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101.
Hideyuki Hyogo Sho-ichi Yamagishi Sayaka Maeda Yuki Kimura Tomokazu Ishitobi Kazuaki Chayama 《Clinical biochemistry》2012
Objectives
Pigment epithelium-derived factor (PEDF) is a glycoprotein that belongs to the superfamily of serine protease inhibitors with complex anti-oxidative, anti-fibrotic, and anti-inflammatory properties, thus being involved in cardiometabolic disorders. Nonalcoholic fatty liver disease (NAFLD) is a hepatic manifestation of the metabolic syndrome as well. However, the pathophysiological role of PEDF in NAFLD remains largely unknown. We studied here the relationship between serum PEDF levels and various clinical markers of NAFLD in humans.Design and methods
The study involved 194 biopsy-proven NAFLD patients (102 male and 92 female) with a mean age of 51.3 ± 13.8 years. We examined which anthropometric, metabolic and inflammatory variables, and liver steatosis and fibrosis markers are independently associated with serum levels of PEDF.Results
Mean serum levels of PEDF were 16.4 ± 5.7 μg/mL. Univariate analysis revealed that age (inversely), male, body mass index, waist circumference, numbers of white blood cells and platelets, aspartate aminotransferase, alanine aminotransferase, fasting plasma glucose, glycated hemoglobin, uric acid, procollagen type III N-terminal peptide (P-III-P), subcutaneous fat areas, visceral fat areas and liver to spleen density ratio in computed tomography, the presence of diabetes and medication for hyperlipidemia were significantly associated with serum levels of PEDF. In multiple stepwise regression analysis, age (p < 0.01, inversely), male (p < 0.05), waist circumference (p < 0.01), white blood cell number (p < 0.05), P-III-P (p < 0.05), and the presence of diabetes (p < 0.05) and medication for hyperlipidemia (p < 0.01), were independently correlated to serum levels of PEDF (R2 = 0.285).Conclusions
The present study reveals that serum levels of PEDF are independently associated with P-III-P levels, suggesting that PEDF level is a novel biomarker of liver fibrosis in patients with NAFLD. 相似文献102.
目的评价联合应用空腹血糖和糖化血红蛋白(HbA1c)检测对糖尿病筛查的临床价值。方法对8669名特定人群,同时进行空腹血糖和糖化血红蛋白(HbA1c)检测,所得数据进行对比分析。结果单独以空腹血糖大于等于6.1mmol/L筛查出的糖尿病风险人群为743人,占总检测人数的8.6%;单独以糖化血红蛋白(HbA1c)大于等于6%筛查出的糖尿病风险人群为627人,占总检测人数的7.2%;联合两种检测进行筛查,以两个指标中任何一个超过切点的都筛出来,可筛查出943人,风险筛出率为10.9%;通过统计学分析,差异有统计学意义(P﹤0.01)。结论空腹血糖或糖化血红蛋白(HbA1c)单个指标进行糖尿病风险筛查,都会有一部分可疑人群无法筛出,二者联合应用,可以筛查出更多处于糖尿病风险的可疑人群。 相似文献
103.
目的研究空腹血糖(FPG)与心血管危险因素的关系。方法将195例健康体检人员根据FPG水平分为3组,A组65例,FPG<5.6 mmol/L;B组64例,FPG<6.1 mmol/L;C组66例,FPG<7.0 mmol/L。检测各组FPG、空腹胰岛素、血脂、血尿酸(UA)、瘦素(LEP)等,并进行分析。结果 B组的UA、HOMA-IR、LEP水平显著高于A组,高密度脂蛋白(HDL-C)水平显著低于A组(P<0.05),而各项指标与C组差异无统计学意义(P>0.05)。结论随着FPG增高可出现胰岛素抵抗加重、血脂异常、UA增高及低度炎症反应,可增加糖尿病及心血管病的发病风险。 相似文献
104.
