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81.
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目的观察来得时联合拜唐平治疗初发Ⅱ型糖尿病的临床疗效,并作安全性评价。方法将符合初发Ⅱ型糖尿病纳入标准病例90例,按入院顺序随机分为治疗组45例与对照组45例,对照组予以诺和灵30R治疗,治疗组给予来得时联合拜唐平治疗,比较两组的疗效,以及两组治疗前后各项实验室指标的变化情况。结果治疗组总有效率明显优于对照组(P〈O.05),且治疗组在降低空服血糖、餐后2小时血糖及糖化血红蛋白水平方面均明显优于对照组(P〈0.05或P〈0.01)。治疗组低血糖发生率明显低于对照组,差异有统计学意义(P〈0.05)。结论来得时联合拜唐平治疗初发Ⅱ型糖尿病疗效确切,安全有效,低血糖发生率低,值得临床推广应用。 相似文献
83.
目的观察和分析盐酸替罗非班对ST段抬高心梗患者急诊经皮冠状动脉介入治疗中血流的影响和临床疗效。方法选取2013年2月~2014年4月我院收治的急诊入院36例STEMI急性心肌梗死行PCI患者,随机分成两组,每组各18例,其中观察组PCI术前开始采用盐酸替罗非班,对照组采用常规PCI术,观察两组患者术前和术后冠状动脉血流情况。结果 观察组患者恢复TIMI3级血流比例明显高于对照组,观察组术后TIMI血流3级发生率为(94.4%),常规PCI的对照组术后TIMI血流为(83.3%),P0.05。结论 在对STEMI患者进行急诊经皮冠状动脉介入治疗采用替罗非班可改善患者梗死相关血管的TIMI血流。 相似文献
84.
Diltiazem hydrochloride-ethylcellulose microspheres were prepared by the water-in-oil emulsion-solvent evaporation technique. Small and spherical microspheres having a mean microsphere diameter in the range of 40-300 µm and entrapment efficiency of ~60-90% were obtained. Scanning electron micrographs of drug-loaded microspheres showed the presence of uniformly distributed small pores and absence of drug crystals on their surface, indicating simultaneous precipitation of drug and the polymer from the solvent during solvent evaporation. Differential scanning calorimetric analysis confirmed the absence of any drug-polymer interaction. The in vitro release profile could be altered significantly by changing various processing parameters to give a controlled release of drug from the microspheres. The stability studies of the drug-loaded microspheres showed that the drug was stable at storage temperatures, 5-55°C, for 12 weeks. 相似文献
85.
目的:采用高效液相色谱法代替国家标准中TLC检测合成盐酸甲基麻黄碱相关物质,完善合成盐酸甲基麻黄碱质量标准。方法:以苯基键合硅胶为固定相(Alhima色谱柱250mm×4.6mm),以0.15M醋酸盐缓冲液:甲醇(94:6)用冰乙酸调节pH值至4.0。检测波长257nm,流速1.0ml/ml。结果:专属性,样品与对照品分离度〉2.0;系统适用性,峰面积变化的RSD为1.1%;在10.13~81.04μg/ml范围内,线性关系良好(1=0.9999);重现性RSD为1.26%、耐用性符合要求、准确度RSD为1.31%;HPLC法检测限为:0.004%;TLC法检测限为0.25%。结论:方法快速、简便,重现性好,灵敏度高,可用于盐酸甲基麻黄碱相关物质检测。 相似文献
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87.
Gabriela Roncholeta De Freitas Giovana Aparecida Moura Ferraz Marcelo Gehlen Thelma L. Skare 《Primary Care Diabetes》2021,15(1):184-186
Dry eyes may be caused by impairment in the tear production or excessive tear evaporation and are associated with photophobia, red eyes, vision impairment, local pain and pruritus. It has been described that patients with Diabetes Mellitus (DM) may have a higher prevalence of dry eyes than normal population.This is a case control study of 120 patients with Diabetes Mellitus (DM) and 120 paired controls aiming to compare their prevalence of dry eyes (by the Schirmer test) and its severity (measured by OSDI or Ocular Surface Disease Index) as well as their association with diseases’ clinical variables.We found that 38.3% of DM patients had dry eyes, a prevalence that was higher than controls (p = 0.02). At univariate analysis, they were found to be more common in older individuals (p = 0.001) with type 2 diabetes (p = 0.001) and in those using metformin (p = 0.001). A multivariate linear regression showed that metformin use was the only independent variable associated with dry eyes. When patients with dry eyes with and without DM were compared, no differences in the symptom’s intensity were found. 相似文献
88.
L. RAMIREZ 《Journal of microencapsulation》2013,30(1):105-115
Tetracaine does not result in effective treatment of intractable pain caused by trigeminal neuralgiabecause of its short duration of effect. In asustained release system a controlled delivery of the drug at the site of administration, would avoid successive administrations. Tetracaine hydrochloride (HCl) has been encapsulated using a technique based on the evaporation of solvent from an O/O emulsion, using poly(dl-lactic-co-glycolic acid) (PLGA) 50:50. Microspheres were separated into three fractions: 106-212, 212-300 and 300-425mum. The effects of two variables of the manufacturing method (volume of the inner phase of the emulsion and volume of surfactant added to the external phase) on the drug loading into microspheres, dissolution profiles and SEM characterization of the microspheres were evaluated. Microspheres containing tetracaine hydrochloride (up to94% referred tothe theoretical) released the drug, in-vitro, over 35 days. Tetracaine HCl was delivered according to zero order kinetics from day 5 until the end of the release assay. The rate of drug release depended mainly on the viscosity of the discontinuous phase and on the size of microparticles. Microsphere size resulted more homogeneous when using the highest volume of the surfactant, being almost 80% of microparticles within the range 212-300mum. 相似文献
89.
目的进行诺氟沙星片粉末直接压片法的工艺研究。方法采用正交实验筛选处方,以物料流动性、硬度、溶出度、脆碎度、片重差异限度范围为评价指标选择最佳处方并验证。通过稳定性试验对片子的外观、含量、溶出度、有关物质进行考察。结果所选处方物料流动性好,有效成分溶出快,各项指标符合规定,稳定性良好。结论本工艺简单、便捷,质量稳定,适合工业化生产。 相似文献
90.