Mass customization of medical devices and implants: state of the art and future directions

The medical field is one in which the need for customization can be clear cut, as providing tailored devices and implants for unique physiologies can provide for a better overall treatment than the use of ‘off the shelf’ devices and implants. Customization in the production of medical products can be roughly divided into consideration of medical devices, and of implantable parts or systems. The present paper outlines the current state of the art in both of these areas, presents details of projects that are ongoing at the University of Leeds and outlines future research directions.     

Comparison of an effect-model-law-based method versus traditional clinical practice guidelines for optimal treatment decision-making: application to statin treatment in the French population

Healthcare authorities make difficult decisions about how to spend limited budgets for interventions that guarantee the best cost-efficacy ratio. We propose a novel approach for treatment decision-making, OMES—in French: Objectif thérapeutique Modèle Effet Seuil (in English: Therapeutic Objective–Threshold–Effect Model; TOTEM). This approach takes into consideration results from clinical trials, adjusted for the patients'' characteristics in treatment decision-making. We compared OMES with the French clinical practice guidelines (CPGs) for the management of dyslipidemia with statin in a computer-generated realistic virtual population, representing the adult French population, in terms of the number of all-cause deaths avoided (number of avoided events: NAEs) under treatment and the individual absolute benefit. The total budget was fixed at the annual amount reimbursed by the French social security for statins. With the CPGs, the NAEs was 292 for an annual cost of 122.54 M€ compared with 443 with OMES. For a fixed NAEs, OMES reduced costs by 50% (60.53 M€ yr⁻¹). The results demonstrate that OMES is at least as good as, and even better than, the standard CPGs when applied to the same population. Hence the OMES approach is a practical, useful alternative which will help to overcome the limitations of treatment decision-making based uniquely on CPGs.     

基于FSA的卫星任务规划流程定制平台设计

随着卫星任务规划资源种类和数量的逐渐增加,基于固定规划流程的卫星任务规划系统凸显出多项弊端,为解决这些问题,通过分析卫星任务规划流程的特点,提出了基于可定制有限状态自动机(FSA)模型的任务规划流程定制平台系统。利用有限状态自动机模型,将卫星任务规划流程中的各业务环节看成该模型中的不同状态,通过状态设置完成流程的定制和调整,以实现对卫星任务规划流程的灵活定制。经过对实验系统的运行结果分析表明,该平台设计可以有效地降低任务规划流程调整的复杂程度,提升卫星任务规划系统的可扩展性。     

The nature of choice in mass customized house building

There is a need to explore the actual uptake of specification options by clients in the context of the self-build housing industry. In so doing all the components in a house that can be customized were categorized so as to highlight the features that must be customizable and those that can be standardized. Through a longitudinal study of a German house builder, data from 16 projects over a 35-year time horizon have been collected. The extent of choice made in these projects has been determined by comparing the original standard building specification with the actual finalized fit-out specification of the project. In scrutinizing the collected data it became apparent that the number of changes made by the clients increased considerably over the timespan studied. More importantly, clients appreciated the freedom of choice as they were prepared to spend increasing amounts on customization. In particular specification options were made in the sanitary, internal design and façade categories. Moreover the results revealed that offering a high degree of choice is appropriate for most, but not all, components for the case house builder. Key areas for choice include those relating to sanitary ware and the façade.     

Managerial identity work in action: performative narratives and anecdotal stories of innovation

Innovation is invariably accepted as a central component of construction sector competitiveness. Yet, there remains a paucity of empirical research, which explores the gap between the way innovation is promoted in the policy discourse and how it is interpreted in practice. We follow the “narrative turn” in organization studies to explore the ways in which senior executives in the UK construction sector ascribe themselves with informal roles while advocating the cause of innovation. Empirical data is derived from narrative interviews with 32 senior executives who self-identify as “innovation champions”. When talking about innovation, the respondents were found to oscillate between performative narratives of innovation and more personalized stories derived from their own experience. The narratives were invariably pre-rehearsed often to the point of being monotonous. In contrast, the personalized stories tended to be engaging and emotionally laden. The tendency for senior executives to oscillate between narratives and stories is seen as an important means through which they search for meaning while at the same time legitimizing their self-identities as “innovation champions”. Of particular note is the way in which senior managers self-ascribe themselves with informal roles which are notably at odds with those described in more formalized narratives.     

面向个性化产品服务方案的推荐方法与应用

针对传统隐语义模型（LFM）未考虑数据库动态更新从而影响方案推荐结果的问题,提出动态更新机制的加权LFM用于推荐个性化产品服务方案。针对余弦相似度 计算忽略个体差异的问题,提出采用云滴距离测度与云的余弦相似度加权后的综合相似度,预测并填充空缺数据,减少数据稀疏性;采用加权LFM推荐产品服务方案,以约束新用户兴趣差异性,提高推荐精度;采用差值平均法更新推荐结果。     

大规模定制模式下定制程度的优选分析

大规模定制运用于生产时,定制程度可作为功能的个性化程度.从制造设计的角度来看,定制化产品的类设计参数与类功能需求间存在映射关系,而类功能需求可由定制程度予以表达后进行加权评分;从顾客认可和销售利润来看,顾客对定制化产品的认可可借以顾客满意度来反应,如果针对具体的产品,顾客满意度和产品销售利润均可找到以定制程度为变量的拟合函数.因此,在追求类功能需求评分、顾客满意度和利润函数值尽可能高的目的下,可以求出定制程度的最优解.     

大规模定制生产的系统协同思想及理论与方法

提出了大规模定制生产有效实施的系统集成和协同思想,强调系统整体规划下的产品设计(包括顾客和市场)、生产过程和供应链管理等多个领域的系统实施;讨论了大规模定制生产核心技术体系为主导的生产协同性,以及大规模定制生产实施技术的集成性.在此基础上,提出了相关的研究问题.     

The Importance of Platelets Response during Antiplatelet Treatment after Ischemic Stroke—Between Benefit and Risk: A Systematic Review

Ischemic stroke is a disease related to abnormal blood flow that leads to brain dysfunction. The early and late phases of the disease are distinguished. A distinction is made between the early and late stages of the disease, and the best effect in treating an ischemic stroke is usually achieved within the first hours after the onset of symptoms. This review looked at studies platelet activity monitoring studies to determine the risks and benefits of various approaches including antiplatelet therapy. A study was conducted on recently published literature based on PRISMA. This review includes 32 research articles directly addressing the importance of monitoring platelet function during antiplatelet therapy (dual or monotherapy) after ischemic stroke. In patients with transient ischemic attack or ischemic stroke, antiplatelet therapy can reduce the risk of stroke by 11–15%, assuming that patients respond well. Secondary prevention results are dependent on platelet reactivity, meaning that patients do not respond equally to antiplatelet therapy. It is very important that aspirin-resistant patients can benefit from the use of dual antiplatelet therapy. The individualized approach to secondary stroke prevention is to administer the most appropriate drug at the correct dose and apply the optimal therapeutic procedure to the individual patient.     

面向大批量定制的层次双向驱动式生产计划生成方法

将基于市场预测的部件主生产计划和面向订单的组装计划相互结合,共同协调企业的生产能力和资源需求,以加强企业对市场的快速响应和满足用户多样化需求的能力.综合销售预测、产品竞争力、企业生产能力和成本效益等因素,提出“综合预测”的概念,以降低库存成本,提高企业效益.结合叉车生产计划系统实例,实现了一种面向大批量定制的层次双向驱动式生产计划生成方法.