参芎注射液对腹膜透析患者转化生长因子β1的影响

目的观察参芎注射液对腹膜透析患者转化生长因子β1(TGFβ1)及腹膜功能的影响。方法选择2012年12月至2014年5月我院肾内科进行腹膜透析的60例患者,随机分为2组:常规腹膜透析组(对照组)和参芎注射液腹膜透析组(观察组),每组30例。比较两组相关临床和生化指标,应用ELISA法检测TGFβ1表达。结果治疗前,两组肌酐透析液与血浓度之比(D/Pcr)、尿素清除指数(KT/V)、肌酐清除率(Ccr)、尿量和超滤量比较差异无统计学意义(P>0.05)。治疗后,对照组上述指标无显著变化(P>0.05);观察组D/Pcr、KT/V、Ccr、尿量与治疗前比较差异无统计学意义(P>0.05),但超滤量升高(P<0.01)。两组血浆白蛋白(ALB)、钙(Ca)、磷(P)、甲状旁腺素(iP TH)在治疗前、后比较差异均无统计学意义(P>0.05)。治疗前,两组TGFβ1表达水平比较差异无统计学意义(P>0.05);治疗后,对照组TGFβ1表达无显著变化(P>0.05),但观察组显著减低(P<0.01)。结论参芎注射液可显著提高腹透患者的超滤量,抑制腹膜细胞的TGFβ1分泌,具有抗腹膜纤维化的功效。     

中药膏剂对钳刮术患者术后阴道流血的作用

目的 观察中药膏剂贴敷于相关穴位对行人工流产钳刮术患者术后阴道流血的改善情况。方法 将来我院妇科行人工流产钳刮术的患者分为对照组87例和观察组82例，对照组患者按照常规人工流产钳刮术后护理方式护理；观察组同时采用中药（包括当归、川芎、三七、炮姜）制作的膏药贴敷于相关穴位（包括神阙、气海、中极穴位），观察两组患者术后不同时间阴道流血量和流血持续时间。结果 与对照组相比，观察组患者术后1h、2h及6h阴道流血量和术后阴道流血持续时间均减少（P〈0．05）。结论 采用此中药膏剂贴敷于相关穴位能减少人工流产钳刮术患者术后出血量和出血时间，促进患者术后康复。     

热毒宁治疗急性肠炎发热疗效观察

目的：观察热毒宁治疗腹泻发热的疗效。方法我院急诊2013年1月-2013年12月就诊的肠炎发热患者82例，将患者随机分为观察组（41例）和对照组（41例）。对照组给予对症处理，观察组在对照组的基础上，静脉滴注热毒宁注射液20 mL，1次/d。两组疗程均为3d。结果观察组治愈36例，好转4例，无效1例；对照组治愈23例，好转9例，无效9例。两组疗效比较差异有统计学意义（P＜0.05）。结论热毒宁注射液治疗急性肠炎发热疗效显著。     

丹红注射液对肾病综合征患者肾血流动力学及血液黏稠状态的影响研究

目的探讨丹红注射液对肾病综合征患者肾血流动力学及血液黏稠状态的影响。方法选取2008年7月～2010年12月于某院进行治疗的64例初发原发肾病综合征患者为研究对象,将其随机分为对照组和观察组各32例,对照组采用泼尼松联合双嘧达莫进行治疗,观察组在对照组的基础上加用丹红注射液进行治疗,后将两组患者治疗前及治疗后4周的肾动脉血流动力学及血液流变学指标进行对比。结果治疗后观察组的肾动脉血流动力学及血液流变学指标的改善幅度均大于对照组,治疗后两组上述检测项目比较,P均﹤0.05,差异均有统计学意义。结论丹红注射液在改善肾病综合征患者肾血流动力学及血液黏稠状态方面均发挥着积极的作用,对于改善肾脏血液循环效果明显。     