Masoume Mansouri Roshanak Abasi Morteza Nasiri Farshad Sharifi Sedyghe Vesaly Omid Sadeghi Nayere Rahimi Nasrin Akbary Sharif 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(3):393-398
Aim
We aimed to assess the association of vitamin D status with metabolic syndrome and its components among high educated Iranian adults.Method
In this cross-sectional study, 352 faculty members with age of 35?years or more, belong to Tarbiat Modares University, Tehran, Islamic Republic of Iran, were recruited during 2016 and 2017. Fasting blood samples were obtained to quantify serum 25(OH)D concentrations, glycemic indicators and lipid profile. Metabolic syndrome was defined based on the guidelines of the National Cholesterol Education Program Adult Treatment Panel III (ATP III). Multivariate logistic regression adjusted for potential confounders was used to evaluate the association between vitamin D status and metabolic syndrome.Result
Metabolic syndrome and vitamin D insufficiency were prevalent among 26% and 60.2% of subjects, respectively. There was no statistically significant difference in the prevalence of metabolic syndrome across quartiles of 25(OH)D levels either before or after adjusting for potential confounders (OR: 0.94, 95% CI: 0.43–1.95). In terms of metabolic syndrome components, subjects in the highest quartile of vitamin D levels had 59% decreased risk of abdominal obesity compared with those in the lowest quartile (OR: 0.41, 95% CI: 0.17–0.99), after adjusting for potential confounders. Such inverse relationship was also seen for elevated blood pressure (OR: 0.37, 95% CI: 0.14–0.99), and abnormal glucose homeostasis (OR: 0.40, 95% CI: 0.19–0.85).Conclusion
Serum levels of 25(OH)D was inversely associated with the risk of abdominal obesity, hypertension, and abnormal glucose homeostasis. However, no significant relationship was seen for metabolic syndrome. 相似文献105.
Mohsen Janghorbani Nouralddin Soltanian Masoud Amini Ashraf Aminorroaya 《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2018,12(5):715-719
Background
Studies reported that lipid-lowering treatment may increase the risk of diabetes, support the hypothesis that low-density lipoprotein cholesterol (LDLC) may be associated with type 2 diabetes (T2D).Objective
The aim of this study was to assess the association between the LDLC levels and the incidence of T2D in an Iranian high-risk population not treated with lipid-lowering medications.Methods
Mean 10-year follow-up data (1819) in non-diabetic first-degree relatives (FDR) of consecutive patients with T2D 30–70 years old, who were not treated with lipid-lowering drugs at baseline were examined. The diagnosis of T2D based on serial oral glucose tolerance test was the primary outcome. Cox proportional hazard model was used to estimate the hazard ratio (HR) for the incidence of T2D within tertiles of LDLC.Results
A higher LDLC concentration was significantly associated with higher risk of T2D. Compared with the first tertile, the adjusted risk of T2D increased for the second (HR 1.20, 95% CI: 1.07, 1.35, P?<?0.01) and third (HR 1.22, 95% CI: 1.08, 1.37, P?<?0.01), tertiles of LDLC.Conclusions
While these results await confirmation, a higher LDLC level was significantly associated with higher risk of T2D, independent of age, gender, fasting plasma glucose, waist circumference or blood pressure, in high-risk individuals in Iran. 相似文献106.
P. Di Bonito E. Miraglia del Giudice C. Chiesa M.R. Licenziati M. Manco F. Franco G. Tornese M.G. Baroni A. Morandi C. Maffeis L. Pacifico G. Valerio 《Nutrition, metabolism, and cardiovascular diseases : NMCD》2018,28(12):1230-1236
Background and aims
We aimed to evaluate whether the metabolically healthy obese (MHO) phenotype was associated with hepatic steatosis (HS) or left ventricular hypertrophy (LVH) in young people with overweight (OW), obesity (OB) and morbid obesity (MOB) and whether the prevalence of these comorbidities was affected by OB severity.Methods and results
An abdominal ultrasound was performed in 1769 children and adolescents, mean age 10.6 years (range 5–18) with MHO phenotype, defined as the absence of traditional cardiometabolic risk factors, in order to identify HS. In a subsample of 177 youth the presence of LVH, defined by 95th percentile of LV mass/h2.7 for age and gender, was also analyzed. The prevalence of HS increased from 23.0% in OW to 27.8% in OB and 45.1% in MOB (P < 0.0001). The proportion of LVH increased from 36.8% in OW to 57.9% in OB and 54.5% in MOB (P < 0.05). As compared with OW, the odds ratio (95% CI) for HS was 2.18 (1.56–3.05), P < 0.0001) in OB and 6.20 (4.26–9.03), P < 0.0001) in MOB, independently of confounding factors. The odds ratio for LVH was 2.46 (1.20–5.06), P < 0.025) in OB and 2.79 (1.18–6.61), P < 0.025) in MOB, as compared with OW.Conclusion
In spite of the absence of traditional cardiometabolic risk factors, the prevalence of HS and LVH progressively increased across BMI categories. MHO phenotype does not represent a “benign” condition in youth. 相似文献107.
