Research on Penetration Rules of LY-12cz Thin Sheet Subjected to Rod-Shaped Fragment

By establishing the finite element models and corresponding calculation methods for the target board and rod-shaped fragment, the penetration effect of the high-velocity rod-shaped fragments＇ impact on the LY- 12cz thin sheet is analyzed by analog calculation. The variation rules of the residual velocity and residual mass of fragments, chock mass and crevasse shape are obtained when the fragment penetrates target board with different incidence velocities and attack angles. Corresponding fitting computation formulas are concluded from the above calculating data. The conclusions are helpful to analyzing the destructivity of fragment and protective ability of aircraft structure. In addition, they can guide the research for battle damage mode and assessment effectively.     

啤酒腐败菌分子检测技术的研究进展

对啤酒腐败菌检测中分子检测技术应用的研究进展作一综述。内容包括聚合酶链式反应，限制性片段长度多态性，免疫学技术，核酸杂交，伏安型生物传感器。     

桉木浆细小纤维表面化学特性

以漂白KP桉木浆中的原生细小纤维(P200)和长纤维(R30)打浆剥落的细小纤维碎片(P′200)为研究对象,发现它们在物理形态与表面化学性能方面存在明显差异。研究结果表明:细小纤维中戊聚糖含量P200为26.16%,P′200为20.06%;羧基含量P200为6.386 mmol/100 g绝干浆,P′200为5.484 mmol/100 g绝干浆;灰分含量P200是P′200的3.6倍;比表面积P200为14.36 m2/g绝干浆,P′200为91.66 m2/g绝干浆。细小纤维比原浆有更大的保水值,且细小纤维的保水值随着系统pH值的升高而增大;P2′00比P200吸附有更多的水和更高的阳离子需求量。纸浆系统电导率的升高对P200的保水值基本上没有影响,对原浆和P′200的水化程度有一定的压缩作用,且都呈缓慢下降趋势。     

Labeling of Anti-MUC-1 Binding Single Chain Fv Fragments to Surface Modified Upconversion Nanoparticles for an Initial in Vivo Molecular Imaging Proof of Principle Approach

In vivo optical Imaging is an inexpensive and highly sensitive modality to investigate and follow up diseases like breast cancer. However, fluorescence labels and specific tracers are still works in progress to bring this promising modality into the clinical day-to-day use. In this study an anti-MUC-1 binding single-chain antibody fragment was screened, produced and afterwards labeled with newly designed and surface modified NaYF(4):Yb,Er upconversion nanoparticles as fluorescence reporter constructs. The MUC-1 binding of the conjugate was examined in vitro and in vivo using modified state-of-the-art small animal Imaging equipment. Binding of the newly generated upconversion nanoparticle based probe to MUC-1 positive cells was clearly shown via laser scanning microscopy and in an initial proof of principal small animal optical imaging approach.     

NAD(P)H:Quinone Oxidoreductase 1 (NQO1) P187S Polymorphism and Prostate Cancer Risk in Caucasians

NAD(P)H:quinone oxidoreductase 1 (NQO1) catalyses the reduction of quinoid compounds to hydroquinones, preventing the generation of free radicals and reactive oxygen. A “C” to “T” transversion at position 609 of NQO1, leading to a nonsynonymous amino acid change (Pro187Ser, P187S), results in an altered enzyme activity. No NQO1 protein activity was detected in NQO1 ⁶⁰⁹TT genotype, and low to intermediate activity was detected in NQO1 ⁶⁰⁹CT genotype compared with ⁶⁰⁹CC genotype. Thus, this polymorphism may result in altered cancer predisposition. For prostate cancer, only sparse data are available. We therefore analyzed the distribution of the NQO1 P187S SNP (single nucleotide polymorphism) in prostate cancer patients and a healthy control group. Allelic variants were determined using RFLP analysis. Overall, 232 patients without any malignancy and 119 consecutive prostate cancer patients were investigated. The genotype distribution in our cohorts followed the Hardy–Weinberg equilibrium in cases and controls. The distribution of the NQO1 codon 187 SNP did not differ significantly between prostate cancer patients and the control group (p = 0.242). There was also no association between the allelic variants and stage or Gleason score of the tumors. The NQO1 P187S SNP was not significantly associated with an increased prostate cancer risk in our cohorts. The SNP has also no influence on histopathological characteristics of the tumors. A combined analysis of all available data from published European studies also showed no significant differences in the genotype distribution between controls and prostate cancer patients. Our data suggest a minor role of the NQO1 nucleotide 609 polymorphism in prostate carcinogenesis.     

