterization for HD were enrolled in this prospective observational study. Swab cultures were obtained from anterior nares, posterior pharynx, axillae, toe web spaces, and vascular access sites at baseline and 1 week later. A patient was defined as a persistent carrier when the same organism was grown in both samples. Staphylococcus aureus bloodstream infections were assessed by blood and catheter tip cultures over a 90‐day period. Findings: The mean age of the patients was 43.71 ± 16.2 years. Persistent S. aureus carriage at anterior nares, throat, axilla, toe web spaces, vascular access site, and all sites was documented in 27.9%, 11.4%, 40%, 32.9%, 4.3%, and 64.2% of patients, respectively. Fifteen patients developed S. aureus infections. Catheter related S. aureus infections (CRI) were more likely in persistent carriers than nonpersistent carriers with odds ratios (95% CI) of 10.2 (2.8–37.1), 8.6 (1.7–42.2), 17.3 (3.4–86.0), 3.0 (0.9–9.8), and 1.9 (0.2–22.4) for anterior nares, throat, axilla, toe web spaces, and vascular access site carriers, respectively. The probability of developing CRI in persistent S. aureus carriers was 55% compared to none in noncarriers at 90 days (P = 0.04). Discussion: Extranasal S. aureus carriage is as significant a risk factor as nasal carriage for staphylococcal infections in patients on HD through catheters. The study is limited by lack of molecular phenotyping.  相似文献   
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Rare-earth ions (RE3+)-doped Ni-Zn ferrite nanoparticles with a structural formula of Ni0.5Zn0.5Fe1.8RE0.2O4 (RE3+ = Nd, Ce, La and Pr) were synthesized at room temperature by a sol-gel auto-combustion method. The structural and magnetic properties of Ni-Zn ferrite samples were carried out by XRD, vibrating sample magnetometer (VSM), field emission scanning electron microscopy (FE-SEM) and FT-IR spectroscopy. XRD pattern of Ni-Zn ferrite revealed that all the diffraction planes are in agreement with cubic spinel phase and the addition of Fe2O3 phase was also observed. In the case of RE ions-doped Ni-Zn ferrite in addition to the Fe2O3 phase, very low intensity peaks corresponding to some secondary phase are also present. The average crystallite sizes were found to be from 42 to 56 nm using the Scherer formula. The lattice constant (a) values are gradually decreased from 8.378 to 8.349 Å with different substitutions of RE3+ ions in the Ni-Zn ferrite samples. VSM analysis revealed that saturation magnetization values are decreased and coercivity values are increased with substitution of different RE3+ ions. FE-SEM images exhibits that particles are spherical in shape. FT-IR interpretation revealed that two main metal oxygen bands (564 and 411 cm?1) are observed in all the substituted Ni-Zn ferrite samples.  相似文献   
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