穿水冷却工艺对HRB400热轧带肋钢筋性能的影响

生产钢筋混凝土用HRB400热轧带肋钢筋时,钒铁和锰铁合金用量占有较大比率对钢材成本的影响很大。为寻求1种可以减少合金元素的替代方法,以降低成本,进行了穿水冷却工艺生产HRB400热轧带肋钢筋性能试验研究。结果表明,采用穿水冷却工艺,可以提高钢筋的屈服强度30~70 MPa,而且能够改善产品表面质量。在产品质量性能满足国家标准要求的情况下,试验的HRB400钢筋吨钢降低合金成本50元左右。     

基于切断称重法的细纱机牵伸区内纤维变速点分布研究

为探究细纱机牵伸区内纤维的变速点分布,以纺制29.2、22.4、18.2 tex棉纱为例,采用CCZ-X三罗拉双区牵伸细纱机进行纺纱实验,采用等长切断称重法对牵伸区内须条的质量分布进行测试,以其质量变化分布表征变速点分布,得到质量变化折线图,对比分析纤维在牵伸区内变速集中的位置,从而探究牵伸区内纤维变速规律.结果表明:...     

求解对称带状广义特征值问题的扩展分治算法

提出了分布式环境下计算对称带状广义特征值问题的一种扩展分治算法,给出了特征值分割定理及其证明．算法在扩展分治的基础上,利用二分压缩结合广义Rayleigh商迭代计算广义特征对．理论分析和数值实验表明,对于窄带宽大规模的广义特征值问题,该分治算法明显优于LAPACK软件包．结合并行性好的多分法,在分布式环境下获得了很好的并行效果．     

Distribution-free double-sampling precedence monitoring scheme to detect unknown shifts in the location parameter

In most applications, parametric monitoring schemes are used to monitor the majority of industrial and nonindustrial processes in order to improve the quality of the outputs or services. However, parametric monitoring schemes are known to underperform when the normality assumption is not met or when there is not enough information about the symmetry or asymmetry nature of the process underlying distribution. Hence, in this paper, a new nonparametric Phase II Shewhart-type double-sampling (DS) monitoring scheme based on the precedence statistic is proposed in order to efficiently monitor quality processes when the underlying process distribution departs from normality. The performance is investigated using the average run length (ARL), standard deviation of the run length (SDRL), expected ARL (EARL) and expected average number of observations to signal (EANOS), and the average sample sizes (ASS) metrics. The latter metrics are computed using Monte Carlo simulation and exact formulae. In general, it is shown that the new DS precedence scheme outperforms the existing basic Shewhart precedence scheme with and without supplementary runs rules in many situations. A real-life illustrative example based on a filling process of milk bottles is provided to demonstrate the application and implementation of the new DS precedence monitoring scheme.     

Physicochemical stability,pharmacokinetic, and biodistribution evaluation of paclitaxel solid dispersion prepared using supercritical antisolvent process

Aim: To investigate the physicochemical stability, pharmacokinetics (PK), and biodistribution of paclitaxel (PTX) from paclitaxel solid dispersion (PSD) prepared by supercritical antisolvent (SAS) process.

Methods: Physicochemical stability was performed in accelerated (40°C 70?±?5% RH) and stress (60°C) storage conditions for a period of 6 months and 4 weeks, respectively. PK and biodistribution studies were performed in rats following i.v. administration of PTX equivalent to 6 and 12?mg/kg formulations.

Results: Physical stability of PSD showed excellent stability with no recrystallization of the amorphous form. Chemical stability of PSD in terms of % PTX remaining was 98.2?±?0.6% at 6 months and 97.9?±?0.3% at 4 weeks of accelerated and stress conditions, respectively. The PK study showed a nonlinear increase in AUC with increasing dose, that is, 100% increase in dose (from 6 to 12?mg/kg) resulted in 405.90% increase in AUC. Unlike PK study, the organ distribution study of PTX from PSD showed linear relationship with dose escalation. The order of organ distribution of PTX from highest to lowest for both PSD and Taxol^® was liver>kidney>lung>brain.

Conclusions: This study demonstrated excellent physicochemical stability with insight information on the PK and biodistribution of PTX from PSD prepared by SAS process.     

对称转台在微波器件加工过程中的应用

为提高微波器件的加工合格率,将对称转台应用于微波器件加工的硬件设施中,并分析了对称加工的特点。以某微波器件加工为例,简要介绍了对称转台的应用。实践证明,对称转台的使用提高了微波器件的加工质量、降低了成本。     

Robustness of differentiation cascades with symmetric stem cell division

Stem cells (SCs) perform the task of maintaining tissue homeostasis by both self-renewal and differentiation. While it has been argued that SCs divide asymmetrically, there is also evidence that SCs undergo symmetric division. Symmetric SC division has been speculated to be key for expanding cell numbers in development and regeneration after injury. However, it might lead to uncontrolled growth and malignancies such as cancer. In order to explore the role of symmetric SC division, we propose a mathematical model of the effect of symmetric SC division on the robustness of a population regulated by a serial differentiation cascade and we show that this may lead to extinction of such population. We examine how the extinction likelihood depends on defining characteristics of the population such as the number of intermediate cell compartments. We show that longer differentiation cascades are more prone to extinction than systems with less intermediate compartments. Furthermore, we have analysed the possibility of mixed symmetric and asymmetric cell division against invasions by mutant invaders in order to find optimal architecture. Our results show that more robust populations are those with unfrequent symmetric behaviour.     

Star graph automorphisms and disjoint Hamilton cycles

The search for edge-disjoint Hamilton cycles in star graphs is important for the design of interconnection network topologies. We define automorphisms for star graphs St _n of degree n?1, for every positive odd integer n, which yield permutations of labels for the edges of St _n taken from the set of integers between 1 and ? n/2 ?. By decomposing these permutations into permutation cycles, we are able to identify edge-disjoint Hamilton cycles that are automorphic images of a known Hamilton cycle in St _n . Our method produces a better than two-fold improvement from ? ? (n)/10 ? to ? 2? (n)/9 ?, where ? is the Euler function, for the known number of edge-disjoint Hamilton cycles in St _n for all odd integers n. For prime n, the improvement is from ? n/8 ? to ? n/5 ?, and we can extend this result to the case when n is the power of a prime greater than 7.     

Implicit Runge–Kutta methods based on Radau quadrature formula

Using W-transformation of Hairer and Wanner, high-order implicit Runge–Kutta methods based on Radau quadrature are studied. Methods constructed and presented include and extend the existing RadauIA, IB, IIA, IIB type RK methods. 2- and 3-stage general Radau RK methods with two parameters (δ, γ) are constructed. The RK methods with five parameters (α, β, γ, δ, τ), which include both Radau and Lobatto type methods, will be discussed at last.     

An accelerated first-order method for solving SOS relaxations of unconstrained polynomial optimization problems

Our interest lies in solving sum of squares (SOS) relaxations of large-scale unconstrained polynomial optimization problems. Because interior-point methods for solving these problems are severely limited by the large-scale, we are motivated to explore efficient implementations of an accelerated first-order method to solve this class of problems. By exploiting special structural properties of this problem class, we greatly reduce the computational cost of the first-order method at each iteration. We report promising computational results as well as a curious observation about the behaviour of the first-order method for the SOS relaxations of the unconstrained polynomial optimization problem.