碎片复写：高强度再利用背景下的首钢 北京冬奥组委总部景观设计营建

当今中国乃至其他国家和地区,对工业旧址采取高强度再开发的模式已成为趋势,工业建筑及户外场所面临存亡的巨大挑战,如何认识和尊重工业遗存成为此类后工业改造项目面临的新课题。随着首钢的搬迁与转型,作为首钢发展的起点与北部对外门户的西十筒仓区域,成为北京冬奥组委总部落户之选。面对建筑的先行与价值的不认同所带来的工业体系破碎化,景观设计重拾了工业系统的价值,在阅读并尊重原有工业空间逻辑的基础上,对原有地形结构进行创造性复写,并将重译的工业碎片谨慎地嵌入景观体系中。"碎片复写"设计方式的提出为高强度开发背景下的工业旧址再利用乃至城市空间更新如何兼顾科学与艺术、法则与自由提供了策略。     

破片对巡航导弹燃油舱冲击引燃的实验研究

为提高导弹对抗生存能力和拦截弹药摧毁来袭导弹的毁伤概率,以巡航导弹燃油舱为研究对象进行了巡航导弹的易损性和毁伤效应研究。利用弹道枪加速发射钢球破片,以不同入射角对加热至75℃的模拟巡航导弹燃油舱等效靶进行了冲击引燃毁伤作用实验,研究了模拟巡航导弹燃油舱在不同打击条件下的毁伤模式,分析了其毁伤机理,给出了模拟巡航导弹燃油舱在不同打击条件下的冲击引燃判据。结果表明,燃油舱温度升高会使其冲击引燃所要求的破片着靶比冲量增大;当破片入射角度大于30°时,燃油舱冲击引燃所需破片的着靶比冲量随破片入射角度的增大而减小。     

柱形破片冲击带壳装药起爆判据研究

为得到柱形破片撞击带壳装药的临界起爆判据,在一维脉冲冲击起爆判据及长杆判据的基础上,构建一种破片撞击起爆带薄壳炸药的等效模型。将破片撞击带壳装药的过程等效为破片撞击裸装药,导出包含破片长度、直径以及炸药壳体厚度等参量的临界起爆判据,并利用仿真软件对所得结论进行模拟验证。仿真结果表明：当壳体厚度较薄时,冲击波冲击起爆是炸药发生爆轰的主控机制,数值模拟与理论计算结果基本一致,该起爆判据适用,且破片长径比存在临界值,当破片长径大于该临界值时,破片长径比的变化对临界起爆速度影响很小。     

Antibody-mediated Prevention of Fusarium Mycotoxins in the Field

Fusarium mycotoxins directly accumulated in grains during the infection of wheat and other cereal crops by Fusarium head blight (FHB) pathogens are detrimental to humans and domesticated animals. Prevention of the mycotoxins via the development of FHB-resistant varieties has been a challenge due to the scarcity of natural resistance against FHB pathogens. Various antibodies specific to Fusarium fungi and mycotoxins are widely used in immunoassays and antibody-mediated resistance in planta against Fusarium pathogens has been demonstrated. Antibodies fused to antifungal proteins have been shown to confer a very significantly enhanced Fusarium resistance in transgenic plants. Thus, antibody fusions hold great promise as an effective tool for the prevention of mycotoxin contaminations in cereal grains. This review highlights the utilization of protective antibodies derived from phage display to increase endogenous resistance of wheat to FHB pathogens and consequently to reduce mycotoxins in field. The role played by Fusarium-specific antibody in the resistance is also discussed.