益气复脉注射液治疗急性心衰临床疗效观察

目的探讨益气复脉注射液治疗急性心功能不全的临床疗效。方法将2012年6月至2013年12月在我院急诊科治疗的85例急性心功能不全患者分为2组。对照组41例给予常规西医抗心衰治疗,给予利尿剂、血管紧张素转换酶抑制剂、β受体阻滞剂、洋地黄等。治疗组44例在西医治疗的基础上应用益气复脉注射液5.2 g加入5%葡萄糖250 m L,1次/d静滴。观察患者的症状、体征、心功能分级。两组患者治疗前及治疗14 d后测定脑钠肽(BNP)。超声心动图检查测定左房径(LAD),左室舒张末期容积(EDV),左室射血分数(LVEF),二尖瓣口舒张早期最大血流速度(E峰)、舒张晚期最大血流速度(A峰)。结果治疗组总有效率高于对照组,差异有统计学意义(P<0.05);观察组患者疲乏、心悸、呼吸困难、心绞痛等症状缓解时间均短于对照组,差异有统计学意义(P<0.05)。治疗后,治疗组BNP浓度低于对照组射血分数及E/A高于对照组,左房内径及左室舒张末期容积低于对照组,差异均有统计学意义(P<0.05)。结论益气复脉注射液能明显改善心衰患者的临床症状及心脏功能,无明显不良反应,是治疗急性心功能不全较理想的药物。     

Does Reduction of Number of Intradetrusor Injection Sites of aboBoNTA (Dysport?) Impact Efficacy and Safety in a Rat Model of Neurogenic Detrusor Overactivity?

Intradetrusor injections of Botulinum toxin A—currently onabotulinumtoxinA—is registered as a second-line treatment to treat neurogenic detrusor overactivity (NDO). The common clinical practice is 30 × 1 mL injections in the detrusor; however, protocols remain variable and standardization is warranted. The effect of reducing the number of injection sites of Dysport^® abobotulinumtoxinA (aboBoNTA) was assessed in the spinal cord-injured rat (SCI). Nineteen days post-spinalization, female rats received intradetrusor injections of saline or aboBoNTA 22.5 U distributed among four or eight sites. Two days after injection, continuous cystometry was performed in conscious rats. Efficacy of aboBoNTA 22.5 U was assessed versus aggregated saline groups on clinically-relevant parameters: maximal pressure, bladder capacity, compliance, voiding efficiency, as well as amplitude, frequency, and volume threshold for nonvoiding contractions (NVC). AboBoNTA 22.5 U significantly decreased maximal pressure, without affecting voiding efficiency. Injected in four sites, aboBoNTA significantly increased bladder capacity and compliance while only the latter when in eight sites. AboBoNTA significantly reduced NVC frequency and amplitude. This preclinical investigation showed similar inhibiting effects of aboBoNTA despite the number of sites reduction. Further studies are warranted to optimize dosing schemes to improve the risk-benefit ratio of BoNTA-based treatment modalities for NDO and further idiopathic overactive bladder.     

长效青霉素注射法的改进

<正>长效青霉素又名苄星青霉素,是青霉素二苄基乙胺盐与适量缓冲剂及混悬剂合制成的无菌粉末。为了延长药物的稀释和吸收,在制作过程中加入了缓冲剂及混悬剂,混悬剂在重力作用下会发生沉淀后聚集而不能分散,极易发生药液堵塞针头,反复多次注射不仅给患者带来痛苦,而且还浪费了药液,影响了治疗效果。我科采用改良方法注射,效果好。现介绍如下。1方法首先用5ml注射器抽取无菌生理盐水3.5ml稀释长效青霉素,摇匀后抽取药液,排尽空气后备     

Clinical Evaluation of Intravitreal Injection of Ganciclovir in Refractory Corneal Endotheliitis

ABSTRACT

Purpose: To evaluate the efficacy and safety of intravitreal ganciclovir (GCV) injection in refractory endotheliitis.

Methods: Retrospectively recruited 25 eyes with endotheliitis, proved by clinical manifestations, positive PCR for viral DNA and responded poor to topical and systemic antiviral medications. All patients received additional continued intravitreal GCV injections.

Results: Cytomegalovirus (CMV), varicella zoster virus (VZV), and herpes simplex virus (HSV) DNA were detected in 64.0%, 28.0%, and 8.0% of the eyes, respectively. Within 2 weeks after the last injection, 16/25 eyes recovered corneal clarity; active keratic precipitates (KPs) were eliminated in 21/25 eyes; intraocular pressure (IOP) was controlled in 12/15 eyes with elevated IOP on study entry. Best-corrected visual acuity increased at the last follow-up (p = 0.016). Clinical recurrence occurred in three patients. No complications were detected.

Conclusions: CMV endotheliitis was the main type of refractory endotheliitis. Despite its invasive nature, intravitreal GCV injection appears to be an effective method for refractory endotheliitis.