108.
《Nutrition, metabolism, and cardiovascular diseases : NMCD》2022,32(12):2830-2838
Background & aimsThis study aimed to investigate whether neck circumference (NC) could be used to predict future cardiovascular (CV) events in a community-based Chinese cohort.Methods and resultsWe enrolled 1435 participants aged 50–80 years (men, 43.62%) from communities in Shanghai. High NC was defined as NC ≥ 38.5 cm in men and NC ≥ 34.5 cm in women. Kaplan-Meier analysis and Cox proportional hazards regression were performed to explore the association between NC and CV events. During a mean follow-up period of 7.6 years, 148 CV events (10.31%) occurred. The incidence of CV events was higher in men than in women (83 (13.26%) vs. 65 (8.03%), P = 0.002). Multivariable-adjusted Cox regression analysis showed that for every 1-SD increase in NC in the whole population, the hazard ratio (HR) of CV events was 1.45 (95% confidence interval [CI], 1.15–1.83). The dose-response association between NC and CV events was significant in men (HR, 1.37, 95% CI, 1.10–1.71) but not in women (HR, 1.19, 95% CI, 0.94–1.52). In comparison with participants showing low baseline NC, those with high baseline NC showed a significantly higher risk of CV events (HR, 1.59, 95% CI, 1.14–2.22). Further stratified by sex, the positive association remained significant in men (HR, 1.90, 95% CI, 1.21–2.98) but not in women (HR, 1.25, 95% CI, 0.75–2.07).ConclusionNC was significantly associated with the risk of future CV events in middle-aged and elderly populations in the community and was a better predictor in men. 相似文献
109.
《Diabetes & Metabolic Syndrome: Clinical Research & Reviews》2016,10(4):247-249
BackgroundDiabetic kidney disease is the most common cause of chronic kidney disease, leading to end-stage renal disease (ESRD) and premature death. In addition, it negatively affects a patient’s quality of life and social environment, and poses a burden on national health care budgets. Although various therapeutic approaches, such as hypoglycemic agents, antihypertensive drugs, and renin-angiotensin system inhibitors, have been tried to slow the progression of nephropathy, the number of patients with diabetic kidney disease continues to rise with the prevalence of type 2 diabetes mellitus. Thus, early identification of patients at risk of developing diabetic nephropathy and initiation of appropriate therapy is important to improve patient outcomes. In end stage renal disease (ESRD), diabetic nephropathy is the main cause considered from other diseases. 相似文献
110.
目的 探讨非内分泌科室联合检测HbA1c与FPG筛查高血糖的最佳方法. 方法 选取心内科和骨科新入院,且随机血糖≥7.0 mmol/L或FPG≥5.0mmol/L的非糖尿病患者,检测FPG、HbA1c、糖化血清蛋白(GA),评估患者糖代谢状态. 结果 (1)心内科IGR、糖尿病和糖耐量正常(NGT)者分别为185例、178例、163名,骨科分别为116例、130例、107名.(2)75 g OGTT受试者工作特征曲线(ROC)显示,以FPG为诊断糖尿病切点,心内科为5.81 mmol/L,骨科为6.24 mmol/L;以HbA1 c为诊断切点,心内科为6.15%,骨科为5.75%;以GA为诊断切点,心内科为254.50μmol/L,骨科为250.89μmol/L.(3)FPG和HbA1c联合诊断价值与75 g OGTT比较有效性更高[曲线下面积(AUC>0.8)]. 结论 HbA1c与FPG联合检测能进一步提高非内分泌科住院患者的高血糖筛查效率. 相似文献