人类腺病毒及其相关的皮肤病

人类腺病毒共有6个亚属，49个血清型；可引起众多组织、细胞的急慢性感染和隐伏感染。其E1A、E1B成分可诱导细胞癌变，抑制细胞凋亡。皮肤的很多病变与腺病毒有关，许多证据表明其急慢性感染和隐伏感染可能是银屑病等自身免疫性疾病的病毒灶或激发点，对腺病毒的研究将为银屑病病因学的研究提供证据。     

核因子—κB与银屑病的研究进展

核因子－κB是一个分布广泛的转录因子，可通过调控细胞因子、趋化因子、生长因子、粘附分子等相关基因的表达，参与免疫应答、炎症反应、细胞生长及凋亡等生理和（或）病理过程。现综述了核因子－κB在皮肤炎症反应中的活化过程及其与银屑病之间的可能关系。     

CpG ODN刺激的寻常性银屑病中性粒细胞培养上清液对HaCaT细胞增殖的影响

Objective To investigate the role of nentrophils in the pathogenesis of psoriasis vulgaris. Methods Neutrophils were isolated from venous blood samples of 25 patients with psoriasis vulgaris (including 13 cases of active psoriasis and 12 cases of inactive psoriasis) as well as 25 normal human con-trols, and cultured. Then, these neutrophils were grouped and treated with lipopolysaccharide (LPS, 100 g/L),CpG-A (50 mg/L), CpG-B (50 mg/L), and RPMI 1640 culture medium, respectively, for 24 hours followed by the collection of culture supematants. Human keratinocytes (HaCaT) were cultured in the presence of su-pematants of treated or untreated nentrophils for 72 hours followed by the detection of cell proliferation with MTT assay. To determine the role of proinflammatory factors, SOD/CAT and monoclonal antibody to IL-8 and TNF-alpha of 400 u/mL were used to pretreat HaCaT cells 1 hour prior to the stimulation with super-natants of neutrophils. Results Compared with culture medium, the supematant of unstimulated neutrophils from normal controls or patients with inactive psoriasis had no significant effect on the proliferation of HaCaT cells (P ＞ 0.05), but that from patients with active psoriasis markedly promoted the proliferation of HaCaT cells (t = 2.41, P < 0.05). ARe, stimulation by LPS, CpG-A and CpG-B, the supematant of active patient-derived neutrophils significantly promoted the proliferation of HaCaT cells compared with that of normal control-derived nentrophils (t = 3.11, 2.89, 2.29, respectively, all P < 0.05). In comparison with tmstimulated neutrophils, the supematant from LPS- and CpG-A stimulated nentrophiles significantly accelerated the pro-liferation of HaCaT cells. Furthermore, the proliferation of HaCaT cells induced by the supematants of LPS-,CpG-A-, CpG-B-stimulated neutrophils from psoriatic patients was statistically suppressed by the pretreat-ment with the monoclonal antibody to IL-8, TNF-alpha and SOD/CAT (all P < 0.05). Conclusions In patients with psoriasis vulgaris, there is an abnormal secretion of IL-8, TNF-alpha and superoxide by neutrophils in peripheral blood, and these proinflammatory factors could promote the proliferation of HaCaT cells.     

窄谱中波紫外线治疗银屑病的机制与临床应用

窄谱中波紫外线(NBUVB)越来越多地用于皮肤病的治疗并被证明有很好的效果和安全性。本文从治疗机制及临床应用等方面对NBUVB治疗银屑病的情况及研究进展展开论述。     

银屑病关节炎的X线诊断（附28例分析）

银屑病关节炎的X线表现，国内近年来陆续有报告（1，2），本文除描写本病的特征性表现外，重点讨论本病与类风湿性关节炎的鉴别。     

穴位注射治疗银屑病100例

笔者自1996年以来,采用自血穴位注射疗法治疗银屑病100例,效果满意,报道如下. 1一般资料 收集本院皮肤科门诊寻常型银屑病进展期患者100例,其中男60例,女40例;年龄14～60岁,平均36.5岁;病程最短8个月,最长8年.泛发者60例,仅限于双下肢者15例,头部及四肢者25例.