Experimental Methods for Evaluating the Bacterial Uptake of Trojan Horse Antibacterials

The field of antibacterial siderophore conjugates, referred to as Trojan Horse antibacterials, has received increasing attention in recent years, driven by the rise of antimicrobial resistance. Trojan Horse antibacterials offer an opportunity to exploit the specific pathways present in bacteria for active iron uptake, potentially allowing the drugs to bypass membrane-associated resistance mechanisms. Hence, the Trojan Horse approach might enable the redesigning of old antibiotics and the development of antibacterials that target specific pathogens. Critical parts of evaluating such Trojan Horse antibacterials and improving their design are the quantification of their bacterial uptake and the identification of the pathways by which this occurs. In this minireview, we highlight a selection of the biological and chemical methods used to study the uptake of Trojan Horse antibacterials, exemplified with case studies, some of which have led to drug candidates in clinical development or approved antibiotics.     

基于特征码扫描的挂马监控技术研究

在电子政务越来越普及和重要的今天,政府门户网站的安全不容乐观,如何及时地发现政务网站被挂马并及时通知管理者成为当前政务信息化支撑建设的一个重点。本文结合脚本和反病毒扫描技术,设计了一种基于特征码扫描技术的B/S架构政务门户网站挂马监控系统。     

Nutritional implications and flour functionality of popped/expanded horse gram

Utilization of horse gram and its flour in legume composite flours and products is limited due to the presence of antinutritional components, poor functional and expansion properties. Enzymatic treatment was used to improve the expansion and functional properties of horse gram to facilitate its use as an ingredient in food processing. Xylanase-mediated depolymerization of cell wall polysaccharides of horse gram lead to the development of a new expanded/popped horse gram. Expansion process of enzyme treated horse gram resulted in increased length (5.3–6.8 mm) and higher yield of expanded grains (63–98%). The expanded horse gram had lower bulk density, higher protein digestibility and more resistant starch compared to the control raw grains. Dietary fibre content of raw and processed horse gram was in the range of 14.57–16.14%. High temperature short time (HTST) conditions used during expansion process lowered the levels of phytic acid, tannins and protease inhibitors by 46%, 61% and 92%, respectively. The flour obtained from xylanase treated and expanded horse gram had higher water (204.3 g/100 g) and oil absorption capacities (98.4 g/100 g) than unprocessed flour, which had 135.8 g/100 g and 74.6 g/100 g, respectively at ambient conditions. There was a decrease in foaming capacity and foam stability in expanded gram flour. However, emulsion stability increased significantly in the processed samples. Thus, the study indicated that nutritional value and flour functionality of horse gram could be improved by processing it into a new expanded product that can be used as an ingredient in food processing.     

如何通过端口防木马

上网就是本地计算机和其它计算机传递数据的过程, 如果你(包括木马) 要传递数据必须要用到端口, 因此, 合理地管理端口能有效地预防木马。     

稀水溶液中辣根过氧化物酶和葡萄糖氧化酶辐射失活、后失活及保护效应研究

报道了在稀水溶液中辣根过氧化物酶的辐射失活,并发现有辐射后失活现象。氧是后失活的必要条件;水辐解的分子产物H_2O_2对诱发这一后失活现象起一定作用。微量络合剂EDTA、GDTA等对辣根过氧化酶的辐射失活与后失活有不同程度的保护作用。在稀水溶液中葡萄糖氧化酶的辐射失活亦很严重,但却未发现有后失活现象。     

发酵剂对熏马肠挥发性风味化合物的影响

通过顶空固相微萃取-气相色谱-质谱联用技术(HS-SPME-GC-MS)测定熏马肠中的挥发性风味物质。从5个不同样品中共鉴定出106种风味物质,包括烃类、醇类、酯类、酸类、醛类、酮类、酚类、呋喃类、含氮类等化合物。其中烃类、醇类、酸类、酮类、酚类化合物含量较高,空白组和发酵剂组熏马肠中挥发性风味化合物的种类和含量都存在着一定的差别。     

木马的攻击与防范技术研究

木马技术是最常见的网络攻击手段之一,它对网络环境中计算机信息资源造成了很大的危害。文中介绍了木马程序的概念、基本原理和分类,针对常见的木马攻击方式提出了一些防范措施。     

太阳以西,国境以南--十三世纪野蛮女友的尴尬处境

本运用独一无二性和权宜性这一对概念及其相互关系,分析元代杂剧《裴少俊墙头马上》中女主人公李千金在追求爱情的过程中无奈矛盾的处境,同时分析独一无二性和权宜性这一对关系在社会生活中的表现和影响。