第二届全国激光新晶体材料学术会议简讯

由中国光学学会和中国硅酸盐学会共同组织的第二届全国激光新晶体材料学术会议于1983年11月25-29日在泉州市华侨大学陈嘉庚纪念堂举行.通过46篇学术论文的交流和讨论,反映出我国近三年来激光与非线性光学新晶体研究工作的蓬勃发展. 激光晶体的研究重点是:1.终端声子跃迁的可调谐激光晶体,主要有Cr～(3+):BeAl_2O_4和Ni2+:MgF_2。通过晶格动力学与晶格场理论相结合的分析探索新的基质晶体;2.稀土自激活小型激光晶体.积极研制跃迁通道丰富的HO～(3+),Er～(3+)激活晶体.对TbxDy_(1-N);P_5O_(14),Er-x(Gd,Y)1_(1-x)Al_3(BO_3)_4LiNd_(…     

Studies on Long-acting Insulin:Crystal Structure of Arg-B31 Human Insulin at 2.0 Resolution

The crystal structure of Arg-B31 human insulin(ABHI), a long-acting insulin derivative, has been determined at 2.0 resolution by using X-ray diffraction analysis. The final crystallographic R factor of the structure model after the refinement is 0.189 with the bond length r. m. s deviation of 0.018 . The refined structure of ABHI showed that the conformation of B-chain C-terminal residues was more stable than that in the native molecule. A striking structural feature of ABHI was an additional ion pair formed between ArgB31 of molecule Ⅰ and Glu-B21 of molecule Ⅱ in a dimer, and three ionic bonds between the neighbouring molecules thereby appeared on the surface of ABHI hexamer.These secondary bonds generated by the insertion of the residue Arg-B31 should make the rate of dissociation of ABHI hexamer slow down when it was injected into the body and the property of protraction should be produced by a 'depot effect'. This ought to be the main structure basis of the prolonged action of ABHI. The results o     

纳米铜修饰电极对多巴胺和抗坏血酸的同时测定

用电沉积方法制备了纳米铜修饰电极并将其用于混合溶液中多巴胺(DA)和抗坏血酸的同时测定。在优化的实验条件下,修饰电极对多巴胺和抗坏血酸具有良好的电催化响应,多巴胺的峰电流与浓度在8.0×10-7mol/L~1.0×10-4mol/L范围内成很好的线性关系,抗坏血酸的氧化峰电流与其浓度在8.0×10-6mol/L~1.0×10-3mol/L的范围成良好的线性关系。该修饰电极制备简单、稳定性好,用于样品检测,效果良好。     

并合不变中子质子产额比值角分布各向异性与对称能关系的研究

采用ImQMD05模型分析了非对称反应体系40Ar+197Au,124Sn在中低能区（E_beam=35~100 MeV/u）的半擦边反应的条件下的反应机制,并进一步探索了不同模型参数,如对称能斜率、碰撞参数等,对轻粒子并合不变中子质子产额之比角分布各向异性的影响。通过研究发现:对于出射动能大于每核子10 MeV的动力学出射的轻粒子而言,其并合不变的中子质子产额比值角分布各向异性与对称能的软硬具有明显的关联;碰撞参数对轻粒子动力学发射各向异性的影响最弱。By using the ImQMD05 code,we simulate the 40Ar+197Au,+124Sn at beam energy of 35,50 and 100 MeV/u and semi-peripheral collisions.The reaction mechanism,symmetry potential and Coulomb potential competition around the overlapped neck region and impact parameters effects are investigated for understanding the angular distribution of isospin contents of dynamical emitted light particles.Our results show that the angular anisotropy of the coalescence invariant neutron to proton yield ratios is sensitive to the stiffness of symmetry energy,especially for the dynamical emitted light particles with E_k>10 MeV.     

人肝癌细胞HepG2与正常肝细胞L02的O-糖链的比较分析

以培养的原发性肝细胞癌HepG2细胞和正常肝细胞L02为研究对象, 用细胞裂解液提取总蛋白, 然后采用Carlson还原性β-消除法释放O-糖链, 以阳离子交换柱结合C₁₈柱纯化分离O-糖链, 用电喷雾电离质谱(ESI-MS)和串联质谱(MS/MS)对O-糖链进行序列鉴定, 以β-环糊精为内标对2种细胞系的O-糖链进行定量比较分析. 结果表明, 在肝癌细胞系HepG2中检测到10种O-糖链, 正常细胞系L02中检测到9种O-糖链, 其中9种O-糖链是2种细胞系中共有的, 但HepG2中存在癌细胞中特有的缩短的O-糖链N1A1(NeuAc-GalNAc, sialyl Tn 抗原). t检验结果表明, HepG2与L02相比, 在检测到的10种O-糖链中有5种的含量具有极显著性差异(P<0.01), 2种的含量具有显著性差异(P<0.05).     

1-苯基-3-甲基-5-吡唑啉酮(PMP)柱前衍生化寡糖链的HPLC分离及其激光解吸电离质谱分析

以1-苯基-3-甲基-5-吡唑啉酮(PMP)为衍生化试剂对寡糖链进行标记, 用氨水替代氢氧化钠溶液作碱性介质, 衍生化反应后氨水可通过干燥除去, 省去了脱盐处理过程, 衍生化的寡糖可直接进行激光解吸电离质谱分析. 建立起了PMP衍生化寡糖的RP-HPLC分离分析模式, 在此HPLC分析条件下, 可以对标记的寡糖链进行样品分离及制备.     

应用有机结构数据库系统研究钼簇合物的键价规律

本文基于有机结构数据库CSD中簇合物的大量信息, 依靠计算机检索、图形显示和运算功能, 系统分析了449个钼簇合物的价电子总数和Mo-Mo键的键价, 键长, 提出钼簇合物的价电子Counting规则和Mo-Mo键的总键价计算修正公式, 总结出Mo-Mo键的键价、健长等。     

气态ClO2体积分数与爆炸压力的关系

采用20 L柱状爆炸罐研究了气态ClO2的爆炸特性,得出了气态ClO2分解爆炸的体积分数下限为9.5%,不存在上限。在实验条件下,气态ClO2的爆炸压力随体积分数的增加而增大,体积分数为90%时,最大爆炸超压达到0.64 MPa,且气态ClO2的爆炸压力与其体积分数梯度有关。最大爆炸超压出现的时间随气态ClO2体积分数的增加而缩短,体积分数为10%时,最大爆压在2 195 ms时出现,当体积分数达到70%时,最大爆压出现的时间在10 ms以内,体积分数继续增加,最大爆压出现的时间基本维持在8 ms。     

在重核和超重原子核中量子混沌问题的研究

通过观察和分析重核和超重核中量子谱的统计性质 ,研究有限物理体系中量子混沌的一些问题 .介绍了原子核中量子谱显示的有序 -混沌现象随激发能变化的实验数据 ,研究了超重核体系中量子谱相邻能级间距分布的规则性随体系的依赖关系 ,并预言了稳定的超重体系 .给出了原子核有序混沌相变现象与原子核形变以及原子核转动的依赖关系 ,讨论了量子体系中的对效应对有序 -混沌相变的影响 .最后 ,用有序 -混沌相变的概念解释和理解了核物理中一些重要的实验现象. Some aspects of quantum chaos in a finite system had been studied based on the analysis of statistical behaviors of quantum spectra in heavy and superheavy nuclei. The dependence of the transition from order to chaos on nuclear deformation and nuclear rotatation had been described. The influence of pairing effect on the statistical properties of spectra is also discussed. Some important experiment phenomena in nuclear physics had been understood from the point of view of interplay...     

The Δ mass dependence of the M matrix and its influence on the NΔ→NN cross-sections

TheΔmass dependence of the M matrix and its influence on the NΔ→NN cross-sections are investigated in the one-boson exchange model.Our calculations show that theΔmass dependence of the momentum of the outgoingΔand the M matrix affects the calculations ofσNΔ→NN,especially around the threshold energy.